VWA3A (von Willebrand factor A domain containing 3A)

Gene

• Entrez ID: 146177
• Gene name: Von Willebrand factor A domain containing 3A
• Gene symbol: VWA3A
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16p12.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1488271	hsa-miR-1207-5p	CLIP-seq
MIRT1488272	hsa-miR-1255a	CLIP-seq
MIRT1488273	hsa-miR-1255b	CLIP-seq
MIRT1488274	hsa-miR-1302	CLIP-seq
MIRT1488275	hsa-miR-1343	CLIP-seq
MIRT1488276	hsa-miR-2276	CLIP-seq
MIRT1488277	hsa-miR-2682	CLIP-seq
MIRT1488278	hsa-miR-29a	CLIP-seq
MIRT1488279	hsa-miR-29b	CLIP-seq
MIRT1488280	hsa-miR-29c	CLIP-seq
MIRT1488281	hsa-miR-3134	CLIP-seq
MIRT1488282	hsa-miR-3158-5p	CLIP-seq
MIRT1488283	hsa-miR-3160-3p	CLIP-seq
MIRT1488284	hsa-miR-4298	CLIP-seq
MIRT1488285	hsa-miR-4312	CLIP-seq
MIRT1488286	hsa-miR-4423-3p	CLIP-seq
MIRT1488287	hsa-miR-4487	CLIP-seq
MIRT1488288	hsa-miR-449c	CLIP-seq
MIRT1488289	hsa-miR-4534	CLIP-seq
MIRT1488290	hsa-miR-4696	CLIP-seq
MIRT1488291	hsa-miR-4763-3p	CLIP-seq
MIRT1488292	hsa-miR-548u	CLIP-seq
MIRT1488293	hsa-miR-550a	CLIP-seq
MIRT1488294	hsa-miR-558	CLIP-seq
MIRT1488295	hsa-miR-940	CLIP-seq
MIRT2147031	hsa-miR-4328	CLIP-seq
MIRT2147032	hsa-miR-4468	CLIP-seq
MIRT2367532	hsa-miR-1178	CLIP-seq
MIRT2367533	hsa-miR-1915	CLIP-seq
MIRT1488276	hsa-miR-2276	CLIP-seq
MIRT2367534	hsa-miR-2964a-5p	CLIP-seq
MIRT1488278	hsa-miR-29a	CLIP-seq
MIRT1488279	hsa-miR-29b	CLIP-seq
MIRT1488280	hsa-miR-29c	CLIP-seq
MIRT1488283	hsa-miR-3160-3p	CLIP-seq
MIRT2367535	hsa-miR-4270	CLIP-seq
MIRT2367536	hsa-miR-4300	CLIP-seq
MIRT2367537	hsa-miR-4441	CLIP-seq
MIRT2367538	hsa-miR-450b-5p	CLIP-seq
MIRT1488290	hsa-miR-4696	CLIP-seq
MIRT2367539	hsa-miR-4726-3p	CLIP-seq
MIRT2367540	hsa-miR-920	CLIP-seq
MIRT2396889	hsa-miR-491-3p	CLIP-seq
MIRT2396890	hsa-miR-501-3p	CLIP-seq
MIRT2396891	hsa-miR-502-3p	CLIP-seq
MIRT1488276	hsa-miR-2276	CLIP-seq
MIRT2661031	hsa-miR-4463	CLIP-seq
MIRT1488290	hsa-miR-4696	CLIP-seq
MIRT1488292	hsa-miR-548u	CLIP-seq
MIRT1488276	hsa-miR-2276	CLIP-seq
MIRT2661031	hsa-miR-4463	CLIP-seq
MIRT1488290	hsa-miR-4696	CLIP-seq
MIRT1488292	hsa-miR-548u	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA

Other IDs

• MIM: 621113
• HGNC: 27088
• e!Ensembl: ENSG00000175267

Protein

• UniProt ID: A6NCI4
• Protein name: von Willebrand factor A domain-containing protein 3A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13768	VWA_3	169 → 324	von Willebrand factor type A domain	Domain
  PF13768	VWA_3	510 → 666	von Willebrand factor type A domain	Domain
  PF13768	VWA_3	958 → 1113	von Willebrand factor type A domain	Domain

• Sequence:

  MKKYRKISIGCFAMATQTSHVFHGQENMFLENHCIRRNTGRDSKKPLKQKNMNGLGQNSD
  NGLLVTHVNQTQDLLRLQGSETQSSDWEDSEDWLSAHSLKCQKLTLADLISQGTEVLEEG
  TNVVQKICFSTQIIRHFESKLSDTIEVYQERIQWLTENSKKAFGLIKGARVSILIDVSAI
  SSGPQKEEFQKDLMSLIDEQLSHKEKLFVLSFGTNAGSLWPDPMEVSASTLQELKLWVKT
  LQPDGGSNLLQALKKIFTLKGLDSLVAIMRSCPDQPSEILSDYIQQSTMGRDLIIHFITY
  RCDDQMPPAVLKNLAEAVRGYYHCYSPKMEHYTSRDMDELLAEIQKAQSLLSHVQALQHS
  SPCEALTCTMEEISTEITNGPLISLLPKPPKHDAPLTIEFPNLDKTSAEWLKVNGLKAKK
  LSLYQVLAPNAFSPVEEFVPILQKTVSSTIHEKAMIQFEWHDGTVKNIHVDPPFLYKYQQ
  QLSRAMRMYERRIEWLSLASRRIWGTVCEKRVVVLLDISATNSMYIIHIQHSLRLLLEEQ
  LSNKDCFNLIAFGSTIESWRPEMVPVSHNNLQSAWRWALNLRCRGSRNVLSALRKAVEVD
  FKDKDKHQSQGIYLFTGGIPDQDMPTLSAYMAEACGGCDLQLNVCLFYVGEPKMDTTPPA
  RYASHTDTAAAYKEVTRAAGGRFHWFGDTGIYESDDINSIMSEMEKALNYSQKCAFLMAS
  LKNHSGKVLGSSALPKEKPKTLQLRSQPKKLCPPRPTVPLGARMSIKDDPDREKSPPLKS
  LKWRPLSSRVGISPAAAQPTKEGMMELRRKTKSREAETSLLLFYTEKGNDVGSVYKKYPQ
  GRGLRRTSSSIDLPRKDTVCSSQEWVAKYGLKKLKLEISRCMGPNCTHQKSGQRSASAKH
  CSIFPSVEIHGVVRHIQWTPREMEVYIRHLEKVLRRYVQRLQWLLSGSRRLFGTVLESKV
  CILLDTSGSMGPYLQQVKTELVLLIWEQLRKCCDSFNLLSFAESFQSWQDTLVETTDAAC
  HEAMQWVTHLQAQGSTSILQALLKAFSFHDLEGLYLLTDGKPDTSCSLVLNEVQKLREKR
  DVKVHTISLNCSDRAAVEFLRKLASFTGGRYHCPVGEDTLSKIHSLLTKGFINEKDPTLP
  PFEGDDLRILAQEITKARSFLWQAQSFRSQLQKKNDAEPKVTLS

• Sequence length: 1184

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bladder Neoplasm	Bladder Neoplasm	CTD_human_DG	26039340		★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood coagulation disorder	Pubtator	32106291	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	32106291	Associate	★☆☆☆☆ Found in Text Mining only
Glycogen Storage Disease Type II	Glycogen storage disease	Pubtator	32106291	Associate	★☆☆☆☆ Found in Text Mining only
Hemorrhage	Hemorrhage	Pubtator	32106291	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	CTD_human_DG	26039340		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	25344116	Associate	★☆☆☆☆ Found in Text Mining only