AMZ1 (archaelysin family metallopeptidase 1)

Gene

• Entrez ID: 155185
• Gene name: Archaelysin family metallopeptidase 1
• Gene symbol: AMZ1
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7p22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023825	hsa-miR-1-3p	Microarray	18668037
MIRT045029	hsa-miR-186-5p	CLASH	23622248
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT614379	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT614378	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT614377	hsa-miR-4514	HITS-CLIP	23824327
MIRT614376	hsa-miR-4692	HITS-CLIP	23824327
MIRT614375	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT614374	hsa-miR-4673	HITS-CLIP	23824327
MIRT614373	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT614372	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT614371	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT614370	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT710951	hsa-miR-1470	HITS-CLIP	19536157
MIRT710950	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT710949	hsa-miR-5193	HITS-CLIP	19536157
MIRT710947	hsa-miR-4304	HITS-CLIP	19536157
MIRT710948	hsa-miR-4469	HITS-CLIP	19536157
MIRT710946	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT614379	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT614378	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT614377	hsa-miR-4514	HITS-CLIP	23824327
MIRT614376	hsa-miR-4692	HITS-CLIP	23824327
MIRT614375	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT614374	hsa-miR-4673	HITS-CLIP	23824327
MIRT614373	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT614372	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT614371	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT614370	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT780673	hsa-miR-1207-5p	CLIP-seq
MIRT780674	hsa-miR-1224-3p	CLIP-seq
MIRT780675	hsa-miR-1229	CLIP-seq
MIRT780676	hsa-miR-1237	CLIP-seq
MIRT780677	hsa-miR-1246	CLIP-seq
MIRT780678	hsa-miR-1255a	CLIP-seq
MIRT780679	hsa-miR-1255b	CLIP-seq
MIRT780680	hsa-miR-1260	CLIP-seq
MIRT780681	hsa-miR-1260b	CLIP-seq
MIRT780682	hsa-miR-1263	CLIP-seq
MIRT780683	hsa-miR-1280	CLIP-seq
MIRT780684	hsa-miR-146b-3p	CLIP-seq
MIRT780685	hsa-miR-155	CLIP-seq
MIRT780686	hsa-miR-1827	CLIP-seq
MIRT780687	hsa-miR-188-5p	CLIP-seq
MIRT780688	hsa-miR-197	CLIP-seq
MIRT780689	hsa-miR-199a-3p	CLIP-seq
MIRT780690	hsa-miR-199b-3p	CLIP-seq
MIRT780691	hsa-miR-2116	CLIP-seq
MIRT780692	hsa-miR-22	CLIP-seq
MIRT780693	hsa-miR-221	CLIP-seq
MIRT780694	hsa-miR-222	CLIP-seq
MIRT780695	hsa-miR-3129-5p	CLIP-seq
MIRT780696	hsa-miR-3154	CLIP-seq
MIRT780697	hsa-miR-3155	CLIP-seq
MIRT780698	hsa-miR-3155b	CLIP-seq
MIRT780699	hsa-miR-3173-5p	CLIP-seq
MIRT780700	hsa-miR-3182	CLIP-seq
MIRT780701	hsa-miR-3200-5p	CLIP-seq
MIRT780702	hsa-miR-3609	CLIP-seq
MIRT780703	hsa-miR-3674	CLIP-seq
MIRT780704	hsa-miR-3677-5p	CLIP-seq
MIRT780705	hsa-miR-3973	CLIP-seq
MIRT780706	hsa-miR-4267	CLIP-seq
MIRT780707	hsa-miR-4292	CLIP-seq
MIRT780708	hsa-miR-4303	CLIP-seq
MIRT780709	hsa-miR-4308	CLIP-seq
MIRT780710	hsa-miR-4311	CLIP-seq
MIRT780711	hsa-miR-4316	CLIP-seq
MIRT780712	hsa-miR-4650-5p	CLIP-seq
MIRT780713	hsa-miR-4652-3p	CLIP-seq
MIRT780714	hsa-miR-4677-3p	CLIP-seq
MIRT780715	hsa-miR-4677-5p	CLIP-seq
MIRT780716	hsa-miR-4679	CLIP-seq
MIRT780717	hsa-miR-4716-5p	CLIP-seq
MIRT780718	hsa-miR-4732-5p	CLIP-seq
MIRT780719	hsa-miR-4736	CLIP-seq
MIRT780720	hsa-miR-4757-5p	CLIP-seq
MIRT780721	hsa-miR-4763-3p	CLIP-seq
MIRT780722	hsa-miR-4786-3p	CLIP-seq
MIRT780723	hsa-miR-484	CLIP-seq
MIRT780724	hsa-miR-493	CLIP-seq
MIRT780725	hsa-miR-5096	CLIP-seq
MIRT780726	hsa-miR-520g	CLIP-seq
MIRT780727	hsa-miR-520h	CLIP-seq
MIRT780728	hsa-miR-532-3p	CLIP-seq
MIRT780729	hsa-miR-548ah	CLIP-seq
MIRT780730	hsa-miR-548v	CLIP-seq
MIRT780731	hsa-miR-645	CLIP-seq
MIRT780732	hsa-miR-766	CLIP-seq
MIRT780733	hsa-miR-874	CLIP-seq
MIRT780734	hsa-miR-890	CLIP-seq
MIRT780735	hsa-miR-936	CLIP-seq
MIRT780736	hsa-miR-942	CLIP-seq
MIRT780676	hsa-miR-1237	CLIP-seq
MIRT780697	hsa-miR-3155	CLIP-seq
MIRT780698	hsa-miR-3155b	CLIP-seq
MIRT780700	hsa-miR-3182	CLIP-seq
MIRT780713	hsa-miR-4652-3p	CLIP-seq
MIRT780723	hsa-miR-484	CLIP-seq
MIRT780725	hsa-miR-5096	CLIP-seq
MIRT780676	hsa-miR-1237	CLIP-seq
MIRT1930451	hsa-miR-1254	CLIP-seq
MIRT1930452	hsa-miR-140-3p	CLIP-seq
MIRT1930453	hsa-miR-148a	CLIP-seq
MIRT1930454	hsa-miR-148b	CLIP-seq
MIRT1930455	hsa-miR-152	CLIP-seq
MIRT1930456	hsa-miR-1913	CLIP-seq
MIRT780688	hsa-miR-197	CLIP-seq
MIRT1930457	hsa-miR-2277-3p	CLIP-seq
MIRT1930458	hsa-miR-3116	CLIP-seq
MIRT1930459	hsa-miR-3121-5p	CLIP-seq
MIRT1930460	hsa-miR-3136-3p	CLIP-seq
MIRT1930461	hsa-miR-3137	CLIP-seq
MIRT780697	hsa-miR-3155	CLIP-seq
MIRT780698	hsa-miR-3155b	CLIP-seq
MIRT780700	hsa-miR-3182	CLIP-seq
MIRT1930462	hsa-miR-3202	CLIP-seq
MIRT1930463	hsa-miR-324-3p	CLIP-seq
MIRT1930464	hsa-miR-3660	CLIP-seq
MIRT1930465	hsa-miR-3664-3p	CLIP-seq
MIRT1930466	hsa-miR-3936	CLIP-seq
MIRT780705	hsa-miR-3973	CLIP-seq
MIRT1930467	hsa-miR-4290	CLIP-seq
MIRT1930468	hsa-miR-4324	CLIP-seq
MIRT1930469	hsa-miR-4418	CLIP-seq
MIRT1930470	hsa-miR-4428	CLIP-seq
MIRT1930471	hsa-miR-4479	CLIP-seq
MIRT1930472	hsa-miR-4480	CLIP-seq
MIRT1930473	hsa-miR-4494	CLIP-seq
MIRT1930474	hsa-miR-4526	CLIP-seq
MIRT1930475	hsa-miR-4533	CLIP-seq
MIRT780713	hsa-miR-4652-3p	CLIP-seq
MIRT1930476	hsa-miR-4700-3p	CLIP-seq
MIRT1930477	hsa-miR-4733-3p	CLIP-seq
MIRT1930478	hsa-miR-4738-3p	CLIP-seq
MIRT780720	hsa-miR-4757-5p	CLIP-seq
MIRT1930479	hsa-miR-4776-3p	CLIP-seq
MIRT1930480	hsa-miR-483-3p	CLIP-seq
MIRT780723	hsa-miR-484	CLIP-seq
MIRT1930481	hsa-miR-499-3p	CLIP-seq
MIRT1930482	hsa-miR-499a-3p	CLIP-seq
MIRT1930483	hsa-miR-509-3-5p	CLIP-seq
MIRT1930484	hsa-miR-509-5p	CLIP-seq
MIRT780725	hsa-miR-5096	CLIP-seq
MIRT780726	hsa-miR-520g	CLIP-seq
MIRT780727	hsa-miR-520h	CLIP-seq
MIRT1930485	hsa-miR-548g	CLIP-seq
MIRT1930486	hsa-miR-663b	CLIP-seq
MIRT1930487	hsa-miR-668	CLIP-seq
MIRT1930488	hsa-miR-873	CLIP-seq
MIRT2171142	hsa-miR-1184	CLIP-seq
MIRT2171143	hsa-miR-1205	CLIP-seq
MIRT780674	hsa-miR-1224-3p	CLIP-seq
MIRT2171144	hsa-miR-1226	CLIP-seq
MIRT780676	hsa-miR-1237	CLIP-seq
MIRT780680	hsa-miR-1260	CLIP-seq
MIRT780681	hsa-miR-1260b	CLIP-seq
MIRT780683	hsa-miR-1280	CLIP-seq
MIRT2171145	hsa-miR-1292	CLIP-seq
MIRT2171146	hsa-miR-3140-5p	CLIP-seq
MIRT2171147	hsa-miR-3665	CLIP-seq
MIRT2171148	hsa-miR-3914	CLIP-seq
MIRT1930469	hsa-miR-4418	CLIP-seq
MIRT2171149	hsa-miR-4427	CLIP-seq
MIRT2171150	hsa-miR-4471	CLIP-seq
MIRT2171151	hsa-miR-4646-5p	CLIP-seq
MIRT780713	hsa-miR-4652-3p	CLIP-seq
MIRT2171152	hsa-miR-4695-5p	CLIP-seq
MIRT1930483	hsa-miR-509-3-5p	CLIP-seq
MIRT1930484	hsa-miR-509-5p	CLIP-seq
MIRT780728	hsa-miR-532-3p	CLIP-seq
MIRT2171153	hsa-miR-605	CLIP-seq
MIRT780731	hsa-miR-645	CLIP-seq
MIRT2171154	hsa-miR-764	CLIP-seq
MIRT2171155	hsa-miR-767-5p	CLIP-seq
MIRT1930488	hsa-miR-873	CLIP-seq
MIRT2435329	hsa-miR-4778-5p	CLIP-seq
MIRT2435329	hsa-miR-4778-5p	CLIP-seq
MIRT2443619	hsa-miR-103a	CLIP-seq
MIRT2443620	hsa-miR-107	CLIP-seq
MIRT2443621	hsa-miR-1301	CLIP-seq
MIRT780697	hsa-miR-3155	CLIP-seq
MIRT780698	hsa-miR-3155b	CLIP-seq
MIRT2443622	hsa-miR-4691-3p	CLIP-seq
MIRT1930477	hsa-miR-4733-3p	CLIP-seq
MIRT780723	hsa-miR-484	CLIP-seq
MIRT2443623	hsa-miR-5047	CLIP-seq
MIRT2443619	hsa-miR-103a	CLIP-seq
MIRT2443620	hsa-miR-107	CLIP-seq
MIRT2443621	hsa-miR-1301	CLIP-seq
MIRT780697	hsa-miR-3155	CLIP-seq
MIRT780698	hsa-miR-3155b	CLIP-seq
MIRT2443622	hsa-miR-4691-3p	CLIP-seq
MIRT1930477	hsa-miR-4733-3p	CLIP-seq
MIRT780723	hsa-miR-484	CLIP-seq
MIRT2443623	hsa-miR-5047	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005575	Component	Cellular_component	ND
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 615168
• HGNC: 22231
• e!Ensembl: ENSG00000174945

Protein

• UniProt ID: Q400G9
• Protein name: Archaemetzincin-1 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 1)
• Protein function: Probable zinc metalloprotease.
• Sequence:

  MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI
  RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT
  EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL
  SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD
  RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL
  RKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDSEP
  GTSVSEPLTPDAGSHTFASGPEEGLSYLAASEAPLPPGGPAEAIKEHERWLAMCIQALQR
  EVAEEDLVQVDRAVDALDRWEMFTGQLPATRQDPPSSRDSVGLRKVLGDKFSSLRRKLSA
  RKLARAESAPRPWDGEES

• Sequence length: 498

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	30804561		★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30519544		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30519544		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	28067908		★☆☆☆☆ Found in Text Mining only
Turner Syndrome	Turner syndrome	Pubtator	30530863	Associate	★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	21297633, 23128233, 28067908		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ulcerative Colitis	Ulcerative colitis	GWASDB_DG	21297633, 23128233		★★☆☆☆ Found in Text Mining + Unknown/Other Associations