CLEC12A (C-type lectin domain family 12 member A)

Gene

• Entrez ID: 160364
• Gene name: C-type lectin domain family 12 member A
• Gene symbol: CLEC12A
• Synonyms (NCBI Gene): CD371, CLL-1, CLL1, DCAL-2, MICL, hKLRL1
• Chromosome: 12
• Chromosome location: 12p13.31-p13.2
• Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles i

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT550172	hsa-miR-8485	HITS-CLIP	21572407
MIRT550173	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT550171	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT550170	hsa-miR-603	HITS-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707162	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT707161	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT707160	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT550167	hsa-miR-3941	HITS-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550172	hsa-miR-8485	PAR-CLIP	21572407
MIRT550173	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT550171	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT550170	hsa-miR-603	PAR-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550167	hsa-miR-3941	PAR-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT550172	hsa-miR-8485	HITS-CLIP	21572407
MIRT550173	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT550171	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT550170	hsa-miR-603	HITS-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707162	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT707161	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT707160	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT550167	hsa-miR-3941	HITS-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550172	hsa-miR-8485	PAR-CLIP	21572407
MIRT550173	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT550171	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT550170	hsa-miR-603	PAR-CLIP	21572407
MIRT550168	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT550169	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550167	hsa-miR-3941	PAR-CLIP	21572407
MIRT550166	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT550165	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT895605	hsa-miR-127-5p	CLIP-seq
MIRT895606	hsa-miR-128	CLIP-seq
MIRT895607	hsa-miR-27a	CLIP-seq
MIRT895608	hsa-miR-27b	CLIP-seq
MIRT895609	hsa-miR-3119	CLIP-seq
MIRT895610	hsa-miR-3921	CLIP-seq
MIRT895611	hsa-miR-4653-5p	CLIP-seq
MIRT895612	hsa-miR-4768-5p	CLIP-seq
MIRT895613	hsa-miR-513a-5p	CLIP-seq
MIRT2201502	hsa-miR-4640-3p	CLIP-seq
MIRT2201503	hsa-miR-483-3p	CLIP-seq
MIRT2504454	hsa-miR-3121-5p	CLIP-seq
MIRT2504454	hsa-miR-3121-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002283	Process	Neutrophil activation involved in immune response	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	38367667, 38386511, 39143217
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IMP	15238421
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14739280, 15238421, 16239426, 34234773, 38367667
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030545	Function	Signaling receptor regulator activity	IEA
GO:0032481	Process	Positive regulation of type I interferon production	ISS
GO:0032815	Process	Negative regulation of natural killer cell activation	IEA
GO:0032815	Process	Negative regulation of natural killer cell activation	IMP	15238421, 31269448
GO:0035579	Component	Specific granule membrane	TAS
GO:0038187	Function	Pattern recognition receptor activity	IDA	36542980
GO:0038187	Function	Pattern recognition receptor activity	IEA
GO:0038187	Function	Pattern recognition receptor activity	IMP	31269448
GO:0050728	Process	Negative regulation of inflammatory response	ISS
GO:0050777	Process	Negative regulation of immune response	IDA	14739280
GO:0070821	Component	Tertiary granule membrane	TAS
GO:1902564	Process	Negative regulation of neutrophil activation	IDA	34234773
GO:1902564	Process	Negative regulation of neutrophil activation	IEA
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IDA	16239426
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IEA

Other IDs

• MIM: 612088
• HGNC: 31713
• e!Ensembl: ENSG00000172322

Protein

• UniProt ID: Q5QGZ9
• Protein name: C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)
• Protein function: Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217). Myeloid cell inhibiti
• PDB: 8JAH, 8W8T, 8W9J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00059	Lectin_C	150 → 250	Lectin C-type domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Preferentially expressed in lymphoid tissues and immune cells, including natural killer (NK) cells, T-cells, dendritic cells and monocytes or macrophages (PubMed:14739280, PubMed:15238421, PubMed:15548716, PubMed:16239426, PubMed:16838
• Sequence:

  MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVL
  ASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRE
  LYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFI
  KSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHC
  TYKKRMICEKMANPVQLGSTYFREA

• Sequence length: 265

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARTHRITIS, RHEUMATOID	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	15548716		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	30520015		★☆☆☆☆ Found in Text Mining only
Acute Undifferentiated Leukemia	Leukemia	BEFREE	31055076		★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	26275430		★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	Pubtator	34045571, 34638548	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	34045571, 38302188	Associate	★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	37102643	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	25495265, 25786252, 30338367		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	26095365		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	34555062	Associate	★☆☆☆☆ Found in Text Mining only
Gout	Gout	Pubtator	34638548	Associate	★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	26275430		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	27612176, 28718199, 29316944		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	30467201, 34053123, 36050244, 37818740	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	28810819, 29720577, 29946192, 33094319, 33495835, 33778076, 34053123, 36050244, 39582863	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	15548716, 27612176, 27908880, 28676343, 28718199, 28810819, 29077054, 29206680, 29316944, 29720577, 29959143, 30037800, 30401586, 30520015, 30782669, 30848055, 31014360, 31055076, 31286786		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	LHGDN	17609428		★☆☆☆☆ Found in Text Mining only
Leukocyte adhesion deficiency type 1	Leukocyte adhesion deficiency	Pubtator	33495835	Associate	★☆☆☆☆ Found in Text Mining only
Lung Diseases Interstitial	Lung disease	Pubtator	38302188	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	35672358	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27612176, 28718199, 29411522, 9192768		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36353633	Associate	★☆☆☆☆ Found in Text Mining only
Monoclonal B-Cell Lymphocytosis	B-Cell Lymphocytosis	BEFREE	24579978		★☆☆☆☆ Found in Text Mining only
Monoclonal Gammopathy of Undetermined Significance	Monoclonal Gammapathies	BEFREE	23321251		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	23321251		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	28578388		★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	15548716, 27612176		★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	27612176, 29799854, 33369070, 34053123	Associate	★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	28718199		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	2841846, 30037800, 9192768		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	29578204	Associate	★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	15548716		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	36655999	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Fibrosis	Pulmonary fibrosis	Pubtator	38302188	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	CTD_human_DG	17568789		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	22341585, 26275430		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Waldenstrom Macroglobulinemia	Waldenstrom`s Macroglobulinemia	BEFREE	23321251		★☆☆☆☆ Found in Text Mining only