Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	149563
Gene name	Steroid receptor associated and regulated protein
Gene symbol	SRARP
Synonyms (NCBI Gene)	C1orf64ERRF
Chromosome	1
Chromosome location	1p36.13

Show/Hide all (84)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620005	hsa-miR-1470	HITS-CLIP	23824327
MIRT620003	hsa-miR-1253	HITS-CLIP	23824327
MIRT620002	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT620001	hsa-miR-1911-5p	HITS-CLIP	23824327
MIRT620000	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT619999	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT619998	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT619997	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT619995	hsa-miR-8055	HITS-CLIP	23824327
MIRT635518	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635517	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635516	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635515	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635514	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635513	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635512	hsa-miR-4297	HITS-CLIP	23824327
MIRT635511	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT635510	hsa-miR-4284	HITS-CLIP	23824327
MIRT635509	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT620005	hsa-miR-1470	HITS-CLIP	23824327
MIRT620003	hsa-miR-1253	HITS-CLIP	23824327
MIRT620002	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT620001	hsa-miR-1911-5p	HITS-CLIP	23824327
MIRT620000	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT619999	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT619998	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT619997	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT619995	hsa-miR-8055	HITS-CLIP	23824327
MIRT635518	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635517	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635516	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635515	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635514	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635513	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635512	hsa-miR-4297	HITS-CLIP	23824327
MIRT635511	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT635510	hsa-miR-4284	HITS-CLIP	23824327
MIRT635509	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT620005	hsa-miR-1470	HITS-CLIP	23824327
MIRT620004	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT620003	hsa-miR-1253	HITS-CLIP	23824327
MIRT620002	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT620001	hsa-miR-1911-5p	HITS-CLIP	23824327
MIRT620000	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT619999	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT619998	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT619997	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT619996	hsa-miR-8081	HITS-CLIP	23824327
MIRT619995	hsa-miR-8055	HITS-CLIP	23824327
MIRT529916	hsa-miR-34b-3p	PAR-CLIP	20371350
MIRT529915	hsa-miR-4705	PAR-CLIP	20371350
MIRT529914	hsa-miR-4639-3p	PAR-CLIP	20371350
MIRT529913	hsa-miR-4469	PAR-CLIP	20371350
MIRT529912	hsa-miR-7113-3p	PAR-CLIP	20371350
MIRT529911	hsa-miR-4287	PAR-CLIP	20371350
MIRT529910	hsa-miR-4685-3p	PAR-CLIP	20371350
MIRT529909	hsa-miR-412-3p	PAR-CLIP	20371350
MIRT529908	hsa-miR-6754-3p	PAR-CLIP	20371350
MIRT529907	hsa-miR-6837-3p	PAR-CLIP	20371350
MIRT529905	hsa-miR-6802-3p	PAR-CLIP	20371350
MIRT529904	hsa-miR-6794-3p	PAR-CLIP	20371350
MIRT529903	hsa-miR-6867-3p	PAR-CLIP	20371350
MIRT529916	hsa-miR-34b-3p	PAR-CLIP	22012620
MIRT529915	hsa-miR-4705	PAR-CLIP	22012620
MIRT529914	hsa-miR-4639-3p	PAR-CLIP	22012620
MIRT529913	hsa-miR-4469	PAR-CLIP	22012620
MIRT529912	hsa-miR-7113-3p	PAR-CLIP	22012620
MIRT529911	hsa-miR-4287	PAR-CLIP	22012620
MIRT529910	hsa-miR-4685-3p	PAR-CLIP	22012620
MIRT529909	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT529908	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT529907	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT529906	hsa-miR-6730-5p	PAR-CLIP	22012620
MIRT529905	hsa-miR-6802-3p	PAR-CLIP	22012620
MIRT529904	hsa-miR-6794-3p	PAR-CLIP	22012620
MIRT529903	hsa-miR-6867-3p	PAR-CLIP	22012620
MIRT529902	hsa-miR-3662	PAR-CLIP	22012620
MIRT529901	hsa-miR-224-3p	PAR-CLIP	22012620
MIRT529900	hsa-miR-522-3p	PAR-CLIP	22012620
MIRT529899	hsa-miR-371b-3p	PAR-CLIP	22012620
MIRT529898	hsa-miR-4719	PAR-CLIP	22012620
MIRT529897	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT529896	hsa-miR-4641	PAR-CLIP	22012620
MIRT529895	hsa-miR-5587-5p	PAR-CLIP	22012620

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	22341523
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22341523
GO:0030331	Function	Nuclear estrogen receptor binding	IBA
GO:0030331	Function	Nuclear estrogen receptor binding	IPI	27125460
GO:0033148	Process	Positive regulation of intracellular estrogen receptor signaling pathway	IBA
GO:0033148	Process	Positive regulation of intracellular estrogen receptor signaling pathway	IMP	27125460

MIM	HGNC	e!Ensembl
619448	28339	ENSG00000183888

Q8NEQ6

Protein name

Steroid receptor-associated and regulated protein (Estrogen receptor-related factor) (ER-related factor) (Steroid receptor-regulated protein)

Protein function

May regulate the transcriptional function of androgen and estrogen receptors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15547	C1ORF64	33 → 169	Steroid receptor-associated and regulated protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in breast tumors with a higher expression level in estrogen receptor-positive cancers (PubMed:22341523, PubMed:28915724). {ECO:0000269|PubMed:22341523, ECO:0000269|PubMed:28915724}.

Sequence

MAPSEDPRDWRANLKGTIRETGLETSSGGKLAGHQKTVPTAHLTFVIDCTHGKQLSLAAT
ASPPQAPSPNRGLVTPPMKTYIVFCGENWPHLTRVTPMGGGCLAQARATLPLCRGSVASA
SFPVSPLCPQEVPEAKGKPVKAAPVRSSTWGTVKDSLKALSSCVCGQAD

Sequence length

169

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DILATED CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aortic Valve Insufficiency	Aortic Valve Insufficiency	BEFREE	29577611	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22341523, 28415602, 28915724	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	22341523, 28415602, 28915724	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29577611	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	28915724	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22341523, 28415602, 29577611	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	22341523	★★★★★ ★☆☆☆☆ Found in Text Mining only

SRARP (steroid receptor associated and regulated protein)