Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	161003
Gene name	Stomatin like 3
Gene symbol	STOML3
Synonyms (NCBI Gene)	Epb7.2lSRO
Chromosome	13
Chromosome location	13q13.3

102

Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT454797	hsa-miR-4491	PAR-CLIP	23592263
MIRT454796	hsa-miR-4657	PAR-CLIP	23592263
MIRT454795	hsa-miR-3665	PAR-CLIP	23592263
MIRT454794	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT454793	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT454792	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT454791	hsa-miR-4736	PAR-CLIP	23592263
MIRT454790	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT454789	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT454788	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT454787	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT454786	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT454785	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT454784	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT454783	hsa-miR-5698	PAR-CLIP	23592263
MIRT454782	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT454781	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT454780	hsa-miR-4525	PAR-CLIP	23592263
MIRT454779	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT454778	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT454777	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT454776	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT454774	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT454775	hsa-miR-8056	PAR-CLIP	23592263
MIRT454773	hsa-miR-4447	PAR-CLIP	23592263
MIRT454772	hsa-miR-4472	PAR-CLIP	23592263
MIRT454771	hsa-miR-7150	PAR-CLIP	23592263
MIRT454770	hsa-miR-1275	PAR-CLIP	23592263
MIRT454769	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT454768	hsa-miR-4752	PAR-CLIP	23592263
MIRT454767	hsa-miR-182-5p	PAR-CLIP	23592263
MIRT454766	hsa-miR-1271-5p	PAR-CLIP	23592263
MIRT454765	hsa-miR-96-5p	PAR-CLIP	23592263
MIRT454797	hsa-miR-4491	PAR-CLIP	23592263
MIRT454796	hsa-miR-4657	PAR-CLIP	23592263
MIRT454795	hsa-miR-3665	PAR-CLIP	23592263
MIRT454794	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT454793	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT454792	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT454791	hsa-miR-4736	PAR-CLIP	23592263
MIRT454790	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT454789	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT454788	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT454787	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT454786	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT454785	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT454784	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT454783	hsa-miR-5698	PAR-CLIP	23592263
MIRT454782	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT454781	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT454780	hsa-miR-4525	PAR-CLIP	23592263
MIRT454779	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT454778	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT454777	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT454776	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT454774	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT454775	hsa-miR-8056	PAR-CLIP	23592263
MIRT454773	hsa-miR-4447	PAR-CLIP	23592263
MIRT454772	hsa-miR-4472	PAR-CLIP	23592263
MIRT454771	hsa-miR-7150	PAR-CLIP	23592263
MIRT454770	hsa-miR-1275	PAR-CLIP	23592263
MIRT454769	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT454768	hsa-miR-4752	PAR-CLIP	23592263
MIRT454767	hsa-miR-182-5p	PAR-CLIP	23592263
MIRT454766	hsa-miR-1271-5p	PAR-CLIP	23592263
MIRT454765	hsa-miR-96-5p	PAR-CLIP	23592263
MIRT1399015	hsa-miR-452	CLIP-seq
MIRT1399016	hsa-miR-4653-3p	CLIP-seq
MIRT1399017	hsa-miR-4666-5p	CLIP-seq
MIRT1399018	hsa-miR-4676-3p	CLIP-seq
MIRT1399019	hsa-miR-4693-5p	CLIP-seq
MIRT1399020	hsa-miR-4802-5p	CLIP-seq
MIRT1399021	hsa-miR-1269	CLIP-seq
MIRT1399022	hsa-miR-1269b	CLIP-seq
MIRT1399023	hsa-miR-1288	CLIP-seq
MIRT1399024	hsa-miR-3661	CLIP-seq
MIRT1399025	hsa-miR-3670	CLIP-seq
MIRT1399026	hsa-miR-3690	CLIP-seq
MIRT1399027	hsa-miR-378	CLIP-seq
MIRT1399028	hsa-miR-378b	CLIP-seq
MIRT1399029	hsa-miR-378c	CLIP-seq
MIRT1399030	hsa-miR-378d	CLIP-seq
MIRT1399031	hsa-miR-378e	CLIP-seq
MIRT1399032	hsa-miR-378f	CLIP-seq
MIRT1399033	hsa-miR-378h	CLIP-seq
MIRT1399034	hsa-miR-378i	CLIP-seq
MIRT1399035	hsa-miR-422a	CLIP-seq
MIRT1399036	hsa-miR-4515	CLIP-seq
MIRT1399037	hsa-miR-4677-3p	CLIP-seq
MIRT1399038	hsa-miR-4740-5p	CLIP-seq
MIRT1399039	hsa-miR-619	CLIP-seq
MIRT1399040	hsa-miR-631	CLIP-seq
MIRT1399041	hsa-miR-769-5p	CLIP-seq
MIRT1399015	hsa-miR-452	CLIP-seq
MIRT1399016	hsa-miR-4653-3p	CLIP-seq
MIRT1399017	hsa-miR-4666-5p	CLIP-seq
MIRT1399018	hsa-miR-4676-3p	CLIP-seq
MIRT1399019	hsa-miR-4693-5p	CLIP-seq
MIRT1399020	hsa-miR-4802-5p	CLIP-seq
MIRT2460703	hsa-miR-625	CLIP-seq
MIRT2460703	hsa-miR-625	CLIP-seq
MIRT2460703	hsa-miR-625	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008200	Function	Ion channel inhibitor activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045121	Component	Membrane raft	IEA

MIM	HGNC	e!Ensembl
608327	19420	ENSG00000133115

Q8TAV4

Protein name

Stomatin-like protein 3 (SLP-3)

Protein function

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. {ECO:0000

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01145	Band_7	52 → 225	SPFH domain / Band 7 family	Family

Sequence

MDSRVSSPEKQDKENFVGVNNKRLGVCGWILFSLSFLLVIITFPISIWMCLKIIKEYERA
VVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVY
YRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILAGREEIAHSIQTLLDDATE
LWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAE
SPIALQLRYLQTLSTVATEKNSTIVFPLPMNILEGIGGVSYDNHKKLPNKA

Sequence length

291

Interactions

View interactions

	Reactome
			Stimuli-sensing channels

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Angelman Syndrome	Angelman Syndrome	BEFREE	14962980, 18627066		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	36835202	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bardet-Biedl Syndrome	Bardet-Biedl Syndrome	BEFREE	17959775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31825993		★★★★★ ★☆☆☆☆ Found in Text Mining only
gliosarcoma	Gliosarcoma	BEFREE	22538188		★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	23294540		★★★★★ ★☆☆☆☆ Found in Text Mining only
insulinoma	Insulinoma	BEFREE	15900598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	23294540		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	31825993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31825993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15900598, 20461752, 29180076, 31825993		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	31825993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prader-Willi Syndrome	Prader-Willi Syndrome	BEFREE	14962980, 18627066		★★★★★ ★☆☆☆☆ Found in Text Mining only

STOML3 (stomatin like 3)