Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	152687
Gene name	Zinc finger protein 595
Gene symbol	ZNF595
Synonyms (NCBI Gene)	-
Chromosome	4
Chromosome location	4p16.3
Summary	This gene encodes a protein belonging to the Cys2His2 zinc finger protein family, whose members function as transcription factors that can regulate a broad variety of developmental and cellular processes. Alternative splicing of this gene results in multi

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Show/Hide all (188)

miRTarBase ID	miRNA	Experiments
MIRT1531319	hsa-miR-10a	CLIP-seq
MIRT1531320	hsa-miR-10b	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT1531322	hsa-miR-1273e	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531324	hsa-miR-1827	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531326	hsa-miR-214	CLIP-seq
MIRT1531327	hsa-miR-2964a-3p	CLIP-seq
MIRT1531328	hsa-miR-302f	CLIP-seq
MIRT1531329	hsa-miR-3120-5p	CLIP-seq
MIRT1531330	hsa-miR-339-5p	CLIP-seq
MIRT1531331	hsa-miR-3613-3p	CLIP-seq
MIRT1531332	hsa-miR-3619-5p	CLIP-seq
MIRT1531333	hsa-miR-3647-3p	CLIP-seq
MIRT1531334	hsa-miR-3664-3p	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT1531336	hsa-miR-3665	CLIP-seq
MIRT1531337	hsa-miR-3670	CLIP-seq
MIRT1531338	hsa-miR-3689d	CLIP-seq
MIRT1531339	hsa-miR-371-5p	CLIP-seq
MIRT1531340	hsa-miR-371b-5p	CLIP-seq
MIRT1531341	hsa-miR-4421	CLIP-seq
MIRT1531342	hsa-miR-4433	CLIP-seq
MIRT1531343	hsa-miR-4459	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531345	hsa-miR-4502	CLIP-seq
MIRT1531346	hsa-miR-4522	CLIP-seq
MIRT1531347	hsa-miR-4530	CLIP-seq
MIRT1531348	hsa-miR-4633-5p	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531350	hsa-miR-4684-5p	CLIP-seq
MIRT1531351	hsa-miR-4698	CLIP-seq
MIRT1531352	hsa-miR-4699-3p	CLIP-seq
MIRT1531353	hsa-miR-4714-5p	CLIP-seq
MIRT1531354	hsa-miR-4722-5p	CLIP-seq
MIRT1531355	hsa-miR-4724-5p	CLIP-seq
MIRT1531356	hsa-miR-4729	CLIP-seq
MIRT1531357	hsa-miR-4768-3p	CLIP-seq
MIRT1531358	hsa-miR-4773	CLIP-seq
MIRT1531359	hsa-miR-532-5p	CLIP-seq
MIRT1531360	hsa-miR-593	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531362	hsa-miR-761	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT1531364	hsa-miR-940	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT2160601	hsa-miR-3942-5p	CLIP-seq
MIRT2160602	hsa-miR-4300	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT2160603	hsa-miR-4703-5p	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2160604	hsa-miR-920	CLIP-seq
MIRT2379867	hsa-miR-100	CLIP-seq
MIRT2379868	hsa-miR-1228	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT2379869	hsa-miR-1293	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT2379870	hsa-miR-2467-5p	CLIP-seq
MIRT2379871	hsa-miR-3122	CLIP-seq
MIRT2379872	hsa-miR-3165	CLIP-seq
MIRT2379873	hsa-miR-3188	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT2379874	hsa-miR-3689a-3p	CLIP-seq
MIRT2379875	hsa-miR-3689c	CLIP-seq
MIRT2379876	hsa-miR-3913-5p	CLIP-seq
MIRT2160601	hsa-miR-3942-5p	CLIP-seq
MIRT2379877	hsa-miR-3975	CLIP-seq
MIRT2160602	hsa-miR-4300	CLIP-seq
MIRT2379878	hsa-miR-4483	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT2160603	hsa-miR-4703-5p	CLIP-seq
MIRT2379879	hsa-miR-4728-5p	CLIP-seq
MIRT1531357	hsa-miR-4768-3p	CLIP-seq
MIRT2379880	hsa-miR-485-5p	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2160604	hsa-miR-920	CLIP-seq
MIRT2379881	hsa-miR-99a	CLIP-seq
MIRT2379882	hsa-miR-99b	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2379867	hsa-miR-100	CLIP-seq
MIRT1531319	hsa-miR-10a	CLIP-seq
MIRT1531320	hsa-miR-10b	CLIP-seq
MIRT2379868	hsa-miR-1228	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT2671993	hsa-miR-1285	CLIP-seq
MIRT2379869	hsa-miR-1293	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531329	hsa-miR-3120-5p	CLIP-seq
MIRT2379871	hsa-miR-3122	CLIP-seq
MIRT2379872	hsa-miR-3165	CLIP-seq
MIRT2671994	hsa-miR-3187-5p	CLIP-seq
MIRT2671995	hsa-miR-338-3p	CLIP-seq
MIRT1531330	hsa-miR-339-5p	CLIP-seq
MIRT2671996	hsa-miR-3611	CLIP-seq
MIRT1531331	hsa-miR-3613-3p	CLIP-seq
MIRT2671997	hsa-miR-3622b-5p	CLIP-seq
MIRT1531333	hsa-miR-3647-3p	CLIP-seq
MIRT1531334	hsa-miR-3664-3p	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT1531337	hsa-miR-3670	CLIP-seq
MIRT2379874	hsa-miR-3689a-3p	CLIP-seq
MIRT2379875	hsa-miR-3689c	CLIP-seq
MIRT1531339	hsa-miR-371-5p	CLIP-seq
MIRT1531340	hsa-miR-371b-5p	CLIP-seq
MIRT2379876	hsa-miR-3913-5p	CLIP-seq
MIRT2671998	hsa-miR-3945	CLIP-seq
MIRT2671999	hsa-miR-4253	CLIP-seq
MIRT2672000	hsa-miR-4289	CLIP-seq
MIRT2672001	hsa-miR-4310	CLIP-seq
MIRT1531341	hsa-miR-4421	CLIP-seq
MIRT1531342	hsa-miR-4433	CLIP-seq
MIRT2672002	hsa-miR-4435	CLIP-seq
MIRT1531343	hsa-miR-4459	CLIP-seq
MIRT2379878	hsa-miR-4483	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531346	hsa-miR-4522	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531350	hsa-miR-4684-5p	CLIP-seq
MIRT1531355	hsa-miR-4724-5p	CLIP-seq
MIRT2379879	hsa-miR-4728-5p	CLIP-seq
MIRT1531357	hsa-miR-4768-3p	CLIP-seq
MIRT1531358	hsa-miR-4773	CLIP-seq
MIRT2672003	hsa-miR-556-5p	CLIP-seq
MIRT1531360	hsa-miR-593	CLIP-seq
MIRT2672004	hsa-miR-612	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2379881	hsa-miR-99a	CLIP-seq
MIRT2379882	hsa-miR-99b	CLIP-seq
MIRT2379867	hsa-miR-100	CLIP-seq
MIRT1531319	hsa-miR-10a	CLIP-seq
MIRT1531320	hsa-miR-10b	CLIP-seq
MIRT2379868	hsa-miR-1228	CLIP-seq
MIRT1531321	hsa-miR-1273	CLIP-seq
MIRT2671993	hsa-miR-1285	CLIP-seq
MIRT2379869	hsa-miR-1293	CLIP-seq
MIRT1531323	hsa-miR-141	CLIP-seq
MIRT1531325	hsa-miR-200a	CLIP-seq
MIRT1531329	hsa-miR-3120-5p	CLIP-seq
MIRT2379871	hsa-miR-3122	CLIP-seq
MIRT2671994	hsa-miR-3187-5p	CLIP-seq
MIRT2671995	hsa-miR-338-3p	CLIP-seq
MIRT1531330	hsa-miR-339-5p	CLIP-seq
MIRT2671996	hsa-miR-3611	CLIP-seq
MIRT1531331	hsa-miR-3613-3p	CLIP-seq
MIRT2671997	hsa-miR-3622b-5p	CLIP-seq
MIRT1531333	hsa-miR-3647-3p	CLIP-seq
MIRT1531335	hsa-miR-3664-5p	CLIP-seq
MIRT2379874	hsa-miR-3689a-3p	CLIP-seq
MIRT2379875	hsa-miR-3689c	CLIP-seq
MIRT1531339	hsa-miR-371-5p	CLIP-seq
MIRT1531340	hsa-miR-371b-5p	CLIP-seq
MIRT2379876	hsa-miR-3913-5p	CLIP-seq
MIRT2671998	hsa-miR-3945	CLIP-seq
MIRT2671999	hsa-miR-4253	CLIP-seq
MIRT2672000	hsa-miR-4289	CLIP-seq
MIRT2672001	hsa-miR-4310	CLIP-seq
MIRT1531341	hsa-miR-4421	CLIP-seq
MIRT2672002	hsa-miR-4435	CLIP-seq
MIRT2379878	hsa-miR-4483	CLIP-seq
MIRT1531344	hsa-miR-4486	CLIP-seq
MIRT1531346	hsa-miR-4522	CLIP-seq
MIRT1531349	hsa-miR-4649-5p	CLIP-seq
MIRT1531350	hsa-miR-4684-5p	CLIP-seq
MIRT1531355	hsa-miR-4724-5p	CLIP-seq
MIRT2379879	hsa-miR-4728-5p	CLIP-seq
MIRT1531358	hsa-miR-4773	CLIP-seq
MIRT1531360	hsa-miR-593	CLIP-seq
MIRT2672004	hsa-miR-612	CLIP-seq
MIRT1531361	hsa-miR-661	CLIP-seq
MIRT1531363	hsa-miR-766	CLIP-seq
MIRT2379881	hsa-miR-99a	CLIP-seq
MIRT2379882	hsa-miR-99b	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8IYB9

Protein name

Zinc finger protein 595

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	3 → 44	KRAB box	Family
PF00096	zf-C2H2	200 → 222	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	228 → 250	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	256 → 278	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	284 → 308		Domain
PF00096	zf-C2H2	312 → 334	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	340 → 362	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	368 → 390	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	396 → 418	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	424 → 446	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	452 → 474	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	508 → 530	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	535 → 561		Domain
PF00096	zf-C2H2	564 → 586	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	592 → 614	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	620 → 642	Zinc finger, C2H2 type	Domain

Sequence

MELVTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLGFVISNPDLVTCLEQIK
EPCNLKIHETAAKPPAICSPFSQDLSPVQGIEDSFHKLILKRYEKCGHENLQLRKGCKRV
NECKVQKGVNNGVYQCLSTTQSKIFQCNTCVKVFSKFSNSNKHKIRHTGEKPFKCTECGR
SFYMSHLTQHTGIHAGEKPYKCEKCGKAFNRSTSLSKHKRIHTGEKPYTCEECGKAFRRS
TVLNEHKKIHTGEKPYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCKECGKAFRWSTSLN
EHKNIHTGEKPYKCKECGKAFRQSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLIIHRS
IHSEQKLYKCEECGKAFTWSSSLNKHKRIHTGEKPYTCEECGKAFYRSSHLAKHKRIHTG
EKPYTCEECGKAFNQSSTLILHKRIHSGQKPYKCEECGKAFTRSTTLNEHKKIHTGEKPY
KCEECGKAFIWSASLNEHKNIHTGEKPYKCKECGKAFNQSSGLIIHRSIHSEQKLYKCEE
CGKAFTRSTALNEHKKIHSGEKPYKCKECGKAYNLSSTLTKHKRIHTGEKPFTCEECGKA
FNWSSSLTKHKIIHTGEKSYKCEECGKAFNRPSTLTVHKRIHTGKEHS

Sequence length

648

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GENETIC PREDISPOSITION TO DISEASE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atrial Fibrillation	Atrial fibrillation	Pubtator	36952494	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	GWASCAT_DG	30166627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	36952494	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF595 (zinc finger protein 595)