SHISA4 (shisa family member 4)

Gene

• Entrez ID: 149345
• Gene name: Shisa family member 4
• Gene symbol: SHISA4
• Synonyms (NCBI Gene): C1orf40, TMEM58
• Chromosome: 1
• Chromosome location: 1q32.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018206	hsa-miR-335-5p	Microarray	18185580
MIRT722598	hsa-miR-4687-5p	HITS-CLIP	19536157
MIRT722597	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT722596	hsa-miR-4290	HITS-CLIP	19536157
MIRT722598	hsa-miR-4687-5p	HITS-CLIP	19536157
MIRT722597	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT722596	hsa-miR-4290	HITS-CLIP	19536157
MIRT1346895	hsa-miR-1976	CLIP-seq
MIRT1346896	hsa-miR-3151	CLIP-seq
MIRT1346897	hsa-miR-361-3p	CLIP-seq
MIRT1346898	hsa-miR-3665	CLIP-seq
MIRT1346899	hsa-miR-4283	CLIP-seq
MIRT1346900	hsa-miR-4292	CLIP-seq
MIRT1346901	hsa-miR-4308	CLIP-seq
MIRT1346902	hsa-miR-4436b-5p	CLIP-seq
MIRT1346903	hsa-miR-4489	CLIP-seq
MIRT1346904	hsa-miR-4715-3p	CLIP-seq
MIRT1346905	hsa-miR-4721	CLIP-seq
MIRT1346906	hsa-miR-4722-3p	CLIP-seq
MIRT1346907	hsa-miR-4779	CLIP-seq
MIRT1346908	hsa-miR-486-3p	CLIP-seq
MIRT1346909	hsa-miR-657	CLIP-seq
MIRT1346910	hsa-miR-670	CLIP-seq
MIRT1346911	hsa-miR-760	CLIP-seq
MIRT1346912	hsa-miR-765	CLIP-seq
MIRT1346905	hsa-miR-4721	CLIP-seq
MIRT2102700	hsa-miR-1193	CLIP-seq
MIRT2102701	hsa-miR-2392	CLIP-seq
MIRT2102702	hsa-miR-3179	CLIP-seq
MIRT2102703	hsa-miR-3605-5p	CLIP-seq
MIRT2102704	hsa-miR-3652	CLIP-seq
MIRT2102705	hsa-miR-3907	CLIP-seq
MIRT2102706	hsa-miR-4420	CLIP-seq
MIRT2102707	hsa-miR-4430	CLIP-seq
MIRT2102708	hsa-miR-4505	CLIP-seq
MIRT2102709	hsa-miR-4642	CLIP-seq
MIRT2102710	hsa-miR-4688	CLIP-seq
MIRT1346908	hsa-miR-486-3p	CLIP-seq
MIRT1346905	hsa-miR-4721	CLIP-seq
MIRT1346907	hsa-miR-4779	CLIP-seq
MIRT1346908	hsa-miR-486-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 617326
• HGNC: 27139
• e!Ensembl: ENSG00000198892

Protein

• UniProt ID: Q96DD7
• Protein name: Protein shisa-4 (Transmembrane protein 58)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13908	Shisa	28 → 193	Wnt and FGF inhibitory regulator	Family

• Sequence:

  MPPAGLRRAAPLTAIALLVLGAPLVLAGEDCLWYLDRNGSWHPGFNCEFFTFCCGTCYHR
  YCCRDLTLLITERQQKHCLAFSPKTIAGIASAVILFVAVVATTICCFLCSCCYLYRRRQQ
  LQSPFEGQEIPMTGIPVQPVYPYPQDPKAGPAPPQPGFIYPPSGPAPQYPLYPAGPPVYN
  PAAPPPYMPPQPSYPGA

• Sequence length: 197

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations