Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	146894
Gene name	CD300 molecule like family member g
Gene symbol	CD300LG
Synonyms (NCBI Gene)	CLM-9CLM9NEPMUCINTREM-4TREM4
Chromosome	17
Chromosome location	17q21.31
Summary	Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 20

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Show/Hide all (179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718651	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT718650	hsa-miR-4435	HITS-CLIP	19536157
MIRT694714	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT694713	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT694712	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT694711	hsa-miR-3929	HITS-CLIP	23313552
MIRT694710	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694709	hsa-miR-4478	HITS-CLIP	23313552
MIRT694708	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT694707	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT694706	hsa-miR-4459	HITS-CLIP	23313552
MIRT694705	hsa-miR-665	HITS-CLIP	23313552
MIRT694704	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT694703	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694702	hsa-miR-1827	HITS-CLIP	23313552
MIRT694701	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694700	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694699	hsa-miR-298	HITS-CLIP	23313552
MIRT694698	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694697	hsa-miR-1273e	HITS-CLIP	23313552
MIRT694696	hsa-miR-548n	HITS-CLIP	23313552
MIRT694695	hsa-miR-548az-5p	HITS-CLIP	23313552
MIRT694694	hsa-miR-548t-5p	HITS-CLIP	23313552
MIRT694693	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT694692	hsa-miR-548av-5p	HITS-CLIP	23313552
MIRT694691	hsa-miR-548k	HITS-CLIP	23313552
MIRT694690	hsa-miR-8054	HITS-CLIP	23313552
MIRT694689	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT694688	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT694687	hsa-miR-575	HITS-CLIP	23313552
MIRT694686	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT694685	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT694684	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT694683	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT495835	hsa-miR-1273d	PAR-CLIP	22291592
MIRT495834	hsa-miR-449b-3p	PAR-CLIP	22291592
MIRT718651	hsa-miR-3190-5p	PAR-CLIP	27292025
MIRT694686	hsa-miR-3675-3p	PAR-CLIP	27292025
MIRT694683	hsa-miR-4684-5p	PAR-CLIP	27292025
MIRT694692	hsa-miR-548av-5p	PAR-CLIP	27292025
MIRT694695	hsa-miR-548az-5p	PAR-CLIP	27292025
MIRT694691	hsa-miR-548k	PAR-CLIP	27292025
MIRT694696	hsa-miR-548n	PAR-CLIP	27292025
MIRT694694	hsa-miR-548t-5p	PAR-CLIP	27292025
MIRT694693	hsa-miR-6771-3p	PAR-CLIP	27292025
MIRT694690	hsa-miR-8054	PAR-CLIP	27292025
MIRT718651	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT718650	hsa-miR-4435	HITS-CLIP	19536157
MIRT694714	hsa-miR-34b-3p	HITS-CLIP	23313552
MIRT694713	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT694712	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT694711	hsa-miR-3929	HITS-CLIP	23313552
MIRT694710	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694709	hsa-miR-4478	HITS-CLIP	23313552
MIRT694708	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT694707	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT694706	hsa-miR-4459	HITS-CLIP	23313552
MIRT694705	hsa-miR-665	HITS-CLIP	23313552
MIRT694704	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT694703	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694702	hsa-miR-1827	HITS-CLIP	23313552
MIRT694701	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694700	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694699	hsa-miR-298	HITS-CLIP	23313552
MIRT694698	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694697	hsa-miR-1273e	HITS-CLIP	23313552
MIRT694696	hsa-miR-548n	HITS-CLIP	23313552
MIRT694695	hsa-miR-548az-5p	HITS-CLIP	23313552
MIRT694694	hsa-miR-548t-5p	HITS-CLIP	23313552
MIRT694693	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT694692	hsa-miR-548av-5p	HITS-CLIP	23313552
MIRT694691	hsa-miR-548k	HITS-CLIP	23313552
MIRT694690	hsa-miR-8054	HITS-CLIP	23313552
MIRT694689	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT694688	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT694687	hsa-miR-575	HITS-CLIP	23313552
MIRT694686	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT694685	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT694684	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT694683	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT495835	hsa-miR-1273d	PAR-CLIP	22291592
MIRT495834	hsa-miR-449b-3p	PAR-CLIP	22291592
MIRT874980	hsa-miR-3692	CLIP-seq
MIRT874981	hsa-miR-4667-3p	CLIP-seq
MIRT874982	hsa-miR-1207-3p	CLIP-seq
MIRT874983	hsa-miR-1207-5p	CLIP-seq
MIRT874984	hsa-miR-1285	CLIP-seq
MIRT874985	hsa-miR-146b-3p	CLIP-seq
MIRT874986	hsa-miR-2467-5p	CLIP-seq
MIRT874987	hsa-miR-3185	CLIP-seq
MIRT874988	hsa-miR-3187-5p	CLIP-seq
MIRT874989	hsa-miR-3188	CLIP-seq
MIRT874990	hsa-miR-3190	CLIP-seq
MIRT874991	hsa-miR-34b	CLIP-seq
MIRT874992	hsa-miR-3611	CLIP-seq
MIRT874993	hsa-miR-3685	CLIP-seq
MIRT874994	hsa-miR-3713	CLIP-seq
MIRT874995	hsa-miR-3714	CLIP-seq
MIRT874996	hsa-miR-378	CLIP-seq
MIRT874997	hsa-miR-378b	CLIP-seq
MIRT874998	hsa-miR-378c	CLIP-seq
MIRT874999	hsa-miR-378d	CLIP-seq
MIRT875000	hsa-miR-378e	CLIP-seq
MIRT875001	hsa-miR-378f	CLIP-seq
MIRT875002	hsa-miR-378h	CLIP-seq
MIRT875003	hsa-miR-378i	CLIP-seq
MIRT875004	hsa-miR-3921	CLIP-seq
MIRT875005	hsa-miR-3975	CLIP-seq
MIRT875006	hsa-miR-422a	CLIP-seq
MIRT875007	hsa-miR-4279	CLIP-seq
MIRT875008	hsa-miR-4326	CLIP-seq
MIRT875009	hsa-miR-4476	CLIP-seq
MIRT875010	hsa-miR-4501	CLIP-seq
MIRT875011	hsa-miR-4522	CLIP-seq
MIRT875012	hsa-miR-4653-5p	CLIP-seq
MIRT875013	hsa-miR-4714-5p	CLIP-seq
MIRT875014	hsa-miR-4763-3p	CLIP-seq
MIRT875015	hsa-miR-550a	CLIP-seq
MIRT875016	hsa-miR-612	CLIP-seq
MIRT875017	hsa-miR-940	CLIP-seq
MIRT1959454	hsa-miR-128	CLIP-seq
MIRT1959455	hsa-miR-1296	CLIP-seq
MIRT1959456	hsa-miR-24	CLIP-seq
MIRT874986	hsa-miR-2467-5p	CLIP-seq
MIRT1959457	hsa-miR-4284	CLIP-seq
MIRT1959458	hsa-miR-4512	CLIP-seq
MIRT1959459	hsa-miR-4640-5p	CLIP-seq
MIRT1959460	hsa-miR-4726-5p	CLIP-seq
MIRT2196434	hsa-miR-1226	CLIP-seq
MIRT2196435	hsa-miR-1304	CLIP-seq
MIRT874991	hsa-miR-34b	CLIP-seq
MIRT2196436	hsa-miR-4268	CLIP-seq
MIRT2196437	hsa-miR-4433	CLIP-seq
MIRT2196438	hsa-miR-4448	CLIP-seq
MIRT2196439	hsa-miR-4728-5p	CLIP-seq
MIRT2196440	hsa-miR-4733-3p	CLIP-seq
MIRT2196441	hsa-miR-4768-3p	CLIP-seq
MIRT2196442	hsa-miR-579	CLIP-seq
MIRT2196435	hsa-miR-1304	CLIP-seq
MIRT874986	hsa-miR-2467-5p	CLIP-seq
MIRT2196437	hsa-miR-4433	CLIP-seq
MIRT2196441	hsa-miR-4768-3p	CLIP-seq
MIRT2196442	hsa-miR-579	CLIP-seq
MIRT2446575	hsa-miR-2964a-5p	CLIP-seq
MIRT2446576	hsa-miR-3925-3p	CLIP-seq
MIRT2446577	hsa-miR-3934	CLIP-seq
MIRT2446578	hsa-miR-548t	CLIP-seq
MIRT2446579	hsa-miR-766	CLIP-seq
MIRT2446578	hsa-miR-548t	CLIP-seq
MIRT2499367	hsa-miR-2114	CLIP-seq
MIRT2499368	hsa-miR-331-3p	CLIP-seq
MIRT2499369	hsa-miR-3690	CLIP-seq
MIRT2499370	hsa-miR-4254	CLIP-seq
MIRT2499371	hsa-miR-4292	CLIP-seq
MIRT2499372	hsa-miR-4308	CLIP-seq
MIRT2499373	hsa-miR-711	CLIP-seq
MIRT2196434	hsa-miR-1226	CLIP-seq
MIRT874984	hsa-miR-1285	CLIP-seq
MIRT2677682	hsa-miR-15a	CLIP-seq
MIRT2677683	hsa-miR-15b	CLIP-seq
MIRT2677684	hsa-miR-16	CLIP-seq
MIRT2677685	hsa-miR-195	CLIP-seq
MIRT874988	hsa-miR-3187-5p	CLIP-seq
MIRT2677686	hsa-miR-338-3p	CLIP-seq
MIRT2446577	hsa-miR-3934	CLIP-seq
MIRT2677687	hsa-miR-424	CLIP-seq
MIRT2677688	hsa-miR-4252	CLIP-seq
MIRT2196436	hsa-miR-4268	CLIP-seq
MIRT2196438	hsa-miR-4448	CLIP-seq
MIRT2677689	hsa-miR-4466	CLIP-seq
MIRT2196440	hsa-miR-4733-3p	CLIP-seq
MIRT2677690	hsa-miR-4793-3p	CLIP-seq
MIRT2677691	hsa-miR-497	CLIP-seq
MIRT2677692	hsa-miR-508-5p	CLIP-seq
MIRT2446578	hsa-miR-548t	CLIP-seq
MIRT875016	hsa-miR-612	CLIP-seq
MIRT2677693	hsa-miR-661	CLIP-seq
MIRT2677694	hsa-miR-675	CLIP-seq
MIRT2446579	hsa-miR-766	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0032585	Component	Multivesicular body membrane	IEA

MIM	HGNC	e!Ensembl
610520	30455	ENSG00000161649

Q6UXG3

Protein name

CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Triggering receptor expressed on myeloid cells 4) (TREM-4) (CD antigen CD300g)

Protein function

Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	20 → 121	Immunoglobulin V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and placenta. {ECO:0000269|PubMed:16876123}.

Sequence

MRLLVLLWGCLLLPGYEALEGPEEISGFEGDTVSLQCTYREELRDHRKYWCRKGGILFSR
CSGTIYAEEEGQETMKGRVSIRDSRQELSLIVTLWNLTLQDAGEYWCGVEKRGPDESLLI
SLFVFPGPCCPPSPSPTFQPLATTRLQPKAKAQQTQPPGLTSPGLYPAATTAKQGKTGAE
APPLPGTSQYGHERTSQYTGTSPHPATSPPAGSSRPPMQLDSTSAEDTSPALSSGSSKPR
VSIPMVRILAPVLVLLSLLSAAGLIAFCSHLLLWRKEAQQATETQRNEKFCLSRLTAEEK
EAPSQAPEGDVISMPPLHTSEEELGFSKFVSA

Sequence length

332

Interactions

View interactions

	Reactome
			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	31182966	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	37442189	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	23160641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	25314291		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	35642341	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	40382513	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CD300LG (CD300 molecule like family member g)