Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	150353
Gene name	DnaJ heat shock protein family (Hsp40) member B7
Gene symbol	DNAJB7
Synonyms (NCBI Gene)	DJ5HSC3
Chromosome	22
Chromosome location	22q13.2
Summary	The protein encoded by this intronless gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-

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miRTarBase ID	miRNA	Experiments
MIRT940296	hsa-miR-1237	CLIP-seq
MIRT940297	hsa-miR-1245b-5p	CLIP-seq
MIRT940298	hsa-miR-1248	CLIP-seq
MIRT940299	hsa-miR-150	CLIP-seq
MIRT940300	hsa-miR-181a	CLIP-seq
MIRT940301	hsa-miR-181b	CLIP-seq
MIRT940302	hsa-miR-181c	CLIP-seq
MIRT940303	hsa-miR-181d	CLIP-seq
MIRT940304	hsa-miR-1913	CLIP-seq
MIRT940305	hsa-miR-193a-3p	CLIP-seq
MIRT940306	hsa-miR-193b	CLIP-seq
MIRT940307	hsa-miR-3124-3p	CLIP-seq
MIRT940308	hsa-miR-3142	CLIP-seq
MIRT940309	hsa-miR-3149	CLIP-seq
MIRT940310	hsa-miR-3176	CLIP-seq
MIRT940311	hsa-miR-324-3p	CLIP-seq
MIRT940312	hsa-miR-3622a-5p	CLIP-seq
MIRT940313	hsa-miR-3922-3p	CLIP-seq
MIRT940314	hsa-miR-4262	CLIP-seq
MIRT940315	hsa-miR-4263	CLIP-seq
MIRT940316	hsa-miR-4269	CLIP-seq
MIRT940317	hsa-miR-431	CLIP-seq
MIRT940318	hsa-miR-4438	CLIP-seq
MIRT940319	hsa-miR-4536	CLIP-seq
MIRT940320	hsa-miR-4539	CLIP-seq
MIRT940321	hsa-miR-4711-3p	CLIP-seq
MIRT940322	hsa-miR-4713-5p	CLIP-seq
MIRT940323	hsa-miR-4735-5p	CLIP-seq
MIRT940324	hsa-miR-5095	CLIP-seq
MIRT940325	hsa-miR-513a-3p	CLIP-seq
MIRT940326	hsa-miR-532-3p	CLIP-seq
MIRT940327	hsa-miR-562	CLIP-seq
MIRT940328	hsa-miR-576-5p	CLIP-seq
MIRT940329	hsa-miR-649	CLIP-seq
MIRT1978075	hsa-miR-3614-5p	CLIP-seq
MIRT1978076	hsa-miR-371-5p	CLIP-seq
MIRT940323	hsa-miR-4735-5p	CLIP-seq
MIRT1978077	hsa-miR-4775	CLIP-seq
MIRT1978078	hsa-miR-552	CLIP-seq
MIRT1978079	hsa-miR-590-3p	CLIP-seq
MIRT2213627	hsa-miR-1224-3p	CLIP-seq
MIRT940297	hsa-miR-1245b-5p	CLIP-seq
MIRT2213628	hsa-miR-1260	CLIP-seq
MIRT2213629	hsa-miR-1260b	CLIP-seq
MIRT2213630	hsa-miR-1280	CLIP-seq
MIRT940308	hsa-miR-3142	CLIP-seq
MIRT940312	hsa-miR-3622a-5p	CLIP-seq
MIRT940316	hsa-miR-4269	CLIP-seq
MIRT940318	hsa-miR-4438	CLIP-seq
MIRT940324	hsa-miR-5095	CLIP-seq
MIRT940326	hsa-miR-532-3p	CLIP-seq
MIRT940327	hsa-miR-562	CLIP-seq
MIRT2386964	hsa-miR-1207-3p	CLIP-seq
MIRT2386965	hsa-miR-122	CLIP-seq
MIRT2386966	hsa-miR-130a	CLIP-seq
MIRT2386967	hsa-miR-130b	CLIP-seq
MIRT2386968	hsa-miR-301a	CLIP-seq
MIRT2386969	hsa-miR-301b	CLIP-seq
MIRT2386970	hsa-miR-31	CLIP-seq
MIRT2386971	hsa-miR-3135b	CLIP-seq
MIRT2386972	hsa-miR-3666	CLIP-seq
MIRT2386973	hsa-miR-4295	CLIP-seq
MIRT2386974	hsa-miR-454	CLIP-seq
MIRT2448404	hsa-miR-433	CLIP-seq
MIRT940325	hsa-miR-513a-3p	CLIP-seq
MIRT2517448	hsa-miR-561	CLIP-seq
MIRT2213627	hsa-miR-1224-3p	CLIP-seq
MIRT2213628	hsa-miR-1260	CLIP-seq
MIRT2213629	hsa-miR-1260b	CLIP-seq
MIRT2213630	hsa-miR-1280	CLIP-seq
MIRT940325	hsa-miR-513a-3p	CLIP-seq
MIRT940326	hsa-miR-532-3p	CLIP-seq
MIRT2517448	hsa-miR-561	CLIP-seq
MIRT940327	hsa-miR-562	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IEA
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0044183	Function	Protein folding chaperone	IBA
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051087	Function	Protein-folding chaperone binding	IBA
GO:0051087	Function	Protein-folding chaperone binding	IPI	21231916

MIM	HGNC	e!Ensembl
611336	24986	ENSG00000172404

Q7Z6W7

Protein name

DnaJ homolog subfamily B member 7

Protein function

Probably acts as a co-chaperone.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00226	DnaJ	3 → 66	DnaJ domain	Domain

Sequence

MVDYYEVLGLQRYASPEDIKKAYHKVALKWHPDKNPENKEEAERKFKEVAEAYEVLSNDE
KRDIYDKYGTEGLNGGGSHFDDECEYGFTFHKPDDVFKEIFHERDPFSFHFFEDSLEDLL
NRPGSSYGNRNRDAGYFFSTASEYPIFEKFSSYDTGYTSQGSLGHEGLTSFSSLAFDNSG
MDNYISVTTSDKIVNGRNINTKKIIESDQEREAEDNGELTFFLVNSVANEEGFAKECSWR
TQSFNNYSPNSHSSKHVSQYTFVDNDEGGISWVTSNRDPPIFSAGVKEGGKRKKKKRKEV
QKKSTKRNC

Sequence length

309

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	29061824		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibroid Tumor	Leiomyoma	BEFREE	28947958		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	12081207, 21332579, 31623058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	17595767, 23499553, 23634222, 29102932, 29522917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	21332579, 31623058		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	17595767, 23499553, 23634222, 29102932, 29522917		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	27633099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of tongue	Malignant Neoplasm Of Tongue	BEFREE	25633184		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17968683, 24647829, 28092646, 28612520, 30569110		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12081207, 18167129, 20067447, 23618529, 26458285, 28470144		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis, Type 3, mixed central and peripheral	Neurofibromatosis	BEFREE	26430762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	27633099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	12081207, 12824922, 18302674, 30172246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	28612520, 31356815		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	25633184, 28092646, 31258760		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tongue Neoplasms	Tongue Neoplasms	BEFREE	19065664		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tongue Neoplasms	Tongue cancer	Pubtator	25633184	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	28947958		★★★★★ ★☆☆☆☆ Found in Text Mining only

DNAJB7 (DnaJ heat shock protein family (Hsp40) member B7)