SPRED1 (sprouty related EVH1 domain containing 1)

Gene

• Entrez ID: 161742
• Gene name: Sprouty related EVH1 domain containing 1
• Gene symbol: SPRED1
• Synonyms (NCBI Gene): LGSS, NFLS, PPP1R147, hSpred1, spred-1
• Chromosome: 15
• Chromosome location: 15q14
• Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activatio

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs115440602	C>T	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs121434312	C>T	Pathogenic	Coding sequence variant, stop gained
rs121434313	C>T	Pathogenic	Coding sequence variant, stop gained
rs121434314	C>G,T	Pathogenic	Missense variant, coding sequence variant, stop gained
rs121434315	C>T	Pathogenic	Coding sequence variant, stop gained
rs121434316	C>T	Pathogenic	Coding sequence variant, stop gained
rs121434317	A>T	Pathogenic	Coding sequence variant, stop gained
rs121434318	T>A	Pathogenic	Missense variant, coding sequence variant
rs147204964	G>A	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs147474792	C>T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs750777752	C>A,G,T	Pathogenic	Stop gained, coding sequence variant, missense variant, 5 prime UTR variant, synonymous variant
rs754706111	C>G,T	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs864622410	AT>-	Pathogenic	Frameshift variant, coding sequence variant
rs878855228	AG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1057517941	C>T	Pathogenic	Stop gained, 5 prime UTR variant, coding sequence variant
rs1057517943	GGAAAATGTCAGG>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1057518150	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057518683	C>T	Pathogenic	Stop gained, coding sequence variant
rs1060502505	C>T	Pathogenic	Stop gained, coding sequence variant
rs1555389690	G>T	Pathogenic	Stop gained, coding sequence variant
rs1555391053	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1555391061	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555391161	T>C	Pathogenic	Splice donor variant
rs1555392032	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1555392609	C>T	Pathogenic	Stop gained, coding sequence variant
rs1555392750	->TA	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1555392759	CT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555392783	AGTT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555392791	->A	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1566867209	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1566867246	CTTACGT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1566868022	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1566868058	G>A	Pathogenic	Splice donor variant
rs1566876690	T>G	Likely-pathogenic	Coding sequence variant, stop gained
rs1566876895	C>T	Pathogenic	Coding sequence variant, stop gained
rs1566876929	TAG>C	Pathogenic	Coding sequence variant, frameshift variant
rs1566876941	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1566876954	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1595733611	G>A	Likely-pathogenic	Splice donor variant
rs1595746834	->GT	Pathogenic	Coding sequence variant, frameshift variant
rs1595746858	->CTAG	Likely-pathogenic	Coding sequence variant, inframe indel, stop gained
rs1595763557	G>A	Pathogenic	Coding sequence variant, stop gained
rs1595763656	->T	Pathogenic	Coding sequence variant, stop gained
rs1595763659	AAGTT>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1595763662	GTTA>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1595763925	AGAG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1595763928	A>-	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000343	hsa-miR-126-3p	Luciferase reporter assay	18694566
MIRT000343	hsa-miR-126-3p	Review	20029422
MIRT004643	hsa-miR-126-5p	Review	20029422
MIRT000343	hsa-miR-126-3p	Luciferase reporter assay	18832181
MIRT000343	hsa-miR-126-3p	Luciferase reporter assay, Western blot	18987025
MIRT000343	hsa-miR-126-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	22525256
MIRT018666	hsa-miR-335-5p	Microarray	18185580
MIRT019967	hsa-miR-375	Microarray	20215506
MIRT021849	hsa-miR-132-3p	Microarray	17612493
MIRT027190	hsa-miR-103a-3p	Sequencing	20371350
MIRT028118	hsa-miR-93-5p	Sequencing	20371350
MIRT031930	hsa-miR-16-5p	Sequencing	20371350
MIRT437883	hsa-miR-1-3p	Luciferase reporter assay, Western blot	23625462
MIRT000343	hsa-miR-126-3p	qRT-PCR, Western blot	23811937
MIRT000343	hsa-miR-126-3p	qRT-PCR, Western blot	23811937
MIRT192434	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT706952	hsa-miR-589-3p	HITS-CLIP	21572407
MIRT706951	hsa-miR-138-1-3p	HITS-CLIP	21572407
MIRT706950	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT706949	hsa-miR-1277-3p	HITS-CLIP	21572407
MIRT706948	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT706465	hsa-miR-4695-5p	HITS-CLIP	22927820
MIRT380522	hsa-miR-4768-3p	HITS-CLIP	22927820
MIRT380521	hsa-miR-4459	HITS-CLIP	22927820
MIRT380519	hsa-miR-665	HITS-CLIP	22927820
MIRT706464	hsa-miR-6840-3p	HITS-CLIP	22927820
MIRT706463	hsa-miR-3160-3p	HITS-CLIP	22927820
MIRT706462	hsa-miR-558	HITS-CLIP	22927820
MIRT706461	hsa-miR-4487	HITS-CLIP	22927820
MIRT706460	hsa-miR-6087	HITS-CLIP	22927820
MIRT706459	hsa-miR-377-5p	HITS-CLIP	22927820
MIRT706458	hsa-miR-6086	HITS-CLIP	22927820
MIRT706457	hsa-miR-4722-5p	HITS-CLIP	22927820
MIRT706455	hsa-miR-6499-3p	HITS-CLIP	22927820
MIRT706456	hsa-miR-658	HITS-CLIP	22927820
MIRT706454	hsa-miR-25-5p	HITS-CLIP	22927820
MIRT706453	hsa-miR-455-3p	HITS-CLIP	22927820
MIRT706452	hsa-miR-6516-5p	HITS-CLIP	22927820
MIRT706451	hsa-miR-1273e	HITS-CLIP	22927820
MIRT505520	hsa-miR-155-5p	PAR-CLIP	23446348
MIRT140150	hsa-miR-140-5p	PAR-CLIP	23446348
MIRT140174	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT140154	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT140152	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT140151	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT140146	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT140149	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT031930	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT520965	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT140170	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT140147	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT140148	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT505519	hsa-miR-5700	PAR-CLIP	23446348
MIRT520964	hsa-miR-646	PAR-CLIP	23446348
MIRT140175	hsa-miR-8063	PAR-CLIP	23446348
MIRT140155	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT140156	hsa-miR-520h	PAR-CLIP	23446348
MIRT140157	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT140167	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT140171	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT140160	hsa-miR-374b-3p	PAR-CLIP	23446348
MIRT505520	hsa-miR-155-5p	PAR-CLIP	23446348
MIRT505519	hsa-miR-5700	PAR-CLIP	23446348
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT242290	hsa-miR-520f-3p	PAR-CLIP	23592263
MIRT280997	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT280994	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT280995	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT281011	hsa-miR-302e	PAR-CLIP	23592263
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT281001	hsa-miR-520e	PAR-CLIP	23592263
MIRT280998	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT281007	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT281006	hsa-miR-520b	PAR-CLIP	23592263
MIRT281009	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT281003	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT280999	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT028118	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT280990	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT280991	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT280993	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT281000	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT280992	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT281008	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT281004	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT192453	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT192450	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT140168	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT192404	hsa-miR-379-3p	PAR-CLIP	23592263
MIRT192405	hsa-miR-411-3p	PAR-CLIP	23592263
MIRT467241	hsa-miR-380-3p	PAR-CLIP	23592263
MIRT192448	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT192449	hsa-miR-190b	PAR-CLIP	23592263
MIRT242293	hsa-miR-4804-3p	PAR-CLIP	23592263
MIRT467240	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT192451	hsa-miR-3201	PAR-CLIP	23592263
MIRT192452	hsa-miR-4791	PAR-CLIP	23592263
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT242290	hsa-miR-520f-3p	PAR-CLIP	23592263
MIRT280997	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT280994	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT280995	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT281011	hsa-miR-302e	PAR-CLIP	23592263
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT281001	hsa-miR-520e	PAR-CLIP	23592263
MIRT280998	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT281007	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT281006	hsa-miR-520b	PAR-CLIP	23592263
MIRT281009	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT281003	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT280999	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT028118	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT280990	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT280991	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT280993	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT281000	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT280992	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT281008	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT281004	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT192453	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT192450	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT140168	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT467242	hsa-miR-4495	PAR-CLIP	23592263
MIRT192404	hsa-miR-379-3p	PAR-CLIP	23592263
MIRT192405	hsa-miR-411-3p	PAR-CLIP	23592263
MIRT467241	hsa-miR-380-3p	PAR-CLIP	23592263
MIRT192448	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT192449	hsa-miR-190b	PAR-CLIP	23592263
MIRT242293	hsa-miR-4804-3p	PAR-CLIP	23592263
MIRT467240	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT192451	hsa-miR-3201	PAR-CLIP	23592263
MIRT192452	hsa-miR-4791	PAR-CLIP	23592263
MIRT467239	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT467238	hsa-miR-3125	PAR-CLIP	23592263
MIRT467237	hsa-miR-3916	PAR-CLIP	23592263
MIRT467236	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT467235	hsa-miR-451b	PAR-CLIP	23592263
MIRT467234	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT467233	hsa-miR-4696	PAR-CLIP	23592263
MIRT467232	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT467231	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT467230	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT467229	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT467227	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT467228	hsa-miR-8085	PAR-CLIP	23592263
MIRT467226	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT467225	hsa-miR-3175	PAR-CLIP	23592263
MIRT467224	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT467223	hsa-miR-602	PAR-CLIP	23592263
MIRT467222	hsa-miR-802	PAR-CLIP	23592263
MIRT467220	hsa-miR-4686	PAR-CLIP	23592263
MIRT467221	hsa-miR-6834-3p	PAR-CLIP	23592263
MIRT467219	hsa-miR-4275	PAR-CLIP	23592263
MIRT467218	hsa-miR-548ao-5p	PAR-CLIP	23592263
MIRT467217	hsa-miR-548ax	PAR-CLIP	23592263
MIRT467216	hsa-miR-5585-5p	PAR-CLIP	23592263
MIRT467215	hsa-miR-31-3p	PAR-CLIP	23592263
MIRT467214	hsa-miR-194-5p	PAR-CLIP	23592263
MIRT442257	hsa-miR-425-5p	PAR-CLIP	22100165
MIRT442256	hsa-miR-3117-5p	PAR-CLIP	22100165
MIRT442255	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT140146	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT140149	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT031930	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT140151	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT000343	hsa-miR-126-3p	Immunohistochemistry, In situ hybridization, qRT-PCR, Western blot	26381870
MIRT004643	hsa-miR-126-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	28100645
MIRT021849	hsa-miR-132-3p	Luciferase reporter assay, Western blot	25945589
MIRT021849	hsa-miR-132-3p	Luciferase reporter assay, Western blot	25945589
MIRT437883	hsa-miR-1-3p	RNA-seq, Western blotting	32396270
MIRT734474	hsa-miR-21-3p	RNA-seq, Western blotting	32396270
MIRT000343	hsa-miR-126-3p	qRT-PCR	32425976
MIRT192434	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT706952	hsa-miR-589-3p	HITS-CLIP	21572407
MIRT706951	hsa-miR-138-1-3p	HITS-CLIP	21572407
MIRT706950	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT706949	hsa-miR-1277-3p	HITS-CLIP	21572407
MIRT706948	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT706465	hsa-miR-4695-5p	HITS-CLIP	22927820
MIRT380522	hsa-miR-4768-3p	HITS-CLIP	22927820
MIRT380521	hsa-miR-4459	HITS-CLIP	22927820
MIRT380519	hsa-miR-665	HITS-CLIP	22927820
MIRT706464	hsa-miR-6840-3p	HITS-CLIP	22927820
MIRT706463	hsa-miR-3160-3p	HITS-CLIP	22927820
MIRT706462	hsa-miR-558	HITS-CLIP	22927820
MIRT706461	hsa-miR-4487	HITS-CLIP	22927820
MIRT706460	hsa-miR-6087	HITS-CLIP	22927820
MIRT706459	hsa-miR-377-5p	HITS-CLIP	22927820
MIRT706458	hsa-miR-6086	HITS-CLIP	22927820
MIRT706457	hsa-miR-4722-5p	HITS-CLIP	22927820
MIRT706455	hsa-miR-6499-3p	HITS-CLIP	22927820
MIRT706456	hsa-miR-658	HITS-CLIP	22927820
MIRT706454	hsa-miR-25-5p	HITS-CLIP	22927820
MIRT706453	hsa-miR-455-3p	HITS-CLIP	22927820
MIRT706452	hsa-miR-6516-5p	HITS-CLIP	22927820
MIRT706451	hsa-miR-1273e	HITS-CLIP	22927820
MIRT505520	hsa-miR-155-5p	PAR-CLIP	23446348
MIRT140150	hsa-miR-140-5p	PAR-CLIP	23446348
MIRT140174	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT140154	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT140152	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT140151	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT140146	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT140149	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT031930	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT520965	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT140170	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT140147	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT140148	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT505519	hsa-miR-5700	PAR-CLIP	23446348
MIRT520964	hsa-miR-646	PAR-CLIP	23446348
MIRT140175	hsa-miR-8063	PAR-CLIP	23446348
MIRT140155	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT140156	hsa-miR-520h	PAR-CLIP	23446348
MIRT140157	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT140167	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT140171	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT140160	hsa-miR-374b-3p	PAR-CLIP	23446348
MIRT505520	hsa-miR-155-5p	PAR-CLIP	23446348
MIRT505519	hsa-miR-5700	PAR-CLIP	23446348
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT242290	hsa-miR-520f-3p	PAR-CLIP	23592263
MIRT280997	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT280994	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT280995	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT281011	hsa-miR-302e	PAR-CLIP	23592263
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT281001	hsa-miR-520e	PAR-CLIP	23592263
MIRT280998	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT281007	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT281006	hsa-miR-520b	PAR-CLIP	23592263
MIRT281009	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT281003	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT280999	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT028118	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT280990	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT280991	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT280993	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT281000	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT280992	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT281008	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT281004	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT192453	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT192450	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT140168	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT192404	hsa-miR-379-3p	PAR-CLIP	23592263
MIRT192405	hsa-miR-411-3p	PAR-CLIP	23592263
MIRT467241	hsa-miR-380-3p	PAR-CLIP	23592263
MIRT192448	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT192449	hsa-miR-190b	PAR-CLIP	23592263
MIRT242293	hsa-miR-4804-3p	PAR-CLIP	23592263
MIRT467240	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT192451	hsa-miR-3201	PAR-CLIP	23592263
MIRT192452	hsa-miR-4791	PAR-CLIP	23592263
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT242290	hsa-miR-520f-3p	PAR-CLIP	23592263
MIRT280997	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT280994	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT280995	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT281011	hsa-miR-302e	PAR-CLIP	23592263
MIRT280996	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT281001	hsa-miR-520e	PAR-CLIP	23592263
MIRT280998	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT281007	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT281006	hsa-miR-520b	PAR-CLIP	23592263
MIRT281009	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT281003	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT280999	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT028118	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT280990	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT280991	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT280993	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT281000	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT280992	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT281008	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT281004	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT192453	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT192450	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT140168	hsa-miR-4668-3p	PAR-CLIP	23592263
MIRT467242	hsa-miR-4495	PAR-CLIP	23592263
MIRT192404	hsa-miR-379-3p	PAR-CLIP	23592263
MIRT192405	hsa-miR-411-3p	PAR-CLIP	23592263
MIRT467241	hsa-miR-380-3p	PAR-CLIP	23592263
MIRT192448	hsa-miR-190a-5p	PAR-CLIP	23592263
MIRT192449	hsa-miR-190b	PAR-CLIP	23592263
MIRT242293	hsa-miR-4804-3p	PAR-CLIP	23592263
MIRT467240	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT192451	hsa-miR-3201	PAR-CLIP	23592263
MIRT192452	hsa-miR-4791	PAR-CLIP	23592263
MIRT467239	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT467238	hsa-miR-3125	PAR-CLIP	23592263
MIRT467237	hsa-miR-3916	PAR-CLIP	23592263
MIRT467236	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT467235	hsa-miR-451b	PAR-CLIP	23592263
MIRT467234	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT467233	hsa-miR-4696	PAR-CLIP	23592263
MIRT467232	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT467231	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT467230	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT467229	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT467227	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT467228	hsa-miR-8085	PAR-CLIP	23592263
MIRT467226	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT467225	hsa-miR-3175	PAR-CLIP	23592263
MIRT467224	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT467223	hsa-miR-602	PAR-CLIP	23592263
MIRT467222	hsa-miR-802	PAR-CLIP	23592263
MIRT467220	hsa-miR-4686	PAR-CLIP	23592263
MIRT467221	hsa-miR-6834-3p	PAR-CLIP	23592263
MIRT467219	hsa-miR-4275	PAR-CLIP	23592263
MIRT467218	hsa-miR-548ao-5p	PAR-CLIP	23592263
MIRT467217	hsa-miR-548ax	PAR-CLIP	23592263
MIRT467216	hsa-miR-5585-5p	PAR-CLIP	23592263
MIRT467215	hsa-miR-31-3p	PAR-CLIP	23592263
MIRT467214	hsa-miR-194-5p	PAR-CLIP	23592263
MIRT442257	hsa-miR-425-5p	PAR-CLIP	22100165
MIRT442256	hsa-miR-3117-5p	PAR-CLIP	22100165
MIRT442255	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT000343	hsa-miR-126-3p	qRT-PCR	36559150
MIRT1385605	hsa-miR-103a	CLIP-seq
MIRT1385606	hsa-miR-107	CLIP-seq
MIRT1385607	hsa-miR-1179	CLIP-seq
MIRT1385608	hsa-miR-1267	CLIP-seq
MIRT1385609	hsa-miR-1271	CLIP-seq
MIRT1385610	hsa-miR-127-5p	CLIP-seq
MIRT1385611	hsa-miR-1279	CLIP-seq
MIRT1385612	hsa-miR-1285	CLIP-seq
MIRT1385613	hsa-miR-130a	CLIP-seq
MIRT1385614	hsa-miR-130b	CLIP-seq
MIRT1385615	hsa-miR-135a	CLIP-seq
MIRT1385616	hsa-miR-135b	CLIP-seq
MIRT1385617	hsa-miR-15a	CLIP-seq
MIRT1385618	hsa-miR-15b	CLIP-seq
MIRT1385619	hsa-miR-16	CLIP-seq
MIRT1385620	hsa-miR-182	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT1385622	hsa-miR-186	CLIP-seq
MIRT1385623	hsa-miR-195	CLIP-seq
MIRT1385624	hsa-miR-25	CLIP-seq
MIRT1385625	hsa-miR-301a	CLIP-seq
MIRT1385626	hsa-miR-301b	CLIP-seq
MIRT1385627	hsa-miR-3065-5p	CLIP-seq
MIRT1385628	hsa-miR-3119	CLIP-seq
MIRT1385629	hsa-miR-3156-5p	CLIP-seq
MIRT1385630	hsa-miR-3163	CLIP-seq
MIRT1385631	hsa-miR-3187-5p	CLIP-seq
MIRT1385632	hsa-miR-32	CLIP-seq
MIRT1385633	hsa-miR-323-5p	CLIP-seq
MIRT1385634	hsa-miR-337-3p	CLIP-seq
MIRT1385635	hsa-miR-3591-5p	CLIP-seq
MIRT1385636	hsa-miR-3613-5p	CLIP-seq
MIRT1385637	hsa-miR-363	CLIP-seq
MIRT1385638	hsa-miR-365	CLIP-seq
MIRT1385639	hsa-miR-3651	CLIP-seq
MIRT1385640	hsa-miR-3653	CLIP-seq
MIRT1385641	hsa-miR-3658	CLIP-seq
MIRT1385642	hsa-miR-3666	CLIP-seq
MIRT1385643	hsa-miR-367	CLIP-seq
MIRT1385644	hsa-miR-3671	CLIP-seq
MIRT1385645	hsa-miR-3685	CLIP-seq
MIRT1385646	hsa-miR-3689a-3p	CLIP-seq
MIRT1385647	hsa-miR-3689c	CLIP-seq
MIRT1385648	hsa-miR-3692	CLIP-seq
MIRT1385649	hsa-miR-384	CLIP-seq
MIRT1385650	hsa-miR-3920	CLIP-seq
MIRT1385651	hsa-miR-3926	CLIP-seq
MIRT1385652	hsa-miR-3929	CLIP-seq
MIRT1385653	hsa-miR-3942-3p	CLIP-seq
MIRT1385654	hsa-miR-3974	CLIP-seq
MIRT1385655	hsa-miR-424	CLIP-seq
MIRT1385656	hsa-miR-4295	CLIP-seq
MIRT1385657	hsa-miR-4310	CLIP-seq
MIRT1385658	hsa-miR-4325	CLIP-seq
MIRT1385659	hsa-miR-4326	CLIP-seq
MIRT1385660	hsa-miR-4419b	CLIP-seq
MIRT1385661	hsa-miR-4433	CLIP-seq
MIRT1385662	hsa-miR-4473	CLIP-seq
MIRT1385663	hsa-miR-4477a	CLIP-seq
MIRT1385664	hsa-miR-4478	CLIP-seq
MIRT1385665	hsa-miR-4503	CLIP-seq
MIRT1385666	hsa-miR-4524	CLIP-seq
MIRT1385667	hsa-miR-454	CLIP-seq
MIRT1385668	hsa-miR-4637	CLIP-seq
MIRT1385669	hsa-miR-4649-3p	CLIP-seq
MIRT1385670	hsa-miR-4671-3p	CLIP-seq
MIRT1385671	hsa-miR-4672	CLIP-seq
MIRT1385672	hsa-miR-4676-5p	CLIP-seq
MIRT1385673	hsa-miR-4691-5p	CLIP-seq
MIRT1385674	hsa-miR-4695-3p	CLIP-seq
MIRT1385675	hsa-miR-4699-5p	CLIP-seq
MIRT1385676	hsa-miR-4704-5p	CLIP-seq
MIRT1385677	hsa-miR-4727-5p	CLIP-seq
MIRT1385678	hsa-miR-4728-3p	CLIP-seq
MIRT1385679	hsa-miR-4728-5p	CLIP-seq
MIRT1385680	hsa-miR-4738-3p	CLIP-seq
MIRT1385681	hsa-miR-4789-5p	CLIP-seq
MIRT1385682	hsa-miR-485-5p	CLIP-seq
MIRT1385683	hsa-miR-491-3p	CLIP-seq
MIRT1385684	hsa-miR-494	CLIP-seq
MIRT1385685	hsa-miR-497	CLIP-seq
MIRT1385686	hsa-miR-503	CLIP-seq
MIRT1385687	hsa-miR-508-5p	CLIP-seq
MIRT1385688	hsa-miR-512-3p	CLIP-seq
MIRT1385689	hsa-miR-513a-3p	CLIP-seq
MIRT1385690	hsa-miR-520f	CLIP-seq
MIRT1385691	hsa-miR-520g	CLIP-seq
MIRT1385692	hsa-miR-541	CLIP-seq
MIRT1385693	hsa-miR-544	CLIP-seq
MIRT1385694	hsa-miR-545	CLIP-seq
MIRT1385695	hsa-miR-548ac	CLIP-seq
MIRT1385696	hsa-miR-548ae	CLIP-seq
MIRT1385697	hsa-miR-548aj	CLIP-seq
MIRT1385698	hsa-miR-548al	CLIP-seq
MIRT1385699	hsa-miR-548am	CLIP-seq
MIRT1385700	hsa-miR-548c-3p	CLIP-seq
MIRT1385701	hsa-miR-548d-3p	CLIP-seq
MIRT1385702	hsa-miR-548s	CLIP-seq
MIRT1385703	hsa-miR-548x	CLIP-seq
MIRT1385704	hsa-miR-548z	CLIP-seq
MIRT1385705	hsa-miR-550a	CLIP-seq
MIRT1385706	hsa-miR-567	CLIP-seq
MIRT1385707	hsa-miR-575	CLIP-seq
MIRT1385708	hsa-miR-579	CLIP-seq
MIRT1385709	hsa-miR-607	CLIP-seq
MIRT1385710	hsa-miR-612	CLIP-seq
MIRT1385711	hsa-miR-628-5p	CLIP-seq
MIRT1385712	hsa-miR-654-5p	CLIP-seq
MIRT1385713	hsa-miR-661	CLIP-seq
MIRT1385714	hsa-miR-766	CLIP-seq
MIRT1385715	hsa-miR-767-5p	CLIP-seq
MIRT1385716	hsa-miR-876-3p	CLIP-seq
MIRT1385717	hsa-miR-890	CLIP-seq
MIRT1385718	hsa-miR-92a	CLIP-seq
MIRT1385719	hsa-miR-92b	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq
MIRT1385721	hsa-miR-96	CLIP-seq
MIRT1554114	hsa-miR-4762-5p	CLIP-seq
MIRT1554115	hsa-miR-4802-3p	CLIP-seq
MIRT1385630	hsa-miR-3163	CLIP-seq
MIRT1557116	hsa-miR-410	CLIP-seq
MIRT1557117	hsa-miR-4264	CLIP-seq
MIRT1557118	hsa-miR-4753-3p	CLIP-seq
MIRT1385700	hsa-miR-548c-3p	CLIP-seq
MIRT1557119	hsa-miR-595	CLIP-seq
MIRT1557120	hsa-miR-622	CLIP-seq
MIRT2115451	hsa-miR-101	CLIP-seq
MIRT1385610	hsa-miR-127-5p	CLIP-seq
MIRT2115452	hsa-miR-1293	CLIP-seq
MIRT2115453	hsa-miR-144	CLIP-seq
MIRT2115454	hsa-miR-153	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT1385622	hsa-miR-186	CLIP-seq
MIRT1385630	hsa-miR-3163	CLIP-seq
MIRT2115455	hsa-miR-3165	CLIP-seq
MIRT1385646	hsa-miR-3689a-3p	CLIP-seq
MIRT1385647	hsa-miR-3689c	CLIP-seq
MIRT1385648	hsa-miR-3692	CLIP-seq
MIRT1385650	hsa-miR-3920	CLIP-seq
MIRT1385651	hsa-miR-3926	CLIP-seq
MIRT1385652	hsa-miR-3929	CLIP-seq
MIRT1385654	hsa-miR-3974	CLIP-seq
MIRT1385657	hsa-miR-4310	CLIP-seq
MIRT1385658	hsa-miR-4325	CLIP-seq
MIRT1385660	hsa-miR-4419b	CLIP-seq
MIRT1385661	hsa-miR-4433	CLIP-seq
MIRT1385662	hsa-miR-4473	CLIP-seq
MIRT1385664	hsa-miR-4478	CLIP-seq
MIRT2115456	hsa-miR-448	CLIP-seq
MIRT2115457	hsa-miR-4483	CLIP-seq
MIRT1385669	hsa-miR-4649-3p	CLIP-seq
MIRT1385670	hsa-miR-4671-3p	CLIP-seq
MIRT2115458	hsa-miR-4684-3p	CLIP-seq
MIRT1385674	hsa-miR-4695-3p	CLIP-seq
MIRT2115459	hsa-miR-4719	CLIP-seq
MIRT1385679	hsa-miR-4728-5p	CLIP-seq
MIRT2115460	hsa-miR-4729	CLIP-seq
MIRT2115461	hsa-miR-4781-3p	CLIP-seq
MIRT1385682	hsa-miR-485-5p	CLIP-seq
MIRT1385688	hsa-miR-512-3p	CLIP-seq
MIRT1385690	hsa-miR-520f	CLIP-seq
MIRT1385692	hsa-miR-541	CLIP-seq
MIRT1385693	hsa-miR-544	CLIP-seq
MIRT1385702	hsa-miR-548s	CLIP-seq
MIRT1385705	hsa-miR-550a	CLIP-seq
MIRT1385708	hsa-miR-579	CLIP-seq
MIRT1385712	hsa-miR-654-5p	CLIP-seq
MIRT1385717	hsa-miR-890	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq
MIRT2115451	hsa-miR-101	CLIP-seq
MIRT1385605	hsa-miR-103a	CLIP-seq
MIRT1385606	hsa-miR-107	CLIP-seq
MIRT1385607	hsa-miR-1179	CLIP-seq
MIRT1385608	hsa-miR-1267	CLIP-seq
MIRT1385612	hsa-miR-1285	CLIP-seq
MIRT2115452	hsa-miR-1293	CLIP-seq
MIRT2338102	hsa-miR-1303	CLIP-seq
MIRT1385613	hsa-miR-130a	CLIP-seq
MIRT1385614	hsa-miR-130b	CLIP-seq
MIRT2115453	hsa-miR-144	CLIP-seq
MIRT1385617	hsa-miR-15a	CLIP-seq
MIRT1385618	hsa-miR-15b	CLIP-seq
MIRT1385619	hsa-miR-16	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT2338103	hsa-miR-194	CLIP-seq
MIRT1385623	hsa-miR-195	CLIP-seq
MIRT2338104	hsa-miR-197	CLIP-seq
MIRT1385624	hsa-miR-25	CLIP-seq
MIRT1385625	hsa-miR-301a	CLIP-seq
MIRT1385626	hsa-miR-301b	CLIP-seq
MIRT2338105	hsa-miR-3122	CLIP-seq
MIRT1385630	hsa-miR-3163	CLIP-seq
MIRT2115455	hsa-miR-3165	CLIP-seq
MIRT1385631	hsa-miR-3187-5p	CLIP-seq
MIRT1385632	hsa-miR-32	CLIP-seq
MIRT1385634	hsa-miR-337-3p	CLIP-seq
MIRT2338106	hsa-miR-340	CLIP-seq
MIRT1385635	hsa-miR-3591-5p	CLIP-seq
MIRT1385636	hsa-miR-3613-5p	CLIP-seq
MIRT1385637	hsa-miR-363	CLIP-seq
MIRT1385639	hsa-miR-3651	CLIP-seq
MIRT1385642	hsa-miR-3666	CLIP-seq
MIRT1385643	hsa-miR-367	CLIP-seq
MIRT1385644	hsa-miR-3671	CLIP-seq
MIRT1385645	hsa-miR-3685	CLIP-seq
MIRT1385646	hsa-miR-3689a-3p	CLIP-seq
MIRT1385647	hsa-miR-3689c	CLIP-seq
MIRT1385648	hsa-miR-3692	CLIP-seq
MIRT1385649	hsa-miR-384	CLIP-seq
MIRT2338107	hsa-miR-3913-5p	CLIP-seq
MIRT2338108	hsa-miR-3919	CLIP-seq
MIRT1385651	hsa-miR-3926	CLIP-seq
MIRT1385652	hsa-miR-3929	CLIP-seq
MIRT1385654	hsa-miR-3974	CLIP-seq
MIRT1557116	hsa-miR-410	CLIP-seq
MIRT1385655	hsa-miR-424	CLIP-seq
MIRT2338109	hsa-miR-4282	CLIP-seq
MIRT2338110	hsa-miR-4291	CLIP-seq
MIRT1385656	hsa-miR-4295	CLIP-seq
MIRT1385657	hsa-miR-4310	CLIP-seq
MIRT1385658	hsa-miR-4325	CLIP-seq
MIRT1385660	hsa-miR-4419b	CLIP-seq
MIRT1385661	hsa-miR-4433	CLIP-seq
MIRT1385662	hsa-miR-4473	CLIP-seq
MIRT1385664	hsa-miR-4478	CLIP-seq
MIRT2115456	hsa-miR-448	CLIP-seq
MIRT2115457	hsa-miR-4483	CLIP-seq
MIRT1385666	hsa-miR-4524	CLIP-seq
MIRT1385667	hsa-miR-454	CLIP-seq
MIRT1385669	hsa-miR-4649-3p	CLIP-seq
MIRT1385670	hsa-miR-4671-3p	CLIP-seq
MIRT1385671	hsa-miR-4672	CLIP-seq
MIRT1385672	hsa-miR-4676-5p	CLIP-seq
MIRT1385679	hsa-miR-4728-5p	CLIP-seq
MIRT2338111	hsa-miR-4772-3p	CLIP-seq
MIRT1385682	hsa-miR-485-5p	CLIP-seq
MIRT2338112	hsa-miR-495	CLIP-seq
MIRT1385685	hsa-miR-497	CLIP-seq
MIRT1385686	hsa-miR-503	CLIP-seq
MIRT1385687	hsa-miR-508-5p	CLIP-seq
MIRT2338113	hsa-miR-5096	CLIP-seq
MIRT1385691	hsa-miR-520g	CLIP-seq
MIRT2338114	hsa-miR-522	CLIP-seq
MIRT1385694	hsa-miR-545	CLIP-seq
MIRT1385695	hsa-miR-548ac	CLIP-seq
MIRT1385696	hsa-miR-548ae	CLIP-seq
MIRT1385697	hsa-miR-548aj	CLIP-seq
MIRT1385699	hsa-miR-548am	CLIP-seq
MIRT1385700	hsa-miR-548c-3p	CLIP-seq
MIRT1385701	hsa-miR-548d-3p	CLIP-seq
MIRT2338115	hsa-miR-548n	CLIP-seq
MIRT1385702	hsa-miR-548s	CLIP-seq
MIRT2338116	hsa-miR-548t	CLIP-seq
MIRT1385703	hsa-miR-548x	CLIP-seq
MIRT1385704	hsa-miR-548z	CLIP-seq
MIRT2338117	hsa-miR-561	CLIP-seq
MIRT1385707	hsa-miR-575	CLIP-seq
MIRT1385708	hsa-miR-579	CLIP-seq
MIRT2338118	hsa-miR-587	CLIP-seq
MIRT2338119	hsa-miR-603	CLIP-seq
MIRT1385709	hsa-miR-607	CLIP-seq
MIRT1385710	hsa-miR-612	CLIP-seq
MIRT2338120	hsa-miR-642b	CLIP-seq
MIRT1385713	hsa-miR-661	CLIP-seq
MIRT1385714	hsa-miR-766	CLIP-seq
MIRT1385715	hsa-miR-767-5p	CLIP-seq
MIRT2338121	hsa-miR-877	CLIP-seq
MIRT1385717	hsa-miR-890	CLIP-seq
MIRT1385718	hsa-miR-92a	CLIP-seq
MIRT1385719	hsa-miR-92b	CLIP-seq
MIRT2338122	hsa-miR-935	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq
MIRT1385612	hsa-miR-1285	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT2395043	hsa-miR-2053	CLIP-seq
MIRT2395044	hsa-miR-208a	CLIP-seq
MIRT2395045	hsa-miR-208b	CLIP-seq
MIRT1385624	hsa-miR-25	CLIP-seq
MIRT1385631	hsa-miR-3187-5p	CLIP-seq
MIRT1385632	hsa-miR-32	CLIP-seq
MIRT1385637	hsa-miR-363	CLIP-seq
MIRT1385643	hsa-miR-367	CLIP-seq
MIRT1385658	hsa-miR-4325	CLIP-seq
MIRT2395046	hsa-miR-4432	CLIP-seq
MIRT2395047	hsa-miR-4795-3p	CLIP-seq
MIRT2395048	hsa-miR-499-5p	CLIP-seq
MIRT1385687	hsa-miR-508-5p	CLIP-seq
MIRT1385694	hsa-miR-545	CLIP-seq
MIRT1385710	hsa-miR-612	CLIP-seq
MIRT1385713	hsa-miR-661	CLIP-seq
MIRT1385714	hsa-miR-766	CLIP-seq
MIRT1385715	hsa-miR-767-5p	CLIP-seq
MIRT1385718	hsa-miR-92a	CLIP-seq
MIRT1385719	hsa-miR-92b	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq
MIRT1385645	hsa-miR-3685	CLIP-seq
MIRT1385648	hsa-miR-3692	CLIP-seq
MIRT1385649	hsa-miR-384	CLIP-seq
MIRT1385657	hsa-miR-4310	CLIP-seq
MIRT1385659	hsa-miR-4326	CLIP-seq
MIRT1385671	hsa-miR-4672	CLIP-seq
MIRT1385673	hsa-miR-4691-5p	CLIP-seq
MIRT1385681	hsa-miR-4789-5p	CLIP-seq
MIRT1385689	hsa-miR-513a-3p	CLIP-seq
MIRT1385708	hsa-miR-579	CLIP-seq
MIRT2440787	hsa-miR-1228	CLIP-seq
MIRT2440788	hsa-miR-3123	CLIP-seq
MIRT2440789	hsa-miR-3140-5p	CLIP-seq
MIRT2338106	hsa-miR-340	CLIP-seq
MIRT2338108	hsa-miR-3919	CLIP-seq
MIRT2440790	hsa-miR-4680-3p	CLIP-seq
MIRT2440791	hsa-miR-4797-5p	CLIP-seq
MIRT2440792	hsa-miR-539	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT1385622	hsa-miR-186	CLIP-seq
MIRT2460480	hsa-miR-3133	CLIP-seq
MIRT1385646	hsa-miR-3689a-3p	CLIP-seq
MIRT1385647	hsa-miR-3689c	CLIP-seq
MIRT1385652	hsa-miR-3929	CLIP-seq
MIRT1385660	hsa-miR-4419b	CLIP-seq
MIRT1385664	hsa-miR-4478	CLIP-seq
MIRT1385669	hsa-miR-4649-3p	CLIP-seq
MIRT1385679	hsa-miR-4728-5p	CLIP-seq
MIRT2460481	hsa-miR-4773	CLIP-seq
MIRT1385682	hsa-miR-485-5p	CLIP-seq
MIRT1385692	hsa-miR-541	CLIP-seq
MIRT2460482	hsa-miR-548l	CLIP-seq
MIRT2338115	hsa-miR-548n	CLIP-seq
MIRT1385705	hsa-miR-550a	CLIP-seq
MIRT1385712	hsa-miR-654-5p	CLIP-seq
MIRT1385717	hsa-miR-890	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq
MIRT2631646	hsa-miR-1	CLIP-seq
MIRT2631647	hsa-miR-106a	CLIP-seq
MIRT2631648	hsa-miR-106b	CLIP-seq
MIRT2440787	hsa-miR-1228	CLIP-seq
MIRT2631649	hsa-miR-124	CLIP-seq
MIRT2631650	hsa-miR-1245b-3p	CLIP-seq
MIRT1385610	hsa-miR-127-5p	CLIP-seq
MIRT1385611	hsa-miR-1279	CLIP-seq
MIRT2631651	hsa-miR-1284	CLIP-seq
MIRT1385612	hsa-miR-1285	CLIP-seq
MIRT2115452	hsa-miR-1293	CLIP-seq
MIRT2631652	hsa-miR-1298	CLIP-seq
MIRT2631653	hsa-miR-132	CLIP-seq
MIRT2631654	hsa-miR-1323	CLIP-seq
MIRT2631655	hsa-miR-137	CLIP-seq
MIRT2115453	hsa-miR-144	CLIP-seq
MIRT2631656	hsa-miR-17	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT2631657	hsa-miR-183	CLIP-seq
MIRT1385622	hsa-miR-186	CLIP-seq
MIRT2631658	hsa-miR-188-5p	CLIP-seq
MIRT2338104	hsa-miR-197	CLIP-seq
MIRT2631659	hsa-miR-1973	CLIP-seq
MIRT2631660	hsa-miR-206	CLIP-seq
MIRT2631661	hsa-miR-20a	CLIP-seq
MIRT2631662	hsa-miR-20b	CLIP-seq
MIRT2631663	hsa-miR-2115	CLIP-seq
MIRT2631664	hsa-miR-2116	CLIP-seq
MIRT2631665	hsa-miR-212	CLIP-seq
MIRT2631666	hsa-miR-219-2-3p	CLIP-seq
MIRT1385624	hsa-miR-25	CLIP-seq
MIRT2631667	hsa-miR-2964a-3p	CLIP-seq
MIRT2631668	hsa-miR-3074-3p	CLIP-seq
MIRT2631669	hsa-miR-31	CLIP-seq
MIRT2338105	hsa-miR-3122	CLIP-seq
MIRT2631670	hsa-miR-3124-3p	CLIP-seq
MIRT2460480	hsa-miR-3133	CLIP-seq
MIRT2440789	hsa-miR-3140-5p	CLIP-seq
MIRT2631671	hsa-miR-3148	CLIP-seq
MIRT1385629	hsa-miR-3156-5p	CLIP-seq
MIRT1385630	hsa-miR-3163	CLIP-seq
MIRT2115455	hsa-miR-3165	CLIP-seq
MIRT1385631	hsa-miR-3187-5p	CLIP-seq
MIRT2631672	hsa-miR-3189-3p	CLIP-seq
MIRT1385632	hsa-miR-32	CLIP-seq
MIRT2631673	hsa-miR-323-3p	CLIP-seq
MIRT1385633	hsa-miR-323-5p	CLIP-seq
MIRT2631674	hsa-miR-329	CLIP-seq
MIRT2338106	hsa-miR-340	CLIP-seq
MIRT2631675	hsa-miR-361-5p	CLIP-seq
MIRT2631676	hsa-miR-3622b-5p	CLIP-seq
MIRT2631677	hsa-miR-362-3p	CLIP-seq
MIRT1385637	hsa-miR-363	CLIP-seq
MIRT2631678	hsa-miR-3647-3p	CLIP-seq
MIRT1385643	hsa-miR-367	CLIP-seq
MIRT1385644	hsa-miR-3671	CLIP-seq
MIRT2631679	hsa-miR-3675-3p	CLIP-seq
MIRT2631680	hsa-miR-3682-5p	CLIP-seq
MIRT1385646	hsa-miR-3689a-3p	CLIP-seq
MIRT1385647	hsa-miR-3689c	CLIP-seq
MIRT2631681	hsa-miR-3691-3p	CLIP-seq
MIRT1385648	hsa-miR-3692	CLIP-seq
MIRT2631682	hsa-miR-371-5p	CLIP-seq
MIRT2631683	hsa-miR-371b-5p	CLIP-seq
MIRT2338107	hsa-miR-3913-5p	CLIP-seq
MIRT1385652	hsa-miR-3929	CLIP-seq
MIRT2631684	hsa-miR-3941	CLIP-seq
MIRT2631685	hsa-miR-3945	CLIP-seq
MIRT1385654	hsa-miR-3974	CLIP-seq
MIRT2631686	hsa-miR-4253	CLIP-seq
MIRT2338109	hsa-miR-4282	CLIP-seq
MIRT2631687	hsa-miR-4311	CLIP-seq
MIRT2631688	hsa-miR-4312	CLIP-seq
MIRT1385658	hsa-miR-4325	CLIP-seq
MIRT2631689	hsa-miR-4327	CLIP-seq
MIRT1385660	hsa-miR-4419b	CLIP-seq
MIRT1385661	hsa-miR-4433	CLIP-seq
MIRT2631690	hsa-miR-4457	CLIP-seq
MIRT2631691	hsa-miR-4475	CLIP-seq
MIRT1385664	hsa-miR-4478	CLIP-seq
MIRT2115457	hsa-miR-4483	CLIP-seq
MIRT2631692	hsa-miR-4517	CLIP-seq
MIRT2631693	hsa-miR-4521	CLIP-seq
MIRT1385668	hsa-miR-4637	CLIP-seq
MIRT2631694	hsa-miR-4643	CLIP-seq
MIRT2631695	hsa-miR-4645-5p	CLIP-seq
MIRT1385669	hsa-miR-4649-3p	CLIP-seq
MIRT2631696	hsa-miR-466	CLIP-seq
MIRT2631697	hsa-miR-4673	CLIP-seq
MIRT2631698	hsa-miR-4677-5p	CLIP-seq
MIRT2440790	hsa-miR-4680-3p	CLIP-seq
MIRT2631699	hsa-miR-4684-5p	CLIP-seq
MIRT1385674	hsa-miR-4695-3p	CLIP-seq
MIRT1385675	hsa-miR-4699-5p	CLIP-seq
MIRT1385676	hsa-miR-4704-5p	CLIP-seq
MIRT2631700	hsa-miR-4712-5p	CLIP-seq
MIRT2115459	hsa-miR-4719	CLIP-seq
MIRT1385677	hsa-miR-4727-5p	CLIP-seq
MIRT1385679	hsa-miR-4728-5p	CLIP-seq
MIRT1385680	hsa-miR-4738-3p	CLIP-seq
MIRT2631701	hsa-miR-4742-5p	CLIP-seq
MIRT2631702	hsa-miR-4760-3p	CLIP-seq
MIRT2631703	hsa-miR-4761-5p	CLIP-seq
MIRT2631704	hsa-miR-4789-3p	CLIP-seq
MIRT1385681	hsa-miR-4789-5p	CLIP-seq
MIRT1385682	hsa-miR-485-5p	CLIP-seq
MIRT2631705	hsa-miR-488	CLIP-seq
MIRT1385684	hsa-miR-494	CLIP-seq
MIRT2631706	hsa-miR-498	CLIP-seq
MIRT2631707	hsa-miR-502-5p	CLIP-seq
MIRT2631708	hsa-miR-506	CLIP-seq
MIRT1385687	hsa-miR-508-5p	CLIP-seq
MIRT2338113	hsa-miR-5096	CLIP-seq
MIRT1385689	hsa-miR-513a-3p	CLIP-seq
MIRT2631709	hsa-miR-513b	CLIP-seq
MIRT2631710	hsa-miR-513c	CLIP-seq
MIRT2631711	hsa-miR-514b-5p	CLIP-seq
MIRT2631712	hsa-miR-519a	CLIP-seq
MIRT2631713	hsa-miR-519b-3p	CLIP-seq
MIRT2631714	hsa-miR-519c-3p	CLIP-seq
MIRT2631715	hsa-miR-519d	CLIP-seq
MIRT2631716	hsa-miR-520d-5p	CLIP-seq
MIRT2631717	hsa-miR-524-5p	CLIP-seq
MIRT1385692	hsa-miR-541	CLIP-seq
MIRT1385693	hsa-miR-544	CLIP-seq
MIRT2631718	hsa-miR-548an	CLIP-seq
MIRT2631719	hsa-miR-548b-3p	CLIP-seq
MIRT1385700	hsa-miR-548c-3p	CLIP-seq
MIRT2631720	hsa-miR-548o	CLIP-seq
MIRT1385705	hsa-miR-550a	CLIP-seq
MIRT2338117	hsa-miR-561	CLIP-seq
MIRT2338118	hsa-miR-587	CLIP-seq
MIRT2338119	hsa-miR-603	CLIP-seq
MIRT1385710	hsa-miR-612	CLIP-seq
MIRT2631721	hsa-miR-613	CLIP-seq
MIRT2631722	hsa-miR-617	CLIP-seq
MIRT2631723	hsa-miR-642a	CLIP-seq
MIRT1385712	hsa-miR-654-5p	CLIP-seq
MIRT1385713	hsa-miR-661	CLIP-seq
MIRT2631724	hsa-miR-664	CLIP-seq
MIRT1385714	hsa-miR-766	CLIP-seq
MIRT1385715	hsa-miR-767-5p	CLIP-seq
MIRT2631725	hsa-miR-770-5p	CLIP-seq
MIRT1385716	hsa-miR-876-3p	CLIP-seq
MIRT1385717	hsa-miR-890	CLIP-seq
MIRT1385718	hsa-miR-92a	CLIP-seq
MIRT1385719	hsa-miR-92b	CLIP-seq
MIRT2631726	hsa-miR-93	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq
MIRT2440787	hsa-miR-1228	CLIP-seq
MIRT1385610	hsa-miR-127-5p	CLIP-seq
MIRT1385612	hsa-miR-1285	CLIP-seq
MIRT2115452	hsa-miR-1293	CLIP-seq
MIRT2631654	hsa-miR-1323	CLIP-seq
MIRT1385621	hsa-miR-1827	CLIP-seq
MIRT1385622	hsa-miR-186	CLIP-seq
MIRT2631659	hsa-miR-1973	CLIP-seq
MIRT1385624	hsa-miR-25	CLIP-seq
MIRT2338105	hsa-miR-3122	CLIP-seq
MIRT2460480	hsa-miR-3133	CLIP-seq
MIRT2440789	hsa-miR-3140-5p	CLIP-seq
MIRT1385629	hsa-miR-3156-5p	CLIP-seq
MIRT2115455	hsa-miR-3165	CLIP-seq
MIRT1385631	hsa-miR-3187-5p	CLIP-seq
MIRT1385632	hsa-miR-32	CLIP-seq
MIRT2338106	hsa-miR-340	CLIP-seq
MIRT2631675	hsa-miR-361-5p	CLIP-seq
MIRT2691910	hsa-miR-3616-5p	CLIP-seq
MIRT1385637	hsa-miR-363	CLIP-seq
MIRT2691911	hsa-miR-3647-5p	CLIP-seq
MIRT1385643	hsa-miR-367	CLIP-seq
MIRT1385644	hsa-miR-3671	CLIP-seq
MIRT2631679	hsa-miR-3675-3p	CLIP-seq
MIRT1385646	hsa-miR-3689a-3p	CLIP-seq
MIRT1385647	hsa-miR-3689c	CLIP-seq
MIRT2631682	hsa-miR-371-5p	CLIP-seq
MIRT2631683	hsa-miR-371b-5p	CLIP-seq
MIRT2338107	hsa-miR-3913-5p	CLIP-seq
MIRT1385651	hsa-miR-3926	CLIP-seq
MIRT1385652	hsa-miR-3929	CLIP-seq
MIRT1385654	hsa-miR-3974	CLIP-seq
MIRT2631687	hsa-miR-4311	CLIP-seq
MIRT1385658	hsa-miR-4325	CLIP-seq
MIRT1385660	hsa-miR-4419b	CLIP-seq
MIRT1385661	hsa-miR-4433	CLIP-seq
MIRT1385664	hsa-miR-4478	CLIP-seq
MIRT2115457	hsa-miR-4483	CLIP-seq
MIRT1385669	hsa-miR-4649-3p	CLIP-seq
MIRT2440790	hsa-miR-4680-3p	CLIP-seq
MIRT2631699	hsa-miR-4684-5p	CLIP-seq
MIRT1385674	hsa-miR-4695-3p	CLIP-seq
MIRT1385675	hsa-miR-4699-5p	CLIP-seq
MIRT1385679	hsa-miR-4728-5p	CLIP-seq
MIRT1385680	hsa-miR-4738-3p	CLIP-seq
MIRT1554114	hsa-miR-4762-5p	CLIP-seq
MIRT2691912	hsa-miR-4795-5p	CLIP-seq
MIRT1554115	hsa-miR-4802-3p	CLIP-seq
MIRT1385682	hsa-miR-485-5p	CLIP-seq
MIRT1385684	hsa-miR-494	CLIP-seq
MIRT2631707	hsa-miR-502-5p	CLIP-seq
MIRT1385687	hsa-miR-508-5p	CLIP-seq
MIRT2631716	hsa-miR-520d-5p	CLIP-seq
MIRT2631717	hsa-miR-524-5p	CLIP-seq
MIRT1385692	hsa-miR-541	CLIP-seq
MIRT2631720	hsa-miR-548o	CLIP-seq
MIRT1385702	hsa-miR-548s	CLIP-seq
MIRT1385705	hsa-miR-550a	CLIP-seq
MIRT2691913	hsa-miR-573	CLIP-seq
MIRT2338118	hsa-miR-587	CLIP-seq
MIRT1557119	hsa-miR-595	CLIP-seq
MIRT1385710	hsa-miR-612	CLIP-seq
MIRT1385712	hsa-miR-654-5p	CLIP-seq
MIRT1385713	hsa-miR-661	CLIP-seq
MIRT1385714	hsa-miR-766	CLIP-seq
MIRT1385715	hsa-miR-767-5p	CLIP-seq
MIRT1385717	hsa-miR-890	CLIP-seq
MIRT1385718	hsa-miR-92a	CLIP-seq
MIRT1385719	hsa-miR-92b	CLIP-seq
MIRT1385720	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005173	Function	Stem cell factor receptor binding	IEA
GO:0005173	Function	Stem cell factor receptor binding	ISS
GO:0005515	Function	Protein binding	IPI	15231748, 19389623, 21900206, 22321011, 24705354, 26635368, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18216281
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005901	Component	Caveola	IEA
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	IEA
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	ISS
GO:0016020	Component	Membrane	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IMP	23136161
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	18216281, 20736167
GO:0019902	Function	Phosphatase binding	IDA	19389623
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	IDA	18216281
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	IEA
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	ISS	20736167
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0031410	Component	Cytoplasmic vesicle	IDA	18216281
GO:0043408	Process	Regulation of MAPK cascade	TAS	18216281
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IMP	18694566
GO:0043517	Process	Positive regulation of DNA damage response, signal transduction by p53 class mediator	IEA
GO:0043517	Process	Positive regulation of DNA damage response, signal transduction by p53 class mediator	ISS	20736167
GO:0060979	Process	Vasculogenesis involved in coronary vascular morphogenesis	IMP	23625462
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IBA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	ISS
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IEA
GO:1902532	Process	Negative regulation of intracellular signal transduction	IEA
GO:1902532	Process	Negative regulation of intracellular signal transduction	IMP	20736167
GO:1902747	Process	Negative regulation of lens fiber cell differentiation	IEA
GO:1902747	Process	Negative regulation of lens fiber cell differentiation	ISS

Other IDs

• MIM: 609291
• HGNC: 20249
• e!Ensembl: ENSG00000166068

Protein

• UniProt ID: Q7Z699
• Protein name: Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
• Protein function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differ
• PDB: 3SYX, 6V65, 6V6F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00568	WH1	10 → 120	WH1 domain	Domain
  PF05210	Sprouty	332 → 441	Sprouty protein (Spry)	Family

• Tissue specificity: TISSUE SPECIFICITY: Weakly expressed in embryonic cell line HEK293. {ECO:0000269|PubMed:15580519}.
• Sequence:

  MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI
  RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI
  EDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFED
  LNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQ
  DEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDET
  KLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIK
  RCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCY
  VPLRMCHRCGEACGCCGGKHKAAG

• Sequence length: 444

Pathways

Reactome:

Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
RAS signaling downstream of NF1 loss-of-function variants

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Cardiovascular phenotype	Pathogenic; Likely pathogenic	rs121434312, rs2542742614, rs2542743815, rs2542744037, rs864622410, rs1057517941, rs1057518150, rs1057518683, rs1566876941, rs1566867209, rs1595763925	RCV002336072 RCV002416682 RCV002419574 RCV006342577 RCV004992078 RCV002328900 RCV002374619 RCV002379279 RCV002399334 RCV004025231 RCV002458462	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Incidental Discovery	Pathogenic	rs750777752	RCV005438016	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Legius syndrome	Pathogenic; Likely pathogenic	rs1595733611, rs764823722, rs1888473716, rs2141016108, rs755557783, rs2141016685, rs1895105626, rs2141016500, rs2141016462, rs1172820756, rs2140978331, rs2141016692, rs2141016437, rs2141014847, rs2140943462, rs2141016553, rs2141016007, rs1345810751, rs2140994872, rs2140943428, rs121434312, rs121434313, rs1566868058, rs121434314, rs121434315, rs121434316, rs121434317, rs121434318, rs2141016737, rs2141007796, rs2542743104, rs2542743206, rs727504170, rs2542743179, rs1201851975, rs1595756946, rs752775519, rs2542742440, rs2542744037, rs2542723633, rs2542695643, rs2542744385, rs2542695902, rs2542700396, rs2542743874, rs1595746804, rs2542695865, rs864622410, rs2542723848, rs878855228, rs1424526290, rs2542743630, rs2542744343, rs2542743797, rs2542660907, rs2542742348, rs1184012360, rs2542723522, rs2542743989, rs764234046, rs2542744046, rs2542723735, rs2542700259, rs2542742417, rs200142785, rs1895110802, rs2542743623, rs2542723680, rs2542742376, rs1057517941, rs1057518683, rs1566876941, rs1060502505, rs1555392791, rs1555392759, rs1555392783, rs1555391161, rs754706111, rs750777752, rs1555391053, rs1555391061, rs1555392609, rs1555386649, rs1555386651, rs1555386654, rs1555389690, rs1555392750, rs1566867246, rs1566868022, rs1566876954, rs1566867209, rs1566876929, rs1566876895, rs1566876690, rs1595746858, rs1595763659, rs1595746834, rs1595763557, rs1595763656, rs1595763925, rs1595763928, rs1595763662, rs148646547, rs1324903101, rs1895677481, rs1894017295, rs1895621783, rs368660900	RCV001379509 RCV001385557 RCV001388493 RCV001380648 RCV001386578 RCV001380281 RCV002032687 RCV001775243 RCV001869612 RCV003497943 RCV001905815 RCV001999753 RCV001911100 RCV002035341 RCV002011666 RCV001913158 RCV001945500 RCV001889204 RCV001914026 RCV002221827 RCV000001882 RCV000001883 RCV000001884 RCV000001885 RCV000001886 RCV000001887 RCV000001888 RCV000001889 RCV002261478 RCV002272971 RCV002288366 RCV002290167 RCV002541493 RCV002471413 RCV002612253 RCV002580096 RCV002622196 RCV002760187 RCV002796197 RCV002824795 RCV002872225 RCV002875584 RCV002867644 RCV002872425 RCV002972139 RCV003012519 RCV003042454 RCV000204318 RCV003152989 RCV000226597 RCV003314118 RCV003498083 RCV003498094 RCV003499984 RCV003497672 RCV003498299 RCV003498489 RCV003601384 RCV003601451 RCV003601762 RCV003602262 RCV003602076 RCV003602091 RCV003600031 RCV003600231 RCV003848946 RCV003859726 RCV003885418 RCV004585110 RCV000705365 RCV000415388 RCV000023764 RCV000473065 RCV000546970 RCV000543442 RCV000558214 RCV000604056 RCV000689010 RCV000645301 RCV000645296 RCV000645295 RCV000645294 RCV000660290 RCV000660291 RCV000660292 RCV000660293 RCV000660294 RCV000701246 RCV000688736 RCV000705583 RCV000695156 RCV000685042 RCV001862131 RCV003155306 RCV001042648 RCV001228821 RCV000805503 RCV000794672 RCV000793307 RCV000801189 RCV000795942 RCV000816212 RCV001235430 RCV001731129 RCV001059001 RCV001052268 RCV001196448 RCV001213292 RCV001227572 RCV001233615 RCV001248365 RCV001301254	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Male infertility with spermatogenesis disorder	Likely pathogenic; Pathogenic	rs1057518683	RCV003991577	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental delay	Pathogenic	rs121434312	RCV002273919	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurofibromatosis, type 1	Likely pathogenic; Pathogenic	rs2140943462, rs1057518683, rs1595763925	RCV004584165 RCV005416033 RCV005626221	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Noonan syndrome and Noonan-related syndrome	Pathogenic; Likely pathogenic	rs1366401484, rs1300035418, rs2141016305, rs2141016462, rs2140978513, rs2141016711, rs121434312, rs727504170, rs864622410, rs750777752, rs1555391053	RCV001813611 RCV001813612 RCV001813613 RCV001813619 RCV001813625 RCV001813727 RCV001813180 RCV001813725 RCV001813427 RCV001813536 RCV001813534	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
SPRED1-related disorder	Likely pathogenic	rs2542739288	RCV003404232	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CAFE-AU-LAIT SPOTS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL NEUROLOGIC ANOMALIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Costello syndrome	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
DESBUQUOIS SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROFIBROMATOSIS 1	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROFIBROMATOSIS TYPE 1-LIKE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurofibromatosis-Noonan syndrome	Likely benign	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Noonan syndrome	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RASopathy	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Bohring syndrome	Bohring syndrome	Pubtator	34121041	Associate	★☆☆☆☆ Found in Text Mining only
Bone Diseases Developmental	Bone disease	Pubtator	32697994	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29685157		★☆☆☆☆ Found in Text Mining only
Byzanthine arch palate	High palate	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cafe-au-lait macules with pulmonary stenosis	Cafe-Au-Lait Macules With Pulmonary Stenosis	CTD_human_DG	17704776		★☆☆☆☆ Found in Text Mining only
CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION (disorder)	Capillary Malformation-Arteriovenous Malformation	BEFREE	28643916		★☆☆☆☆ Found in Text Mining only
Chronic myeloproliferative disorder	Myeloproliferative disorder	BEFREE	29706577		★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital neurologic anomalies	Drachtman Weinblatt Sitarz syndrome	CTD_human_DG	17704776		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cranioschisis	Anencephaly	CTD_human_DG	17704776		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	22525256		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	29942117	Associate	★☆☆☆☆ Found in Text Mining only
Dysmorphic features	Dysmorphic Features	CLINVAR_DG	11493923, 17704776, 19366998, 19443465, 19920235, 20179001, 20339110, 21089071, 21495177, 21548021, 21649642, 22753041, 24334617, 3128965		★☆☆☆☆ Found in Text Mining only
Hamartoma Syndrome, Multiple	Hamartoma	BEFREE	22707495		★☆☆☆☆ Found in Text Mining only
Hepatolenticular Degeneration	Hepatolenticular degeneration	Pubtator	36071243	Associate	★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	24977625		★☆☆☆☆ Found in Text Mining only
Learning Disabilities	Learning disorders	Pubtator	26635368, 27322474	Associate	★☆☆☆☆ Found in Text Mining only
Legius syndrome	Legius Syndrome	Orphanet			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
leukemia	Leukemia	BEFREE	24469042		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	35412895	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	30745814	Inhibit	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	35412895	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	30745814	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	24469042, 30745814		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	LHGDN	16652141		★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	BEFREE	19920235, 21548021, 24469042, 26635368		★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29685157		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23169297		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30385465		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	30385465		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Melanoma	Pubtator	30657954	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Meningioma	Meningioma	Pubtator	26943583	Associate	★☆☆☆☆ Found in Text Mining only
Micrognathism	Micrognathism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Multiple congenital anomalies	Multiple Congenital Anomalies	CLINVAR_DG	11493923, 17704776, 19366998, 19443465, 19920235, 20179001, 20339110, 21089071, 21495177, 21548021, 21649642, 22753041, 24334617, 3128965		★☆☆☆☆ Found in Text Mining only
Multiple lipomata	Multiple Lipomata	HPO_DG			★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	29505034		★☆☆☆☆ Found in Text Mining only
Myeloproliferative disease	Myeloproliferative disorder	BEFREE	29706577		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20602485, 24469042, 30745814		★☆☆☆☆ Found in Text Mining only
neurofibroma	Neurofibroma	BEFREE	19366998, 19443465		★☆☆☆☆ Found in Text Mining only
neurofibroma	Neurofibroma	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neurofibromatoses	Neurofibromatosis	BEFREE	19366998, 19443465, 20179001		★☆☆☆☆ Found in Text Mining only
Neurofibromatoses	Neurofibromatosis	Pubtator	20179001	Associate	★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	BEFREE	17704776, 19366998, 19443465, 19920235, 19966658, 20179001, 20602485, 22438235, 22751498, 23016555, 23401230, 23947441, 24469042, 25074460, 27322474, 28150585, 28503822, 29681099, 30014477, 30290804, 31401120, 31573083		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurofibromatosis 1	Neurofibromatosis	LHGDN	17704776		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurofibromatosis 1	Neurofibromatosis	CTD_human_DG	17704776		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurofibromatosis 1	Neurofibromatosis	Pubtator	20179001, 20602485, 31443423, 32147744	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME	Neurofibromatosis	CLINVAR_DG	15683364, 17704776, 19366998, 19443465, 19920235, 20179001, 21089071, 21649642, 22751498, 25074460, 25981987		★☆☆☆☆ Found in Text Mining only
NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME	Neurofibromatosis	GENOMICS_ENGLAND_DG	17704776, 19366998, 19443465, 21548021, 23875798, 27423141		★☆☆☆☆ Found in Text Mining only
NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME	Neurofibromatosis	CLINGEN_DG	17704776, 21089071, 27313208, 27503857		★☆☆☆☆ Found in Text Mining only
NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME	Neurofibromatosis	UNIPROT_DG	17704776, 19443465, 20108422, 21089071		★☆☆☆☆ Found in Text Mining only
NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME	Neurofibromatosis	BEFREE	19366998, 19443465, 19966658, 20179001, 20602485, 21548021, 22751498, 22753041, 23016555, 24469042, 25981987, 26635368, 27322474, 27503857, 28150585, 28643916, 31401120		★☆☆☆☆ Found in Text Mining only
NEUROFIBROMATOSIS, TYPE 1-LIKE SYNDROME	Neurofibromatosis	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Noonan Syndrome	Noonan Syndrome	BEFREE	28643916		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Noonan Syndrome	Noonan syndrome	Pubtator	32107864	Associate	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Piebaldism	Piebaldism	BEFREE	22438235, 23016555		★☆☆☆☆ Found in Text Mining only
Plexiform Neurofibroma	Plexiform neurofibroma	BEFREE	19920235		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23169297		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	31629629		★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Sarcoidosis	Sarcoidosis	Pubtator	22984568	Associate	★☆☆☆☆ Found in Text Mining only
Specific learning disability	Specific Learning Disorder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	25202123	Associate	★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	29942117	Associate	★☆☆☆☆ Found in Text Mining only