Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	151242
Gene name	Protein phosphatase 1 regulatory inhibitor subunit 1C
Gene symbol	PPP1R1C
Synonyms (NCBI Gene)	IPP5
Chromosome	2
Chromosome location	2q31.3-q32.1
Summary	Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or

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Show/Hide all (195)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021217	hsa-miR-146a-5p	Microarray	18057241
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT495628	hsa-miR-4428	PAR-CLIP	22291592
MIRT495627	hsa-miR-3173-3p	PAR-CLIP	22291592
MIRT495626	hsa-miR-6891-5p	PAR-CLIP	22291592
MIRT495625	hsa-miR-4521	PAR-CLIP	22291592
MIRT495624	hsa-miR-1185-5p	PAR-CLIP	22291592
MIRT495623	hsa-miR-3679-5p	PAR-CLIP	22291592
MIRT495622	hsa-miR-6894-5p	PAR-CLIP	22291592
MIRT495621	hsa-miR-5191	PAR-CLIP	22291592
MIRT495620	hsa-miR-3119	PAR-CLIP	22291592
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT613621	hsa-miR-8485	HITS-CLIP	23824327
MIRT613620	hsa-miR-603	HITS-CLIP	23824327
MIRT613619	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT613618	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT613617	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT495628	hsa-miR-4428	PAR-CLIP	22291592
MIRT495627	hsa-miR-3173-3p	PAR-CLIP	22291592
MIRT495626	hsa-miR-6891-5p	PAR-CLIP	22291592
MIRT495625	hsa-miR-4521	PAR-CLIP	22291592
MIRT495624	hsa-miR-1185-5p	PAR-CLIP	22291592
MIRT495623	hsa-miR-3679-5p	PAR-CLIP	22291592
MIRT495622	hsa-miR-6894-5p	PAR-CLIP	22291592
MIRT495621	hsa-miR-5191	PAR-CLIP	22291592
MIRT495620	hsa-miR-3119	PAR-CLIP	22291592
MIRT2302176	hsa-miR-3168	CLIP-seq
MIRT2302177	hsa-miR-3177-5p	CLIP-seq
MIRT2302178	hsa-miR-4509	CLIP-seq
MIRT2302179	hsa-miR-4744	CLIP-seq
MIRT2302180	hsa-miR-4799-5p	CLIP-seq
MIRT2302181	hsa-miR-561	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004864	Function	Protein phosphatase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0051301	Process	Cell division	IEA

MIM	HGNC	e!Ensembl
613240	14940	ENSG00000150722

Q8WVI7

Protein name

Protein phosphatase 1 regulatory subunit 1C (Inhibitor-5 of protein phosphatase 1) (IPP5)

Protein function

May increase cell susceptibility to TNF-induced apoptosis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05395	DARPP-32	2 → 109	Protein phosphatase inhibitor 1/DARPP-32	Family

Sequence

MEPNSPKKIQFAVPVFQSQIAPEAAEQIRKRRPTPASLVILNEHNPPEIDDKRGPNTQGE
LQNASPKQRKQSVYTPPTIKGVKHLKGQNESAFPEEEEGTNEREEQRDH

Sequence length

109

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE IDIOPATHIC ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cardiovascular Abnormalities	Cardiovascular abnormalities	Pubtator	22929023	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	24935604		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29383111		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29383111		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	18310074, 22939397		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	25339026	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PPP1R1C (protein phosphatase 1 regulatory inhibitor subunit 1C)