LGALS16 (galectin 16)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 148003
Gene name Galectin 16
Gene symbol LGALS16
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19q13.2
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (5)
GO ID Ontology Definition Evidence Reference
GO:0006915 Process Apoptotic process IEA
GO:0030246 Function Carbohydrate binding IBA
GO:0030246 Function Carbohydrate binding IEA
GO:0030395 Function Lactose binding IDA 19497882
GO:0070234 Process Positive regulation of T cell apoptotic process IDA 19497882
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A8MUM7
Protein name Galectin-16
Protein function Binds lactose with high affinity. Strong inducer of T-cell apoptosis.
PDB 6LJP , 6LJQ , 6LJR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 5 → 137 Galactoside-binding lectin Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly and highly expressed in the placenta where it is localized mainly in the syncytiotrophoblast and in the endothelia of fetal vessels. Also detected in the amnion and chorionic trophoblasts in fetal membranes. {ECO:0000269|
Sequence
Sequence length 142
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDER — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (7)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Brain Diseases Brain disease Pubtator 34944551 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Congestive heart failure Congestive Heart Failure BEFREE 26312551
★★★★★
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes mellitus Pubtator 34944551 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Diffuse Large B-Cell Lymphoma Diffuse Lymphoma BEFREE 15754003
★★★★★
★☆☆☆☆
Found in Text Mining only
Heart failure Heart Failure BEFREE 26312551
★★★★★
★☆☆☆☆
Found in Text Mining only
Heart Failure Heart failure Pubtator 33727431 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Thyroid Gland Follicular Adenoma Thyroid Gland Follicular Adenoma BEFREE 12767519
★★★★★
★☆☆☆☆
Found in Text Mining only