Gene Gene information from NCBI Gene database.
Entrez ID 151230
Gene name Kelch like family member 23
Gene symbol KLHL23
Synonyms (NCBI Gene)
DITHP
Chromosome 2
Chromosome location 2q31.1
miRNA miRNA information provided by mirtarbase database.
591
miRTarBase ID miRNA Experiments Reference
MIRT021998 hsa-miR-128-3p Sequencing 20371350
MIRT024447 hsa-miR-215-5p Microarray 19074876
MIRT026423 hsa-miR-192-5p Microarray 19074876
MIRT027259 hsa-miR-101-3p Sequencing 20371350
MIRT030436 hsa-miR-24-3p Microarray 19748357
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25036637, 28514442, 32814053, 33961781
GO:0005737 Component Cytoplasm IBA
GO:0031463 Component Cul3-RING ubiquitin ligase complex IBA
GO:0043161 Process Proteasome-mediated ubiquitin-dependent protein catabolic process IBA
GO:1990756 Function Ubiquitin-like ligase-substrate adaptor activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NBE8
Protein name Kelch-like protein 23
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 26 134 BTB/POZ domain Domain
PF07707 BACK 139 240 BTB And C-terminal Kelch Domain
PF01344 Kelch_1 274 306 Kelch motif Repeat
PF01344 Kelch_1 309 356 Kelch motif Repeat
PF01344 Kelch_1 358 403 Kelch motif Repeat
PF01344 Kelch_1 406 453 Kelch motif Repeat
PF01344 Kelch_1 457 495 Kelch motif Repeat
PF01344 Kelch_1 497 544 Kelch motif Repeat
Sequence
Sequence length 558
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Bipolar Disorder Bipolar Disorder GWASCAT_DG 31164008
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 35833210, 37960718 Associate
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression GWASCAT_DG 31164008
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia GWASCAT_DG 31164008
★☆☆☆☆
Found in Text Mining only
Urinary Bladder Neoplasms Urinary bladder neoplasms Pubtator 34169920 Associate
★☆☆☆☆
Found in Text Mining only