Gene Gene information from NCBI Gene database.
Entrez ID 160897
Gene name G protein-coupled receptor 180
Gene symbol GPR180
Synonyms (NCBI Gene)
ITR
Chromosome 13
Chromosome location 13q32.1
Summary This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq
miRNA miRNA information provided by mirtarbase database.
585
miRTarBase ID miRNA Experiments Reference
MIRT024681 hsa-miR-215-5p Microarray 19074876
MIRT026775 hsa-miR-192-5p Microarray 19074876
MIRT027173 hsa-miR-103a-3p Sequencing 20371350
MIRT031916 hsa-miR-16-5p Sequencing 20371350
MIRT668067 hsa-miR-627-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0006091 Process Generation of precursor metabolites and energy IEA
GO:0006629 Process Lipid metabolic process IEA
GO:0007186 Process G protein-coupled receptor signaling pathway IEA
GO:0010467 Process Gene expression IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607787 28899 ENSG00000152749
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86V85
Protein name Integral membrane protein GPR180 (Intimal thickness-related receptor)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10192 GpcrRhopsn4 141 405 Rhodopsin-like GPCR transmembrane domain Family
Sequence
Sequence length 440
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GPR180-related disorder Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 29138846
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 28098885
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 28098885
★☆☆☆☆
Found in Text Mining only
Hepatoblastoma Hepatoblastoma Pubtator 26991471 Associate
★☆☆☆☆
Found in Text Mining only
Hypertriglyceridemia Hypertriglyceridemia Pubtator 31868224 Associate
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 28098885, 29138846
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 28098885
★☆☆☆☆
Found in Text Mining only
Myeloid Leukemia, Chronic Myeloid Leukemia BEFREE 29138846
★☆☆☆☆
Found in Text Mining only
Osteogenesis Imperfecta Osteogenesis Imperfecta BEFREE 30179947
★☆☆☆☆
Found in Text Mining only