KLB (klotho beta)

Gene

• Entrez ID: 152831
• Gene name: Klotho beta
• Gene symbol: KLB
• Synonyms (NCBI Gene): BKL
• Chromosome: 4
• Chromosome location: 4p14

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006874	hsa-miR-34a-5p	Luciferase reporter assay	22988100
MIRT048903	hsa-miR-93-5p	CLASH	23622248
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	19536157
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	19536157
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT650011	hsa-miR-764	HITS-CLIP	23313552
MIRT696279	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT650015	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650014	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT650013	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT650012	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT650011	hsa-miR-764	HITS-CLIP	23824327
MIRT650010	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650009	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT650008	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT650007	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT650006	hsa-miR-6131	HITS-CLIP	23824327
MIRT650005	hsa-miR-7641	HITS-CLIP	23824327
MIRT650004	hsa-miR-548s	HITS-CLIP	23824327
MIRT650003	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT650002	hsa-miR-588	HITS-CLIP	23824327
MIRT650001	hsa-miR-4435	HITS-CLIP	23824327
MIRT650000	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT649999	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT649998	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	19536157
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	19536157
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT650011	hsa-miR-764	HITS-CLIP	23313552
MIRT696279	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT650015	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650014	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT650013	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT650012	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT650011	hsa-miR-764	HITS-CLIP	23824327
MIRT650010	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT650009	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT650008	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT650007	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT650006	hsa-miR-6131	HITS-CLIP	23824327
MIRT650005	hsa-miR-7641	HITS-CLIP	23824327
MIRT650004	hsa-miR-548s	HITS-CLIP	23824327
MIRT650003	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT650002	hsa-miR-588	HITS-CLIP	23824327
MIRT650001	hsa-miR-4435	HITS-CLIP	23824327
MIRT650000	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT649999	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT649998	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT623429	hsa-miR-4780	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612056	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT612055	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT612054	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT612053	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1095494	hsa-miR-101	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT1095496	hsa-miR-1227	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT1095498	hsa-miR-1273f	CLIP-seq
MIRT1095499	hsa-miR-129-3p	CLIP-seq
MIRT1095500	hsa-miR-135a	CLIP-seq
MIRT1095501	hsa-miR-135b	CLIP-seq
MIRT1095502	hsa-miR-144	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT1095504	hsa-miR-197	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT1095506	hsa-miR-2053	CLIP-seq
MIRT1095507	hsa-miR-21	CLIP-seq
MIRT1095508	hsa-miR-3168	CLIP-seq
MIRT1095509	hsa-miR-3170	CLIP-seq
MIRT1095510	hsa-miR-3923	CLIP-seq
MIRT1095511	hsa-miR-3978	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1095513	hsa-miR-4252	CLIP-seq
MIRT1095514	hsa-miR-4257	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT1095517	hsa-miR-4330	CLIP-seq
MIRT1095518	hsa-miR-4419a	CLIP-seq
MIRT1095519	hsa-miR-4474-5p	CLIP-seq
MIRT1095520	hsa-miR-4510	CLIP-seq
MIRT1095521	hsa-miR-4659a-5p	CLIP-seq
MIRT1095522	hsa-miR-4659b-5p	CLIP-seq
MIRT1095523	hsa-miR-4693-5p	CLIP-seq
MIRT1095524	hsa-miR-4716-5p	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT1095526	hsa-miR-4776-3p	CLIP-seq
MIRT1095527	hsa-miR-4786-3p	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095530	hsa-miR-548ac	CLIP-seq
MIRT1095531	hsa-miR-548ae	CLIP-seq
MIRT1095532	hsa-miR-548aj	CLIP-seq
MIRT1095533	hsa-miR-548am	CLIP-seq
MIRT1095534	hsa-miR-548d-3p	CLIP-seq
MIRT1095535	hsa-miR-548x	CLIP-seq
MIRT1095536	hsa-miR-548z	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT1095538	hsa-miR-569	CLIP-seq
MIRT1095539	hsa-miR-582-5p	CLIP-seq
MIRT1095540	hsa-miR-590-5p	CLIP-seq
MIRT1095541	hsa-miR-628-3p	CLIP-seq
MIRT1095504	hsa-miR-197	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1922196	hsa-miR-4503	CLIP-seq
MIRT1095524	hsa-miR-4716-5p	CLIP-seq
MIRT1922197	hsa-miR-5096	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT2025656	hsa-miR-122	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT2025657	hsa-miR-129-5p	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2025658	hsa-miR-186	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT2025659	hsa-miR-3133	CLIP-seq
MIRT2025660	hsa-miR-3135	CLIP-seq
MIRT2025661	hsa-miR-3135b	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2025663	hsa-miR-3652	CLIP-seq
MIRT2025664	hsa-miR-3929	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT2025665	hsa-miR-3937	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT2025666	hsa-miR-4317	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT2025667	hsa-miR-4419b	CLIP-seq
MIRT2025668	hsa-miR-4430	CLIP-seq
MIRT1095519	hsa-miR-4474-5p	CLIP-seq
MIRT2025669	hsa-miR-4478	CLIP-seq
MIRT2025670	hsa-miR-4520a-3p	CLIP-seq
MIRT2025671	hsa-miR-4520b-3p	CLIP-seq
MIRT2025672	hsa-miR-4529-3p	CLIP-seq
MIRT1095521	hsa-miR-4659a-5p	CLIP-seq
MIRT1095522	hsa-miR-4659b-5p	CLIP-seq
MIRT1095524	hsa-miR-4716-5p	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT2025673	hsa-miR-4757-5p	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1922197	hsa-miR-5096	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2025677	hsa-miR-645	CLIP-seq
MIRT2256830	hsa-miR-106a	CLIP-seq
MIRT2256831	hsa-miR-106b	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT2025656	hsa-miR-122	CLIP-seq
MIRT1095496	hsa-miR-1227	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT2256832	hsa-miR-130a	CLIP-seq
MIRT2256833	hsa-miR-130b	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2256834	hsa-miR-17	CLIP-seq
MIRT2256835	hsa-miR-183	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT2256836	hsa-miR-20a	CLIP-seq
MIRT2256837	hsa-miR-20b	CLIP-seq
MIRT2256838	hsa-miR-24	CLIP-seq
MIRT2256839	hsa-miR-301a	CLIP-seq
MIRT2256840	hsa-miR-301b	CLIP-seq
MIRT2256841	hsa-miR-302a	CLIP-seq
MIRT2256842	hsa-miR-302b	CLIP-seq
MIRT2256843	hsa-miR-302c	CLIP-seq
MIRT2256844	hsa-miR-302d	CLIP-seq
MIRT2256845	hsa-miR-302e	CLIP-seq
MIRT2025660	hsa-miR-3135	CLIP-seq
MIRT2025661	hsa-miR-3135b	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2025663	hsa-miR-3652	CLIP-seq
MIRT2256846	hsa-miR-3666	CLIP-seq
MIRT2256847	hsa-miR-372	CLIP-seq
MIRT2256848	hsa-miR-373	CLIP-seq
MIRT2025664	hsa-miR-3929	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT2025665	hsa-miR-3937	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT2256849	hsa-miR-4284	CLIP-seq
MIRT2256850	hsa-miR-4295	CLIP-seq
MIRT2025666	hsa-miR-4317	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT1095517	hsa-miR-4330	CLIP-seq
MIRT2025667	hsa-miR-4419b	CLIP-seq
MIRT2025668	hsa-miR-4430	CLIP-seq
MIRT2256851	hsa-miR-4438	CLIP-seq
MIRT2025669	hsa-miR-4478	CLIP-seq
MIRT2256852	hsa-miR-454	CLIP-seq
MIRT2256853	hsa-miR-4663	CLIP-seq
MIRT2256854	hsa-miR-4715-3p	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT2256855	hsa-miR-4746-3p	CLIP-seq
MIRT1095526	hsa-miR-4776-3p	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1922197	hsa-miR-5096	CLIP-seq
MIRT2256856	hsa-miR-512-3p	CLIP-seq
MIRT2256857	hsa-miR-519d	CLIP-seq
MIRT2256858	hsa-miR-520a-3p	CLIP-seq
MIRT2256859	hsa-miR-520b	CLIP-seq
MIRT2256860	hsa-miR-520c-3p	CLIP-seq
MIRT2256861	hsa-miR-520d-3p	CLIP-seq
MIRT2256862	hsa-miR-520e	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2256863	hsa-miR-564	CLIP-seq
MIRT2025677	hsa-miR-645	CLIP-seq
MIRT2256864	hsa-miR-922	CLIP-seq
MIRT2256865	hsa-miR-93	CLIP-seq
MIRT1095495	hsa-miR-1200	CLIP-seq
MIRT2025656	hsa-miR-122	CLIP-seq
MIRT1095497	hsa-miR-1234	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2025661	hsa-miR-3135b	CLIP-seq
MIRT2025663	hsa-miR-3652	CLIP-seq
MIRT1095516	hsa-miR-4324	CLIP-seq
MIRT2025668	hsa-miR-4430	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095529	hsa-miR-544b	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2256830	hsa-miR-106a	CLIP-seq
MIRT2256831	hsa-miR-106b	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2256834	hsa-miR-17	CLIP-seq
MIRT2256836	hsa-miR-20a	CLIP-seq
MIRT2256837	hsa-miR-20b	CLIP-seq
MIRT2256841	hsa-miR-302a	CLIP-seq
MIRT2256842	hsa-miR-302b	CLIP-seq
MIRT2256843	hsa-miR-302c	CLIP-seq
MIRT2256844	hsa-miR-302d	CLIP-seq
MIRT2256845	hsa-miR-302e	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT2558287	hsa-miR-3150a-5p	CLIP-seq
MIRT2558288	hsa-miR-3150b-5p	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2256847	hsa-miR-372	CLIP-seq
MIRT2256848	hsa-miR-373	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT2025665	hsa-miR-3937	CLIP-seq
MIRT2558289	hsa-miR-4312	CLIP-seq
MIRT2256851	hsa-miR-4438	CLIP-seq
MIRT2558290	hsa-miR-4731-5p	CLIP-seq
MIRT2025673	hsa-miR-4757-5p	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT2256856	hsa-miR-512-3p	CLIP-seq
MIRT2256857	hsa-miR-519d	CLIP-seq
MIRT2256858	hsa-miR-520a-3p	CLIP-seq
MIRT2256859	hsa-miR-520b	CLIP-seq
MIRT2256860	hsa-miR-520c-3p	CLIP-seq
MIRT2256861	hsa-miR-520d-3p	CLIP-seq
MIRT2256862	hsa-miR-520e	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2558291	hsa-miR-640	CLIP-seq
MIRT2256865	hsa-miR-93	CLIP-seq
MIRT2256830	hsa-miR-106a	CLIP-seq
MIRT2256831	hsa-miR-106b	CLIP-seq
MIRT2025657	hsa-miR-129-5p	CLIP-seq
MIRT1095503	hsa-miR-150	CLIP-seq
MIRT2256834	hsa-miR-17	CLIP-seq
MIRT1095504	hsa-miR-197	CLIP-seq
MIRT1095505	hsa-miR-1976	CLIP-seq
MIRT2256836	hsa-miR-20a	CLIP-seq
MIRT2256837	hsa-miR-20b	CLIP-seq
MIRT2256841	hsa-miR-302a	CLIP-seq
MIRT2256842	hsa-miR-302b	CLIP-seq
MIRT2256843	hsa-miR-302c	CLIP-seq
MIRT2256844	hsa-miR-302d	CLIP-seq
MIRT2256845	hsa-miR-302e	CLIP-seq
MIRT1922194	hsa-miR-3149	CLIP-seq
MIRT2558287	hsa-miR-3150a-5p	CLIP-seq
MIRT2558288	hsa-miR-3150b-5p	CLIP-seq
MIRT1095509	hsa-miR-3170	CLIP-seq
MIRT2025662	hsa-miR-3615	CLIP-seq
MIRT2256847	hsa-miR-372	CLIP-seq
MIRT2256848	hsa-miR-373	CLIP-seq
MIRT1922195	hsa-miR-3934	CLIP-seq
MIRT1095512	hsa-miR-411	CLIP-seq
MIRT1095515	hsa-miR-4279	CLIP-seq
MIRT2558289	hsa-miR-4312	CLIP-seq
MIRT2256851	hsa-miR-4438	CLIP-seq
MIRT1095525	hsa-miR-4722-3p	CLIP-seq
MIRT2558290	hsa-miR-4731-5p	CLIP-seq
MIRT2683527	hsa-miR-4735-5p	CLIP-seq
MIRT2025673	hsa-miR-4757-5p	CLIP-seq
MIRT2683528	hsa-miR-4775	CLIP-seq
MIRT2683529	hsa-miR-4794	CLIP-seq
MIRT2025674	hsa-miR-498	CLIP-seq
MIRT1095528	hsa-miR-5095	CLIP-seq
MIRT2256856	hsa-miR-512-3p	CLIP-seq
MIRT2256857	hsa-miR-519d	CLIP-seq
MIRT2256858	hsa-miR-520a-3p	CLIP-seq
MIRT2256859	hsa-miR-520b	CLIP-seq
MIRT2256860	hsa-miR-520c-3p	CLIP-seq
MIRT2256861	hsa-miR-520d-3p	CLIP-seq
MIRT2256862	hsa-miR-520e	CLIP-seq
MIRT2025675	hsa-miR-520g	CLIP-seq
MIRT2025676	hsa-miR-520h	CLIP-seq
MIRT1095537	hsa-miR-552	CLIP-seq
MIRT2683530	hsa-miR-590-3p	CLIP-seq
MIRT2558291	hsa-miR-640	CLIP-seq
MIRT2256865	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0005104	Function	Fibroblast growth factor receptor binding	IPI	17627937
GO:0005515	Function	Protein binding	IPI	19059246
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0017134	Function	Fibroblast growth factor binding	IEA
GO:0017134	Function	Fibroblast growth factor binding	IPI	18829467, 19117008
GO:0090080	Process	Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IEA

Other IDs

• MIM: 611135
• HGNC: 15527
• e!Ensembl: ENSG00000134962

Protein

• UniProt ID: Q86Z14
• Protein name: Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
• Protein function: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity
• PDB: 5VAK, 5VAN, 5VAQ, 5WI9, 6NFJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00232	Glyco_hydro_1	77 → 388	Glycosyl hydrolase family 1	Domain
  PF00232	Glyco_hydro_1	376 → 508	Glycosyl hydrolase family 1	Domain
  PF00232	Glyco_hydro_1	517 → 967	Glycosyl hydrolase family 1	Domain

• Sequence:

  MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSALILLRAVTGFSGDGRAI
  WSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKN
  VSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLD
  ALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIH
  NPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITL
  GSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEK
  HEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWF
  TDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFY
  VDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVA
  SSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFA
  LDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADG
  WLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHA
  LAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTG
  DYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSR
  YDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDD
  RLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNK
  VISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQ
  KRRKFWKAKNLQHIPLKKGKRVVS

• Sequence length: 1044

Pathways

KEGG:

Thermogenesis

Reactome:

PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Male infertility with azoospermia or oligozoospermia due to single gene mutation	Likely pathogenic	rs2474965849	RCV003991614	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Amenorrhea	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypogonadotropic hypogonadism	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KLB-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Martsolf syndrome 1	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ocular motility disease	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Allergic rhinitis (disorder)	Allergic rhinitis	BEFREE	28713926		★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	29438906		★☆☆☆☆ Found in Text Mining only
Autosomal dominant hypophosphatemic rickets	Hypophosphatemic Rickets	BEFREE	21177529		★☆☆☆☆ Found in Text Mining only
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	29749458		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23317273, 29344186		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23317273	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	29749458	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	22439738, 36179047	Associate	★☆☆☆☆ Found in Text Mining only
Cartilage-hair hypoplasia	Cartilage-Hair Hypoplasia	BEFREE	28754744		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	28445152	Associate	★☆☆☆☆ Found in Text Mining only
Cholestasis of pregnancy	Cholestasis of pregnancy	BEFREE	30697260		★☆☆☆☆ Found in Text Mining only
Congenital hypogonadotropic hypogonadism	Congenital Hypogonadotropic Hypogonadism	BEFREE	28754744		★☆☆☆☆ Found in Text Mining only
Congenital hypogonadotropic hypogonadism	Congenital Hypogonadotropic Hypogonadism	GENOMICS_ENGLAND_DG	28754744		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	21177529		★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	29734515	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	34912302	Inhibit	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	21177529		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	27916483, 28721439, 30042059		★☆☆☆☆ Found in Text Mining only
Diarrhea	Diarrhea	Pubtator	21396369	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	26824324, 35762530	Inhibit	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	30393845	Associate	★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty liver	Pubtator	33640795	Associate	★☆☆☆☆ Found in Text Mining only
Follicular thyroid carcinoma	Follicular Thyroid Carcinoma	BEFREE	29438906		★☆☆☆☆ Found in Text Mining only
Graves Ophthalmopathy	Graves ophthalmopathy	Pubtator	37900130	Associate	★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	30840894		★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	29344186		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable bowel syndrome	Pubtator	21396369, 22271411	Associate	★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	22403795		★☆☆☆☆ Found in Text Mining only
Kidney Failure	Kidney Failure	BEFREE	28183805		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	20657013, 22439738, 23383245, 24728076		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver cirrhosis	Pubtator	29699061, 33640795	Associate	★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	23383245		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	31695781	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23317273, 29344186		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23440425, 29749458		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	29438906, 31408968		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23002168, 23383245, 29731962		★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	26901091		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23383245, 28334808, 29344186, 29749458, 30593273, 31408968		★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	CTD_human_DG	29289645		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	31548436, 31655133		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31695781		★☆☆☆☆ Found in Text Mining only
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	CTD_human_DG	29289645		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	BEFREE	22641000, 22988100, 26901091, 27125742, 28422755, 28552744, 28721439, 28895785, 29348470, 31548436		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	31548436, 33640795	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian Diseases	LHGDN	18259951		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	29438906, 31408968		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23440425, 29749458		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	29749458		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	29749458	Inhibit	★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	22988100		★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	29438906, 31408968		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	29438906, 31408968		★☆☆☆☆ Found in Text Mining only
Trigeminal Neuralgia	Trigeminal neuralgia	Pubtator	38158702	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	26556877		★☆☆☆☆ Found in Text Mining only
Vitiligo	Vitiligo	Pubtator	39177325	Associate	★☆☆☆☆ Found in Text Mining only