Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	158747
Gene name	Motile sperm domain containing 2
Gene symbol	MOSPD2
Synonyms (NCBI Gene)	-
Chromosome	X
Chromosome location	Xp22.2

233

Show/Hide all (233)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001535	hsa-miR-155-5p	pSILAC	18668040
MIRT001535	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT028398	hsa-miR-30a-5p	Proteomics	18668040
MIRT031102	hsa-miR-19b-3p	Sequencing	20371350
MIRT1155784	hsa-miR-1305	CLIP-seq
MIRT1155785	hsa-miR-3138	CLIP-seq
MIRT1155786	hsa-miR-3617	CLIP-seq
MIRT1155787	hsa-miR-3681	CLIP-seq
MIRT1155788	hsa-miR-4274	CLIP-seq
MIRT1155789	hsa-miR-4519	CLIP-seq
MIRT1155790	hsa-miR-4738-3p	CLIP-seq
MIRT1155791	hsa-miR-498	CLIP-seq
MIRT1155792	hsa-miR-548c-3p	CLIP-seq
MIRT1155793	hsa-miR-641	CLIP-seq
MIRT1155794	hsa-miR-1256	CLIP-seq
MIRT1155795	hsa-miR-1268	CLIP-seq
MIRT1155796	hsa-miR-1268b	CLIP-seq
MIRT1155797	hsa-miR-1271	CLIP-seq
MIRT1155798	hsa-miR-130a	CLIP-seq
MIRT1155799	hsa-miR-130b	CLIP-seq
MIRT1155800	hsa-miR-133a	CLIP-seq
MIRT1155801	hsa-miR-133b	CLIP-seq
MIRT1155802	hsa-miR-142-5p	CLIP-seq
MIRT1155803	hsa-miR-148a	CLIP-seq
MIRT1155804	hsa-miR-148b	CLIP-seq
MIRT1155805	hsa-miR-152	CLIP-seq
MIRT1155806	hsa-miR-181a	CLIP-seq
MIRT1155807	hsa-miR-181b	CLIP-seq
MIRT1155808	hsa-miR-181c	CLIP-seq
MIRT1155809	hsa-miR-181d	CLIP-seq
MIRT1155810	hsa-miR-182	CLIP-seq
MIRT1155811	hsa-miR-186	CLIP-seq
MIRT1155812	hsa-miR-200b	CLIP-seq
MIRT1155813	hsa-miR-200c	CLIP-seq
MIRT1155814	hsa-miR-224	CLIP-seq
MIRT1155815	hsa-miR-299-5p	CLIP-seq
MIRT1155816	hsa-miR-301a	CLIP-seq
MIRT1155817	hsa-miR-301b	CLIP-seq
MIRT1155818	hsa-miR-3150b-3p	CLIP-seq
MIRT1155819	hsa-miR-3160-3p	CLIP-seq
MIRT1155820	hsa-miR-3192	CLIP-seq
MIRT1155821	hsa-miR-340	CLIP-seq
MIRT1155822	hsa-miR-3607-5p	CLIP-seq
MIRT1155823	hsa-miR-3666	CLIP-seq
MIRT1155824	hsa-miR-3942-3p	CLIP-seq
MIRT1155825	hsa-miR-4262	CLIP-seq
MIRT1155826	hsa-miR-429	CLIP-seq
MIRT1155827	hsa-miR-4295	CLIP-seq
MIRT1155828	hsa-miR-4419a	CLIP-seq
MIRT1155829	hsa-miR-4486	CLIP-seq
MIRT1155830	hsa-miR-4510	CLIP-seq
MIRT1155831	hsa-miR-454	CLIP-seq
MIRT1155832	hsa-miR-4642	CLIP-seq
MIRT1155833	hsa-miR-4666-5p	CLIP-seq
MIRT1155834	hsa-miR-4689	CLIP-seq
MIRT1155835	hsa-miR-4760-3p	CLIP-seq
MIRT1155836	hsa-miR-4779	CLIP-seq
MIRT1155837	hsa-miR-4784	CLIP-seq
MIRT1155838	hsa-miR-548a-5p	CLIP-seq
MIRT1155839	hsa-miR-548ab	CLIP-seq
MIRT1155840	hsa-miR-548ak	CLIP-seq
MIRT1155841	hsa-miR-548b-5p	CLIP-seq
MIRT1155842	hsa-miR-548c-5p	CLIP-seq
MIRT1155843	hsa-miR-548d-5p	CLIP-seq
MIRT1155844	hsa-miR-548h	CLIP-seq
MIRT1155845	hsa-miR-548i	CLIP-seq
MIRT1155846	hsa-miR-548j	CLIP-seq
MIRT1155847	hsa-miR-548k	CLIP-seq
MIRT1155848	hsa-miR-548l	CLIP-seq
MIRT1155849	hsa-miR-548n	CLIP-seq
MIRT1155850	hsa-miR-548t	CLIP-seq
MIRT1155851	hsa-miR-548w	CLIP-seq
MIRT1155852	hsa-miR-548y	CLIP-seq
MIRT1155853	hsa-miR-553	CLIP-seq
MIRT1155854	hsa-miR-559	CLIP-seq
MIRT1155855	hsa-miR-576-3p	CLIP-seq
MIRT1155856	hsa-miR-585	CLIP-seq
MIRT1155857	hsa-miR-591	CLIP-seq
MIRT1155858	hsa-miR-96	CLIP-seq
MIRT1155795	hsa-miR-1268	CLIP-seq
MIRT1155796	hsa-miR-1268b	CLIP-seq
MIRT2044530	hsa-miR-129-5p	CLIP-seq
MIRT1155784	hsa-miR-1305	CLIP-seq
MIRT2044531	hsa-miR-2116	CLIP-seq
MIRT2044532	hsa-miR-3065-5p	CLIP-seq
MIRT2044533	hsa-miR-3163	CLIP-seq
MIRT1155820	hsa-miR-3192	CLIP-seq
MIRT2044534	hsa-miR-325	CLIP-seq
MIRT2044535	hsa-miR-330-3p	CLIP-seq
MIRT1155786	hsa-miR-3617	CLIP-seq
MIRT2044536	hsa-miR-3620	CLIP-seq
MIRT2044537	hsa-miR-3689a-3p	CLIP-seq
MIRT2044538	hsa-miR-3689c	CLIP-seq
MIRT2044539	hsa-miR-371-5p	CLIP-seq
MIRT2044540	hsa-miR-371b-5p	CLIP-seq
MIRT2044541	hsa-miR-376c	CLIP-seq
MIRT1155788	hsa-miR-4274	CLIP-seq
MIRT2044542	hsa-miR-4328	CLIP-seq
MIRT2044543	hsa-miR-4422	CLIP-seq
MIRT1155829	hsa-miR-4486	CLIP-seq
MIRT1155789	hsa-miR-4519	CLIP-seq
MIRT2044544	hsa-miR-4659a-3p	CLIP-seq
MIRT2044545	hsa-miR-4659b-3p	CLIP-seq
MIRT1155833	hsa-miR-4666-5p	CLIP-seq
MIRT2044546	hsa-miR-4668-3p	CLIP-seq
MIRT2044547	hsa-miR-4677-5p	CLIP-seq
MIRT2044548	hsa-miR-4698	CLIP-seq
MIRT2044549	hsa-miR-4699-3p	CLIP-seq
MIRT2044550	hsa-miR-4728-5p	CLIP-seq
MIRT2044551	hsa-miR-4772-3p	CLIP-seq
MIRT2044552	hsa-miR-4777-5p	CLIP-seq
MIRT1155791	hsa-miR-498	CLIP-seq
MIRT2044553	hsa-miR-5096	CLIP-seq
MIRT2044554	hsa-miR-513a-3p	CLIP-seq
MIRT2044555	hsa-miR-513c	CLIP-seq
MIRT2044556	hsa-miR-514b-5p	CLIP-seq
MIRT2044557	hsa-miR-518d-5p	CLIP-seq
MIRT2044558	hsa-miR-519b-5p	CLIP-seq
MIRT2044559	hsa-miR-519c-5p	CLIP-seq
MIRT2044560	hsa-miR-520c-5p	CLIP-seq
MIRT2044561	hsa-miR-526a	CLIP-seq
MIRT2044562	hsa-miR-567	CLIP-seq
MIRT1155856	hsa-miR-585	CLIP-seq
MIRT1155857	hsa-miR-591	CLIP-seq
MIRT2044563	hsa-miR-604	CLIP-seq
MIRT2044564	hsa-miR-628-3p	CLIP-seq
MIRT1155793	hsa-miR-641	CLIP-seq
MIRT2044565	hsa-miR-647	CLIP-seq
MIRT1155784	hsa-miR-1305	CLIP-seq
MIRT1155806	hsa-miR-181a	CLIP-seq
MIRT1155807	hsa-miR-181b	CLIP-seq
MIRT1155808	hsa-miR-181c	CLIP-seq
MIRT1155809	hsa-miR-181d	CLIP-seq
MIRT1155811	hsa-miR-186	CLIP-seq
MIRT1155812	hsa-miR-200b	CLIP-seq
MIRT1155813	hsa-miR-200c	CLIP-seq
MIRT1155814	hsa-miR-224	CLIP-seq
MIRT1155815	hsa-miR-299-5p	CLIP-seq
MIRT1155820	hsa-miR-3192	CLIP-seq
MIRT2273752	hsa-miR-338-3p	CLIP-seq
MIRT1155786	hsa-miR-3617	CLIP-seq
MIRT2044537	hsa-miR-3689a-3p	CLIP-seq
MIRT2044538	hsa-miR-3689c	CLIP-seq
MIRT2273753	hsa-miR-369-3p	CLIP-seq
MIRT2273754	hsa-miR-374a	CLIP-seq
MIRT2273755	hsa-miR-374b	CLIP-seq
MIRT2044541	hsa-miR-376c	CLIP-seq
MIRT2273756	hsa-miR-3925-3p	CLIP-seq
MIRT1155825	hsa-miR-4262	CLIP-seq
MIRT1155788	hsa-miR-4274	CLIP-seq
MIRT1155826	hsa-miR-429	CLIP-seq
MIRT2273757	hsa-miR-4307	CLIP-seq
MIRT2273758	hsa-miR-4310	CLIP-seq
MIRT2044542	hsa-miR-4328	CLIP-seq
MIRT2273759	hsa-miR-4474-5p	CLIP-seq
MIRT1155789	hsa-miR-4519	CLIP-seq
MIRT2273760	hsa-miR-4530	CLIP-seq
MIRT2273761	hsa-miR-4637	CLIP-seq
MIRT2044550	hsa-miR-4728-5p	CLIP-seq
MIRT1155791	hsa-miR-498	CLIP-seq
MIRT2044555	hsa-miR-513c	CLIP-seq
MIRT2044556	hsa-miR-514b-5p	CLIP-seq
MIRT2273762	hsa-miR-515-5p	CLIP-seq
MIRT2044562	hsa-miR-567	CLIP-seq
MIRT1155857	hsa-miR-591	CLIP-seq
MIRT2044564	hsa-miR-628-3p	CLIP-seq
MIRT1155793	hsa-miR-641	CLIP-seq
MIRT2273763	hsa-miR-766	CLIP-seq
MIRT2572635	hsa-miR-1	CLIP-seq
MIRT2572636	hsa-miR-1245b-5p	CLIP-seq
MIRT1155794	hsa-miR-1256	CLIP-seq
MIRT1155795	hsa-miR-1268	CLIP-seq
MIRT1155796	hsa-miR-1268b	CLIP-seq
MIRT1155797	hsa-miR-1271	CLIP-seq
MIRT2044530	hsa-miR-129-5p	CLIP-seq
MIRT2572637	hsa-miR-1299	CLIP-seq
MIRT2572638	hsa-miR-1302	CLIP-seq
MIRT1155810	hsa-miR-182	CLIP-seq
MIRT2572639	hsa-miR-18a	CLIP-seq
MIRT2572640	hsa-miR-18b	CLIP-seq
MIRT2572641	hsa-miR-1972	CLIP-seq
MIRT2572642	hsa-miR-206	CLIP-seq
MIRT2572643	hsa-miR-3142	CLIP-seq
MIRT2572644	hsa-miR-3194-3p	CLIP-seq
MIRT2044536	hsa-miR-3620	CLIP-seq
MIRT2572645	hsa-miR-3673	CLIP-seq
MIRT2572646	hsa-miR-4298	CLIP-seq
MIRT2572647	hsa-miR-4426	CLIP-seq
MIRT1155829	hsa-miR-4486	CLIP-seq
MIRT1155832	hsa-miR-4642	CLIP-seq
MIRT2572648	hsa-miR-4647	CLIP-seq
MIRT2572649	hsa-miR-4650-5p	CLIP-seq
MIRT2572650	hsa-miR-4662b	CLIP-seq
MIRT2572651	hsa-miR-4699-5p	CLIP-seq
MIRT2572652	hsa-miR-4735-3p	CLIP-seq
MIRT2044552	hsa-miR-4777-5p	CLIP-seq
MIRT2044553	hsa-miR-5096	CLIP-seq
MIRT2044557	hsa-miR-518d-5p	CLIP-seq
MIRT2044558	hsa-miR-519b-5p	CLIP-seq
MIRT2044559	hsa-miR-519c-5p	CLIP-seq
MIRT2044560	hsa-miR-520c-5p	CLIP-seq
MIRT2044561	hsa-miR-526a	CLIP-seq
MIRT2572653	hsa-miR-539	CLIP-seq
MIRT1155856	hsa-miR-585	CLIP-seq
MIRT2572654	hsa-miR-613	CLIP-seq
MIRT2572655	hsa-miR-767-3p	CLIP-seq
MIRT2572656	hsa-miR-875-3p	CLIP-seq
MIRT2572657	hsa-miR-876-3p	CLIP-seq
MIRT1155858	hsa-miR-96	CLIP-seq
MIRT2572635	hsa-miR-1	CLIP-seq
MIRT1155794	hsa-miR-1256	CLIP-seq
MIRT1155797	hsa-miR-1271	CLIP-seq
MIRT2572637	hsa-miR-1299	CLIP-seq
MIRT1155806	hsa-miR-181a	CLIP-seq
MIRT1155807	hsa-miR-181b	CLIP-seq
MIRT1155808	hsa-miR-181c	CLIP-seq
MIRT1155809	hsa-miR-181d	CLIP-seq
MIRT1155810	hsa-miR-182	CLIP-seq
MIRT2572639	hsa-miR-18a	CLIP-seq
MIRT2572640	hsa-miR-18b	CLIP-seq
MIRT2572642	hsa-miR-206	CLIP-seq
MIRT1155815	hsa-miR-299-5p	CLIP-seq
MIRT2572644	hsa-miR-3194-3p	CLIP-seq
MIRT2572645	hsa-miR-3673	CLIP-seq
MIRT1155825	hsa-miR-4262	CLIP-seq
MIRT1155832	hsa-miR-4642	CLIP-seq
MIRT2572652	hsa-miR-4735-3p	CLIP-seq
MIRT2572653	hsa-miR-539	CLIP-seq
MIRT2572654	hsa-miR-613	CLIP-seq
MIRT2572655	hsa-miR-767-3p	CLIP-seq
MIRT2572656	hsa-miR-875-3p	CLIP-seq
MIRT2572657	hsa-miR-876-3p	CLIP-seq
MIRT1155858	hsa-miR-96	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	29858488, 32296183, 33124732, 33961781
GO:0005783	Component	Endoplasmic reticulum	IDA	29858488
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	35389430
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	28137892
GO:0005886	Component	Plasma membrane	TAS
GO:0006935	Process	Chemotaxis	IEA
GO:0012505	Component	Endomembrane system	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0033149	Function	FFAT motif binding	IDA	33124732
GO:0035579	Component	Specific granule membrane	TAS
GO:0044232	Component	Organelle membrane contact site	IDA	29858488, 35389430
GO:0051260	Process	Protein homooligomerization	IDA	33124732
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	IDA	28137892
GO:0090026	Process	Positive regulation of monocyte chemotaxis	IDA	28137892
GO:0140042	Process	Lipid droplet formation	IDA	35389430
GO:0140284	Component	Endoplasmic reticulum-endosome membrane contact site	IBA
GO:0140284	Component	Endoplasmic reticulum-endosome membrane contact site	IDA	29858488

MIM	HGNC	e!Ensembl
301086	28381	ENSG00000130150

Q8NHP6

Protein name

Motile sperm domain-containing protein 2

Protein function

Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound prote

PDB

6TQS , 6TQT , 6TQU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00650	CRAL_TRIO	89 → 234	CRAL/TRIO domain	Domain
PF00635	Motile_Sperm	327 → 432	MSP (Major sperm protein) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in CD14(+) monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells. {ECO:0000269|PubMed:28137892}.

Sequence

MAENHAQNKAKLISETRRRFEAEYVTDKSDKYDARDVERLQQDDNWVESYLSWRHNIVDE
TLKMLDESFQWRKEISVNDLNESSIPRWLLEIGVIYLHGYDKEGNKLFWIRVKYHVKDQK
TILDKKKLIAFWLERYAKRENGKPVTVMFDLSETGINSIDMDFVRFIINCFKVYYPKYLS
KIVIFDMPWLMNAAFKIVKTWLGPEAVSLLKFTSKNEVQDYVSVEYLPPHMGGTDPFKYS
YPPLVDDDFQTPLCENGPITSEDETSSKEDIESDGKETLETISNEEQTPLLKKINPTEST
SKAEENEKVDSKVKAFKKPLSVFKGPLLHISPAEELYFGSTESGEKKTLIVLTNVTKNIV
AFKVRTTAPEKYRVKPSNSSCDPGASVDIVVSPHGGLTVSAQDRFLIMAAEMEQSSGTGP
AELTQFWKEVPRNKVMEHRLRCHTVESSKPNTLTLKDNAFNMSDKTSEDICLQLSRLLES
NRKLEDQVQRCIWFQQLLLSLTMLLLAFVTSFFYLLYS

Sequence length

518

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	29978511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	34555062	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29978511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29978511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	29978511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	35907914	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29978511		★★★★★ ★☆☆☆☆ Found in Text Mining only

MOSPD2 (motile sperm domain containing 2)