Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	148113
Gene name	Cartilage intermediate layer protein 2
Gene symbol	CILP2
Synonyms (NCBI Gene)	CLIP-2
Chromosome	19
Chromosome location	19p13.11

Show/Hide all (74)

miRTarBase ID	miRNA	Experiments	Reference
MIRT642423	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT642422	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT642421	hsa-miR-5193	HITS-CLIP	23824327
MIRT642420	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT642419	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT642418	hsa-miR-1292-5p	HITS-CLIP	23824327
MIRT642417	hsa-miR-4471	HITS-CLIP	23824327
MIRT642416	hsa-miR-8059	HITS-CLIP	23824327
MIRT642415	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT642414	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT642412	hsa-miR-4420	HITS-CLIP	23824327
MIRT642413	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT642410	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT642411	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT642409	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT642408	hsa-miR-5096	HITS-CLIP	23824327
MIRT642423	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT642422	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT642421	hsa-miR-5193	HITS-CLIP	23824327
MIRT642420	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT642419	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT642418	hsa-miR-1292-5p	HITS-CLIP	23824327
MIRT642417	hsa-miR-4471	HITS-CLIP	23824327
MIRT642416	hsa-miR-8059	HITS-CLIP	23824327
MIRT642415	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT642414	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT642412	hsa-miR-4420	HITS-CLIP	23824327
MIRT642413	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT642410	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT642411	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT642409	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT642408	hsa-miR-5096	HITS-CLIP	23824327
MIRT642423	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT642422	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT642421	hsa-miR-5193	HITS-CLIP	23824327
MIRT642420	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT642419	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT642418	hsa-miR-1292-5p	HITS-CLIP	23824327
MIRT642417	hsa-miR-4471	HITS-CLIP	23824327
MIRT642416	hsa-miR-8059	HITS-CLIP	23824327
MIRT642415	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT642414	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT642412	hsa-miR-4420	HITS-CLIP	23824327
MIRT642413	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT642410	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT642411	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT642409	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT642408	hsa-miR-5096	HITS-CLIP	23824327
MIRT642423	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT642422	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT642421	hsa-miR-5193	HITS-CLIP	23824327
MIRT642420	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT642419	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT642418	hsa-miR-1292-5p	HITS-CLIP	23824327
MIRT642417	hsa-miR-4471	HITS-CLIP	23824327
MIRT642416	hsa-miR-8059	HITS-CLIP	23824327
MIRT642415	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT642414	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT642412	hsa-miR-4420	HITS-CLIP	23824327
MIRT642413	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT642410	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT642411	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT642409	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT642408	hsa-miR-5096	HITS-CLIP	23824327
MIRT893543	hsa-miR-1321	CLIP-seq
MIRT893544	hsa-miR-3153	CLIP-seq
MIRT893545	hsa-miR-3689d	CLIP-seq
MIRT893546	hsa-miR-4419a	CLIP-seq
MIRT893547	hsa-miR-4510	CLIP-seq
MIRT893548	hsa-miR-4668-5p	CLIP-seq
MIRT893549	hsa-miR-4739	CLIP-seq
MIRT893550	hsa-miR-4756-5p	CLIP-seq
MIRT893551	hsa-miR-516b	CLIP-seq
MIRT1964897	hsa-miR-1343	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004035	Function	Alkaline phosphatase activity	IDA	12746903
GO:0004551	Function	Dinucleotide phosphatase activity	IDA	12746903
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
612419	24213	ENSG00000160161

Q8IUL8

Protein name

Cartilage intermediate layer protein 2 (CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2]

Protein function

May play a role in cartilage scaffolding.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13330	Mucin2_WxxW	59 → 143	Mucin-2 protein WxxW repeating region	Family
PF00090	TSP_1	150 → 196	Thrombospondin type 1 domain	Domain
PF13620	CarboxypepD_reg	210 → 287		Domain
PF13927	Ig_3	291 → 363		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in articular chondrocytes but not in knee meniscal cartilage cells (PubMed:12746903). Localizes to the intermediate to deep zone of articular cartilage (PubMed:21880736). {ECO:0000269|PubMed:12746903, ECO:0000269|PubMed:21880

Sequence

MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWT
SWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRG
FWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSGSCGPGRRLRRRHCPSPAGDA
CPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLGARVSLRDQPGTVATS
DAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPES
RVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCK
AWNEAGAVRSGTARLTVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRC
PSLAGSSPRCGDASSRCCSVRRLERREIHCPGYVLPVKVVAECGCQKCLPPRGLVRGRVV
AADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPF
DPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYS
GPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGP
VAVRVAASQIHMPGHVEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVE
IRERRLFNLDVPERRRCFVKVRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGR
FDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLD
RLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFA
RVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGG
SHPRTRGQLYGLRDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRR
VAVNGLLRDYLTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRC
FDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQ
ARASGPLRTRRGRVRQ

Sequence length

1156

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
FAMILIAL HYPERLIPIDEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (22)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	32792518	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	24350279		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33099318, 38466182	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital clubfoot	Congenital Clubfoot	BEFREE	30615219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	21880736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	30896018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	30896018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	30896018	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	30896018	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	23457408, 25951451, 30896018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	32792518	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipidemias	Hyperlipidemia	Pubtator	32568739	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	30896018	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	21691831		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	26758378		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	29084944	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30896018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30896018	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	30307059	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	30311632		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	30311632	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32186777, 37337170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CILP2 (cartilage intermediate layer protein 2)