GRK3 (G protein-coupled receptor kinase 3)

Gene

• Entrez ID: 157
• Gene name: G protein-coupled receptor kinase 3
• Gene symbol: GRK3
• Synonyms (NCBI Gene): ADRBK2, BARK2
• Chromosome: 22
• Chromosome location: 22q12.1
• Summary: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic rec

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT613352	hsa-miR-8485	HITS-CLIP	22927820
MIRT613351	hsa-miR-602	HITS-CLIP	22927820
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	22927820
MIRT613349	hsa-miR-609	HITS-CLIP	22927820
MIRT613348	hsa-miR-2052	HITS-CLIP	22927820
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	22927820
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	22927820
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	22927820
MIRT636736	hsa-miR-4709-5p	HITS-CLIP	22927820
MIRT628479	hsa-miR-574-5p	HITS-CLIP	22927820
MIRT660878	hsa-miR-122-5p	HITS-CLIP	22927820
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	22927820
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	22927820
MIRT628483	hsa-miR-505-3p	HITS-CLIP	22927820
MIRT628482	hsa-miR-421	HITS-CLIP	22927820
MIRT628481	hsa-miR-1305	HITS-CLIP	22927820
MIRT628480	hsa-miR-4455	HITS-CLIP	22927820
MIRT613351	hsa-miR-602	HITS-CLIP	23313552
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23313552
MIRT613349	hsa-miR-609	HITS-CLIP	23313552
MIRT613348	hsa-miR-2052	HITS-CLIP	23313552
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23313552
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23313552
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23313552
MIRT400048	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT400049	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT400045	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT400046	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT400050	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT400052	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT400051	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT400047	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT680137	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT680136	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT680135	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT680134	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT680133	hsa-miR-520h	HITS-CLIP	23824327
MIRT680132	hsa-miR-8064	HITS-CLIP	23824327
MIRT680131	hsa-miR-6829-5p	HITS-CLIP	23824327
MIRT680130	hsa-miR-185-3p	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT680129	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT680128	hsa-miR-527	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT673535	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT673534	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673533	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT673532	hsa-miR-4532	HITS-CLIP	23824327
MIRT673531	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT673530	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT673529	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT673528	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673527	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT673526	hsa-miR-1976	HITS-CLIP	23824327
MIRT673525	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT673524	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673523	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673522	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673521	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT673520	hsa-miR-1206	HITS-CLIP	23824327
MIRT673519	hsa-miR-4279	HITS-CLIP	23824327
MIRT673518	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673517	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT660878	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT660877	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT660872	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT660876	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT660875	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT660874	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT660873	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT660872	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT660871	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT660870	hsa-miR-1303	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT636736	hsa-miR-4709-5p	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT636735	hsa-miR-4683	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT636734	hsa-miR-4531	HITS-CLIP	23824327
MIRT636733	hsa-miR-1270	HITS-CLIP	23824327
MIRT636732	hsa-miR-620	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT628485	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628484	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT628483	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT628482	hsa-miR-421	HITS-CLIP	23824327
MIRT628481	hsa-miR-1305	HITS-CLIP	23824327
MIRT628480	hsa-miR-4455	HITS-CLIP	23824327
MIRT628479	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613352	hsa-miR-8485	HITS-CLIP	23824327
MIRT613351	hsa-miR-602	HITS-CLIP	23824327
MIRT613350	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT613349	hsa-miR-609	HITS-CLIP	23824327
MIRT613348	hsa-miR-2052	HITS-CLIP	23824327
MIRT613347	hsa-miR-19a-5p	HITS-CLIP	23824327
MIRT613346	hsa-miR-19b-1-5p	HITS-CLIP	23824327
MIRT613345	hsa-miR-19b-2-5p	HITS-CLIP	23824327
MIRT613344	hsa-miR-7850-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001664	Function	G protein-coupled receptor binding	IBA
GO:0002029	Process	Desensitization of G protein-coupled receptor signaling pathway	IBA
GO:0002029	Process	Desensitization of G protein-coupled receptor signaling pathway	IDA	21799898
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	8427589
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004703	Function	G protein-coupled receptor kinase activity	IBA
GO:0004703	Function	G protein-coupled receptor kinase activity	IDA	21799898
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	23455922, 28514442, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	8427589
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031623	Process	Receptor internalization	IDA	20074556
GO:0031623	Process	Receptor internalization	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0047696	Function	Beta-adrenergic receptor kinase activity	IEA
GO:0047696	Function	Beta-adrenergic receptor kinase activity	TAS
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA

Other IDs

• MIM: 109636
• HGNC: 290
• e!Ensembl: ENSG00000100077

Protein

• UniProt ID: P35626
• Protein name: G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2)
• Protein function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00615	RGS	54 → 174	Regulator of G protein signaling domain	Domain
  PF00069	Pkinase	191 → 453	Protein kinase domain	Domain
  PF00169	PH	559 → 652	PH domain	Domain

• Sequence:

  MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
  QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
  SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
  ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
  IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
  IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
  VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
  LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
  DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
  RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
  LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
  APKFLNKPRSGTVELPKPSLCHRNSNGL

• Sequence length: 688

Pathways

KEGG:

Chemokine signaling pathway
Endocytosis
Hedgehog signaling pathway
Glutamatergic synapse
Olfactory transduction
Morphine addiction

Reactome:

G alpha (s) signalling events
Cargo recognition for clathrin-mediated endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BIPOLAR DISORDER	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSION, BIPOLAR	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIXED BIPOLAR I DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	34164834	Associate	★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	29254792		★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	23935208		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	CTD_human_DG	12808434		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	16359584, 19400979, 19766236	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	BEFREE	17106420, 18075471, 18359007, 19400979, 19766236, 20226637		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	18075471, 18359007, 19400979, 19766236, 20226637		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	LHGDN	18359007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar I disorder	Bipolar Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
Borderline Personality Disorder	Borderline personality disorder	BEFREE	12808434, 18075471		★☆☆☆☆ Found in Text Mining only
Brain Ischemia	Brain ischemia	Pubtator	33460396	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	27049755		★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	BEFREE	12808434, 18075471		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Dilated	Cardiomyopathy	BEFREE	22685168		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	26248277, 30837872		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	19400979	Associate	★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29445249		★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	29273639, 30104167, 8293560		★☆☆☆☆ Found in Text Mining only
Depression, Bipolar	Bipolar Disorder	CTD_human_DG	12808434		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyskinetic syndrome	Dyskinetic Syndrome	BEFREE	31306812		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	22086906		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	22086906	Inhibit	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	22086906		★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart Diseases	BEFREE	22685168		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	29273639, 30104167, 8293560		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	37543278	Associate	★☆☆☆☆ Found in Text Mining only
Ischemic cardiomyopathy	Ischemic myocardial dysfunction	BEFREE	22685168		★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	BEFREE	23935208		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28819396		★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 1	Major Affective Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 2	Major Affective Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 4	Major Affective Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 6	Major Affective Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 7	Major Affective Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 8	Major Affective Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
MAJOR AFFECTIVE DISORDER 9	Major Affective Disorder	BEFREE	17106420		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27049755		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	24434559, 27191986		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29445249		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29445249		★☆☆☆☆ Found in Text Mining only
Manic	Manic Disorder	BEFREE	12808434		★☆☆☆☆ Found in Text Mining only
Manic	Manic Disorder	CTD_human_DG	12808434		★☆☆☆☆ Found in Text Mining only
Manic Disorder	Manic Disorder	CTD_human_DG	12808434		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22086906, 27049755, 28819396, 29254792		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	23935208		★☆☆☆☆ Found in Text Mining only
Obsessive compulsive behavior	Obsessive-Compulsive Disorder	BEFREE	28649993		★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	29254792		★☆☆☆☆ Found in Text Mining only
Peritonitis	Peritonitis	Pubtator	35996148	Stimulate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	24434559, 27191986		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	24434559		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	24434559	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	37543278	Stimulate	★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	11166332		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	15006433		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	35996148	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	27049755		★☆☆☆☆ Found in Text Mining only