Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	161198
Gene name	C-type lectin domain containing 14A
Gene symbol	CLEC14A
Synonyms (NCBI Gene)	C14orf27CEG1EGFR-5
Chromosome	14
Chromosome location	14q21.1
Summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles

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Show/Hide all (166)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018973	hsa-miR-335-5p	Microarray	18185580
MIRT607877	hsa-miR-8485	HITS-CLIP	22927820
MIRT607876	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT607875	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT607874	hsa-miR-603	HITS-CLIP	22927820
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	22927820
MIRT607871	hsa-miR-3941	HITS-CLIP	22927820
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	22927820
MIRT607877	hsa-miR-8485	HITS-CLIP	23313552
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23313552
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	24906430
MIRT607876	hsa-miR-329-3p	HITS-CLIP	24906430
MIRT607875	hsa-miR-362-3p	HITS-CLIP	24906430
MIRT607874	hsa-miR-603	HITS-CLIP	24906430
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	24906430
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	24906430
MIRT607871	hsa-miR-3941	HITS-CLIP	24906430
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	24906430
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607876	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT607875	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT670441	hsa-miR-3924	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607871	hsa-miR-3941	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607874	hsa-miR-603	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	27418678
MIRT607877	hsa-miR-8485	HITS-CLIP	22927820
MIRT607876	hsa-miR-329-3p	HITS-CLIP	22927820
MIRT607875	hsa-miR-362-3p	HITS-CLIP	22927820
MIRT607874	hsa-miR-603	HITS-CLIP	22927820
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	22927820
MIRT607871	hsa-miR-3941	HITS-CLIP	22927820
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	22927820
MIRT607877	hsa-miR-8485	HITS-CLIP	23313552
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23313552
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607876	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT607875	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT607874	hsa-miR-603	HITS-CLIP	23824327
MIRT607871	hsa-miR-3941	HITS-CLIP	23824327
MIRT607870	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT670441	hsa-miR-3924	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT639520	hsa-miR-577	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT607877	hsa-miR-8485	HITS-CLIP	23824327
MIRT607873	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT607872	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT2678258	hsa-miR-3675-3p	CLIP-seq
MIRT2678259	hsa-miR-4803	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001946	Process	Lymphangiogenesis	IEA
GO:0002040	Process	Sprouting angiogenesis	IEA
GO:0002042	Process	Cell migration involved in sprouting angiogenesis	IEA
GO:0005515	Function	Protein binding	IPI	27991863, 32296183
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009897	Component	External side of plasma membrane	IDA	25745997
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IBA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031012	Component	Extracellular matrix	HDA	23979707
GO:0036324	Process	Vascular endothelial growth factor receptor-2 signaling pathway	IEA
GO:0036324	Process	Vascular endothelial growth factor receptor-2 signaling pathway	IEA
GO:0036324	Process	Vascular endothelial growth factor receptor-2 signaling pathway	IMP	27991863
GO:0036325	Process	Vascular endothelial growth factor receptor-3 signaling pathway	IEA
GO:0036325	Process	Vascular endothelial growth factor receptor-3 signaling pathway	IEA
GO:0036325	Process	Vascular endothelial growth factor receptor-3 signaling pathway	IMP	27991863
GO:0050840	Function	Extracellular matrix binding	IBA
GO:1990430	Function	Extracellular matrix protein binding	IBA
GO:1990430	Function	Extracellular matrix protein binding	IDA	25745997

MIM	HGNC	e!Ensembl
616845	19832	ENSG00000176435

Q86T13

Protein name

C-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5)

Family and domains

Sequence

MRPAFALCLLWQALWPGPGGGEHPTADRAGCSASGACYSLHHATMKRQAAEEACILRGGA
LSTVRAGAELRAVLALLRAGPGPGGGSKDLLFWVALERRRSHCTLENEPLRGFSWLSSDP
GGLESDTLQWVEEPQRSCTARRCAVLQATGGVEPAGWKEMRCHLRANGYLCKYQFEVLCP
APRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRGQLPISVTCIADEIGARWDKLSG
DVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGKDGRSCVTSGEGQPTLGGTG
VPTRRPPATATSPVPQRTWPIRVDEKLGETPLVPEQDNSVTSIPEIPRWGSQSTMSTLQM
SLQAESKATITPSGSVISKFNSTTSSATPQAFDSSSAVVFIFVSTAVVVLVILTMTVLGL
VKLCFHESPSSQPRKESMGPPGLESDPEPAALGSSSAHCTNNGVKVGDCDLRDRAEGALL
AESPLGSSDA

Sequence length

490

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY VASOSPASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	30191970		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	35641310	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18446232		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18446232	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
CADASIL	Cadasil	Pubtator	35641310	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35576868	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33761933	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	27567920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinosarcoma	Carcinoma	Pubtator	28088687	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	27567920		★★★★★ ★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	BEFREE	21737517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18446232		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	28671670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30132150		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	26967478		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21706054, 25745997, 27991863, 28671670, 28878328, 30191970		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	28671670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21694441	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	35641310	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thymoma	Thymoma	BEFREE	26967478		★★★★★ ★☆☆☆☆ Found in Text Mining only

CLEC14A (C-type lectin domain containing 14A)