Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	153201
Gene name	Solute carrier family 36 member 2
Gene symbol	SLC36A2
Synonyms (NCBI Gene)	PAT2TRAMD1
Chromosome	5
Chromosome location	5q33.1
Summary	This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene

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SNP ID	Visualize variation	Clinical significance	Consequence
rs77010315	C>A	Uncertain-significance, pathogenic, benign	Coding sequence variant, missense variant, 5 prime UTR variant

343

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miRTarBase ID	miRNA	Experiments	Reference
MIRT694168	hsa-miR-606	HITS-CLIP	23313552
MIRT694167	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT694166	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT694165	hsa-miR-940	HITS-CLIP	23313552
MIRT694164	hsa-miR-3929	HITS-CLIP	23313552
MIRT694163	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694162	hsa-miR-4478	HITS-CLIP	23313552
MIRT694161	hsa-miR-4733-5p	HITS-CLIP	23313552
MIRT694160	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694159	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT694158	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694157	hsa-miR-1827	HITS-CLIP	23313552
MIRT694156	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694155	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694154	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT694153	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694152	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT694151	hsa-miR-665	HITS-CLIP	23313552
MIRT694151	hsa-miR-665	PAR-CLIP	26701625
MIRT694151	hsa-miR-665	PAR-CLIP	26701625
MIRT694168	hsa-miR-606	HITS-CLIP	23313552
MIRT694167	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT694166	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT694165	hsa-miR-940	HITS-CLIP	23313552
MIRT694164	hsa-miR-3929	HITS-CLIP	23313552
MIRT694163	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694162	hsa-miR-4478	HITS-CLIP	23313552
MIRT694161	hsa-miR-4733-5p	HITS-CLIP	23313552
MIRT694160	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694159	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT694158	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694157	hsa-miR-1827	HITS-CLIP	23313552
MIRT694156	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694155	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694154	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT694153	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694152	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT694151	hsa-miR-665	HITS-CLIP	23313552
MIRT1361987	hsa-miR-1	CLIP-seq
MIRT1361988	hsa-miR-1227	CLIP-seq
MIRT1361989	hsa-miR-1268	CLIP-seq
MIRT1361990	hsa-miR-1268b	CLIP-seq
MIRT1361991	hsa-miR-1285	CLIP-seq
MIRT1361992	hsa-miR-1293	CLIP-seq
MIRT1361993	hsa-miR-142-3p	CLIP-seq
MIRT1361994	hsa-miR-19a	CLIP-seq
MIRT1361995	hsa-miR-19b	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361997	hsa-miR-206	CLIP-seq
MIRT1361998	hsa-miR-216a	CLIP-seq
MIRT1361999	hsa-miR-216b	CLIP-seq
MIRT1362000	hsa-miR-224	CLIP-seq
MIRT1362001	hsa-miR-23a	CLIP-seq
MIRT1362002	hsa-miR-23b	CLIP-seq
MIRT1362003	hsa-miR-23c	CLIP-seq
MIRT1362004	hsa-miR-24	CLIP-seq
MIRT1362005	hsa-miR-25	CLIP-seq
MIRT1362006	hsa-miR-28-5p	CLIP-seq
MIRT1362007	hsa-miR-298	CLIP-seq
MIRT1362008	hsa-miR-3065-3p	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT1362010	hsa-miR-3126-3p	CLIP-seq
MIRT1362011	hsa-miR-3139	CLIP-seq
MIRT1362012	hsa-miR-3153	CLIP-seq
MIRT1362013	hsa-miR-3165	CLIP-seq
MIRT1362014	hsa-miR-3175	CLIP-seq
MIRT1362015	hsa-miR-3176	CLIP-seq
MIRT1362016	hsa-miR-3187-5p	CLIP-seq
MIRT1362017	hsa-miR-32	CLIP-seq
MIRT1362018	hsa-miR-342-3p	CLIP-seq
MIRT1362019	hsa-miR-3613-3p	CLIP-seq
MIRT1362020	hsa-miR-3622a-3p	CLIP-seq
MIRT1362021	hsa-miR-3622b-3p	CLIP-seq
MIRT1362022	hsa-miR-363	CLIP-seq
MIRT1362023	hsa-miR-3665	CLIP-seq
MIRT1362024	hsa-miR-367	CLIP-seq
MIRT1362025	hsa-miR-3673	CLIP-seq
MIRT1362026	hsa-miR-3681	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362029	hsa-miR-371-5p	CLIP-seq
MIRT1362030	hsa-miR-371b-5p	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT1362032	hsa-miR-3922-3p	CLIP-seq
MIRT1362033	hsa-miR-4284	CLIP-seq
MIRT1362034	hsa-miR-4293	CLIP-seq
MIRT1362035	hsa-miR-4325	CLIP-seq
MIRT1362036	hsa-miR-4434	CLIP-seq
MIRT1362037	hsa-miR-4435	CLIP-seq
MIRT1362038	hsa-miR-4483	CLIP-seq
MIRT1362039	hsa-miR-4486	CLIP-seq
MIRT1362040	hsa-miR-4505	CLIP-seq
MIRT1362041	hsa-miR-4516	CLIP-seq
MIRT1362042	hsa-miR-4531	CLIP-seq
MIRT1362043	hsa-miR-4651	CLIP-seq
MIRT1362044	hsa-miR-4684-5p	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT1362046	hsa-miR-4755-3p	CLIP-seq
MIRT1362047	hsa-miR-4802-3p	CLIP-seq
MIRT1362048	hsa-miR-508-5p	CLIP-seq
MIRT1362049	hsa-miR-518a-5p	CLIP-seq
MIRT1362050	hsa-miR-527	CLIP-seq
MIRT1362051	hsa-miR-544b	CLIP-seq
MIRT1362052	hsa-miR-548c-3p	CLIP-seq
MIRT1362053	hsa-miR-585	CLIP-seq
MIRT1362054	hsa-miR-608	CLIP-seq
MIRT1362055	hsa-miR-612	CLIP-seq
MIRT1362056	hsa-miR-613	CLIP-seq
MIRT1362057	hsa-miR-661	CLIP-seq
MIRT1362058	hsa-miR-708	CLIP-seq
MIRT1362059	hsa-miR-764	CLIP-seq
MIRT1362060	hsa-miR-766	CLIP-seq
MIRT1362061	hsa-miR-890	CLIP-seq
MIRT1362062	hsa-miR-92a	CLIP-seq
MIRT1362063	hsa-miR-92b	CLIP-seq
MIRT1361987	hsa-miR-1	CLIP-seq
MIRT2107234	hsa-miR-1261	CLIP-seq
MIRT1361993	hsa-miR-142-3p	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361997	hsa-miR-206	CLIP-seq
MIRT1361998	hsa-miR-216a	CLIP-seq
MIRT1361999	hsa-miR-216b	CLIP-seq
MIRT1362004	hsa-miR-24	CLIP-seq
MIRT1362007	hsa-miR-298	CLIP-seq
MIRT1362008	hsa-miR-3065-3p	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT1362012	hsa-miR-3153	CLIP-seq
MIRT2107235	hsa-miR-3170	CLIP-seq
MIRT2107236	hsa-miR-3201	CLIP-seq
MIRT1362018	hsa-miR-342-3p	CLIP-seq
MIRT1362020	hsa-miR-3622a-3p	CLIP-seq
MIRT1362021	hsa-miR-3622b-3p	CLIP-seq
MIRT1362025	hsa-miR-3673	CLIP-seq
MIRT1362026	hsa-miR-3681	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT1362033	hsa-miR-4284	CLIP-seq
MIRT1362034	hsa-miR-4293	CLIP-seq
MIRT1362036	hsa-miR-4434	CLIP-seq
MIRT1362041	hsa-miR-4516	CLIP-seq
MIRT1362042	hsa-miR-4531	CLIP-seq
MIRT1362044	hsa-miR-4684-5p	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT2107237	hsa-miR-4791	CLIP-seq
MIRT1362047	hsa-miR-4802-3p	CLIP-seq
MIRT1362051	hsa-miR-544b	CLIP-seq
MIRT1362052	hsa-miR-548c-3p	CLIP-seq
MIRT1362056	hsa-miR-613	CLIP-seq
MIRT1362061	hsa-miR-890	CLIP-seq
MIRT1361987	hsa-miR-1	CLIP-seq
MIRT1361988	hsa-miR-1227	CLIP-seq
MIRT2107234	hsa-miR-1261	CLIP-seq
MIRT1361989	hsa-miR-1268	CLIP-seq
MIRT1361990	hsa-miR-1268b	CLIP-seq
MIRT1361991	hsa-miR-1285	CLIP-seq
MIRT1361992	hsa-miR-1293	CLIP-seq
MIRT1361993	hsa-miR-142-3p	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361997	hsa-miR-206	CLIP-seq
MIRT1362004	hsa-miR-24	CLIP-seq
MIRT1362005	hsa-miR-25	CLIP-seq
MIRT1362007	hsa-miR-298	CLIP-seq
MIRT2331338	hsa-miR-3121-5p	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT1362012	hsa-miR-3153	CLIP-seq
MIRT1362013	hsa-miR-3165	CLIP-seq
MIRT2107235	hsa-miR-3170	CLIP-seq
MIRT1362014	hsa-miR-3175	CLIP-seq
MIRT2331339	hsa-miR-3187-3p	CLIP-seq
MIRT1362016	hsa-miR-3187-5p	CLIP-seq
MIRT1362017	hsa-miR-32	CLIP-seq
MIRT2107236	hsa-miR-3201	CLIP-seq
MIRT2331340	hsa-miR-338-3p	CLIP-seq
MIRT1362018	hsa-miR-342-3p	CLIP-seq
MIRT1362020	hsa-miR-3622a-3p	CLIP-seq
MIRT1362021	hsa-miR-3622b-3p	CLIP-seq
MIRT1362022	hsa-miR-363	CLIP-seq
MIRT1362024	hsa-miR-367	CLIP-seq
MIRT1362025	hsa-miR-3673	CLIP-seq
MIRT1362026	hsa-miR-3681	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT1362033	hsa-miR-4284	CLIP-seq
MIRT1362034	hsa-miR-4293	CLIP-seq
MIRT2331341	hsa-miR-4310	CLIP-seq
MIRT1362035	hsa-miR-4325	CLIP-seq
MIRT2331342	hsa-miR-4433	CLIP-seq
MIRT1362036	hsa-miR-4434	CLIP-seq
MIRT1362037	hsa-miR-4435	CLIP-seq
MIRT1362038	hsa-miR-4483	CLIP-seq
MIRT1362039	hsa-miR-4486	CLIP-seq
MIRT1362040	hsa-miR-4505	CLIP-seq
MIRT1362041	hsa-miR-4516	CLIP-seq
MIRT1362042	hsa-miR-4531	CLIP-seq
MIRT2331343	hsa-miR-4679	CLIP-seq
MIRT2331344	hsa-miR-4701-5p	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT2107237	hsa-miR-4791	CLIP-seq
MIRT1362047	hsa-miR-4802-3p	CLIP-seq
MIRT2331345	hsa-miR-500a	CLIP-seq
MIRT1362048	hsa-miR-508-5p	CLIP-seq
MIRT1362051	hsa-miR-544b	CLIP-seq
MIRT2331346	hsa-miR-548s	CLIP-seq
MIRT1362053	hsa-miR-585	CLIP-seq
MIRT2331347	hsa-miR-588	CLIP-seq
MIRT1362055	hsa-miR-612	CLIP-seq
MIRT1362056	hsa-miR-613	CLIP-seq
MIRT1362057	hsa-miR-661	CLIP-seq
MIRT1362060	hsa-miR-766	CLIP-seq
MIRT1362061	hsa-miR-890	CLIP-seq
MIRT1362062	hsa-miR-92a	CLIP-seq
MIRT1362063	hsa-miR-92b	CLIP-seq
MIRT1361987	hsa-miR-1	CLIP-seq
MIRT2107234	hsa-miR-1261	CLIP-seq
MIRT1361992	hsa-miR-1293	CLIP-seq
MIRT1361993	hsa-miR-142-3p	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361997	hsa-miR-206	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT1362012	hsa-miR-3153	CLIP-seq
MIRT1362013	hsa-miR-3165	CLIP-seq
MIRT2107235	hsa-miR-3170	CLIP-seq
MIRT2107236	hsa-miR-3201	CLIP-seq
MIRT1362020	hsa-miR-3622a-3p	CLIP-seq
MIRT1362021	hsa-miR-3622b-3p	CLIP-seq
MIRT1362025	hsa-miR-3673	CLIP-seq
MIRT1362026	hsa-miR-3681	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT1362034	hsa-miR-4293	CLIP-seq
MIRT1362038	hsa-miR-4483	CLIP-seq
MIRT1362043	hsa-miR-4651	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT2107237	hsa-miR-4791	CLIP-seq
MIRT1362054	hsa-miR-608	CLIP-seq
MIRT1362056	hsa-miR-613	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361998	hsa-miR-216a	CLIP-seq
MIRT1361999	hsa-miR-216b	CLIP-seq
MIRT1362008	hsa-miR-3065-3p	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT1362019	hsa-miR-3613-3p	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362029	hsa-miR-371-5p	CLIP-seq
MIRT1362030	hsa-miR-371b-5p	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT2459729	hsa-miR-4311	CLIP-seq
MIRT1362036	hsa-miR-4434	CLIP-seq
MIRT1362041	hsa-miR-4516	CLIP-seq
MIRT1362042	hsa-miR-4531	CLIP-seq
MIRT2459730	hsa-miR-4662a-5p	CLIP-seq
MIRT2459731	hsa-miR-4676-5p	CLIP-seq
MIRT1362044	hsa-miR-4684-5p	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT1362046	hsa-miR-4755-3p	CLIP-seq
MIRT1362047	hsa-miR-4802-3p	CLIP-seq
MIRT1362052	hsa-miR-548c-3p	CLIP-seq
MIRT2459732	hsa-miR-575	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361998	hsa-miR-216a	CLIP-seq
MIRT1361999	hsa-miR-216b	CLIP-seq
MIRT1362008	hsa-miR-3065-3p	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT1361991	hsa-miR-1285	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361998	hsa-miR-216a	CLIP-seq
MIRT1361999	hsa-miR-216b	CLIP-seq
MIRT1362005	hsa-miR-25	CLIP-seq
MIRT1362007	hsa-miR-298	CLIP-seq
MIRT1362008	hsa-miR-3065-3p	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT1362016	hsa-miR-3187-5p	CLIP-seq
MIRT1362017	hsa-miR-32	CLIP-seq
MIRT2331340	hsa-miR-338-3p	CLIP-seq
MIRT1362019	hsa-miR-3613-3p	CLIP-seq
MIRT1362022	hsa-miR-363	CLIP-seq
MIRT1362024	hsa-miR-367	CLIP-seq
MIRT2625814	hsa-miR-3675-3p	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362029	hsa-miR-371-5p	CLIP-seq
MIRT1362030	hsa-miR-371b-5p	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT2625815	hsa-miR-3926	CLIP-seq
MIRT1362034	hsa-miR-4293	CLIP-seq
MIRT2331341	hsa-miR-4310	CLIP-seq
MIRT1362035	hsa-miR-4325	CLIP-seq
MIRT1362036	hsa-miR-4434	CLIP-seq
MIRT1362041	hsa-miR-4516	CLIP-seq
MIRT1362042	hsa-miR-4531	CLIP-seq
MIRT2459730	hsa-miR-4662a-5p	CLIP-seq
MIRT2459731	hsa-miR-4676-5p	CLIP-seq
MIRT2331343	hsa-miR-4679	CLIP-seq
MIRT1362044	hsa-miR-4684-5p	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT1362046	hsa-miR-4755-3p	CLIP-seq
MIRT2625816	hsa-miR-4786-5p	CLIP-seq
MIRT1362047	hsa-miR-4802-3p	CLIP-seq
MIRT1362048	hsa-miR-508-5p	CLIP-seq
MIRT2625817	hsa-miR-548aa	CLIP-seq
MIRT1362052	hsa-miR-548c-3p	CLIP-seq
MIRT2331346	hsa-miR-548s	CLIP-seq
MIRT2459732	hsa-miR-575	CLIP-seq
MIRT1362055	hsa-miR-612	CLIP-seq
MIRT1362057	hsa-miR-661	CLIP-seq
MIRT1362060	hsa-miR-766	CLIP-seq
MIRT2625818	hsa-miR-769-5p	CLIP-seq
MIRT1362062	hsa-miR-92a	CLIP-seq
MIRT1362063	hsa-miR-92b	CLIP-seq
MIRT1361996	hsa-miR-2054	CLIP-seq
MIRT1361998	hsa-miR-216a	CLIP-seq
MIRT1361999	hsa-miR-216b	CLIP-seq
MIRT1362007	hsa-miR-298	CLIP-seq
MIRT1362008	hsa-miR-3065-3p	CLIP-seq
MIRT1362009	hsa-miR-3122	CLIP-seq
MIRT2331340	hsa-miR-338-3p	CLIP-seq
MIRT1362019	hsa-miR-3613-3p	CLIP-seq
MIRT1362027	hsa-miR-3689a-3p	CLIP-seq
MIRT1362028	hsa-miR-3689c	CLIP-seq
MIRT1362029	hsa-miR-371-5p	CLIP-seq
MIRT1362030	hsa-miR-371b-5p	CLIP-seq
MIRT1362031	hsa-miR-3913-5p	CLIP-seq
MIRT2331341	hsa-miR-4310	CLIP-seq
MIRT1362036	hsa-miR-4434	CLIP-seq
MIRT1362041	hsa-miR-4516	CLIP-seq
MIRT1362042	hsa-miR-4531	CLIP-seq
MIRT2459730	hsa-miR-4662a-5p	CLIP-seq
MIRT2459731	hsa-miR-4676-5p	CLIP-seq
MIRT2331343	hsa-miR-4679	CLIP-seq
MIRT1362044	hsa-miR-4684-5p	CLIP-seq
MIRT1362045	hsa-miR-4728-5p	CLIP-seq
MIRT1362046	hsa-miR-4755-3p	CLIP-seq
MIRT1362047	hsa-miR-4802-3p	CLIP-seq
MIRT1362052	hsa-miR-548c-3p	CLIP-seq
MIRT2459732	hsa-miR-575	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005280	Function	Amino acid:proton symporter activity	IBA
GO:0005280	Function	Amino acid:proton symporter activity	IDA	12809675, 19033659
GO:0005280	Function	Amino acid:proton symporter activity	IEA
GO:0005280	Function	Amino acid:proton symporter activity	ISS
GO:0005297	Function	Proline:proton symporter activity	IDA	12809675, 19033659
GO:0005297	Function	Proline:proton symporter activity	IEA
GO:0005768	Component	Endosome	IEA
GO:0005774	Component	Vacuolar membrane	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005886	Component	Plasma membrane	IDA	19033659
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006865	Process	Amino acid transport	IEA
GO:0006865	Process	Amino acid transport	TAS
GO:0015171	Function	Amino acid transmembrane transporter activity	TAS
GO:0015180	Function	L-alanine transmembrane transporter activity	IBA
GO:0015180	Function	L-alanine transmembrane transporter activity	IEA
GO:0015187	Function	Glycine transmembrane transporter activity	IBA
GO:0015187	Function	Glycine transmembrane transporter activity	IEA
GO:0015193	Function	L-proline transmembrane transporter activity	IBA
GO:0015193	Function	L-proline transmembrane transporter activity	IEA
GO:0015808	Process	L-alanine transport	IBA
GO:0015808	Process	L-alanine transport	IEA
GO:0015816	Process	Glycine transport	IBA
GO:0015816	Process	Glycine transport	IEA
GO:0015824	Process	Proline transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0035524	Process	Proline transmembrane transport	IBA
GO:0035524	Process	Proline transmembrane transport	IMP	19033659
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0055038	Component	Recycling endosome membrane	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1902600	Process	Proton transmembrane transport	IBA
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
608331	18762	ENSG00000186335

Q495M3

Protein name

Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Transmembrane domain rich protein 1) (Tramdorin-1)

Protein function

Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-amin

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01490	Aa_trans	52 → 463	Transmembrane amino acid transporter protein	Family

Tissue specificity

TISSUE SPECIFICITY: Abundantly expressed in kidney and muscle. Expressed in the S1 segment of the proximal tubule close to the glomerulus. {ECO:0000269|PubMed:15058382, ECO:0000269|PubMed:19033659}.

Sequence

MSVTKSTEGPQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQAL
IHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPF
MDYGDTVMHGLEANPNAWLQNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAV
NSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLV
IIIQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILS
LGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYV
PAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALAL
IIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYQALDELLKSEDSHPFSNSTT
FVR

Sequence length

483

Interactions

View interactions

	KEGG		Reactome
	Protein digestion and absorption		Amino acid transport across the plasma membrane Proton-coupled neutral amino acid transporters Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CANNABIS DEPENDENCE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLYCINURIA WITH OR WITHOUT OXALATE UROLITHIASIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyperglycinuria	Benign; Conflicting classifications of pathogenicity; Uncertain significance; Likely benign	ClinVar CTD, ClinVar, HPO, Orphanet CTD, ClinVar, HPO, Orphanet CTD, ClinVar, HPO, Orphanet CTD, ClinVar, HPO, Orphanet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Iminoglycinuria	Conflicting classifications of pathogenicity; Uncertain significance; Benign; Likely benign	ClinVar CTD, ClinGen, ClinVar, Disgenet, HPO, Orphanet CTD, ClinGen, ClinVar, Disgenet, HPO, Orphanet CTD, ClinGen, ClinVar, Disgenet, HPO, Orphanet CTD, ClinGen, ClinVar, Disgenet, HPO, Orphanet CTD, ClinGen, ClinVar, Disgenet, HPO, Orphanet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SLC36A2-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cerebral Infarction	Ischemic stroke	Pubtator	26352407	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
HYPERGLYCINURIA (disorder)	Hyperglycinuria	GENOMICS_ENGLAND_DG	19033659		★★★★★ ★☆☆☆☆ Found in Text Mining only
HYPERGLYCINURIA (disorder)	Hyperglycinuria	UNIPROT_DG	19033659		★★★★★ ★☆☆☆☆ Found in Text Mining only
HYPERGLYCINURIA (disorder)	Hyperglycinuria	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
HYPERGLYCINURIA (disorder)	Hyperglycinuria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Iminoglycinuria	Iminoglycinuria	BEFREE	19033659		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Iminoglycinuria	Iminoglycinuria	ORPHANET_DG	19033659		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Iminoglycinuria	Iminoglycinuria	GENOMICS_ENGLAND_DG	19033659		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Iminoglycinuria	Iminoglycinuria	UNIPROT_DG	19033659		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Iminoglycinuria	Iminoglycinuria	Pubtator	19033659	Associate	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Iminoglycinuria	Iminoglycinuria	Orphanet			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Iminoglycinuria	Iminoglycinuria	CTD_human_DG			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
NEPHROLITHIASIS, CALCIUM OXALATE	Nephronophthisis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Prolinuria	Prolinuria	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC36A2 (solute carrier family 36 member 2)