ADRB3 (adrenoceptor beta 3)

Gene

• Entrez ID: 155
• Gene name: Adrenoceptor beta 3
• Gene symbol: ADRB3
• Synonyms (NCBI Gene): BETA3AR
• Chromosome: 8
• Chromosome location: 8p11.23
• Summary: The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involve

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs4994	A>G	Risk-factor	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT610941	hsa-miR-8485	HITS-CLIP	23313552
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT610943	hsa-miR-3714	HITS-CLIP	23313552
MIRT610942	hsa-miR-3910	HITS-CLIP	23313552
MIRT610941	hsa-miR-8485	HITS-CLIP	23313552
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23313552
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT610940	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT610939	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT610939	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT610941	hsa-miR-8485	HITS-CLIP	27418678
MIRT610941	hsa-miR-8485	HITS-CLIP	27418678
MIRT610941	hsa-miR-8485	HITS-CLIP	27418678
MIRT610941	hsa-miR-8485	HITS-CLIP	23313552
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT610943	hsa-miR-3714	HITS-CLIP	23313552
MIRT610942	hsa-miR-3910	HITS-CLIP	23313552
MIRT610941	hsa-miR-8485	HITS-CLIP	23313552
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23313552
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23313552
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610943	hsa-miR-3714	HITS-CLIP	23824327
MIRT610942	hsa-miR-3910	HITS-CLIP	23824327
MIRT610941	hsa-miR-8485	HITS-CLIP	23824327
MIRT610940	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610938	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT610937	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT770028	hsa-miR-106a	CLIP-seq
MIRT770029	hsa-miR-106b	CLIP-seq
MIRT770030	hsa-miR-1321	CLIP-seq
MIRT770031	hsa-miR-17	CLIP-seq
MIRT770032	hsa-miR-20a	CLIP-seq
MIRT770033	hsa-miR-20b	CLIP-seq
MIRT770034	hsa-miR-2110	CLIP-seq
MIRT770035	hsa-miR-3117-5p	CLIP-seq
MIRT770036	hsa-miR-3126-5p	CLIP-seq
MIRT770037	hsa-miR-3170	CLIP-seq
MIRT770038	hsa-miR-329	CLIP-seq
MIRT770039	hsa-miR-3609	CLIP-seq
MIRT770040	hsa-miR-3690	CLIP-seq
MIRT770041	hsa-miR-3922-5p	CLIP-seq
MIRT770042	hsa-miR-3927	CLIP-seq
MIRT770043	hsa-miR-4271	CLIP-seq
MIRT770044	hsa-miR-4419a	CLIP-seq
MIRT770045	hsa-miR-4451	CLIP-seq
MIRT770046	hsa-miR-4476	CLIP-seq
MIRT770047	hsa-miR-4481	CLIP-seq
MIRT770048	hsa-miR-4505	CLIP-seq
MIRT770049	hsa-miR-4510	CLIP-seq
MIRT770050	hsa-miR-4638-3p	CLIP-seq
MIRT770051	hsa-miR-4667-5p	CLIP-seq
MIRT770052	hsa-miR-4670-3p	CLIP-seq
MIRT770053	hsa-miR-4699-5p	CLIP-seq
MIRT770054	hsa-miR-4700-5p	CLIP-seq
MIRT770055	hsa-miR-4725-3p	CLIP-seq
MIRT770056	hsa-miR-4731-5p	CLIP-seq
MIRT770057	hsa-miR-4739	CLIP-seq
MIRT770058	hsa-miR-4745-5p	CLIP-seq
MIRT770059	hsa-miR-4747-5p	CLIP-seq
MIRT770060	hsa-miR-4756-5p	CLIP-seq
MIRT770061	hsa-miR-4758-5p	CLIP-seq
MIRT770062	hsa-miR-4796-3p	CLIP-seq
MIRT770063	hsa-miR-519d	CLIP-seq
MIRT770064	hsa-miR-548ah	CLIP-seq
MIRT770065	hsa-miR-570	CLIP-seq
MIRT770066	hsa-miR-619	CLIP-seq
MIRT770067	hsa-miR-629	CLIP-seq
MIRT770068	hsa-miR-765	CLIP-seq
MIRT770069	hsa-miR-93	CLIP-seq
MIRT770038	hsa-miR-329	CLIP-seq
MIRT770038	hsa-miR-329	CLIP-seq
MIRT770059	hsa-miR-4747-5p	CLIP-seq
MIRT2168042	hsa-miR-1299	CLIP-seq
MIRT2168043	hsa-miR-3132	CLIP-seq
MIRT770038	hsa-miR-329	CLIP-seq
MIRT770045	hsa-miR-4451	CLIP-seq
MIRT2168044	hsa-miR-4782-5p	CLIP-seq
MIRT2168045	hsa-miR-516b	CLIP-seq
MIRT770038	hsa-miR-329	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	11316759

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002024	Process	Diet induced thermogenesis	IEA
GO:0002025	Process	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA
GO:0002025	Process	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004935	Function	Adrenergic receptor activity	IEA
GO:0004939	Function	Beta-adrenergic receptor activity	IDA	15123695
GO:0004939	Function	Beta-adrenergic receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	15123695
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1718744
GO:0005975	Process	Carbohydrate metabolic process	TAS	2570461
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	2570461
GO:0006112	Process	Energy reserve metabolic process	TAS	1718744
GO:0006898	Process	Receptor-mediated endocytosis	IDA	15123695
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	2570461
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	1718744
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0009409	Process	Response to cold	IEA
GO:0015052	Function	Beta3-adrenergic receptor activity	IBA
GO:0015052	Function	Beta3-adrenergic receptor activity	IMP	9892244
GO:0016020	Component	Membrane	IEA
GO:0031649	Process	Heat generation	IEA
GO:0031699	Function	Beta-3 adrenergic receptor binding	IEA
GO:0040015	Process	Negative regulation of multicellular organism growth	IEA
GO:0042755	Process	Eating behavior	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	15123695
GO:0043235	Component	Receptor complex	IDA	15123695
GO:0043410	Process	Positive regulation of MAPK cascade	IBA
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	15123695
GO:0045744	Process	Negative regulation of G protein-coupled receptor signaling pathway	IDA	15123695
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0051379	Function	Epinephrine binding	IBA
GO:0051379	Function	Epinephrine binding	IEA
GO:0051380	Function	Norepinephrine binding	IDA	15123695
GO:0051380	Function	Norepinephrine binding	IEA
GO:0071880	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IBA
GO:0071880	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IDA	15123695
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	7493988, 12387862

Other IDs

• MIM: 109691
• HGNC: 288
• e!Ensembl: ENSG00000188778

Protein

• UniProt ID: P13945
• Protein name: Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor)
• Protein function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
• PDB: 9IJD, 9IJE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	54 → 346	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed mainly in adipose tissues.
• Sequence:

  MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
  AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
  VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
  GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
  ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
  FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
  CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS

• Sequence length: 408

Pathways

KEGG:

Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Thermogenesis
Regulation of lipolysis in adipocytes
Renin secretion
Salivary secretion
Chemical carcinogenesis - receptor activation

Reactome:

Adrenoceptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMERS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, GOUTY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED, 1H	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGESTIVE HEART FAILURE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERLIPIDEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERLIPIDEMIAS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERLIPOPROTEINEMIAS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHY, LEFT VENTRICULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEFT VENTRICULAR HYPERTROPHY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Uncertain significance; Benign	ClinVar CTD, Disgenet CTD, Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	19271249	Associate	★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	24658877		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	10395234	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	24658877		★☆☆☆☆ Found in Text Mining only
Bladder neck obstruction	Bladder neck obstruction	BEFREE	22692629		★☆☆☆☆ Found in Text Mining only
Body Weight	Body weight	Pubtator	29587766	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	11434877, 28031536		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	11434877, 17264845, 18611262	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	28276515		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	28276515		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	22609474, 23113754, 24658877		★☆☆☆☆ Found in Text Mining only
Cholecystolithiasis	Cholecystolithiasis	BEFREE	17640319		★☆☆☆☆ Found in Text Mining only
Cholelithiasis	Cholelithiasis	BEFREE	17640319		★☆☆☆☆ Found in Text Mining only
Cholelithiasis	Cholecystolithiasis	Pubtator	23577061, 24556804	Associate	★☆☆☆☆ Found in Text Mining only
Cholesterol gallstones	Cholesterol gallstones	BEFREE	23577061		★☆☆☆☆ Found in Text Mining only
Chronic interstitial cystitis	Interstitial Cystitis	BEFREE	12442007		★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	19842096		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	18492028		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	LHGDN	18852493		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	11706779		★☆☆☆☆ Found in Text Mining only
Congenital Generalized Lipodystrophy Type 2	Congenital Lipodystrophy	BEFREE	9329375		★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	CTD_human_DG	15009959, 17440824		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congestive heart failure	Congestive Heart Failure	BEFREE	19120134, 27990717		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Connective Tissue Diseases	Connective Tissue Disease	BEFREE	29606859		★☆☆☆☆ Found in Text Mining only
Connective Tissue Diseases	Connective tissue disease	Pubtator	29606859, 32090130	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	16715838, 18088254, 24201118, 9126344		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	BEFREE	16715838, 18088254, 24201118, 9126344		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	LHGDN	16715838		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	16715838, 18088254, 24201118, 9126344		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive disorder	Mental Depression	BEFREE	29566368		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	16444766, 20536507, 24658877, 28401400, 29772697, 8826971, 8954053, 9279471, 9313761		★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	30618040, 31651836	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	10395234, 21992420, 24972470, 29464546, 34347822, 7609751	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	16027735, 16444766, 20536507, 24658877, 28401400, 29772697, 8826971, 8954053, 9279471, 9313761		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	17825092, 17852419, 18335327, 19133996, 19576569, 21992420, 24972470, 29361938, 30618040, 34072007, 7609750, 7609751, 9313101	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	10441039, 10714358, 10826514, 10981554, 11213599, 11380082, 11522702, 11573151, 11699048, 12411100, 12943691, 12965109, 15743038, 16444766, 16634992, 17046546, 17727676, 17852419, 18249219, 18335327, 20503258, 22391941, 22609474, 22937051, 23640967, 23968135, 24138564, 26808167, 28521197, 7609750, 7609751, 8690160, 8721782, 8923875, 8954053, 8960833, 9049481, 9105779, 9250462, 9313761, 9315379, 9589254, 9709965, 9828912		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	LHGDN	15355441		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	9313761		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyslipidemias	Dyslipidemias	BEFREE	10826514, 16027735, 17087055, 24579945, 8960833, 9112025		★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	Pubtator	17087055, 29083445, 29361938, 29606859, 30954083	Associate	★☆☆☆☆ Found in Text Mining only
Dystrophia myotonica 2	Myotonic dystrophy	BEFREE	17727676		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial Neoplasms	LHGDN	15743038		★☆☆☆☆ Found in Text Mining only
Erectile dysfunction	Erectile Dysfunction	BEFREE	30978726, 31228454		★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	BEFREE	10100091, 11003049, 15824464, 25099490, 29670643		★☆☆☆☆ Found in Text Mining only
Ewings sarcoma	Ewing sarcoma	BEFREE	31052299		★☆☆☆☆ Found in Text Mining only
Familial generalized lipodystrophy	Lipodystrophy	BEFREE	9329375		★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	14506613		★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	26602921		★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	24556804	Stimulate	★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	24556804, 26602921	Associate	★☆☆☆☆ Found in Text Mining only
Gallstones	Gallstones	Pubtator	24556804	Associate	★☆☆☆☆ Found in Text Mining only
Ganglioneuroblastoma	Ganglioneuroblastoma	BEFREE	31030945		★☆☆☆☆ Found in Text Mining only
Ganglioneuroma	Ganglioneuroma	BEFREE	31030945		★☆☆☆☆ Found in Text Mining only
Gastric ulcer	Gastric ulcer	BEFREE	18492028		★☆☆☆☆ Found in Text Mining only
Gout	Gout	Pubtator	32124961	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Heart failure	Heart Failure	CTD_human_DG	15009959, 17440824		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Heart failure	Heart Failure	BEFREE	19120134, 27990717		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Heart Failure	Heart failure	Pubtator	8755668	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Heart Failure, Right-Sided	Heart Failure	CTD_human_DG	15009959, 17440824		★☆☆☆☆ Found in Text Mining only
Hyperandrogenism	Hyperandrogenism	BEFREE	10689004, 11287026		★☆☆☆☆ Found in Text Mining only
Hyperandrogenism	Hyperandrogenism	Pubtator	11287026	Associate	★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia	Hypercholesterolemia	Pubtator	29587766, 30954083	Associate	★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia, Familial	Hypercholesterolemia	BEFREE	24579945		★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	12411100, 29464546		★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	24885710	Associate	★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	BEFREE	7487991, 9240761		★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	Pubtator	7487991	Associate	★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	11699048, 12965109		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyperlipidemia	Hyperlipidemia	CTD_human_DG	16027735		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyperlipoproteinemia Type IIa	Hyperlipoproteinemia	BEFREE	24579945		★☆☆☆☆ Found in Text Mining only
Hypersomnia	Hypersomnia	BEFREE	28424466		★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	14742851, 17626108, 20044737, 21992420, 25827163, 32090130, 34347822, 36089400	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	10100091, 10826514, 10981554, 12965109, 17626108, 18088254, 25827163, 26910302, 28404887		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertensive disease	Hypertension	LHGDN	15824464		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertriglyceridemia	Hypertriglyceridemia	Pubtator	29606859	Associate	★☆☆☆☆ Found in Text Mining only
Hyperuricemia	Hyperuricemia	Pubtator	10395234	Associate	★☆☆☆☆ Found in Text Mining only
Hyperuricemia	Hyperuricemia	BEFREE	17225053, 20008926, 21285172, 23729572		★☆☆☆☆ Found in Text Mining only
Immune thrombocytopenic purpura	Immune Thrombocytopenic Purpura	BEFREE	31053569		★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	10395234, 10689004, 11924722, 17852419, 18335327, 26268075, 28421794, 31929840, 34072007, 34347822, 34872092, 7487991, 7609751, 8903328	Associate	★☆☆☆☆ Found in Text Mining only
Interstitial Cystitis	Interstitial Cystitis	BEFREE	12442007		★☆☆☆☆ Found in Text Mining only
Left Ventricular Hypertrophy	Left Ventricular Hypertrophy	CTD_human_DG	17345787		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Left-Sided Heart Failure	Heart Failure	CTD_human_DG	15009959, 17440824		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	32545695	Associate	★☆☆☆☆ Found in Text Mining only
Lipoatrophic Diabetes Mellitus	Lipoatrophic Diabetes Mellitus	BEFREE	9329375		★☆☆☆☆ Found in Text Mining only
Lipomatosis, Multiple Symmetrical	Lipomatosis	BEFREE	12375271		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	19842096		★☆☆☆☆ Found in Text Mining only
Lung diseases	Lung Diseases	BEFREE	20203292		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	12739037		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	22609474		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	11434877, 28031536		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	26602921		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	25516658		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15743038, 25474135, 29772697, 31052299		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	25474135, 31477835		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	25474135	Associate	★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	29566368		★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	11213599, 27246401, 31270323		★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic syndrome	Pubtator	15751274, 21992420, 27246401	Associate	★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	10395234, 18335327, 21992420, 24972470, 28421794, 31670283	Associate	★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	10441039, 12965109, 17299491, 17345789, 18335327, 18393130, 20503258, 21034552, 21992420, 23282015, 24138564, 28100847, 7609751, 8721782, 8923875, 8954053, 9049481, 9240761, 9250462		★☆☆☆☆ Found in Text Mining only
Microvascular Angina	Microvascular Angina	BEFREE	9112025		★☆☆☆☆ Found in Text Mining only
Myocardial Failure	Myocardial Infarction	CTD_human_DG	15009959, 17440824		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	17786291		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25474135, 30813850, 31477835		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	11316759, 31030945, 31477835		★☆☆☆☆ Found in Text Mining only
Neurogenic Urinary Bladder	Neurogenic Urinary Bladder	BEFREE	30511212		★☆☆☆☆ Found in Text Mining only
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	BEFREE	15318095		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	Pubtator	10689004, 11434877, 11576322, 12406043, 14742851, 16276029, 17087055, 17190106, 17264845, 17616777, 17626108, 18239290, 18273796, 18335327, 18426866, 18441513, 18611262, 19133996, 19576569, 20662153, 20686326, 21959333, 21992420, 23292548, 23950976, 24827746, 24905907, 25622596, 25800470, 25928572, 27246401, 28421794, 29046732, 29361938, 29587766, 30926952, 30954083, 31353327, 31670283, 31929840, 34072007, 34347822, 35059043, 36089400, 39294633, 39336728, 39457458, 7487991, 7609750, 7609752, 9169485, 9449691	Associate	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Obesity	Obesity	BEFREE	10714358, 10826514, 10948198, 11213599, 11288039, 11434877, 11522702, 11532330, 11706779, 12037740, 12169859, 12406043, 12943691, 12965109, 14671190, 14742851, 15334374, 15743038, 15942638, 16276029, 16634992, 17087055, 17264845, 17512307, 17616777, 17624182, 17626108, 17785925, 17852419, 18088254, 18239290, 18249022, 18335327, 18393130, 21034552, 21992420, 22391136, 22609474, 22937051, 24138564, 24460850, 24579945, 24827746, 25800470, 25928572, 26808167, 27794199, 28401400, 28521197, 29264745, 29587766, 29661693, 30580338, 30954083, 31270323, 31353327, 7487991, 7609750, 7609751, 8690160, 8817112, 8903328, 8923875, 8954053, 8960833, 9049481, 9100608, 9279471, 9326333, 9439659, 9449691, 9589254, 9709965, 9828912		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Obesity	Obesity	Pubtator	30580338	Inhibit	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Obesity	Obesity	HPO_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Obesity	Obesity	CTD_human_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Obesity	Obesity	CLINVAR_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Obesity Abdominal	Obesity	Pubtator	17087055, 21992420, 31929840, 32090130, 34072007, 7609751	Associate	★☆☆☆☆ Found in Text Mining only
Obesity Morbid	Obesity	Pubtator	7609752	Associate	★☆☆☆☆ Found in Text Mining only
Obesity, Morbid	Obesity	BEFREE	15479221, 17299491, 29866117, 7609752, 9416435		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	34425806	Inhibit	★☆☆☆☆ Found in Text Mining only
Osteosclerosis	Osteosclerosis	BEFREE	30153111		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	25516658		★☆☆☆☆ Found in Text Mining only
Pediatric Obesity	Childhood obesity	BEFREE	10689004, 15479221, 25800470		★☆☆☆☆ Found in Text Mining only
Pelvic Organ Prolapse	Pelvic Organ Prolapse	BEFREE	29635716		★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Periodontal Diseases	BEFREE	24460850, 25855572, 31002408		★☆☆☆☆ Found in Text Mining only
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS	Pigmentary Disorder, Reticulate, With Systemic Manifestations	BEFREE	9313761		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	10689004, 15670186		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	10689004	Associate	★☆☆☆☆ Found in Text Mining only
Portal Hypertension	Portal Hypertension	BEFREE	19842096		★☆☆☆☆ Found in Text Mining only
Precocious pubarche	Precocious Pubarche	BEFREE	10689004, 11287026		★☆☆☆☆ Found in Text Mining only
Proliferative diabetic retinopathy	Proliferative Diabetic Retinopathy	BEFREE	9313761		★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	31680950		★☆☆☆☆ Found in Text Mining only
Retinopathy of Prematurity	Retinopathy	BEFREE	20739470		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	12739037		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	LHGDN	12739037		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma Ewing	Sarcoma	Pubtator	27447745	Stimulate	★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	31052299	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	22037178, 22609474		★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	29566368		★☆☆☆☆ Found in Text Mining only
Sleep Apnea Syndromes	Sleep apnea	Pubtator	17626108	Associate	★☆☆☆☆ Found in Text Mining only
Sleep Apnea, Obstructive	Sleep Apnea	BEFREE	17626108		★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	14506613		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Diseases	Urinary bladder diseases	Pubtator	19133996	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Overactive	Overactive bladder	Pubtator	31009102	Associate	★☆☆☆☆ Found in Text Mining only
Ventricular Remodeling	Ventricular remodeling	Pubtator	20136828	Associate	★☆☆☆☆ Found in Text Mining only