MOB3C (MOB kinase activator 3C)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 148932
Gene name MOB kinase activator 3C
Gene symbol MOB3C
Synonyms (NCBI Gene)
MOB1EMOBKL2C
Chromosome 1
Chromosome location 1p33
Summary The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isof
miRNA miRNA information provided by mirtarbase database.
198
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (198)
miRTarBase ID miRNA Experiments Reference
MIRT051110 hsa-miR-16-5p CLASH 23622248
MIRT047605 hsa-miR-10a-5p CLASH 23622248
MIRT611300 hsa-miR-8485 HITS-CLIP 23824327
MIRT611299 hsa-miR-329-3p HITS-CLIP 23824327
MIRT611298 hsa-miR-362-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (6)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 28514442, 29892012, 32296183, 33961781
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IBA
GO:0007165 Process Signal transduction IBA
GO:0030295 Function Protein kinase activator activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
620804 29800 ENSG00000142961
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q70IA8
Protein name MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C)
Protein function May regulate the activity of kinases.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03637 Mob1_phocein 35 → 207 Mob1/phocein family Family
Sequence
Sequence length 216
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (3)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHRONIC KIDNEY DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SINUSITIS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (5)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Chronic Kidney Diseases Kidney Disease BEFREE 30226566
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 34573430 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Coronary artery disease Pubtator 34385509 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Hypertensive disease Hypertension BEFREE 30226566
★★★★★
★☆☆☆☆
Found in Text Mining only
Myocardial Infarction Myocardial Infarction BEFREE 30226566
★★★★★
★☆☆☆☆
Found in Text Mining only