SIX5 (SIX homeobox 5)

Gene

• Entrez ID: 147912
• Gene name: SIX homeobox 5
• Gene symbol: SIX5
• Synonyms (NCBI Gene): BOR2, DMAHP
• Chromosome: 19
• Chromosome location: 19q13.32
• Summary: The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a ca

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029180	hsa-miR-26b-5p	Microarray	19088304
MIRT653770	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT653769	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT653768	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT653767	hsa-miR-3657	HITS-CLIP	23824327
MIRT653766	hsa-miR-4669	HITS-CLIP	23824327
MIRT653765	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT653764	hsa-miR-572	HITS-CLIP	23824327
MIRT653763	hsa-miR-718	HITS-CLIP	23824327
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486132	hsa-miR-3147	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23592263
MIRT486150	hsa-miR-4299	PAR-CLIP	23592263
MIRT486149	hsa-miR-548q	PAR-CLIP	23592263
MIRT486148	hsa-miR-4456	PAR-CLIP	23592263
MIRT486146	hsa-miR-7978	PAR-CLIP	23592263
MIRT486147	hsa-miR-3195	PAR-CLIP	23592263
MIRT486145	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486143	hsa-miR-4488	PAR-CLIP	23592263
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT486134	hsa-miR-4447	PAR-CLIP	23592263
MIRT486133	hsa-miR-4472	PAR-CLIP	23592263
MIRT486132	hsa-miR-3147	PAR-CLIP	23592263
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT653770	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT653769	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT653768	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT653767	hsa-miR-3657	HITS-CLIP	23824327
MIRT653766	hsa-miR-4669	HITS-CLIP	23824327
MIRT653765	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT653764	hsa-miR-572	HITS-CLIP	23824327
MIRT653763	hsa-miR-718	HITS-CLIP	23824327
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	20371350
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	20371350
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	20371350
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	20371350
MIRT486150	hsa-miR-4299	PAR-CLIP	20371350
MIRT486149	hsa-miR-548q	PAR-CLIP	20371350
MIRT486148	hsa-miR-4456	PAR-CLIP	20371350
MIRT486146	hsa-miR-7978	PAR-CLIP	20371350
MIRT486147	hsa-miR-3195	PAR-CLIP	20371350
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486143	hsa-miR-4488	PAR-CLIP	20371350
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT486138	hsa-miR-541-3p	PAR-CLIP	20371350
MIRT486139	hsa-miR-654-5p	PAR-CLIP	20371350
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	20371350
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	20371350
MIRT486134	hsa-miR-4447	PAR-CLIP	20371350
MIRT486133	hsa-miR-4472	PAR-CLIP	20371350
MIRT486132	hsa-miR-3147	PAR-CLIP	20371350
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23446348
MIRT508303	hsa-miR-2276-5p	PAR-CLIP	23446348
MIRT508302	hsa-miR-6764-3p	PAR-CLIP	23446348
MIRT508301	hsa-miR-6824-3p	PAR-CLIP	23446348
MIRT486150	hsa-miR-4299	PAR-CLIP	23446348
MIRT486149	hsa-miR-548q	PAR-CLIP	23446348
MIRT486148	hsa-miR-4456	PAR-CLIP	23446348
MIRT486146	hsa-miR-7978	PAR-CLIP	23446348
MIRT508300	hsa-miR-4749-3p	PAR-CLIP	23446348
MIRT486147	hsa-miR-3195	PAR-CLIP	23446348
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23446348
MIRT486143	hsa-miR-4488	PAR-CLIP	23446348
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23446348
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23446348
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23446348
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT486134	hsa-miR-4447	PAR-CLIP	23446348
MIRT486133	hsa-miR-4472	PAR-CLIP	23446348
MIRT486132	hsa-miR-3147	PAR-CLIP	23446348
MIRT486151	hsa-miR-4259	PAR-CLIP	23592263
MIRT486150	hsa-miR-4299	PAR-CLIP	23592263
MIRT486149	hsa-miR-548q	PAR-CLIP	23592263
MIRT486148	hsa-miR-4456	PAR-CLIP	23592263
MIRT486146	hsa-miR-7978	PAR-CLIP	23592263
MIRT486147	hsa-miR-3195	PAR-CLIP	23592263
MIRT486145	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT486144	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486143	hsa-miR-4488	PAR-CLIP	23592263
MIRT486142	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT486141	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT486140	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT486138	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT486139	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT486137	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT486136	hsa-miR-6769a-5p	PAR-CLIP	23592263
MIRT486135	hsa-miR-6769b-5p	PAR-CLIP	23592263
MIRT486134	hsa-miR-4447	PAR-CLIP	23592263
MIRT486133	hsa-miR-4472	PAR-CLIP	23592263
MIRT486132	hsa-miR-3147	PAR-CLIP	23592263
MIRT486130	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT2103880	hsa-miR-1226	CLIP-seq
MIRT2103881	hsa-miR-29a	CLIP-seq
MIRT2103882	hsa-miR-29b	CLIP-seq
MIRT2103883	hsa-miR-29c	CLIP-seq
MIRT2103884	hsa-miR-3591-3p	CLIP-seq
MIRT2103885	hsa-miR-4421	CLIP-seq
MIRT2103886	hsa-miR-633	CLIP-seq
MIRT2328038	hsa-miR-1207-5p	CLIP-seq
MIRT2103880	hsa-miR-1226	CLIP-seq
MIRT2328039	hsa-miR-183	CLIP-seq
MIRT2328040	hsa-miR-194	CLIP-seq
MIRT2328041	hsa-miR-2682	CLIP-seq
MIRT2103881	hsa-miR-29a	CLIP-seq
MIRT2103882	hsa-miR-29b	CLIP-seq
MIRT2103883	hsa-miR-29c	CLIP-seq
MIRT2328042	hsa-miR-3150a-3p	CLIP-seq
MIRT2328043	hsa-miR-3175	CLIP-seq
MIRT2328044	hsa-miR-3193	CLIP-seq
MIRT2103884	hsa-miR-3591-3p	CLIP-seq
MIRT2328045	hsa-miR-361-3p	CLIP-seq
MIRT2103885	hsa-miR-4421	CLIP-seq
MIRT2328046	hsa-miR-4446-3p	CLIP-seq
MIRT2328047	hsa-miR-449c	CLIP-seq
MIRT2328048	hsa-miR-4504	CLIP-seq
MIRT2328049	hsa-miR-4514	CLIP-seq
MIRT2328050	hsa-miR-4645-5p	CLIP-seq
MIRT2328051	hsa-miR-4673	CLIP-seq
MIRT2328052	hsa-miR-4675	CLIP-seq
MIRT2328053	hsa-miR-4692	CLIP-seq
MIRT2328054	hsa-miR-4721	CLIP-seq
MIRT2328055	hsa-miR-4728-5p	CLIP-seq
MIRT2328056	hsa-miR-4736	CLIP-seq
MIRT2328057	hsa-miR-4741	CLIP-seq
MIRT2328058	hsa-miR-4763-3p	CLIP-seq
MIRT2328059	hsa-miR-542-3p	CLIP-seq
MIRT2328060	hsa-miR-549	CLIP-seq
MIRT2103886	hsa-miR-633	CLIP-seq
MIRT2328061	hsa-miR-758	CLIP-seq
MIRT2328062	hsa-miR-939	CLIP-seq
MIRT2328054	hsa-miR-4721	CLIP-seq
MIRT2459431	hsa-miR-3667-5p	CLIP-seq
MIRT2459432	hsa-miR-4286	CLIP-seq
MIRT2459433	hsa-miR-7	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CTCF	Unknown	11479593

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0002088	Process	Lens development in camera-type eye	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16713569
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007286	Process	Spermatid development	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0160024	Process	Leydig cell proliferation	IEA
GO:1902723	Process	Negative regulation of skeletal muscle satellite cell proliferation	IEA

Other IDs

• MIM: 600963
• HGNC: 10891
• e!Ensembl: ENSG00000177045

Protein

• UniProt ID: Q8N196
• Protein name: Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5)
• Protein function: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16878	SIX1_SD	86 → 196	Transcriptional regulator, SIX1, N-terminal SD domain	Domain
  PF00046	Homeodomain	206 → 258	Homeodomain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera. {ECO:0000269|PubMed:9949207}.
• Sequence:

  MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG
  AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL
  RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL
  GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL
  SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA
  QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL
  LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE
  VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP
  TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL
  LANPVSGSPIVTGVALQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL
  PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA
  AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA
  EAKVLTQLQSVPVEEPLEL

• Sequence length: 739

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Branchiootorenal syndrome 2	Pathogenic	rs80356463	RCV000009131	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BOR SYNDROME	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRANCHIO-OTO-RENAL SYNDROME	—	CTD, ClinGen, Disgenet, GWAS catalog CTD, ClinGen, Disgenet, GWAS catalog CTD, ClinGen, Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SIX5-related disorder	Conflicting classifications of pathogenicity; Likely benign; Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autoimmune Diseases	Autoimmune Diseases	BEFREE	8200991		★☆☆☆☆ Found in Text Mining only
BOR syndrome	BOR Syndrome	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Branchio-Oculo-Facial Syndrome	Branchiooculofacial Syndrome	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Branchio-Oto-Renal Syndrome	Branchiootorenal Syndrome	CLINGEN_DG	10802667, 10802668, 11950062, 14704431, 17357085, 24429398		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Branchio-Oto-Renal Syndrome	Branchiootorenal Syndrome	BEFREE	17357085, 22447252, 23840632		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Branchio-Oto-Renal Syndrome	Branchiootorenal Syndrome	LHGDN	17357085		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Branchio-Oto-Renal Syndrome	Branchiootorenal Syndrome	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Branchioma	Branchioma	HPO_DG			★☆☆☆☆ Found in Text Mining only
Branchiootorenal Syndrome 1	Melnick-Fraser syndrome	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Branchiootorenal Syndrome 2	Branchiootorenal Syndrome	UNIPROT_DG	17357085		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Branchiootorenal Syndrome 2	Branchiootorenal Syndrome	GENOMICS_ENGLAND_DG	17357085, 9949207		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Branchiootorenal Syndrome 2	Branchiootorenal Syndrome	CTD_human_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Branchiootorenal Syndrome 2	Branchiootorenal Syndrome	CLINVAR_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Bronchiolitis Obliterans	Bronchiolitis Obliterans	BEFREE	23840632, 29257230		★☆☆☆☆ Found in Text Mining only
Cakut	Congenital anomalies of the kidney and urinary tract	Pubtator	24429398	Associate	★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	BEFREE	9949207		★☆☆☆☆ Found in Text Mining only
Congenital Myotonic Dystrophy	Congenital Myotonic Dystrophy	BEFREE	10573472, 20360842		★☆☆☆☆ Found in Text Mining only
Congenital small ears	Microtia	GENOMICS_ENGLAND_DG	9949207		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	27864399		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	27864399	Associate	★☆☆☆☆ Found in Text Mining only
Facial paralysis	Facial paralysis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	35709191	Associate	★☆☆☆☆ Found in Text Mining only
Hemifacial hypoplasia	Hemifacial hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hydronephrosis	Hydronephrosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hyperandrogenism	Hyperandrogenism	BEFREE	30224242		★☆☆☆☆ Found in Text Mining only
Multicystic Dysplastic Kidney	Multicystic renal dysplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	BEFREE	10838245, 10951446, 11479593, 11592825, 11978764, 14526185, 9207102, 9241282, 9241283, 9949207		★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	26190529, 28211918	Associate	★☆☆☆☆ Found in Text Mining only
MYOTONIC DYSTROPHY 1	Myotonic dystrophy	BEFREE	11592825, 11978764, 9241282, 9241283		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26449484	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	10823141		★☆☆☆☆ Found in Text Mining only
Renal Cell Dysplasia	Renal dysplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Renal dysplasia	Renal dysplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Renal Insufficiency	HPO_DG			★☆☆☆☆ Found in Text Mining only
Stenosis of external auditory canal	Stenosis Of External Auditory Canal	HPO_DG			★☆☆☆☆ Found in Text Mining only
Vesico-Ureteral Reflux	Vesicoureteral Reflux	HPO_DG			★☆☆☆☆ Found in Text Mining only