Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	1539
Gene name	Cylicin 2
Gene symbol	CYLC2
Synonyms (NCBI Gene)	-
Chromosome	9
Chromosome location	9q31.1
Summary	Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]

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Show/Hide all (143)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030343	hsa-miR-26b-5p	Microarray	19088304
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607784	hsa-miR-548av-3p	HITS-CLIP	24906430
MIRT607783	hsa-miR-548g-3p	HITS-CLIP	24906430
MIRT607782	hsa-miR-892a	HITS-CLIP	24906430
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT607780	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT618815	hsa-miR-3657	HITS-CLIP	27418678
MIRT618815	hsa-miR-3657	HITS-CLIP	27418678
MIRT618815	hsa-miR-3657	HITS-CLIP	27418678
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	27418678
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	27418678
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	27418678
MIRT618814	hsa-miR-4669	HITS-CLIP	27418678
MIRT618814	hsa-miR-4669	HITS-CLIP	27418678
MIRT618814	hsa-miR-4669	HITS-CLIP	27418678
MIRT607784	hsa-miR-548av-3p	HITS-CLIP	27418678
MIRT607784	hsa-miR-548av-3p	HITS-CLIP	27418678
MIRT607784	hsa-miR-548av-3p	HITS-CLIP	27418678
MIRT607783	hsa-miR-548g-3p	HITS-CLIP	27418678
MIRT607783	hsa-miR-548g-3p	HITS-CLIP	27418678
MIRT607783	hsa-miR-548g-3p	HITS-CLIP	27418678
MIRT607780	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607780	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607780	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607782	hsa-miR-892a	HITS-CLIP	27418678
MIRT607782	hsa-miR-892a	HITS-CLIP	27418678
MIRT607782	hsa-miR-892a	HITS-CLIP	27418678
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618815	hsa-miR-3657	HITS-CLIP	23824327
MIRT618814	hsa-miR-4669	HITS-CLIP	23824327
MIRT607781	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT618813	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT607780	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT920242	hsa-miR-205	CLIP-seq
MIRT920243	hsa-miR-218	CLIP-seq
MIRT920244	hsa-miR-500a	CLIP-seq
MIRT920245	hsa-miR-595	CLIP-seq
MIRT920246	hsa-miR-636	CLIP-seq
MIRT920247	hsa-miR-648	CLIP-seq
MIRT1972716	hsa-miR-1297	CLIP-seq
MIRT1972717	hsa-miR-26a	CLIP-seq
MIRT1972718	hsa-miR-26b	CLIP-seq
MIRT1972719	hsa-miR-3924	CLIP-seq
MIRT1972720	hsa-miR-4465	CLIP-seq
MIRT1972721	hsa-miR-630	CLIP-seq
MIRT2208414	hsa-miR-1264	CLIP-seq
MIRT1972716	hsa-miR-1297	CLIP-seq
MIRT1972717	hsa-miR-26a	CLIP-seq
MIRT1972718	hsa-miR-26b	CLIP-seq
MIRT1972719	hsa-miR-3924	CLIP-seq
MIRT1972720	hsa-miR-4465	CLIP-seq
MIRT2208415	hsa-miR-548g	CLIP-seq
MIRT1972721	hsa-miR-630	CLIP-seq
MIRT2447880	hsa-miR-485-5p	CLIP-seq
MIRT2447880	hsa-miR-485-5p	CLIP-seq
MIRT2447880	hsa-miR-485-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005200	Function	Structural constituent of cytoskeleton	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	7737358
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IMP	38013430
GO:0030154	Process	Cell differentiation	IEA
GO:0033011	Component	Perinuclear theca	IEA
GO:0033150	Component	Cytoskeletal calyx	IEA

MIM	HGNC	e!Ensembl
604035	2583	ENSG00000155833

Q14093

Protein name

Cylicin-2 (Cylicin II) (Multiple-band polypeptide II)

Protein function

Plays a role in the establishment of normal sperm morphology during spermatogenesis. It is required for acrosome attachment to the nuclear envelope, and proper manchette elongation and disassembly.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15241	Cylicin_N	8 → 113	Cylicin N-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Testis. {ECO:0000269|PubMed:7737358}.

Sequence

MSLPRFQRVNFGPYDNYIPVSELSKKSWNQQHFALLFPKPQRPGTKRRSKPSQIRDNTVS
IIDEEQLRGDRRQPLWMYRSLMRISERPSVYLAARRQPLKPTRTVEVDSKAAEIGKKGED
KTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESED
EKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKAD
EKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDA
KKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK

Sequence length

348

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC RHINOSINUSITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Erythroblastic Leukemia	Erythroblastic Leukemia	BEFREE	1372445		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31827196		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	34313325	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Major depressive disorder	Pubtator	30718454	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30297789	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31827196		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	30569177	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CYLC2 (cylicin 2)