GSG1L (GSG1 like)

Gene

• Entrez ID: 146395
• Gene name: GSG1 like
• Gene symbol: GSG1L
• Synonyms (NCBI Gene): PRO19651
• Chromosome: 16
• Chromosome location: 16p12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017935	hsa-miR-335-5p	Microarray	18185580
MIRT737700	hsa-miR-1193	CLIP-seq
MIRT1035825	hsa-miR-1245b-3p	CLIP-seq
MIRT1035826	hsa-miR-1255a	CLIP-seq
MIRT1035827	hsa-miR-1255b	CLIP-seq
MIRT1035828	hsa-miR-1261	CLIP-seq
MIRT1035829	hsa-miR-1287	CLIP-seq
MIRT737699	hsa-miR-1293	CLIP-seq
MIRT1035830	hsa-miR-146a	CLIP-seq
MIRT1035831	hsa-miR-146b-5p	CLIP-seq
MIRT1035832	hsa-miR-214	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT737697	hsa-miR-3165	CLIP-seq
MIRT1035833	hsa-miR-335	CLIP-seq
MIRT1035834	hsa-miR-3607-5p	CLIP-seq
MIRT1035835	hsa-miR-3609	CLIP-seq
MIRT1035836	hsa-miR-3619-5p	CLIP-seq
MIRT1035837	hsa-miR-3652	CLIP-seq
MIRT1035838	hsa-miR-3688-3p	CLIP-seq
MIRT737696	hsa-miR-3691-5p	CLIP-seq
MIRT1035839	hsa-miR-3978	CLIP-seq
MIRT1035840	hsa-miR-4426	CLIP-seq
MIRT1035841	hsa-miR-4430	CLIP-seq
MIRT1035842	hsa-miR-4437	CLIP-seq
MIRT1035843	hsa-miR-4481	CLIP-seq
MIRT737698	hsa-miR-4483	CLIP-seq
MIRT1035844	hsa-miR-4505	CLIP-seq
MIRT1035845	hsa-miR-4530	CLIP-seq
MIRT737701	hsa-miR-4534	CLIP-seq
MIRT1035846	hsa-miR-4647	CLIP-seq
MIRT1035847	hsa-miR-4662b	CLIP-seq
MIRT1035848	hsa-miR-4745-5p	CLIP-seq
MIRT1035849	hsa-miR-4758-5p	CLIP-seq
MIRT1035850	hsa-miR-4765	CLIP-seq
MIRT1035851	hsa-miR-4790-3p	CLIP-seq
MIRT1035852	hsa-miR-495	CLIP-seq
MIRT1035853	hsa-miR-548ah	CLIP-seq
MIRT1035854	hsa-miR-589	CLIP-seq
MIRT1035855	hsa-miR-761	CLIP-seq
MIRT737700	hsa-miR-1193	CLIP-seq
MIRT1035825	hsa-miR-1245b-3p	CLIP-seq
MIRT1035856	hsa-miR-1252	CLIP-seq
MIRT1035826	hsa-miR-1255a	CLIP-seq
MIRT1035827	hsa-miR-1255b	CLIP-seq
MIRT1035828	hsa-miR-1261	CLIP-seq
MIRT1035857	hsa-miR-1272	CLIP-seq
MIRT1035829	hsa-miR-1287	CLIP-seq
MIRT737699	hsa-miR-1293	CLIP-seq
MIRT1035858	hsa-miR-1301	CLIP-seq
MIRT1035859	hsa-miR-188-3p	CLIP-seq
MIRT1035860	hsa-miR-1972	CLIP-seq
MIRT1035861	hsa-miR-2392	CLIP-seq
MIRT1035862	hsa-miR-3127-3p	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT1035863	hsa-miR-3135b	CLIP-seq
MIRT1035864	hsa-miR-3136-5p	CLIP-seq
MIRT1035865	hsa-miR-3155	CLIP-seq
MIRT1035866	hsa-miR-3155b	CLIP-seq
MIRT737697	hsa-miR-3165	CLIP-seq
MIRT1035867	hsa-miR-3185	CLIP-seq
MIRT1035868	hsa-miR-3202	CLIP-seq
MIRT1035869	hsa-miR-323-5p	CLIP-seq
MIRT1035835	hsa-miR-3609	CLIP-seq
MIRT1035870	hsa-miR-3646	CLIP-seq
MIRT1035871	hsa-miR-3660	CLIP-seq
MIRT1035872	hsa-miR-3679-3p	CLIP-seq
MIRT1035873	hsa-miR-3681	CLIP-seq
MIRT1035838	hsa-miR-3688-3p	CLIP-seq
MIRT737696	hsa-miR-3691-5p	CLIP-seq
MIRT1035839	hsa-miR-3978	CLIP-seq
MIRT1035874	hsa-miR-4256	CLIP-seq
MIRT1035875	hsa-miR-4273	CLIP-seq
MIRT1035876	hsa-miR-4299	CLIP-seq
MIRT1035877	hsa-miR-431	CLIP-seq
MIRT1035878	hsa-miR-4314	CLIP-seq
MIRT1035879	hsa-miR-4434	CLIP-seq
MIRT1035880	hsa-miR-4439	CLIP-seq
MIRT1035881	hsa-miR-4456	CLIP-seq
MIRT1035843	hsa-miR-4481	CLIP-seq
MIRT737698	hsa-miR-4483	CLIP-seq
MIRT1035882	hsa-miR-4488	CLIP-seq
MIRT1035883	hsa-miR-4502	CLIP-seq
MIRT1035884	hsa-miR-4513	CLIP-seq
MIRT1035885	hsa-miR-4516	CLIP-seq
MIRT1035886	hsa-miR-4526	CLIP-seq
MIRT1035887	hsa-miR-4531	CLIP-seq
MIRT1035888	hsa-miR-4533	CLIP-seq
MIRT737701	hsa-miR-4534	CLIP-seq
MIRT1035889	hsa-miR-4539	CLIP-seq
MIRT1035890	hsa-miR-4646-5p	CLIP-seq
MIRT1035891	hsa-miR-4667-5p	CLIP-seq
MIRT1035892	hsa-miR-4677-5p	CLIP-seq
MIRT1035893	hsa-miR-4682	CLIP-seq
MIRT1035894	hsa-miR-4697-5p	CLIP-seq
MIRT1035895	hsa-miR-4699-3p	CLIP-seq
MIRT1035896	hsa-miR-4700-5p	CLIP-seq
MIRT1035897	hsa-miR-4724-5p	CLIP-seq
MIRT1035848	hsa-miR-4745-5p	CLIP-seq
MIRT1035898	hsa-miR-4747-5p	CLIP-seq
MIRT1035899	hsa-miR-4753-5p	CLIP-seq
MIRT1035900	hsa-miR-4757-5p	CLIP-seq
MIRT1035849	hsa-miR-4758-5p	CLIP-seq
MIRT1035851	hsa-miR-4790-3p	CLIP-seq
MIRT1035901	hsa-miR-484	CLIP-seq
MIRT1035902	hsa-miR-502-5p	CLIP-seq
MIRT1035903	hsa-miR-5047	CLIP-seq
MIRT1035904	hsa-miR-532-3p	CLIP-seq
MIRT1035853	hsa-miR-548ah	CLIP-seq
MIRT1035905	hsa-miR-548q	CLIP-seq
MIRT1035906	hsa-miR-563	CLIP-seq
MIRT1035907	hsa-miR-635	CLIP-seq
MIRT1035908	hsa-miR-637	CLIP-seq
MIRT1035909	hsa-miR-876-3p	CLIP-seq
MIRT1035910	hsa-miR-889	CLIP-seq
MIRT737700	hsa-miR-1193	CLIP-seq
MIRT1035826	hsa-miR-1255a	CLIP-seq
MIRT1035827	hsa-miR-1255b	CLIP-seq
MIRT1035857	hsa-miR-1272	CLIP-seq
MIRT737699	hsa-miR-1293	CLIP-seq
MIRT1035861	hsa-miR-2392	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT737697	hsa-miR-3165	CLIP-seq
MIRT737696	hsa-miR-3691-5p	CLIP-seq
MIRT737698	hsa-miR-4483	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT737700	hsa-miR-1193	CLIP-seq
MIRT1035825	hsa-miR-1245b-3p	CLIP-seq
MIRT1035826	hsa-miR-1255a	CLIP-seq
MIRT1035827	hsa-miR-1255b	CLIP-seq
MIRT2007071	hsa-miR-31	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT1035868	hsa-miR-3202	CLIP-seq
MIRT1035873	hsa-miR-3681	CLIP-seq
MIRT2007072	hsa-miR-3682-3p	CLIP-seq
MIRT737696	hsa-miR-3691-5p	CLIP-seq
MIRT2007073	hsa-miR-3915	CLIP-seq
MIRT2007074	hsa-miR-3928	CLIP-seq
MIRT2007075	hsa-miR-4261	CLIP-seq
MIRT1035843	hsa-miR-4481	CLIP-seq
MIRT2007076	hsa-miR-4496	CLIP-seq
MIRT2007077	hsa-miR-4520a-3p	CLIP-seq
MIRT1035888	hsa-miR-4533	CLIP-seq
MIRT737701	hsa-miR-4534	CLIP-seq
MIRT2007078	hsa-miR-4694-3p	CLIP-seq
MIRT1035848	hsa-miR-4745-5p	CLIP-seq
MIRT1035849	hsa-miR-4758-5p	CLIP-seq
MIRT2007079	hsa-miR-766	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT2239610	hsa-miR-4713-5p	CLIP-seq
MIRT1035904	hsa-miR-532-3p	CLIP-seq
MIRT737700	hsa-miR-1193	CLIP-seq
MIRT1035826	hsa-miR-1255a	CLIP-seq
MIRT1035827	hsa-miR-1255b	CLIP-seq
MIRT1035828	hsa-miR-1261	CLIP-seq
MIRT2239611	hsa-miR-128	CLIP-seq
MIRT1035829	hsa-miR-1287	CLIP-seq
MIRT2239612	hsa-miR-1913	CLIP-seq
MIRT2239613	hsa-miR-2355-5p	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT2239614	hsa-miR-324-3p	CLIP-seq
MIRT2239615	hsa-miR-4281	CLIP-seq
MIRT737701	hsa-miR-4534	CLIP-seq
MIRT2239616	hsa-miR-4688	CLIP-seq
MIRT2239617	hsa-miR-4707-3p	CLIP-seq
MIRT2239618	hsa-miR-593	CLIP-seq
MIRT2239619	hsa-miR-626	CLIP-seq
MIRT1035826	hsa-miR-1255a	CLIP-seq
MIRT1035827	hsa-miR-1255b	CLIP-seq
MIRT2239611	hsa-miR-128	CLIP-seq
MIRT2239612	hsa-miR-1913	CLIP-seq
MIRT737695	hsa-miR-3134	CLIP-seq
MIRT2239614	hsa-miR-324-3p	CLIP-seq
MIRT737701	hsa-miR-4534	CLIP-seq
MIRT2239616	hsa-miR-4688	CLIP-seq
MIRT2429471	hsa-miR-374c	CLIP-seq
MIRT2429472	hsa-miR-4263	CLIP-seq
MIRT2429473	hsa-miR-4643	CLIP-seq
MIRT2429474	hsa-miR-466	CLIP-seq
MIRT2429475	hsa-miR-4789-3p	CLIP-seq
MIRT2429476	hsa-miR-576-5p	CLIP-seq
MIRT2429477	hsa-miR-655	CLIP-seq
MIRT2543320	hsa-miR-1290	CLIP-seq
MIRT2543321	hsa-miR-3607-3p	CLIP-seq
MIRT2543322	hsa-miR-3686	CLIP-seq
MIRT2543323	hsa-miR-4292	CLIP-seq
MIRT2543324	hsa-miR-4652-3p	CLIP-seq
MIRT2543325	hsa-miR-548m	CLIP-seq
MIRT2682113	hsa-miR-1257	CLIP-seq
MIRT2543320	hsa-miR-1290	CLIP-seq
MIRT2543321	hsa-miR-3607-3p	CLIP-seq
MIRT2543322	hsa-miR-3686	CLIP-seq
MIRT2543323	hsa-miR-4292	CLIP-seq
MIRT2543324	hsa-miR-4652-3p	CLIP-seq
MIRT2543325	hsa-miR-548m	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0010646	Process	Regulation of cell communication	IEA
GO:0016020	Component	Membrane	IEA
GO:0019226	Process	Transmission of nerve impulse	IEA
GO:0023051	Process	Regulation of signaling	IEA
GO:0032279	Component	Asymmetric synapse	IEA
GO:0045202	Component	Synapse	IEA
GO:0048172	Process	Regulation of short-term neuronal synaptic plasticity	IEA
GO:0050808	Process	Synapse organization	IEA
GO:0051049	Process	Regulation of transport	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099149	Process	Regulation of postsynaptic neurotransmitter receptor internalization	IEA

Other IDs

• MIM: 617161
• HGNC: 28283
• e!Ensembl: ENSG00000169181

Protein

• UniProt ID: Q6UXU4
• Protein name: Germ cell-specific gene 1-like protein (GSG1-like protein)
• Protein function: As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07803	GSG-1	5 → 132	GSG1-like protein	Family

• Sequence:

  MKTSRRGRALLAVALNLLALLFATTAFLTTHWCQGTQRVPKPGCGQGGRANCPNSGANAT
  ANGTAAPAAAAAAATASGNGPPGGALYSWETGDDRFLFRNFHTGIWYSCEEELSGLGEKC
  RSFIDLAPASEKGVLWLSVVSEVLYILLLVVGFSLMCLELFHSSNVIDGLKLNAFAAVFT
  VLSGLLGMVAHMMYTQVFQVTVSLGPEDWRPHSWDYGWSFCLAWGSFTCCMAASVTTLNS
  YTKTVIEFRHKRKVFEQGYREEPTFIDPEAIKYFRERMEKRDGSEEDFHLDCRHERYPAR
  HQPHMADSWPRSSAQEAPELNRQCWVLGHWV

• Sequence length: 331

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinogenesis	Carcinogenesis	Pubtator	28257124	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32407802	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28257124		★☆☆☆☆ Found in Text Mining only