Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	147841
Gene name	SPC24 component of NDC80 kinetochore complex
Gene symbol	SPC24
Synonyms (NCBI Gene)	SPBC24
Chromosome	19
Chromosome location	19p13.2

131

Show/Hide all (131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023587	hsa-miR-1-3p	Proteomics	18668040
MIRT040615	hsa-miR-92b-3p	CLASH	23622248
MIRT715711	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT715710	hsa-miR-4738-3p	HITS-CLIP	19536157
MIRT715709	hsa-miR-4684-5p	HITS-CLIP	19536157
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT625038	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT625037	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT625036	hsa-miR-6834-3p	HITS-CLIP	23824327
MIRT625035	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT625034	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT625033	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT625032	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT625031	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT625030	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT625029	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT625032	hsa-miR-371a-5p	PAR-CLIP	27292025
MIRT625035	hsa-miR-371b-5p	PAR-CLIP	27292025
MIRT625031	hsa-miR-372-5p	PAR-CLIP	27292025
MIRT625034	hsa-miR-373-5p	PAR-CLIP	27292025
MIRT625033	hsa-miR-616-5p	PAR-CLIP	27292025
MIRT715711	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT715710	hsa-miR-4738-3p	HITS-CLIP	19536157
MIRT715709	hsa-miR-4684-5p	HITS-CLIP	19536157
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630991	hsa-miR-5690	HITS-CLIP	23824327
MIRT630990	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT630989	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT630988	hsa-miR-3612	HITS-CLIP	23824327
MIRT630987	hsa-miR-650	HITS-CLIP	23824327
MIRT630986	hsa-miR-7977	HITS-CLIP	23824327
MIRT630985	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT630983	hsa-miR-4443	HITS-CLIP	23824327
MIRT630984	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT630982	hsa-miR-665	HITS-CLIP	23824327
MIRT625038	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT625037	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT625036	hsa-miR-6834-3p	HITS-CLIP	23824327
MIRT625035	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT625034	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT625033	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT625032	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT625031	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT625030	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT625029	hsa-miR-6888-3p	HITS-CLIP	23824327

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	15961401
GO:0000776	Component	Kinetochore	IEA
GO:0000776	Component	Kinetochore	NAS	23418356
GO:0000940	Component	Outer kinetochore	IDA	24530301
GO:0005515	Function	Protein binding	IPI	14738735, 15961401, 26496610, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007059	Process	Chromosome segregation	IBA
GO:0007059	Process	Chromosome segregation	NAS	18455984
GO:0007094	Process	Mitotic spindle assembly checkpoint signaling	NAS	18455984
GO:0008017	Function	Microtubule binding	IBA
GO:0008608	Process	Attachment of spindle microtubules to kinetochore	IDA	18455984
GO:0031262	Component	Ndc80 complex	IBA
GO:0031262	Component	Ndc80 complex	IDA	14699129, 20819937
GO:0031262	Component	Ndc80 complex	IPI	18455984
GO:0051301	Process	Cell division	IEA

MIM	HGNC	e!Ensembl
609394	26913	ENSG00000161888

Q8NBT2

Protein name

Kinetochore protein Spc24 (hSpc24)

Protein function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtub

PDB

2VE7 , 3IZ0 , 8PPR , 8Q5H

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08286	Spc24	79 → 192	Spc24 subunit of Ndc80	Family

Sequence

MAAFRDIEEVSQGLLSLLGANRAEAQQRRLLGRHEQVVERLLETQDGAEKQLREILTMEK
EVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKASLLYLTRELEELKEIEADLER
QEKEVDEDTTVTIPSAVYVAQLYHQVSKIEWDYECEPGMVKGIHHGPSVAQPIHLDSTQL
SRKFISDYLWSLVDTEW

Sequence length

197

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARPAL TUNNEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPC24-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (22)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	28423533, 30180968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30180968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36591654	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26515591	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	29029446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	39907402	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	39907402	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26515591, 28423533		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	29029446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30180968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	29190974		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	29029446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	28423533		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29029446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26515591, 28423533, 29029446, 29285250		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29029446		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	32541446	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29285250, 30180968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	33153400	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34933074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	28423533		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	28423533		★★★★★ ★☆☆☆☆ Found in Text Mining only

SPC24 (SPC24 component of NDC80 kinetochore complex)