Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	146852
Gene name	Outer dense fiber of sperm tails 4
Gene symbol	ODF4
Synonyms (NCBI Gene)	CT134CT136OPPO1
Chromosome	17
Chromosome location	17p13.1
Summary	This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq,

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Show/Hide all (187)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620063	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT647425	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT620062	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT620061	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT620060	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT620059	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT620058	hsa-miR-3666	HITS-CLIP	23824327
MIRT620057	hsa-miR-4295	HITS-CLIP	23824327
MIRT620056	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT620055	hsa-miR-8063	HITS-CLIP	23824327
MIRT620054	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647424	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT647423	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT620053	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT620052	hsa-miR-4287	HITS-CLIP	23824327
MIRT620051	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620050	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT620049	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT620048	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT620047	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT620046	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT647422	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620045	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT620044	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT620043	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT620042	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620040	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620041	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT620039	hsa-miR-548aw	HITS-CLIP	23824327
MIRT620063	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT647425	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT620062	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT620061	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT620060	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT620059	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT620058	hsa-miR-3666	HITS-CLIP	23824327
MIRT620057	hsa-miR-4295	HITS-CLIP	23824327
MIRT620056	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT620055	hsa-miR-8063	HITS-CLIP	23824327
MIRT620054	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647424	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT647423	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT620053	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT620052	hsa-miR-4287	HITS-CLIP	23824327
MIRT620051	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620050	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT620049	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT620048	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT620047	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT620046	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT647422	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620045	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT620044	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT620043	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT620042	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620040	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620041	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT620039	hsa-miR-548aw	HITS-CLIP	23824327
MIRT647421	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT620063	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620062	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT620061	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT620060	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT620059	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT620058	hsa-miR-3666	HITS-CLIP	23824327
MIRT620057	hsa-miR-4295	HITS-CLIP	23824327
MIRT620056	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT620055	hsa-miR-8063	HITS-CLIP	23824327
MIRT620054	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620053	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT620052	hsa-miR-4287	HITS-CLIP	23824327
MIRT620051	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620050	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT620049	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT620048	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT620047	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT620046	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT620045	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT620044	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT620043	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT620042	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620040	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620041	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT620039	hsa-miR-548aw	HITS-CLIP	23824327
MIRT620063	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT647425	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT620062	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT620061	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT620060	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT620059	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT620058	hsa-miR-3666	HITS-CLIP	23824327
MIRT620057	hsa-miR-4295	HITS-CLIP	23824327
MIRT620056	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT620055	hsa-miR-8063	HITS-CLIP	23824327
MIRT620054	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647424	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT647423	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT620053	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT620052	hsa-miR-4287	HITS-CLIP	23824327
MIRT620051	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620050	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT620049	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT620048	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT620047	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT620046	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT647422	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620045	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT620044	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT620043	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT620042	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620040	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620041	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT620039	hsa-miR-548aw	HITS-CLIP	23824327
MIRT620063	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT647425	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT620062	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT620061	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT620060	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT620059	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT620058	hsa-miR-3666	HITS-CLIP	23824327
MIRT620057	hsa-miR-4295	HITS-CLIP	23824327
MIRT620056	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT620055	hsa-miR-8063	HITS-CLIP	23824327
MIRT620054	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647424	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT647423	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT620053	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT620052	hsa-miR-4287	HITS-CLIP	23824327
MIRT620051	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620050	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT620049	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT620048	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT620047	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT620046	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT647422	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT620045	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT620044	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT620043	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT620042	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620040	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620041	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT620039	hsa-miR-548aw	HITS-CLIP	23824327
MIRT647421	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT620063	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620062	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT620061	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT620060	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT620059	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT620058	hsa-miR-3666	HITS-CLIP	23824327
MIRT620057	hsa-miR-4295	HITS-CLIP	23824327
MIRT620056	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT620055	hsa-miR-8063	HITS-CLIP	23824327
MIRT620054	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620053	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT620052	hsa-miR-4287	HITS-CLIP	23824327
MIRT620051	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620050	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT620049	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT620048	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT620047	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT620046	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT620045	hsa-miR-19a-3p	HITS-CLIP	23824327
MIRT620044	hsa-miR-19b-3p	HITS-CLIP	23824327
MIRT620043	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT620042	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620040	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620041	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT620039	hsa-miR-548aw	HITS-CLIP	23824327
MIRT1202348	hsa-miR-1255a	CLIP-seq
MIRT1202349	hsa-miR-1255b	CLIP-seq
MIRT1202350	hsa-miR-1273f	CLIP-seq
MIRT1202351	hsa-miR-1275	CLIP-seq
MIRT1202352	hsa-miR-3150b-3p	CLIP-seq
MIRT1202353	hsa-miR-3605-5p	CLIP-seq
MIRT1202354	hsa-miR-4446-3p	CLIP-seq
MIRT1202355	hsa-miR-4492	CLIP-seq
MIRT1202356	hsa-miR-4498	CLIP-seq
MIRT1202357	hsa-miR-4505	CLIP-seq
MIRT1202358	hsa-miR-4525	CLIP-seq
MIRT1202359	hsa-miR-4665-5p	CLIP-seq
MIRT1202360	hsa-miR-4689	CLIP-seq
MIRT1202361	hsa-miR-4723-5p	CLIP-seq
MIRT1202362	hsa-miR-4731-5p	CLIP-seq
MIRT1202363	hsa-miR-4784	CLIP-seq
MIRT1202364	hsa-miR-625	CLIP-seq
MIRT1202365	hsa-miR-637	CLIP-seq
MIRT1202366	hsa-miR-762	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23355646, 28514442, 32296183, 33961781
GO:0007283	Process	Spermatogenesis	IEA
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA

MIM	HGNC	e!Ensembl
610097	19056	ENSG00000184650

Q2M2E3

Protein name

Outer dense fiber protein 4 (Outer dense fiber of sperm tails protein 4) (Testis-specific protein oppo 1) (hOPPO1)

Protein function

Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis and sperm; especially localized to sperm tail (at protein level). {ECO:0000269|PubMed:12728016}.

Sequence

MDAEYSGNEFPRSEGERDQHQRPGKERKSGEAGWGTGELGQDGRLLSSTLSLSSNRSLGQ
RQNSPLPFQWRITHSFRWMAQVLASELSLVAFILLLVVAFSKKWLDLSRSLFYQRWPVDV
SNRIHTSAHVMSMGLLHFYKSRSCSDLENGKVTFIFSTLMLFPINIWIFELERNVSIPIG
WSYFIGWLVLILYFTCAILCYFNHKSFWSLILSHPSGAVSCSSSFGSVEESPRAQTITDT
PITQEGVLDPEQKDTHV

Sequence length

257

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	23096689		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Transitional Cell	Transitional cell carcinoma	Pubtator	29058301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	19886887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	23096689		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	23096689		★★★★★ ★☆☆☆☆ Found in Text Mining only
TARSAL-CARPAL COALITION SYNDROME	Tarsal-Carpal Coalition Syndrome	BEFREE	29058301		★★★★★ ★☆☆☆☆ Found in Text Mining only

ODF4 (outer dense fiber of sperm tails 4)