Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	154214
Gene name	Ring finger protein 217
Gene symbol	RNF217
Synonyms (NCBI Gene)	C6orf172IBRDC1OSTLdJ84N20.1
Chromosome	6
Chromosome location	6q22.31
Summary	This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protei

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Show/Hide all (148)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027193	hsa-miR-103a-3p	Sequencing	20371350
MIRT031927	hsa-miR-16-5p	Sequencing	20371350
MIRT469048	hsa-miR-5190	HITS-CLIP	19536157
MIRT720700	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT469047	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT720698	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT720699	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT720696	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT720697	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT469046	hsa-miR-4276	HITS-CLIP	19536157
MIRT720695	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT720694	hsa-miR-4279	HITS-CLIP	19536157
MIRT720693	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT622446	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT622445	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622444	hsa-miR-4530	HITS-CLIP	23824327
MIRT622440	hsa-miR-198	HITS-CLIP	23824327
MIRT622446	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT622445	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622444	hsa-miR-4530	HITS-CLIP	23824327
MIRT622443	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT622442	hsa-miR-4421	HITS-CLIP	23824327
MIRT622441	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT622440	hsa-miR-198	HITS-CLIP	23824327
MIRT622439	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT622438	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT622437	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT622446	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT622445	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622444	hsa-miR-4530	HITS-CLIP	23824327
MIRT622443	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT622442	hsa-miR-4421	HITS-CLIP	23824327
MIRT622441	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT622440	hsa-miR-198	HITS-CLIP	23824327
MIRT622439	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT622438	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT622437	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT546735	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT546734	hsa-miR-4280	PAR-CLIP	21572407
MIRT546733	hsa-miR-4491	PAR-CLIP	21572407
MIRT546732	hsa-miR-4657	PAR-CLIP	21572407
MIRT546730	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT546728	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT546735	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT546734	hsa-miR-4280	PAR-CLIP	21572407
MIRT546733	hsa-miR-4491	PAR-CLIP	21572407
MIRT546732	hsa-miR-4657	PAR-CLIP	21572407
MIRT546731	hsa-miR-3148	PAR-CLIP	21572407
MIRT546729	hsa-miR-6124	PAR-CLIP	21572407
MIRT546730	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT546728	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT469055	hsa-miR-6507-5p	PAR-CLIP	23592263
MIRT469054	hsa-miR-138-2-3p	PAR-CLIP	23592263
MIRT469053	hsa-miR-7159-3p	PAR-CLIP	23592263
MIRT469052	hsa-miR-4482-3p	PAR-CLIP	23592263
MIRT469051	hsa-miR-3125	PAR-CLIP	23592263
MIRT469050	hsa-miR-3916	PAR-CLIP	23592263
MIRT469049	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT469048	hsa-miR-5190	PAR-CLIP	23592263
MIRT469047	hsa-miR-205-5p	PAR-CLIP	23592263
MIRT469046	hsa-miR-4276	PAR-CLIP	23592263
MIRT469048	hsa-miR-5190	HITS-CLIP	19536157
MIRT720700	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT469047	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT720698	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT720699	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT720696	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT720697	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT469046	hsa-miR-4276	HITS-CLIP	19536157
MIRT720695	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT720694	hsa-miR-4279	HITS-CLIP	19536157
MIRT720693	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT622446	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT622445	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622444	hsa-miR-4530	HITS-CLIP	23824327
MIRT622440	hsa-miR-198	HITS-CLIP	23824327
MIRT622446	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT622445	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622444	hsa-miR-4530	HITS-CLIP	23824327
MIRT622443	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT622442	hsa-miR-4421	HITS-CLIP	23824327
MIRT622441	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT622440	hsa-miR-198	HITS-CLIP	23824327
MIRT622439	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT622438	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT622437	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT622446	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT622445	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622444	hsa-miR-4530	HITS-CLIP	23824327
MIRT622443	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT622442	hsa-miR-4421	HITS-CLIP	23824327
MIRT622441	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT622440	hsa-miR-198	HITS-CLIP	23824327
MIRT622439	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT622438	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT622437	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT546735	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT546734	hsa-miR-4280	PAR-CLIP	21572407
MIRT546733	hsa-miR-4491	PAR-CLIP	21572407
MIRT546732	hsa-miR-4657	PAR-CLIP	21572407
MIRT546730	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT546728	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT546735	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT546734	hsa-miR-4280	PAR-CLIP	21572407
MIRT546733	hsa-miR-4491	PAR-CLIP	21572407
MIRT546732	hsa-miR-4657	PAR-CLIP	21572407
MIRT546731	hsa-miR-3148	PAR-CLIP	21572407
MIRT546729	hsa-miR-6124	PAR-CLIP	21572407
MIRT546730	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT546728	hsa-miR-6833-5p	PAR-CLIP	21572407
MIRT469055	hsa-miR-6507-5p	PAR-CLIP	23592263
MIRT469054	hsa-miR-138-2-3p	PAR-CLIP	23592263
MIRT469053	hsa-miR-7159-3p	PAR-CLIP	23592263
MIRT469052	hsa-miR-4482-3p	PAR-CLIP	23592263
MIRT469051	hsa-miR-3125	PAR-CLIP	23592263
MIRT469050	hsa-miR-3916	PAR-CLIP	23592263
MIRT469049	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT469048	hsa-miR-5190	PAR-CLIP	23592263
MIRT469047	hsa-miR-205-5p	PAR-CLIP	23592263
MIRT469046	hsa-miR-4276	PAR-CLIP	23592263
MIRT1312283	hsa-miR-15a	CLIP-seq
MIRT1312284	hsa-miR-15b	CLIP-seq
MIRT1312285	hsa-miR-16	CLIP-seq
MIRT1312286	hsa-miR-195	CLIP-seq
MIRT1312287	hsa-miR-3145-5p	CLIP-seq
MIRT1312288	hsa-miR-3974	CLIP-seq
MIRT1312289	hsa-miR-424	CLIP-seq
MIRT1312290	hsa-miR-497	CLIP-seq
MIRT1312291	hsa-miR-508-5p	CLIP-seq
MIRT1312292	hsa-miR-548b-3p	CLIP-seq
MIRT1312293	hsa-miR-9	CLIP-seq
MIRT2317416	hsa-miR-1256	CLIP-seq
MIRT2317417	hsa-miR-3136-3p	CLIP-seq
MIRT2317418	hsa-miR-3192	CLIP-seq
MIRT2317419	hsa-miR-34b	CLIP-seq
MIRT1312288	hsa-miR-3974	CLIP-seq
MIRT2317420	hsa-miR-4289	CLIP-seq
MIRT2317421	hsa-miR-4474-3p	CLIP-seq
MIRT2317422	hsa-miR-4778-3p	CLIP-seq
MIRT1312292	hsa-miR-548b-3p	CLIP-seq
MIRT2317423	hsa-miR-663b	CLIP-seq
MIRT2317424	hsa-miR-759	CLIP-seq
MIRT2317425	hsa-miR-767-5p	CLIP-seq
MIRT1312287	hsa-miR-3145-5p	CLIP-seq
MIRT2613266	hsa-miR-4455	CLIP-seq
MIRT1312291	hsa-miR-508-5p	CLIP-seq
MIRT2613267	hsa-miR-609	CLIP-seq
MIRT1312293	hsa-miR-9	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence
GO:0000151	Component	Ubiquitin ligase complex	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
618592	21487	ENSG00000146373

Q8TC41

Protein name

E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (Opposite STL) (RING finger protein 217)

Protein function

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01485	IBR	327 → 396	IBR domain, a half RING-finger domain	Domain
PF01485	IBR	403 → 461	IBR domain, a half RING-finger domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in testis and skeletal muscle. {ECO:0000269|PubMed:25298122}.

Sequence

MGEEQSTVSGGGGPQESQTLASGTAGHPEPPRPQGDSARAPPLRAASAEPSGGGCGSDWG
CADTSAPEPARSLGPPGWSKSRAPAQPAGLALTGPLNPQTLPLQLELEEEEEEAGDRKEG
GDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAKRQVFCSVYCVESDLPEAPASE
QLSPPASPPGAPPVLNPPSTRSSFPSPRLSLPTDSLSPDGGSIELEFYLAPEPFSMPSLL
GAPPYSGLGGVGDPYVPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKVYLSAQVQLGQV
EIKCPITECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGH
IPTPSRSESKYKIQCPTCQFVWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRNA
QKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLP
ERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRKRSRTGM
HW

Sequence length

542

Interactions

View interactions

	Reactome
			Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Multiple sclerosis, susceptibility to	risk factor	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TONSILLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	25298122		★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	Pubtator	39300613	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	25298122	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	25298122	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	31948430	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	25298122		★★★★★ ★☆☆☆☆ Found in Text Mining only

RNF217 (ring finger protein 217)