VKORC1L1 (vitamin K epoxide reductase complex subunit 1L1)

Gene

• Entrez ID: 154807
• Gene name: Vitamin K epoxide reductase complex subunit 1L1
• Gene symbol: VKORC1L1
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q11.21
• Summary: This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT722666	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT722665	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT722664	hsa-miR-8073	HITS-CLIP	19536157
MIRT722663	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT722662	hsa-miR-4794	HITS-CLIP	19536157
MIRT722661	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT722660	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT722659	hsa-miR-4775	HITS-CLIP	19536157
MIRT722658	hsa-miR-3686	HITS-CLIP	19536157
MIRT722657	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT722656	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT697719	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT697718	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT697717	hsa-miR-4328	HITS-CLIP	23313552
MIRT697716	hsa-miR-552-5p	HITS-CLIP	23313552
MIRT552942	hsa-miR-3133	PAR-CLIP	21572407
MIRT552943	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT552940	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT552941	hsa-miR-4643	PAR-CLIP	21572407
MIRT552939	hsa-miR-4661-5p	PAR-CLIP	21572407
MIRT552938	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT552937	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT552936	hsa-miR-3908	PAR-CLIP	21572407
MIRT552935	hsa-miR-758-5p	PAR-CLIP	21572407
MIRT552934	hsa-miR-656-5p	PAR-CLIP	21572407
MIRT552933	hsa-miR-466	PAR-CLIP	21572407
MIRT552932	hsa-miR-4766-3p	PAR-CLIP	21572407
MIRT552931	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT533245	hsa-miR-548ac	PAR-CLIP	22012620
MIRT533244	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT533243	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT533242	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT533241	hsa-miR-548z	PAR-CLIP	22012620
MIRT533240	hsa-miR-370-3p	PAR-CLIP	22012620
MIRT533239	hsa-miR-6893-3p	PAR-CLIP	22012620
MIRT533238	hsa-miR-1267	PAR-CLIP	22012620
MIRT533237	hsa-miR-367-5p	PAR-CLIP	22012620
MIRT533236	hsa-miR-1257	PAR-CLIP	22012620
MIRT533235	hsa-miR-3611	PAR-CLIP	22012620
MIRT446208	hsa-miR-1264	PAR-CLIP	22100165
MIRT446207	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT446208	hsa-miR-1264	PAR-CLIP	22100165
MIRT446207	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT722666	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT722665	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT722664	hsa-miR-8073	HITS-CLIP	19536157
MIRT722663	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT722662	hsa-miR-4794	HITS-CLIP	19536157
MIRT722661	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT722660	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT722659	hsa-miR-4775	HITS-CLIP	19536157
MIRT722658	hsa-miR-3686	HITS-CLIP	19536157
MIRT722657	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT722656	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT697719	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT697718	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT697717	hsa-miR-4328	HITS-CLIP	23313552
MIRT697716	hsa-miR-552-5p	HITS-CLIP	23313552
MIRT552942	hsa-miR-3133	PAR-CLIP	21572407
MIRT552943	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT552940	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT552941	hsa-miR-4643	PAR-CLIP	21572407
MIRT552939	hsa-miR-4661-5p	PAR-CLIP	21572407
MIRT552938	hsa-miR-3942-5p	PAR-CLIP	21572407
MIRT552937	hsa-miR-4703-5p	PAR-CLIP	21572407
MIRT552936	hsa-miR-3908	PAR-CLIP	21572407
MIRT552935	hsa-miR-758-5p	PAR-CLIP	21572407
MIRT552934	hsa-miR-656-5p	PAR-CLIP	21572407
MIRT552933	hsa-miR-466	PAR-CLIP	21572407
MIRT552932	hsa-miR-4766-3p	PAR-CLIP	21572407
MIRT552931	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT533245	hsa-miR-548ac	PAR-CLIP	22012620
MIRT533244	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT533243	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT533242	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT533241	hsa-miR-548z	PAR-CLIP	22012620
MIRT533240	hsa-miR-370-3p	PAR-CLIP	22012620
MIRT533239	hsa-miR-6893-3p	PAR-CLIP	22012620
MIRT533238	hsa-miR-1267	PAR-CLIP	22012620
MIRT533237	hsa-miR-367-5p	PAR-CLIP	22012620
MIRT533236	hsa-miR-1257	PAR-CLIP	22012620
MIRT533235	hsa-miR-3611	PAR-CLIP	22012620
MIRT446208	hsa-miR-1264	PAR-CLIP	22100165
MIRT446207	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT446208	hsa-miR-1264	PAR-CLIP	22100165
MIRT446207	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT1485129	hsa-miR-101	CLIP-seq
MIRT1485130	hsa-miR-1178	CLIP-seq
MIRT1485131	hsa-miR-1207-5p	CLIP-seq
MIRT1485132	hsa-miR-1258	CLIP-seq
MIRT1485133	hsa-miR-1279	CLIP-seq
MIRT1485134	hsa-miR-1289	CLIP-seq
MIRT1485135	hsa-miR-1290	CLIP-seq
MIRT1485136	hsa-miR-1307	CLIP-seq
MIRT1485137	hsa-miR-144	CLIP-seq
MIRT1485138	hsa-miR-1909	CLIP-seq
MIRT1485139	hsa-miR-221	CLIP-seq
MIRT1485140	hsa-miR-222	CLIP-seq
MIRT1485141	hsa-miR-23a	CLIP-seq
MIRT1485142	hsa-miR-23b	CLIP-seq
MIRT1485143	hsa-miR-23c	CLIP-seq
MIRT1485144	hsa-miR-296-5p	CLIP-seq
MIRT1485145	hsa-miR-30a	CLIP-seq
MIRT1485146	hsa-miR-30b	CLIP-seq
MIRT1485147	hsa-miR-30c	CLIP-seq
MIRT1485148	hsa-miR-30d	CLIP-seq
MIRT1485149	hsa-miR-30e	CLIP-seq
MIRT1485150	hsa-miR-3127-3p	CLIP-seq
MIRT1485151	hsa-miR-3144-3p	CLIP-seq
MIRT1485152	hsa-miR-3149	CLIP-seq
MIRT1485153	hsa-miR-3153	CLIP-seq
MIRT1485154	hsa-miR-3158-3p	CLIP-seq
MIRT1485155	hsa-miR-3162-5p	CLIP-seq
MIRT1485156	hsa-miR-3198	CLIP-seq
MIRT1485157	hsa-miR-320a	CLIP-seq
MIRT1485158	hsa-miR-320b	CLIP-seq
MIRT1485159	hsa-miR-320c	CLIP-seq
MIRT1485160	hsa-miR-320d	CLIP-seq
MIRT1485161	hsa-miR-3616-3p	CLIP-seq
MIRT1485162	hsa-miR-362-5p	CLIP-seq
MIRT1485163	hsa-miR-3646	CLIP-seq
MIRT1485164	hsa-miR-3662	CLIP-seq
MIRT1485165	hsa-miR-3672	CLIP-seq
MIRT1485166	hsa-miR-3688-3p	CLIP-seq
MIRT1485167	hsa-miR-3713	CLIP-seq
MIRT1485168	hsa-miR-374c	CLIP-seq
MIRT1485169	hsa-miR-3942-3p	CLIP-seq
MIRT1485170	hsa-miR-3973	CLIP-seq
MIRT1485171	hsa-miR-3978	CLIP-seq
MIRT1485172	hsa-miR-4294	CLIP-seq
MIRT1485173	hsa-miR-4309	CLIP-seq
MIRT1485174	hsa-miR-433	CLIP-seq
MIRT1485175	hsa-miR-4429	CLIP-seq
MIRT1485176	hsa-miR-4436b-3p	CLIP-seq
MIRT1485177	hsa-miR-4446-3p	CLIP-seq
MIRT1485178	hsa-miR-4452	CLIP-seq
MIRT1485179	hsa-miR-4489	CLIP-seq
MIRT1485180	hsa-miR-4499	CLIP-seq
MIRT1485181	hsa-miR-4513	CLIP-seq
MIRT1485182	hsa-miR-4666-5p	CLIP-seq
MIRT1485183	hsa-miR-4721	CLIP-seq
MIRT1485184	hsa-miR-4750	CLIP-seq
MIRT1485185	hsa-miR-4763-3p	CLIP-seq
MIRT1485186	hsa-miR-4777-5p	CLIP-seq
MIRT1485187	hsa-miR-4790-3p	CLIP-seq
MIRT1485188	hsa-miR-500b	CLIP-seq
MIRT1485189	hsa-miR-501-5p	CLIP-seq
MIRT1485190	hsa-miR-509-3p	CLIP-seq
MIRT1485191	hsa-miR-518d-5p	CLIP-seq
MIRT1485192	hsa-miR-519b-5p	CLIP-seq
MIRT1485193	hsa-miR-519c-5p	CLIP-seq
MIRT1485194	hsa-miR-520c-5p	CLIP-seq
MIRT1485195	hsa-miR-520g	CLIP-seq
MIRT1485196	hsa-miR-520h	CLIP-seq
MIRT1485197	hsa-miR-526a	CLIP-seq
MIRT1485198	hsa-miR-548a-5p	CLIP-seq
MIRT1485199	hsa-miR-548ab	CLIP-seq
MIRT1485200	hsa-miR-548ae	CLIP-seq
MIRT1485201	hsa-miR-548aj	CLIP-seq
MIRT1485202	hsa-miR-548ak	CLIP-seq
MIRT1485203	hsa-miR-548am	CLIP-seq
MIRT1485204	hsa-miR-548b-5p	CLIP-seq
MIRT1485205	hsa-miR-548c-3p	CLIP-seq
MIRT1485206	hsa-miR-548c-5p	CLIP-seq
MIRT1485207	hsa-miR-548d-5p	CLIP-seq
MIRT1485208	hsa-miR-548h	CLIP-seq
MIRT1485209	hsa-miR-548i	CLIP-seq
MIRT1485210	hsa-miR-548j	CLIP-seq
MIRT1485211	hsa-miR-548w	CLIP-seq
MIRT1485212	hsa-miR-548x	CLIP-seq
MIRT1485213	hsa-miR-548y	CLIP-seq
MIRT1485214	hsa-miR-559	CLIP-seq
MIRT1485215	hsa-miR-561	CLIP-seq
MIRT1485216	hsa-miR-576-5p	CLIP-seq
MIRT1485217	hsa-miR-605	CLIP-seq
MIRT1485218	hsa-miR-642b	CLIP-seq
MIRT1485219	hsa-miR-655	CLIP-seq
MIRT1485220	hsa-miR-875-5p	CLIP-seq
MIRT1485129	hsa-miR-101	CLIP-seq
MIRT1485130	hsa-miR-1178	CLIP-seq
MIRT1485131	hsa-miR-1207-5p	CLIP-seq
MIRT1485133	hsa-miR-1279	CLIP-seq
MIRT1485135	hsa-miR-1290	CLIP-seq
MIRT1485136	hsa-miR-1307	CLIP-seq
MIRT1485137	hsa-miR-144	CLIP-seq
MIRT2145955	hsa-miR-186	CLIP-seq
MIRT1485138	hsa-miR-1909	CLIP-seq
MIRT1485139	hsa-miR-221	CLIP-seq
MIRT1485140	hsa-miR-222	CLIP-seq
MIRT1485141	hsa-miR-23a	CLIP-seq
MIRT1485142	hsa-miR-23b	CLIP-seq
MIRT1485143	hsa-miR-23c	CLIP-seq
MIRT1485144	hsa-miR-296-5p	CLIP-seq
MIRT1485145	hsa-miR-30a	CLIP-seq
MIRT1485146	hsa-miR-30b	CLIP-seq
MIRT1485147	hsa-miR-30c	CLIP-seq
MIRT1485148	hsa-miR-30d	CLIP-seq
MIRT1485149	hsa-miR-30e	CLIP-seq
MIRT1485150	hsa-miR-3127-3p	CLIP-seq
MIRT1485151	hsa-miR-3144-3p	CLIP-seq
MIRT1485153	hsa-miR-3153	CLIP-seq
MIRT1485154	hsa-miR-3158-3p	CLIP-seq
MIRT1485155	hsa-miR-3162-5p	CLIP-seq
MIRT1485157	hsa-miR-320a	CLIP-seq
MIRT1485158	hsa-miR-320b	CLIP-seq
MIRT1485159	hsa-miR-320c	CLIP-seq
MIRT1485160	hsa-miR-320d	CLIP-seq
MIRT1485161	hsa-miR-3616-3p	CLIP-seq
MIRT1485162	hsa-miR-362-5p	CLIP-seq
MIRT1485163	hsa-miR-3646	CLIP-seq
MIRT1485165	hsa-miR-3672	CLIP-seq
MIRT1485168	hsa-miR-374c	CLIP-seq
MIRT1485169	hsa-miR-3942-3p	CLIP-seq
MIRT1485170	hsa-miR-3973	CLIP-seq
MIRT1485174	hsa-miR-433	CLIP-seq
MIRT1485175	hsa-miR-4429	CLIP-seq
MIRT1485176	hsa-miR-4436b-3p	CLIP-seq
MIRT1485177	hsa-miR-4446-3p	CLIP-seq
MIRT1485178	hsa-miR-4452	CLIP-seq
MIRT1485179	hsa-miR-4489	CLIP-seq
MIRT1485182	hsa-miR-4666-5p	CLIP-seq
MIRT1485183	hsa-miR-4721	CLIP-seq
MIRT1485185	hsa-miR-4763-3p	CLIP-seq
MIRT1485186	hsa-miR-4777-5p	CLIP-seq
MIRT1485188	hsa-miR-500b	CLIP-seq
MIRT1485189	hsa-miR-501-5p	CLIP-seq
MIRT1485190	hsa-miR-509-3p	CLIP-seq
MIRT2145956	hsa-miR-511	CLIP-seq
MIRT1485191	hsa-miR-518d-5p	CLIP-seq
MIRT1485192	hsa-miR-519b-5p	CLIP-seq
MIRT1485193	hsa-miR-519c-5p	CLIP-seq
MIRT1485194	hsa-miR-520c-5p	CLIP-seq
MIRT1485195	hsa-miR-520g	CLIP-seq
MIRT1485196	hsa-miR-520h	CLIP-seq
MIRT1485197	hsa-miR-526a	CLIP-seq
MIRT1485198	hsa-miR-548a-5p	CLIP-seq
MIRT1485199	hsa-miR-548ab	CLIP-seq
MIRT1485200	hsa-miR-548ae	CLIP-seq
MIRT1485201	hsa-miR-548aj	CLIP-seq
MIRT1485202	hsa-miR-548ak	CLIP-seq
MIRT1485203	hsa-miR-548am	CLIP-seq
MIRT1485204	hsa-miR-548b-5p	CLIP-seq
MIRT1485205	hsa-miR-548c-3p	CLIP-seq
MIRT1485206	hsa-miR-548c-5p	CLIP-seq
MIRT1485207	hsa-miR-548d-5p	CLIP-seq
MIRT1485208	hsa-miR-548h	CLIP-seq
MIRT1485209	hsa-miR-548i	CLIP-seq
MIRT1485210	hsa-miR-548j	CLIP-seq
MIRT1485211	hsa-miR-548w	CLIP-seq
MIRT1485212	hsa-miR-548x	CLIP-seq
MIRT1485213	hsa-miR-548y	CLIP-seq
MIRT1485214	hsa-miR-559	CLIP-seq
MIRT1485215	hsa-miR-561	CLIP-seq
MIRT1485216	hsa-miR-576-5p	CLIP-seq
MIRT1485217	hsa-miR-605	CLIP-seq
MIRT1485218	hsa-miR-642b	CLIP-seq
MIRT1485219	hsa-miR-655	CLIP-seq
MIRT1485220	hsa-miR-875-5p	CLIP-seq
MIRT1485129	hsa-miR-101	CLIP-seq
MIRT1485130	hsa-miR-1178	CLIP-seq
MIRT1485131	hsa-miR-1207-5p	CLIP-seq
MIRT1485133	hsa-miR-1279	CLIP-seq
MIRT1485135	hsa-miR-1290	CLIP-seq
MIRT1485136	hsa-miR-1307	CLIP-seq
MIRT1485137	hsa-miR-144	CLIP-seq
MIRT2145955	hsa-miR-186	CLIP-seq
MIRT1485138	hsa-miR-1909	CLIP-seq
MIRT1485139	hsa-miR-221	CLIP-seq
MIRT1485140	hsa-miR-222	CLIP-seq
MIRT1485141	hsa-miR-23a	CLIP-seq
MIRT1485142	hsa-miR-23b	CLIP-seq
MIRT1485143	hsa-miR-23c	CLIP-seq
MIRT1485144	hsa-miR-296-5p	CLIP-seq
MIRT1485150	hsa-miR-3127-3p	CLIP-seq
MIRT1485151	hsa-miR-3144-3p	CLIP-seq
MIRT1485153	hsa-miR-3153	CLIP-seq
MIRT1485154	hsa-miR-3158-3p	CLIP-seq
MIRT1485155	hsa-miR-3162-5p	CLIP-seq
MIRT1485157	hsa-miR-320a	CLIP-seq
MIRT1485158	hsa-miR-320b	CLIP-seq
MIRT1485159	hsa-miR-320c	CLIP-seq
MIRT1485160	hsa-miR-320d	CLIP-seq
MIRT1485161	hsa-miR-3616-3p	CLIP-seq
MIRT1485162	hsa-miR-362-5p	CLIP-seq
MIRT1485168	hsa-miR-374c	CLIP-seq
MIRT1485169	hsa-miR-3942-3p	CLIP-seq
MIRT1485170	hsa-miR-3973	CLIP-seq
MIRT1485174	hsa-miR-433	CLIP-seq
MIRT1485175	hsa-miR-4429	CLIP-seq
MIRT1485176	hsa-miR-4436b-3p	CLIP-seq
MIRT1485177	hsa-miR-4446-3p	CLIP-seq
MIRT1485178	hsa-miR-4452	CLIP-seq
MIRT1485179	hsa-miR-4489	CLIP-seq
MIRT1485182	hsa-miR-4666-5p	CLIP-seq
MIRT1485183	hsa-miR-4721	CLIP-seq
MIRT1485185	hsa-miR-4763-3p	CLIP-seq
MIRT1485186	hsa-miR-4777-5p	CLIP-seq
MIRT1485188	hsa-miR-500b	CLIP-seq
MIRT1485189	hsa-miR-501-5p	CLIP-seq
MIRT1485190	hsa-miR-509-3p	CLIP-seq
MIRT2145956	hsa-miR-511	CLIP-seq
MIRT1485191	hsa-miR-518d-5p	CLIP-seq
MIRT1485192	hsa-miR-519b-5p	CLIP-seq
MIRT1485193	hsa-miR-519c-5p	CLIP-seq
MIRT1485194	hsa-miR-520c-5p	CLIP-seq
MIRT1485195	hsa-miR-520g	CLIP-seq
MIRT1485196	hsa-miR-520h	CLIP-seq
MIRT1485197	hsa-miR-526a	CLIP-seq
MIRT1485198	hsa-miR-548a-5p	CLIP-seq
MIRT1485199	hsa-miR-548ab	CLIP-seq
MIRT1485200	hsa-miR-548ae	CLIP-seq
MIRT1485201	hsa-miR-548aj	CLIP-seq
MIRT1485202	hsa-miR-548ak	CLIP-seq
MIRT1485203	hsa-miR-548am	CLIP-seq
MIRT1485204	hsa-miR-548b-5p	CLIP-seq
MIRT1485205	hsa-miR-548c-3p	CLIP-seq
MIRT1485206	hsa-miR-548c-5p	CLIP-seq
MIRT1485207	hsa-miR-548d-5p	CLIP-seq
MIRT1485208	hsa-miR-548h	CLIP-seq
MIRT1485209	hsa-miR-548i	CLIP-seq
MIRT1485210	hsa-miR-548j	CLIP-seq
MIRT1485211	hsa-miR-548w	CLIP-seq
MIRT1485212	hsa-miR-548x	CLIP-seq
MIRT1485213	hsa-miR-548y	CLIP-seq
MIRT1485214	hsa-miR-559	CLIP-seq
MIRT1485215	hsa-miR-561	CLIP-seq
MIRT1485216	hsa-miR-576-5p	CLIP-seq
MIRT1485217	hsa-miR-605	CLIP-seq
MIRT1485218	hsa-miR-642b	CLIP-seq
MIRT1485219	hsa-miR-655	CLIP-seq
MIRT1485220	hsa-miR-875-5p	CLIP-seq
MIRT1485130	hsa-miR-1178	CLIP-seq
MIRT1485131	hsa-miR-1207-5p	CLIP-seq
MIRT1485135	hsa-miR-1290	CLIP-seq
MIRT1485138	hsa-miR-1909	CLIP-seq
MIRT1485144	hsa-miR-296-5p	CLIP-seq
MIRT1485150	hsa-miR-3127-3p	CLIP-seq
MIRT1485161	hsa-miR-3616-3p	CLIP-seq
MIRT1485176	hsa-miR-4436b-3p	CLIP-seq
MIRT1485183	hsa-miR-4721	CLIP-seq
MIRT1485185	hsa-miR-4763-3p	CLIP-seq
MIRT1485216	hsa-miR-576-5p	CLIP-seq
MIRT1485218	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053, 33961781
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	21367861
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016728	Function	Oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	IEA
GO:0017187	Process	Peptidyl-glutamic acid carboxylation	IMP	24532791
GO:0034599	Process	Cellular response to oxidative stress	IMP	21367861
GO:0042373	Process	Vitamin K metabolic process	IBA
GO:0042373	Process	Vitamin K metabolic process	IDA	21367861
GO:0042373	Process	Vitamin K metabolic process	IEA
GO:0042373	Process	Vitamin K metabolic process	TAS
GO:0047057	Function	Vitamin-K-epoxide reductase (warfarin-sensitive) activity	EXP	21367861, 23928358
GO:0047057	Function	Vitamin-K-epoxide reductase (warfarin-sensitive) activity	IBA
GO:0047057	Function	Vitamin-K-epoxide reductase (warfarin-sensitive) activity	IDA	21367861
GO:0047057	Function	Vitamin-K-epoxide reductase (warfarin-sensitive) activity	IEA
GO:0048038	Function	Quinone binding	IEA

Other IDs

• MIM: 608838
• HGNC: 21492
• e!Ensembl: ENSG00000196715

Protein

• UniProt ID: Q8N0U8
• Protein name: Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4)
• Protein function: Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residue
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07884	VKOR	17 → 157	Vitamin K epoxide reductase family	Domain

• Sequence:

  MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSA
  ALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMS
  VVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD

• Sequence length: 176

Pathways

KEGG:

Ubiquinone and other terpenoid-quinone biosynthesis
Metabolic pathways
Biosynthesis of cofactors

Reactome:

Metabolism of vitamin K

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
KERATOCONUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma of lung	Lung carcinoma	BEFREE	30519133		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30519133		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29963761		★☆☆☆☆ Found in Text Mining only