Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	152519
Gene name	NIPA like domain containing 1
Gene symbol	NIPAL1
Synonyms (NCBI Gene)	NIPA3NPAL1SLC57A3
Chromosome	4
Chromosome location	4p12

165

Show/Hide all (165)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026452	hsa-miR-192-5p	Microarray	19074876
MIRT043429	hsa-miR-331-3p	CLASH	23622248
MIRT667216	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT667215	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT667214	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT667213	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT667212	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT667211	hsa-miR-1913	HITS-CLIP	23824327
MIRT667210	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT667209	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT667208	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT667206	hsa-miR-4284	HITS-CLIP	23824327
MIRT667207	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT667205	hsa-miR-8057	HITS-CLIP	23824327
MIRT627972	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT627971	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT627970	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT627969	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT627968	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT627967	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT627966	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT627965	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT627964	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT627972	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT627971	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT627970	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT627969	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT627968	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT627967	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT627966	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT627965	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT627964	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT509915	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT509914	hsa-miR-3130-5p	PAR-CLIP	23446348
MIRT509913	hsa-miR-4482-5p	PAR-CLIP	23446348
MIRT509912	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509911	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT509910	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT509909	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT509908	hsa-miR-3130-3p	PAR-CLIP	23446348
MIRT509907	hsa-miR-4252	PAR-CLIP	23446348
MIRT509906	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT667216	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT667215	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT667214	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT667213	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT667212	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT667211	hsa-miR-1913	HITS-CLIP	23824327
MIRT667210	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT667209	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT667208	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT667206	hsa-miR-4284	HITS-CLIP	23824327
MIRT667207	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT667205	hsa-miR-8057	HITS-CLIP	23824327
MIRT627972	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT627971	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT627970	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT627969	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT627968	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT627967	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT627966	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT627965	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT627964	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT627972	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT627971	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT627970	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT627969	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT627968	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT627967	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT627966	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT627965	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT627964	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT509915	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT509914	hsa-miR-3130-5p	PAR-CLIP	23446348
MIRT509913	hsa-miR-4482-5p	PAR-CLIP	23446348
MIRT509912	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT509911	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT509910	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT509909	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT509908	hsa-miR-3130-3p	PAR-CLIP	23446348
MIRT509907	hsa-miR-4252	PAR-CLIP	23446348
MIRT509906	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT1185546	hsa-miR-1257	CLIP-seq
MIRT1185547	hsa-miR-1264	CLIP-seq
MIRT1185548	hsa-miR-1279	CLIP-seq
MIRT1185549	hsa-miR-141	CLIP-seq
MIRT1185550	hsa-miR-200a	CLIP-seq
MIRT1185551	hsa-miR-330-3p	CLIP-seq
MIRT1185552	hsa-miR-361-5p	CLIP-seq
MIRT1185553	hsa-miR-3671	CLIP-seq
MIRT1185554	hsa-miR-3926	CLIP-seq
MIRT1185555	hsa-miR-4318	CLIP-seq
MIRT1185556	hsa-miR-4693-5p	CLIP-seq
MIRT1185557	hsa-miR-4711-3p	CLIP-seq
MIRT1185558	hsa-miR-4796-5p	CLIP-seq
MIRT1185559	hsa-miR-548a-3p	CLIP-seq
MIRT1185560	hsa-miR-548c-3p	CLIP-seq
MIRT1185561	hsa-miR-548e	CLIP-seq
MIRT1185562	hsa-miR-548f	CLIP-seq
MIRT1185563	hsa-miR-548s	CLIP-seq
MIRT1185564	hsa-miR-607	CLIP-seq
MIRT1185565	hsa-miR-892a	CLIP-seq
MIRT1185566	hsa-miR-943	CLIP-seq
MIRT2053762	hsa-miR-1236	CLIP-seq
MIRT1185546	hsa-miR-1257	CLIP-seq
MIRT1185547	hsa-miR-1264	CLIP-seq
MIRT2053763	hsa-miR-3135b	CLIP-seq
MIRT2053764	hsa-miR-3652	CLIP-seq
MIRT2053765	hsa-miR-4430	CLIP-seq
MIRT2053766	hsa-miR-4659a-3p	CLIP-seq
MIRT2053767	hsa-miR-4659b-3p	CLIP-seq
MIRT1185557	hsa-miR-4711-3p	CLIP-seq
MIRT2053768	hsa-miR-4753-3p	CLIP-seq
MIRT2053769	hsa-miR-4768-5p	CLIP-seq
MIRT2053770	hsa-miR-4778-3p	CLIP-seq
MIRT1185566	hsa-miR-943	CLIP-seq
MIRT2282947	hsa-miR-1227	CLIP-seq
MIRT2053763	hsa-miR-3135b	CLIP-seq
MIRT2053764	hsa-miR-3652	CLIP-seq
MIRT2053765	hsa-miR-4430	CLIP-seq
MIRT2282948	hsa-miR-455-5p	CLIP-seq
MIRT2282949	hsa-miR-4715-3p	CLIP-seq
MIRT2282950	hsa-miR-4735-5p	CLIP-seq
MIRT2282951	hsa-miR-4775	CLIP-seq
MIRT2282952	hsa-miR-4794	CLIP-seq
MIRT2282953	hsa-miR-590-3p	CLIP-seq
MIRT2282954	hsa-miR-652	CLIP-seq
MIRT2391561	hsa-miR-1254	CLIP-seq
MIRT2391562	hsa-miR-3116	CLIP-seq
MIRT2391563	hsa-miR-3176	CLIP-seq
MIRT2391564	hsa-miR-3922-3p	CLIP-seq
MIRT2391565	hsa-miR-3934	CLIP-seq
MIRT2391566	hsa-miR-552	CLIP-seq
MIRT2391567	hsa-miR-661	CLIP-seq
MIRT2455217	hsa-miR-129-5p	CLIP-seq
MIRT2455218	hsa-miR-3149	CLIP-seq
MIRT2455219	hsa-miR-3674	CLIP-seq
MIRT2282949	hsa-miR-4715-3p	CLIP-seq
MIRT2455220	hsa-miR-4732-5p	CLIP-seq
MIRT2282950	hsa-miR-4735-5p	CLIP-seq
MIRT2282951	hsa-miR-4775	CLIP-seq
MIRT2282952	hsa-miR-4794	CLIP-seq
MIRT2282953	hsa-miR-590-3p	CLIP-seq
MIRT2282947	hsa-miR-1227	CLIP-seq
MIRT2455217	hsa-miR-129-5p	CLIP-seq
MIRT2455218	hsa-miR-3149	CLIP-seq
MIRT2455219	hsa-miR-3674	CLIP-seq
MIRT2581087	hsa-miR-4438	CLIP-seq
MIRT2282948	hsa-miR-455-5p	CLIP-seq
MIRT2282949	hsa-miR-4715-3p	CLIP-seq
MIRT2455220	hsa-miR-4732-5p	CLIP-seq
MIRT2282950	hsa-miR-4735-5p	CLIP-seq
MIRT2282951	hsa-miR-4775	CLIP-seq
MIRT2282952	hsa-miR-4794	CLIP-seq
MIRT2581088	hsa-miR-5095	CLIP-seq
MIRT2282953	hsa-miR-590-3p	CLIP-seq
MIRT2282947	hsa-miR-1227	CLIP-seq
MIRT2455217	hsa-miR-129-5p	CLIP-seq
MIRT2455218	hsa-miR-3149	CLIP-seq
MIRT2282948	hsa-miR-455-5p	CLIP-seq
MIRT2282949	hsa-miR-4715-3p	CLIP-seq
MIRT2282950	hsa-miR-4735-5p	CLIP-seq
MIRT2282951	hsa-miR-4775	CLIP-seq
MIRT2282952	hsa-miR-4794	CLIP-seq
MIRT2282953	hsa-miR-590-3p	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence
GO:0000139	Component	Golgi membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	ISS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IEA
GO:0015693	Process	Magnesium ion transport	IBA
GO:0015693	Process	Magnesium ion transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:1903830	Process	Magnesium ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
620340	27194	ENSG00000163293

Q6NVV3

Protein name

Magnesium transporter NIPA3 (NIPA-like protein 1) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 3)

Protein function

Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05653	Mg_trans_NIPA	66 → 360	Magnesium transporter NIPA	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the pancreatic islets. {ECO:0000269|PubMed:32439805}.

Sequence

MGAQVRLPPGEPCREGYVLSLVCPNSSQAWCEITNVSQLLASPVLYTDLNYSINNLSISA
NVENKYSLYVGLVLAVSSSIFIGSSFILKKKGLLQLASKGFTRAGQGGHSYLKEWLWWVG
LLSMGAGEAANFAAYAFAPATLVTPLGALSVLISAILSSYFLNEHLNIHGKIGCILSILG
STVMVIHAPQEEEVTSLHEMEMKLRDPGFISFAVIITVISLVLILIVAPKKGQTNILVYI
SICSLIGAFSVSSVKGLGIAIKELIEWKPVYKHPLVFVLLAVLVLSVTTQINYLNKALDT
FNTSLVTPIYYVFFTSMVVTCSAILFQEWYGMTAGDIIGTLSGFFTIIIGIFLLHAFKNT
DITWSELTSTAKKEAVSLNVNENNYVLLENLECSAPGYNDDVTLFSRTDD

Sequence length

410

Interactions

View interactions

	Reactome
			Miscellaneous transport and binding events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPONDYLOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis, Gouty	Gouty arthritis	GWASCAT_DG	27899376		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood asthma	Asthma	GWASDB_DG	23829686		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cone-Rod Dystrophies	Cone-rod dystrophy	CLINVAR_DG	30718709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gout	Gout	GWASCAT_DG	27899376		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Macular dystrophy	Macular dystrophy	CLINVAR_DG	30718709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29464350		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	31289279		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	31289279	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
obsolete Rod-cone dystrophy	Rod-cone dystrophy	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Plexiform leiomyoma	Plexiform leiomyoma	GWASCAT_DG	30194396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinal Dystrophies	Retinal Dystrophy	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	CLINVAR_DG	24265693, 25611614, 26306921, 28981474, 30718709, 7479749		★★★★★ ★☆☆☆☆ Found in Text Mining only
RETINITIS PIGMENTOSA 49	Retinitis Pigmentosa	CLINVAR_DG	23462753, 25268133, 7479749		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	29464350		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	GWASCAT_DG	30194396		★★★★★ ★☆☆☆☆ Found in Text Mining only

NIPAL1 (NIPA like domain containing 1)