C18orf54 (chromosome 18 open reading frame 54)

Gene

• Entrez ID: 162681
• Gene name: Chromosome 18 open reading frame 54
• Gene symbol: C18orf54
• Synonyms (NCBI Gene): LAS2
• Chromosome: 18
• Chromosome location: 18q21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024288	hsa-miR-215-5p	Microarray	19074876
MIRT026344	hsa-miR-192-5p	Microarray	19074876
MIRT837803	hsa-miR-103a	CLIP-seq
MIRT837804	hsa-miR-107	CLIP-seq
MIRT837805	hsa-miR-1271	CLIP-seq
MIRT837806	hsa-miR-129-5p	CLIP-seq
MIRT837807	hsa-miR-1303	CLIP-seq
MIRT837808	hsa-miR-133a	CLIP-seq
MIRT837809	hsa-miR-133b	CLIP-seq
MIRT837810	hsa-miR-135a	CLIP-seq
MIRT837811	hsa-miR-135b	CLIP-seq
MIRT837812	hsa-miR-15a	CLIP-seq
MIRT837813	hsa-miR-15b	CLIP-seq
MIRT837814	hsa-miR-16	CLIP-seq
MIRT837815	hsa-miR-195	CLIP-seq
MIRT837816	hsa-miR-2278	CLIP-seq
MIRT837817	hsa-miR-23a	CLIP-seq
MIRT837818	hsa-miR-23b	CLIP-seq
MIRT837819	hsa-miR-23c	CLIP-seq
MIRT837820	hsa-miR-3123	CLIP-seq
MIRT837821	hsa-miR-3148	CLIP-seq
MIRT837822	hsa-miR-3162-5p	CLIP-seq
MIRT837823	hsa-miR-3192	CLIP-seq
MIRT837824	hsa-miR-325	CLIP-seq
MIRT837825	hsa-miR-340	CLIP-seq
MIRT837826	hsa-miR-3605-5p	CLIP-seq
MIRT837827	hsa-miR-3613-3p	CLIP-seq
MIRT837828	hsa-miR-3653	CLIP-seq
MIRT837829	hsa-miR-3689a-3p	CLIP-seq
MIRT837830	hsa-miR-3689c	CLIP-seq
MIRT837831	hsa-miR-375	CLIP-seq
MIRT837832	hsa-miR-3915	CLIP-seq
MIRT837833	hsa-miR-3925-5p	CLIP-seq
MIRT837834	hsa-miR-3928	CLIP-seq
MIRT837835	hsa-miR-3978	CLIP-seq
MIRT837836	hsa-miR-424	CLIP-seq
MIRT837837	hsa-miR-4261	CLIP-seq
MIRT837838	hsa-miR-4273	CLIP-seq
MIRT837839	hsa-miR-4423-3p	CLIP-seq
MIRT837840	hsa-miR-4428	CLIP-seq
MIRT837841	hsa-miR-4635	CLIP-seq
MIRT837842	hsa-miR-4677-5p	CLIP-seq
MIRT837843	hsa-miR-4699-3p	CLIP-seq
MIRT837844	hsa-miR-4728-5p	CLIP-seq
MIRT837845	hsa-miR-4738-3p	CLIP-seq
MIRT837846	hsa-miR-4781-3p	CLIP-seq
MIRT837847	hsa-miR-4789-5p	CLIP-seq
MIRT837848	hsa-miR-497	CLIP-seq
MIRT837849	hsa-miR-502-5p	CLIP-seq
MIRT837850	hsa-miR-526b	CLIP-seq
MIRT837851	hsa-miR-548g	CLIP-seq
MIRT837852	hsa-miR-567	CLIP-seq
MIRT837853	hsa-miR-570	CLIP-seq
MIRT837854	hsa-miR-577	CLIP-seq
MIRT837855	hsa-miR-578	CLIP-seq
MIRT837856	hsa-miR-579	CLIP-seq
MIRT837857	hsa-miR-582-3p	CLIP-seq
MIRT837858	hsa-miR-628-3p	CLIP-seq
MIRT837859	hsa-miR-96	CLIP-seq
MIRT1948246	hsa-miR-1238	CLIP-seq
MIRT1948247	hsa-miR-3121-5p	CLIP-seq
MIRT1948248	hsa-miR-3129-3p	CLIP-seq
MIRT1948249	hsa-miR-3545-3p	CLIP-seq
MIRT1948250	hsa-miR-4289	CLIP-seq
MIRT1948251	hsa-miR-4422	CLIP-seq
MIRT1948252	hsa-miR-4432	CLIP-seq
MIRT837841	hsa-miR-4635	CLIP-seq
MIRT1948253	hsa-miR-4645-3p	CLIP-seq
MIRT1948254	hsa-miR-4704-3p	CLIP-seq
MIRT1948255	hsa-miR-4753-3p	CLIP-seq
MIRT1948256	hsa-miR-499-5p	CLIP-seq
MIRT1948257	hsa-miR-542-3p	CLIP-seq
MIRT1948258	hsa-miR-548a-5p	CLIP-seq
MIRT1948259	hsa-miR-548ab	CLIP-seq
MIRT1948260	hsa-miR-548ak	CLIP-seq
MIRT1948261	hsa-miR-548b-5p	CLIP-seq
MIRT1948262	hsa-miR-548c-5p	CLIP-seq
MIRT1948263	hsa-miR-548d-5p	CLIP-seq
MIRT1948264	hsa-miR-548h	CLIP-seq
MIRT1948265	hsa-miR-548i	CLIP-seq
MIRT1948266	hsa-miR-548j	CLIP-seq
MIRT1948267	hsa-miR-548w	CLIP-seq
MIRT1948268	hsa-miR-548y	CLIP-seq
MIRT1948269	hsa-miR-559	CLIP-seq
MIRT837856	hsa-miR-579	CLIP-seq
MIRT1948270	hsa-miR-587	CLIP-seq
MIRT1948271	hsa-miR-664	CLIP-seq
MIRT2186290	hsa-miR-194	CLIP-seq
MIRT2186291	hsa-miR-2117	CLIP-seq
MIRT1948248	hsa-miR-3129-3p	CLIP-seq
MIRT2186292	hsa-miR-3144-5p	CLIP-seq
MIRT2186293	hsa-miR-3607-3p	CLIP-seq
MIRT2186294	hsa-miR-3649	CLIP-seq
MIRT2186295	hsa-miR-3686	CLIP-seq
MIRT1948251	hsa-miR-4422	CLIP-seq
MIRT837841	hsa-miR-4635	CLIP-seq
MIRT2186296	hsa-miR-543	CLIP-seq
MIRT2490416	hsa-miR-1224-3p	CLIP-seq
MIRT2490417	hsa-miR-1261	CLIP-seq
MIRT2490418	hsa-miR-1302	CLIP-seq
MIRT2490419	hsa-miR-1912	CLIP-seq
MIRT2490420	hsa-miR-3179	CLIP-seq
MIRT2490421	hsa-miR-3614-3p	CLIP-seq
MIRT2490422	hsa-miR-3646	CLIP-seq
MIRT2490423	hsa-miR-3662	CLIP-seq
MIRT2490424	hsa-miR-3977	CLIP-seq
MIRT2490425	hsa-miR-4298	CLIP-seq
MIRT2490426	hsa-miR-4648	CLIP-seq
MIRT2490427	hsa-miR-4668-3p	CLIP-seq
MIRT2490428	hsa-miR-4693-3p	CLIP-seq
MIRT2490429	hsa-miR-4742-3p	CLIP-seq
MIRT2490430	hsa-miR-494	CLIP-seq
MIRT2490431	hsa-miR-548aa	CLIP-seq
MIRT2490432	hsa-miR-548ac	CLIP-seq
MIRT2490433	hsa-miR-548ae	CLIP-seq
MIRT2490434	hsa-miR-548aj	CLIP-seq
MIRT2490435	hsa-miR-548am	CLIP-seq
MIRT2490436	hsa-miR-548d-3p	CLIP-seq
MIRT2490437	hsa-miR-548x	CLIP-seq
MIRT2490438	hsa-miR-548z	CLIP-seq
MIRT2490416	hsa-miR-1224-3p	CLIP-seq
MIRT2490417	hsa-miR-1261	CLIP-seq
MIRT2490419	hsa-miR-1912	CLIP-seq
MIRT2490427	hsa-miR-4668-3p	CLIP-seq
MIRT2676635	hsa-miR-4705	CLIP-seq
MIRT2676636	hsa-miR-4766-5p	CLIP-seq
MIRT2676637	hsa-miR-539	CLIP-seq
MIRT2490431	hsa-miR-548aa	CLIP-seq
MIRT2490432	hsa-miR-548ac	CLIP-seq
MIRT2490433	hsa-miR-548ae	CLIP-seq
MIRT2490434	hsa-miR-548aj	CLIP-seq
MIRT2490435	hsa-miR-548am	CLIP-seq
MIRT2490436	hsa-miR-548d-3p	CLIP-seq
MIRT2490437	hsa-miR-548x	CLIP-seq
MIRT2490438	hsa-miR-548z	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 32296183, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA

Other IDs

• MIM: 613258
• HGNC: 13796
• e!Ensembl: ENSG00000166845

Protein

• UniProt ID: Q8IYD9
• Protein name: Lung adenoma susceptibility protein 2
• Protein function: Might play a role in cell proliferation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15792	LAS2	161 → 233	Lung adenoma susceptibility protein 2	Family

• Sequence:

  MAKSKTKHRLCSQESSVSALLASCTLSGSNSSNSDGSFHYKDKLYRSASQALQAYIDDFD
  LGQIYPGASTGKINIDEDFTNMSQFCNYIYKPNNAFENLDHKKHSNFISCRRHTVNDIDS
  MSLTTDDLLRLPADGSFSYTYVGPSHRTSKKNKKCRGRLGSLDIEKNPHFQGPYTSMGKD
  NFVTPVIRSNINGKQCGDKIELLILKAKRNLEQCTEELPKSMKKDDSPCSLDKLEADRSW
  ENIPVTFKSPVPVNSDDSPQQTSRAKSAKGVLEDFLNNDNQSCTLSGGKHHGPVEALKQM
  LFNLQAVQERFNQNKTTDPKEEIKQVSEDDFSKLQLKESMIPITRSLQKALHHLSRLRDL
  VDDTNGERSPKM

• Sequence length: 372

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	19622765		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	19622765		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19622765		★☆☆☆☆ Found in Text Mining only