HIPK4 (homeodomain interacting protein kinase 4)

Gene

• Entrez ID: 147746
• Gene name: Homeodomain interacting protein kinase 4
• Gene symbol: HIPK4
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.2
• Summary: This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2010741	hsa-miR-1261	CLIP-seq
MIRT2010742	hsa-miR-3607-3p	CLIP-seq
MIRT2010743	hsa-miR-3686	CLIP-seq
MIRT2010744	hsa-miR-3689a-3p	CLIP-seq
MIRT2010745	hsa-miR-3689c	CLIP-seq
MIRT2010746	hsa-miR-4425	CLIP-seq
MIRT2010747	hsa-miR-4652-3p	CLIP-seq
MIRT2010748	hsa-miR-4728-5p	CLIP-seq
MIRT2010741	hsa-miR-1261	CLIP-seq
MIRT2010742	hsa-miR-3607-3p	CLIP-seq
MIRT2010743	hsa-miR-3686	CLIP-seq
MIRT2010747	hsa-miR-4652-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IBA
GO:0005515	Function	Protein binding	IPI	22939624, 25416956, 32707033, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035173	Function	Histone kinase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IEA

Other IDs

• MIM: 611712
• HGNC: 19007
• e!Ensembl: ENSG00000160396

Protein

• UniProt ID: Q8NE63
• Protein name: Homeodomain-interacting protein kinase 4 (EC 2.7.11.1)
• Protein function: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	11 → 347	Protein kinase domain	Domain

• Sequence:

  MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLH
  CMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQV
  LTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRF
  YRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLH
  AACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVA
  SRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH
  YYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAP
  GMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSS
  RLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQ
  RDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHG
  PPRGATSFLQHVTGHH

• Sequence length: 616

Pathways

KEGG:

Cellular senescence

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Azoospermia Nonobstructive	Nonobstructive azoospermia	Pubtator	35931115	Associate	★☆☆☆☆ Found in Text Mining only