DGKG (diacylglycerol kinase gamma)

Gene

• Entrez ID: 1608
• Gene name: Diacylglycerol kinase gamma
• Gene symbol: DGKG
• Synonyms (NCBI Gene): DAGK3, DGK-GAMMA
• Chromosome: 3
• Chromosome location: 3q27.2-q27.3
• Summary: This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid secon

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT615036	hsa-miR-8485	HITS-CLIP	19536157
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504729	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504726	hsa-miR-6083	HITS-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504731	hsa-miR-1295b-3p	HITS-CLIP	23313552
MIRT504729	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT504726	hsa-miR-6083	HITS-CLIP	23313552
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	21572407
MIRT504729	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504726	hsa-miR-6083	PAR-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT615036	hsa-miR-8485	HITS-CLIP	19536157
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504729	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504726	hsa-miR-6083	HITS-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504731	hsa-miR-1295b-3p	HITS-CLIP	23313552
MIRT504729	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT504726	hsa-miR-6083	HITS-CLIP	23313552
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT504727	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504728	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT633045	hsa-miR-208a-3p	HITS-CLIP	23824327
MIRT633044	hsa-miR-208b-3p	HITS-CLIP	23824327
MIRT633043	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT615036	hsa-miR-8485	HITS-CLIP	23824327
MIRT611885	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT504729	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504726	hsa-miR-6083	PAR-CLIP	20371350
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	21572407
MIRT504729	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504726	hsa-miR-6083	PAR-CLIP	21572407
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT504730	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504731	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT504729	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT504727	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504728	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504726	hsa-miR-6083	PAR-CLIP	23446348
MIRT934199	hsa-miR-425	CLIP-seq
MIRT934200	hsa-miR-1225-3p	CLIP-seq
MIRT934201	hsa-miR-1233	CLIP-seq
MIRT934202	hsa-miR-190	CLIP-seq
MIRT934203	hsa-miR-190b	CLIP-seq
MIRT934204	hsa-miR-216a	CLIP-seq
MIRT934205	hsa-miR-3173-5p	CLIP-seq
MIRT934206	hsa-miR-3201	CLIP-seq
MIRT934207	hsa-miR-3653	CLIP-seq
MIRT934208	hsa-miR-370	CLIP-seq
MIRT934209	hsa-miR-3919	CLIP-seq
MIRT934210	hsa-miR-4330	CLIP-seq
MIRT934211	hsa-miR-450b-3p	CLIP-seq
MIRT934212	hsa-miR-4534	CLIP-seq
MIRT934213	hsa-miR-4663	CLIP-seq
MIRT934214	hsa-miR-4722-3p	CLIP-seq
MIRT934215	hsa-miR-4756-3p	CLIP-seq
MIRT934216	hsa-miR-4791	CLIP-seq
MIRT934217	hsa-miR-4802-5p	CLIP-seq
MIRT934218	hsa-miR-769-3p	CLIP-seq
MIRT1976549	hsa-miR-204	CLIP-seq
MIRT1976550	hsa-miR-211	CLIP-seq
MIRT1976551	hsa-miR-4755-5p	CLIP-seq
MIRT1976552	hsa-miR-298	CLIP-seq
MIRT1976553	hsa-miR-3064-5p	CLIP-seq
MIRT1976554	hsa-miR-34a	CLIP-seq
MIRT1976555	hsa-miR-34c-5p	CLIP-seq
MIRT1976556	hsa-miR-3652	CLIP-seq
MIRT1976557	hsa-miR-3678-3p	CLIP-seq
MIRT1976558	hsa-miR-4430	CLIP-seq
MIRT1976559	hsa-miR-449a	CLIP-seq
MIRT1976560	hsa-miR-449b	CLIP-seq
MIRT1976561	hsa-miR-4505	CLIP-seq
MIRT2211931	hsa-miR-1258	CLIP-seq
MIRT2211932	hsa-miR-1271	CLIP-seq
MIRT2211933	hsa-miR-149	CLIP-seq
MIRT2211934	hsa-miR-205	CLIP-seq
MIRT2211935	hsa-miR-4278	CLIP-seq
MIRT2211936	hsa-miR-760	CLIP-seq
MIRT2211937	hsa-miR-892b	CLIP-seq
MIRT2211938	hsa-miR-96	CLIP-seq
MIRT2515662	hsa-miR-3194-3p	CLIP-seq
MIRT2515663	hsa-miR-3670	CLIP-seq
MIRT2515664	hsa-miR-4329	CLIP-seq
MIRT934213	hsa-miR-4663	CLIP-seq
MIRT2515665	hsa-miR-4786-5p	CLIP-seq
MIRT2515666	hsa-miR-769-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREB5	Activation	21132541
CREB5	Repression	21132541

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IBA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IDA	8034597, 22627129
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	IEA
GO:0004143	Function	ATP-dependent diacylglycerol kinase activity	TAS
GO:0005509	Function	Calcium ion binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	8034597
GO:0005829	Component	Cytosol	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006654	Process	Phosphatidic acid biosynthetic process	IBA
GO:0006654	Process	Phosphatidic acid biosynthetic process	IDA	8034597
GO:0006654	Process	Phosphatidic acid biosynthetic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008289	Function	Lipid binding	IDA	22627129
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IDA	8034597
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030168	Process	Platelet activation	IEA
GO:0030168	Process	Platelet activation	TAS
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0046339	Process	Diacylglycerol metabolic process	IBA
GO:0046339	Process	Diacylglycerol metabolic process	IDA	8034597
GO:0046339	Process	Diacylglycerol metabolic process	IEA
GO:0046486	Process	Glycerolipid metabolic process	IDA	22627129
GO:0046486	Process	Glycerolipid metabolic process	IEA
GO:0046834	Process	Lipid phosphorylation	IDA	8034597, 22627129
GO:0046834	Process	Lipid phosphorylation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050773	Process	Regulation of dendrite development	IEA
GO:0160195	Process	Negative regulation of phospholipase C/protein kinase C signal transduction	IEA
GO:0160195	Process	Negative regulation of phospholipase C/protein kinase C signal transduction	ISS

Other IDs

• MIM: 601854
• HGNC: 2853
• e!Ensembl: ENSG00000058866

Protein

• UniProt ID: P49619
• Protein name: Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma)
• Protein function: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways a
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14513	DAG_kinase_N	5 → 175	Diacylglycerol kinase N-terminus	Domain
  PF00130	C1_1	272 → 324	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF00781	DAGK_cat	434 → 554	Diacylglycerol kinase catalytic domain	Family
  PF00609	DAGK_acc	578 → 752	Diacylglycerol kinase accessory domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.
• Sequence:

  MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR
  AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC
  APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL
  EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV
  SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL
  CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS
  VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL
  VMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFR
  DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL
  TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE
  KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI
  PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY
  TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF
  FSLRRKSRSKD

• Sequence length: 791

Pathways

KEGG:

Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Choline metabolism in cancer

Reactome:

Effects of PIP2 hydrolysis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VERTEBRAL COLUMN DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	BEFREE	20816195		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	20816195	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28218473		★☆☆☆☆ Found in Text Mining only
Disorder of eye	Disorder Of Eye	BEFREE	10071200		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	35421845	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30399372		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	27622933		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30399372		★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	GWASCAT_DG	27622933		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28218473, 30399372		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	GWASDB_DG	23563607		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	GWASCAT_DG	23563607		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Optic Atrophy 1	Optic Atrophy	BEFREE	10071200		★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	GWASCAT_DG	27622933		★☆☆☆☆ Found in Text Mining only
Urticaria	Urticaria	BEFREE	21132541		★☆☆☆☆ Found in Text Mining only