Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	155066
Gene name	ATPase H+ transporting V0 subunit e2
Gene symbol	ATP6V0E2
Synonyms (NCBI Gene)	ATP6V0E2LC7orf32
Chromosome	7
Chromosome location	7q36.1
Summary	Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT526900	hsa-miR-3606-3p	PAR-CLIP	22012620
MIRT526899	hsa-miR-513a-3p	PAR-CLIP	22012620
MIRT526898	hsa-miR-513c-3p	PAR-CLIP	22012620
MIRT526897	hsa-miR-6863	PAR-CLIP	22012620
MIRT526896	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526895	hsa-miR-4305	PAR-CLIP	22012620
MIRT526894	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT526893	hsa-miR-30a-3p	PAR-CLIP	22012620
MIRT526892	hsa-miR-30d-3p	PAR-CLIP	22012620
MIRT526891	hsa-miR-30e-3p	PAR-CLIP	22012620
MIRT526900	hsa-miR-3606-3p	PAR-CLIP	22012620
MIRT526899	hsa-miR-513a-3p	PAR-CLIP	22012620
MIRT526898	hsa-miR-513c-3p	PAR-CLIP	22012620
MIRT526897	hsa-miR-6863	PAR-CLIP	22012620
MIRT526896	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526895	hsa-miR-4305	PAR-CLIP	22012620
MIRT526894	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT526893	hsa-miR-30a-3p	PAR-CLIP	22012620
MIRT526892	hsa-miR-30d-3p	PAR-CLIP	22012620
MIRT526891	hsa-miR-30e-3p	PAR-CLIP	22012620
MIRT808942	hsa-miR-122	CLIP-seq
MIRT808943	hsa-miR-1976	CLIP-seq
MIRT808944	hsa-miR-24	CLIP-seq
MIRT808945	hsa-miR-2467-5p	CLIP-seq
MIRT808946	hsa-miR-3184	CLIP-seq
MIRT808947	hsa-miR-365	CLIP-seq
MIRT808948	hsa-miR-3691-3p	CLIP-seq
MIRT808949	hsa-miR-370	CLIP-seq
MIRT808950	hsa-miR-3919	CLIP-seq
MIRT808951	hsa-miR-423-5p	CLIP-seq
MIRT808952	hsa-miR-4278	CLIP-seq
MIRT808953	hsa-miR-4280	CLIP-seq
MIRT808954	hsa-miR-4419a	CLIP-seq
MIRT808955	hsa-miR-4438	CLIP-seq
MIRT808956	hsa-miR-4459	CLIP-seq
MIRT808957	hsa-miR-4505	CLIP-seq
MIRT808958	hsa-miR-4510	CLIP-seq
MIRT808959	hsa-miR-4659a-5p	CLIP-seq
MIRT808960	hsa-miR-4659b-5p	CLIP-seq
MIRT808961	hsa-miR-4712-3p	CLIP-seq
MIRT808962	hsa-miR-4716-3p	CLIP-seq
MIRT808963	hsa-miR-4723-5p	CLIP-seq
MIRT808964	hsa-miR-4728-5p	CLIP-seq
MIRT808965	hsa-miR-4731-5p	CLIP-seq
MIRT808966	hsa-miR-4756-3p	CLIP-seq
MIRT808967	hsa-miR-4766-5p	CLIP-seq
MIRT808968	hsa-miR-4769-3p	CLIP-seq
MIRT808969	hsa-miR-4779	CLIP-seq
MIRT808970	hsa-miR-4787-5p	CLIP-seq
MIRT808971	hsa-miR-4793-3p	CLIP-seq
MIRT808972	hsa-miR-615-5p	CLIP-seq
MIRT808973	hsa-miR-7	CLIP-seq
MIRT808974	hsa-miR-760	CLIP-seq
MIRT808942	hsa-miR-122	CLIP-seq
MIRT1938911	hsa-miR-1262	CLIP-seq
MIRT1938912	hsa-miR-1265	CLIP-seq
MIRT1938913	hsa-miR-214	CLIP-seq
MIRT808944	hsa-miR-24	CLIP-seq
MIRT808945	hsa-miR-2467-5p	CLIP-seq
MIRT808946	hsa-miR-3184	CLIP-seq
MIRT1938914	hsa-miR-3605-5p	CLIP-seq
MIRT1938915	hsa-miR-3619-5p	CLIP-seq
MIRT1938916	hsa-miR-3670	CLIP-seq
MIRT808950	hsa-miR-3919	CLIP-seq
MIRT1938917	hsa-miR-3977	CLIP-seq
MIRT1938918	hsa-miR-421	CLIP-seq
MIRT808951	hsa-miR-423-5p	CLIP-seq
MIRT808952	hsa-miR-4278	CLIP-seq
MIRT808953	hsa-miR-4280	CLIP-seq
MIRT1938919	hsa-miR-4300	CLIP-seq
MIRT1938920	hsa-miR-4316	CLIP-seq
MIRT808954	hsa-miR-4419a	CLIP-seq
MIRT808956	hsa-miR-4459	CLIP-seq
MIRT808958	hsa-miR-4510	CLIP-seq
MIRT1938921	hsa-miR-4645-5p	CLIP-seq
MIRT1938922	hsa-miR-4673	CLIP-seq
MIRT1938923	hsa-miR-4701-3p	CLIP-seq
MIRT808962	hsa-miR-4716-3p	CLIP-seq
MIRT808963	hsa-miR-4723-5p	CLIP-seq
MIRT1938924	hsa-miR-4742-5p	CLIP-seq
MIRT1938925	hsa-miR-4755-3p	CLIP-seq
MIRT808966	hsa-miR-4756-3p	CLIP-seq
MIRT1938926	hsa-miR-4761-5p	CLIP-seq
MIRT808969	hsa-miR-4779	CLIP-seq
MIRT1938927	hsa-miR-4792	CLIP-seq
MIRT1938928	hsa-miR-761	CLIP-seq
MIRT1938929	hsa-miR-920	CLIP-seq
MIRT808954	hsa-miR-4419a	CLIP-seq
MIRT808956	hsa-miR-4459	CLIP-seq
MIRT808958	hsa-miR-4510	CLIP-seq
MIRT2178058	hsa-miR-1538	CLIP-seq
MIRT2178059	hsa-miR-4745-3p	CLIP-seq
MIRT2481645	hsa-miR-1207-5p	CLIP-seq
MIRT2481646	hsa-miR-1247	CLIP-seq
MIRT2481647	hsa-miR-1257	CLIP-seq
MIRT2481648	hsa-miR-1285	CLIP-seq
MIRT2481649	hsa-miR-1321	CLIP-seq
MIRT2481650	hsa-miR-147	CLIP-seq
MIRT2481651	hsa-miR-149	CLIP-seq
MIRT2178058	hsa-miR-1538	CLIP-seq
MIRT2481652	hsa-miR-1908	CLIP-seq
MIRT2481653	hsa-miR-1915	CLIP-seq
MIRT2481654	hsa-miR-197	CLIP-seq
MIRT2481655	hsa-miR-2113	CLIP-seq
MIRT2481656	hsa-miR-23a	CLIP-seq
MIRT2481657	hsa-miR-23b	CLIP-seq
MIRT2481658	hsa-miR-23c	CLIP-seq
MIRT808944	hsa-miR-24	CLIP-seq
MIRT2481659	hsa-miR-2467-3p	CLIP-seq
MIRT2481660	hsa-miR-3126-5p	CLIP-seq
MIRT2481661	hsa-miR-3127-3p	CLIP-seq
MIRT2481662	hsa-miR-3140-3p	CLIP-seq
MIRT2481663	hsa-miR-3141	CLIP-seq
MIRT2481664	hsa-miR-3183	CLIP-seq
MIRT2481665	hsa-miR-3187-5p	CLIP-seq
MIRT2481666	hsa-miR-3617	CLIP-seq
MIRT2481667	hsa-miR-3663-5p	CLIP-seq
MIRT2481668	hsa-miR-3664-3p	CLIP-seq
MIRT2481669	hsa-miR-3664-5p	CLIP-seq
MIRT2481670	hsa-miR-378	CLIP-seq
MIRT2481671	hsa-miR-378b	CLIP-seq
MIRT2481672	hsa-miR-378c	CLIP-seq
MIRT2481673	hsa-miR-378d	CLIP-seq
MIRT2481674	hsa-miR-378e	CLIP-seq
MIRT2481675	hsa-miR-378f	CLIP-seq
MIRT2481676	hsa-miR-378h	CLIP-seq
MIRT2481677	hsa-miR-378i	CLIP-seq
MIRT2481678	hsa-miR-3918	CLIP-seq
MIRT1938917	hsa-miR-3977	CLIP-seq
MIRT2481679	hsa-miR-412	CLIP-seq
MIRT1938918	hsa-miR-421	CLIP-seq
MIRT2481680	hsa-miR-422a	CLIP-seq
MIRT2481681	hsa-miR-4267	CLIP-seq
MIRT2481682	hsa-miR-4284	CLIP-seq
MIRT2481683	hsa-miR-4317	CLIP-seq
MIRT808954	hsa-miR-4419a	CLIP-seq
MIRT2481684	hsa-miR-4433	CLIP-seq
MIRT808955	hsa-miR-4438	CLIP-seq
MIRT2481685	hsa-miR-4446-3p	CLIP-seq
MIRT808956	hsa-miR-4459	CLIP-seq
MIRT2481686	hsa-miR-4492	CLIP-seq
MIRT2481687	hsa-miR-4498	CLIP-seq
MIRT808957	hsa-miR-4505	CLIP-seq
MIRT2481688	hsa-miR-4508	CLIP-seq
MIRT808958	hsa-miR-4510	CLIP-seq
MIRT2481689	hsa-miR-4529-5p	CLIP-seq
MIRT2481690	hsa-miR-4638-3p	CLIP-seq
MIRT2481691	hsa-miR-4640-5p	CLIP-seq
MIRT2481692	hsa-miR-4685-5p	CLIP-seq
MIRT2481693	hsa-miR-4695-5p	CLIP-seq
MIRT2481694	hsa-miR-4714-5p	CLIP-seq
MIRT2481695	hsa-miR-4722-5p	CLIP-seq
MIRT2481696	hsa-miR-4723-3p	CLIP-seq
MIRT808963	hsa-miR-4723-5p	CLIP-seq
MIRT2481697	hsa-miR-4726-5p	CLIP-seq
MIRT808964	hsa-miR-4728-5p	CLIP-seq
MIRT808965	hsa-miR-4731-5p	CLIP-seq
MIRT2481698	hsa-miR-4736	CLIP-seq
MIRT2481699	hsa-miR-4739	CLIP-seq
MIRT2178059	hsa-miR-4745-3p	CLIP-seq
MIRT2481700	hsa-miR-4749-3p	CLIP-seq
MIRT2481701	hsa-miR-4756-5p	CLIP-seq
MIRT2481702	hsa-miR-4763-3p	CLIP-seq
MIRT2481703	hsa-miR-4768-3p	CLIP-seq
MIRT2481704	hsa-miR-4768-5p	CLIP-seq
MIRT2481705	hsa-miR-4781-3p	CLIP-seq
MIRT808970	hsa-miR-4787-5p	CLIP-seq
MIRT2481706	hsa-miR-486-3p	CLIP-seq
MIRT2481707	hsa-miR-558	CLIP-seq
MIRT2481708	hsa-miR-564	CLIP-seq
MIRT2481709	hsa-miR-599	CLIP-seq
MIRT2481710	hsa-miR-612	CLIP-seq
MIRT808972	hsa-miR-615-5p	CLIP-seq
MIRT2481711	hsa-miR-628-5p	CLIP-seq
MIRT2481712	hsa-miR-641	CLIP-seq
MIRT2481713	hsa-miR-663	CLIP-seq
MIRT808973	hsa-miR-7	CLIP-seq
MIRT2481714	hsa-miR-711	CLIP-seq
MIRT2481715	hsa-miR-744	CLIP-seq
MIRT2481716	hsa-miR-762	CLIP-seq
MIRT2481645	hsa-miR-1207-5p	CLIP-seq
MIRT2481646	hsa-miR-1247	CLIP-seq
MIRT2481649	hsa-miR-1321	CLIP-seq
MIRT2481651	hsa-miR-149	CLIP-seq
MIRT2178058	hsa-miR-1538	CLIP-seq
MIRT2481652	hsa-miR-1908	CLIP-seq
MIRT2481653	hsa-miR-1915	CLIP-seq
MIRT2481654	hsa-miR-197	CLIP-seq
MIRT2481656	hsa-miR-23a	CLIP-seq
MIRT2481657	hsa-miR-23b	CLIP-seq
MIRT2481658	hsa-miR-23c	CLIP-seq
MIRT808944	hsa-miR-24	CLIP-seq
MIRT2481659	hsa-miR-2467-3p	CLIP-seq
MIRT2481660	hsa-miR-3126-5p	CLIP-seq
MIRT2481661	hsa-miR-3127-3p	CLIP-seq
MIRT2481663	hsa-miR-3141	CLIP-seq
MIRT2481664	hsa-miR-3183	CLIP-seq
MIRT2481666	hsa-miR-3617	CLIP-seq
MIRT2481668	hsa-miR-3664-3p	CLIP-seq
MIRT2481670	hsa-miR-378	CLIP-seq
MIRT2481671	hsa-miR-378b	CLIP-seq
MIRT2481672	hsa-miR-378c	CLIP-seq
MIRT2481673	hsa-miR-378d	CLIP-seq
MIRT2481674	hsa-miR-378e	CLIP-seq
MIRT2481675	hsa-miR-378f	CLIP-seq
MIRT2481676	hsa-miR-378h	CLIP-seq
MIRT2481677	hsa-miR-378i	CLIP-seq
MIRT2481678	hsa-miR-3918	CLIP-seq
MIRT2481679	hsa-miR-412	CLIP-seq
MIRT2481680	hsa-miR-422a	CLIP-seq
MIRT2481682	hsa-miR-4284	CLIP-seq
MIRT2481683	hsa-miR-4317	CLIP-seq
MIRT808954	hsa-miR-4419a	CLIP-seq
MIRT2481684	hsa-miR-4433	CLIP-seq
MIRT808955	hsa-miR-4438	CLIP-seq
MIRT2481685	hsa-miR-4446-3p	CLIP-seq
MIRT808956	hsa-miR-4459	CLIP-seq
MIRT2481686	hsa-miR-4492	CLIP-seq
MIRT2481687	hsa-miR-4498	CLIP-seq
MIRT808957	hsa-miR-4505	CLIP-seq
MIRT2481688	hsa-miR-4508	CLIP-seq
MIRT808958	hsa-miR-4510	CLIP-seq
MIRT2481689	hsa-miR-4529-5p	CLIP-seq
MIRT2481690	hsa-miR-4638-3p	CLIP-seq
MIRT2481691	hsa-miR-4640-5p	CLIP-seq
MIRT2481692	hsa-miR-4685-5p	CLIP-seq
MIRT2481693	hsa-miR-4695-5p	CLIP-seq
MIRT2481695	hsa-miR-4722-5p	CLIP-seq
MIRT2481696	hsa-miR-4723-3p	CLIP-seq
MIRT808963	hsa-miR-4723-5p	CLIP-seq
MIRT2481697	hsa-miR-4726-5p	CLIP-seq
MIRT808964	hsa-miR-4728-5p	CLIP-seq
MIRT808965	hsa-miR-4731-5p	CLIP-seq
MIRT2481698	hsa-miR-4736	CLIP-seq
MIRT2481699	hsa-miR-4739	CLIP-seq
MIRT2178059	hsa-miR-4745-3p	CLIP-seq
MIRT2481700	hsa-miR-4749-3p	CLIP-seq
MIRT2481701	hsa-miR-4756-5p	CLIP-seq
MIRT2481702	hsa-miR-4763-3p	CLIP-seq
MIRT2481703	hsa-miR-4768-3p	CLIP-seq
MIRT2481705	hsa-miR-4781-3p	CLIP-seq
MIRT808970	hsa-miR-4787-5p	CLIP-seq
MIRT2481706	hsa-miR-486-3p	CLIP-seq
MIRT2481708	hsa-miR-564	CLIP-seq
MIRT808972	hsa-miR-615-5p	CLIP-seq
MIRT2481712	hsa-miR-641	CLIP-seq
MIRT2481713	hsa-miR-663	CLIP-seq
MIRT808973	hsa-miR-7	CLIP-seq
MIRT2481714	hsa-miR-711	CLIP-seq
MIRT2481715	hsa-miR-744	CLIP-seq
MIRT2481716	hsa-miR-762	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000220	Component	Vacuolar proton-transporting V-type ATPase, V0 domain	ISS
GO:0005765	Component	Lysosomal membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007035	Process	Vacuolar acidification	ISS
GO:0010008	Component	Endosome membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	17350184
GO:0016241	Process	Regulation of macroautophagy	NAS	22982048
GO:0030665	Component	Clathrin-coated vesicle membrane	IEA
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0033179	Component	Proton-transporting V-type ATPase, V0 domain	IEA
GO:0042625	Function	ATPase-coupled ion transmembrane transporter activity	ISS
GO:0045202	Component	Synapse	IEA
GO:0046961	Function	Proton-transporting ATPase activity, rotational mechanism	IEA
GO:0046961	Function	Proton-transporting ATPase activity, rotational mechanism	IGI	17350184
GO:0055085	Process	Transmembrane transport	IBA
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1902600	Process	Proton transmembrane transport	IGI	17350184

MIM	HGNC	e!Ensembl
611019	21723	ENSG00000171130

Q8NHE4

Protein name

V-type proton ATPase subunit e 2 (V-ATPase subunit e 2) (Lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2) (Vacuolar proton pump subunit e 2)

Protein function

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05493	ATP_synt_H	9 → 70	ATP synthase subunit H	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is expressed at high levels in heart, brain and kidney and also detected in inner ear epithelium, vestibule, testis, epididymis and bladder. Isoform 2 is expressed in heart, kidney, placenta and pancreas. Isoform 2 is not det

Sequence

MTAHSFALPVIIFTTFWGLVGIAGPWFVPKGPNRGVIITMLVATAVCCYLFWLIAILAQL
NPLFGPQLKNETIWYVRFLWE

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Oxidative phosphorylation Metabolic pathways Phagosome Synaptic vesicle cycle Collecting duct acid secretion Vibrio cholerae infection Epithelial cell signaling in Helicobacter pylori infection Human papillomavirus infection Rheumatoid arthritis		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	37418994	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ATP6V0E2 (ATPase H+ transporting V0 subunit e2)