GRK2 (G protein-coupled receptor kinase 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 156
Gene name G protein-coupled receptor kinase 2
Gene symbol GRK2
Synonyms (NCBI Gene)
ADRBK1BARK1BETA-ARK1
Chromosome 11
Chromosome location 11q13.2
Summary This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal
miRNA miRNA information provided by mirtarbase database.
47
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (47)
miRTarBase ID miRNA Experiments Reference
MIRT459273 hsa-miR-4676-5p PAR-CLIP 23592263
MIRT459272 hsa-miR-575 PAR-CLIP 23592263
MIRT459271 hsa-miR-9500 PAR-CLIP 23592263
MIRT459270 hsa-miR-211-3p PAR-CLIP 23592263
MIRT459269 hsa-miR-4270 PAR-CLIP 23592263
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
SP1 Activation 12423667
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
58
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001664 Function G protein-coupled receptor binding IBA
GO:0002026 Process Regulation of the force of heart contraction IBA
GO:0002026 Process Regulation of the force of heart contraction IEA
GO:0002029 Process Desensitization of G protein-coupled receptor signaling pathway IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
109635 289 ENSG00000173020
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P25098
Protein name Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Protein function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for
PDB 1BAK , 3CIK , 3KRW , 3KRX , 3V5W , 4MK0 , 4PNK , 5HE1 , 5UKK , 5UKL , 5UUU , 5UVC , 5WG3 , 5WG4 , 5WG5 , 6C2Y , 6U7C , 7K7L , 7K7Z , 7PWD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00615 RGS 54 → 174 Regulator of G protein signaling domain Domain
PF00069 Pkinase 191 → 453 Protein kinase domain Domain
PF00169 PH 559 → 652 PH domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:10085131}.
Sequence
Sequence length 689
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Chemokine signaling pathway
Endocytosis
Hedgehog signaling pathway
Glutamatergic synapse
Olfactory transduction
Morphine addiction 		  Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Jeune thoracic dystrophy Pathogenic; Likely pathogenic rs2136500272, rs2136501226, rs2136504839 RCV001543384
RCV001543386
RCV001543385
★★★★★
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Show/Hide Unknown Diseases (15)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTHRITIS, RHEUMATOID — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOMEGALY — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHIES — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASES — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (122)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acromegaly Acromegaly BEFREE 24169548
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer UNIPROT_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 31554835
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 34164834 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Valve Insufficiency Aortic Valve Insufficiency BEFREE 11027943, 24002692, 29675711
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 30557832
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Gouty Gouty arthritis Pubtator 39511617 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Infectious Infective arthritis Pubtator 16849637 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 24738138, 36969166 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 25819984
★★★★★
★☆☆☆☆
Found in Text Mining only