C2CD4A (C2 calcium dependent domain containing 4A)

Gene

• Entrez ID: 145741
• Gene name: C2 calcium dependent domain containing 4A
• Gene symbol: C2CD4A
• Synonyms (NCBI Gene): FAM148A, NLF1
• Chromosome: 15
• Chromosome location: 15q22.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052623	hsa-let-7a-5p	CLASH	23622248
MIRT659974	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659973	hsa-miR-494-3p	HITS-CLIP	23824327
MIRT659972	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT659971	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT659970	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT441048	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT441049	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT441048	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT441049	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT659974	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659973	hsa-miR-494-3p	HITS-CLIP	23824327
MIRT659972	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT659971	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT659970	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT845362	hsa-let-7a	CLIP-seq
MIRT845363	hsa-let-7b	CLIP-seq
MIRT845364	hsa-let-7c	CLIP-seq
MIRT845365	hsa-let-7d	CLIP-seq
MIRT845366	hsa-let-7e	CLIP-seq
MIRT845367	hsa-let-7f	CLIP-seq
MIRT845368	hsa-let-7g	CLIP-seq
MIRT845369	hsa-let-7i	CLIP-seq
MIRT845370	hsa-miR-1228	CLIP-seq
MIRT845371	hsa-miR-1253	CLIP-seq
MIRT845372	hsa-miR-128	CLIP-seq
MIRT845373	hsa-miR-133a	CLIP-seq
MIRT845374	hsa-miR-133b	CLIP-seq
MIRT845375	hsa-miR-1343	CLIP-seq
MIRT845376	hsa-miR-141	CLIP-seq
MIRT845377	hsa-miR-142-5p	CLIP-seq
MIRT845378	hsa-miR-144	CLIP-seq
MIRT845379	hsa-miR-1913	CLIP-seq
MIRT845380	hsa-miR-200a	CLIP-seq
MIRT845381	hsa-miR-202	CLIP-seq
MIRT845382	hsa-miR-2276	CLIP-seq
MIRT845383	hsa-miR-27a	CLIP-seq
MIRT845384	hsa-miR-27b	CLIP-seq
MIRT845385	hsa-miR-3065-5p	CLIP-seq
MIRT845386	hsa-miR-3148	CLIP-seq
MIRT845387	hsa-miR-3168	CLIP-seq
MIRT845388	hsa-miR-324-3p	CLIP-seq
MIRT845389	hsa-miR-3607-5p	CLIP-seq
MIRT845390	hsa-miR-3688-3p	CLIP-seq
MIRT845391	hsa-miR-376a	CLIP-seq
MIRT845392	hsa-miR-376b	CLIP-seq
MIRT845393	hsa-miR-378g	CLIP-seq
MIRT845394	hsa-miR-3919	CLIP-seq
MIRT845395	hsa-miR-3927	CLIP-seq
MIRT845396	hsa-miR-4433	CLIP-seq
MIRT845397	hsa-miR-4437	CLIP-seq
MIRT845398	hsa-miR-4451	CLIP-seq
MIRT845399	hsa-miR-4458	CLIP-seq
MIRT845400	hsa-miR-4459	CLIP-seq
MIRT845401	hsa-miR-4500	CLIP-seq
MIRT845402	hsa-miR-4674	CLIP-seq
MIRT845403	hsa-miR-4707-3p	CLIP-seq
MIRT845404	hsa-miR-4756-3p	CLIP-seq
MIRT845405	hsa-miR-4768-3p	CLIP-seq
MIRT845406	hsa-miR-4786-3p	CLIP-seq
MIRT845407	hsa-miR-4793-3p	CLIP-seq
MIRT845408	hsa-miR-487a	CLIP-seq
MIRT845409	hsa-miR-500a	CLIP-seq
MIRT845410	hsa-miR-505	CLIP-seq
MIRT845411	hsa-miR-508-5p	CLIP-seq
MIRT845412	hsa-miR-513a-5p	CLIP-seq
MIRT845413	hsa-miR-580	CLIP-seq
MIRT845414	hsa-miR-592	CLIP-seq
MIRT845415	hsa-miR-597	CLIP-seq
MIRT845416	hsa-miR-599	CLIP-seq
MIRT845417	hsa-miR-610	CLIP-seq
MIRT845418	hsa-miR-661	CLIP-seq
MIRT845419	hsa-miR-766	CLIP-seq
MIRT845420	hsa-miR-98	CLIP-seq
MIRT1950749	hsa-miR-1184	CLIP-seq
MIRT1950750	hsa-miR-122	CLIP-seq
MIRT1950751	hsa-miR-1307	CLIP-seq
MIRT845375	hsa-miR-1343	CLIP-seq
MIRT845379	hsa-miR-1913	CLIP-seq
MIRT1950752	hsa-miR-1915	CLIP-seq
MIRT1950753	hsa-miR-192	CLIP-seq
MIRT1950754	hsa-miR-215	CLIP-seq
MIRT1950755	hsa-miR-3155	CLIP-seq
MIRT1950756	hsa-miR-3155b	CLIP-seq
MIRT1950757	hsa-miR-3198	CLIP-seq
MIRT845388	hsa-miR-324-3p	CLIP-seq
MIRT1950758	hsa-miR-3663-5p	CLIP-seq
MIRT1950759	hsa-miR-371-5p	CLIP-seq
MIRT1950760	hsa-miR-371b-5p	CLIP-seq
MIRT845393	hsa-miR-378g	CLIP-seq
MIRT1950761	hsa-miR-4274	CLIP-seq
MIRT1950762	hsa-miR-4284	CLIP-seq
MIRT1950763	hsa-miR-4309	CLIP-seq
MIRT1950764	hsa-miR-4418	CLIP-seq
MIRT1950765	hsa-miR-4423-5p	CLIP-seq
MIRT845397	hsa-miR-4437	CLIP-seq
MIRT1950766	hsa-miR-4519	CLIP-seq
MIRT1950767	hsa-miR-4638-5p	CLIP-seq
MIRT845402	hsa-miR-4674	CLIP-seq
MIRT845403	hsa-miR-4707-3p	CLIP-seq
MIRT1950768	hsa-miR-4716-5p	CLIP-seq
MIRT1950769	hsa-miR-4726-3p	CLIP-seq
MIRT1950770	hsa-miR-484	CLIP-seq
MIRT1950771	hsa-miR-509-3-5p	CLIP-seq
MIRT1950772	hsa-miR-509-5p	CLIP-seq
MIRT1950773	hsa-miR-564	CLIP-seq
MIRT1950749	hsa-miR-1184	CLIP-seq
MIRT1950750	hsa-miR-122	CLIP-seq
MIRT2188608	hsa-miR-1227	CLIP-seq
MIRT845370	hsa-miR-1228	CLIP-seq
MIRT2188609	hsa-miR-1245	CLIP-seq
MIRT845371	hsa-miR-1253	CLIP-seq
MIRT2188610	hsa-miR-1262	CLIP-seq
MIRT845372	hsa-miR-128	CLIP-seq
MIRT2188611	hsa-miR-1299	CLIP-seq
MIRT1950751	hsa-miR-1307	CLIP-seq
MIRT845377	hsa-miR-142-5p	CLIP-seq
MIRT845378	hsa-miR-144	CLIP-seq
MIRT1950752	hsa-miR-1915	CLIP-seq
MIRT1950753	hsa-miR-192	CLIP-seq
MIRT1950754	hsa-miR-215	CLIP-seq
MIRT2188612	hsa-miR-23a	CLIP-seq
MIRT2188613	hsa-miR-23b	CLIP-seq
MIRT2188614	hsa-miR-23c	CLIP-seq
MIRT845383	hsa-miR-27a	CLIP-seq
MIRT845384	hsa-miR-27b	CLIP-seq
MIRT845385	hsa-miR-3065-5p	CLIP-seq
MIRT1950755	hsa-miR-3155	CLIP-seq
MIRT1950756	hsa-miR-3155b	CLIP-seq
MIRT2188615	hsa-miR-3161	CLIP-seq
MIRT1950757	hsa-miR-3198	CLIP-seq
MIRT2188616	hsa-miR-3199	CLIP-seq
MIRT2188617	hsa-miR-375	CLIP-seq
MIRT845391	hsa-miR-376a	CLIP-seq
MIRT845392	hsa-miR-376b	CLIP-seq
MIRT845394	hsa-miR-3919	CLIP-seq
MIRT2188618	hsa-miR-3942-3p	CLIP-seq
MIRT2188619	hsa-miR-412	CLIP-seq
MIRT2188620	hsa-miR-421	CLIP-seq
MIRT2188621	hsa-miR-4276	CLIP-seq
MIRT1950762	hsa-miR-4284	CLIP-seq
MIRT2188622	hsa-miR-4302	CLIP-seq
MIRT1950763	hsa-miR-4309	CLIP-seq
MIRT1950764	hsa-miR-4418	CLIP-seq
MIRT1950767	hsa-miR-4638-5p	CLIP-seq
MIRT2188623	hsa-miR-4701-3p	CLIP-seq
MIRT2188624	hsa-miR-4709-5p	CLIP-seq
MIRT2188625	hsa-miR-4715-3p	CLIP-seq
MIRT1950769	hsa-miR-4726-3p	CLIP-seq
MIRT2188626	hsa-miR-4740-5p	CLIP-seq
MIRT845404	hsa-miR-4756-3p	CLIP-seq
MIRT845407	hsa-miR-4793-3p	CLIP-seq
MIRT2188627	hsa-miR-4797-5p	CLIP-seq
MIRT1950770	hsa-miR-484	CLIP-seq
MIRT845409	hsa-miR-500a	CLIP-seq
MIRT845410	hsa-miR-505	CLIP-seq
MIRT845411	hsa-miR-508-5p	CLIP-seq
MIRT1950771	hsa-miR-509-3-5p	CLIP-seq
MIRT1950772	hsa-miR-509-5p	CLIP-seq
MIRT845412	hsa-miR-513a-5p	CLIP-seq
MIRT2188628	hsa-miR-542-3p	CLIP-seq
MIRT2188629	hsa-miR-552	CLIP-seq
MIRT1950773	hsa-miR-564	CLIP-seq
MIRT845413	hsa-miR-580	CLIP-seq
MIRT845417	hsa-miR-610	CLIP-seq
MIRT2188630	hsa-miR-630	CLIP-seq
MIRT845418	hsa-miR-661	CLIP-seq
MIRT2188631	hsa-miR-764	CLIP-seq
MIRT845419	hsa-miR-766	CLIP-seq
MIRT2188609	hsa-miR-1245	CLIP-seq
MIRT1950753	hsa-miR-192	CLIP-seq
MIRT1950754	hsa-miR-215	CLIP-seq
MIRT2385175	hsa-miR-362-5p	CLIP-seq
MIRT1950769	hsa-miR-4726-3p	CLIP-seq
MIRT2385176	hsa-miR-500b	CLIP-seq
MIRT2385177	hsa-miR-502-5p	CLIP-seq
MIRT845372	hsa-miR-128	CLIP-seq
MIRT845377	hsa-miR-142-5p	CLIP-seq
MIRT845378	hsa-miR-144	CLIP-seq
MIRT845383	hsa-miR-27a	CLIP-seq
MIRT845384	hsa-miR-27b	CLIP-seq
MIRT845391	hsa-miR-376a	CLIP-seq
MIRT845392	hsa-miR-376b	CLIP-seq
MIRT845412	hsa-miR-513a-5p	CLIP-seq
MIRT1950750	hsa-miR-122	CLIP-seq
MIRT845371	hsa-miR-1253	CLIP-seq
MIRT1950751	hsa-miR-1307	CLIP-seq
MIRT2492467	hsa-miR-136	CLIP-seq
MIRT1950757	hsa-miR-3198	CLIP-seq
MIRT1950763	hsa-miR-4309	CLIP-seq
MIRT2492468	hsa-miR-4426	CLIP-seq
MIRT1950767	hsa-miR-4638-5p	CLIP-seq
MIRT2492469	hsa-miR-4647	CLIP-seq
MIRT2492470	hsa-miR-4662b	CLIP-seq
MIRT1950769	hsa-miR-4726-3p	CLIP-seq
MIRT845409	hsa-miR-500a	CLIP-seq
MIRT1950773	hsa-miR-564	CLIP-seq
MIRT845413	hsa-miR-580	CLIP-seq
MIRT1950750	hsa-miR-122	CLIP-seq
MIRT2492467	hsa-miR-136	CLIP-seq
MIRT1950757	hsa-miR-3198	CLIP-seq
MIRT1950763	hsa-miR-4309	CLIP-seq
MIRT2492468	hsa-miR-4426	CLIP-seq
MIRT2492469	hsa-miR-4647	CLIP-seq
MIRT2492470	hsa-miR-4662b	CLIP-seq
MIRT1950769	hsa-miR-4726-3p	CLIP-seq
MIRT845409	hsa-miR-500a	CLIP-seq
MIRT1950773	hsa-miR-564	CLIP-seq
MIRT845413	hsa-miR-580	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002528	Process	Regulation of vascular permeability involved in acute inflammatory response	IDA	15527968
GO:0002675	Process	Positive regulation of acute inflammatory response	IDA	15527968
GO:0005634	Component	Nucleus	IDA	15527968
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0030155	Process	Regulation of cell adhesion	IDA	15527968

Other IDs

• MIM: 610343
• HGNC: 33627
• e!Ensembl: ENSG00000198535

Protein

• UniProt ID: Q8NCU7
• Protein name: C2 calcium-dependent domain-containing protein 4A (Nuclear-localized factor 1) (Protein FAM148A)
• Protein function: May be involved in inflammatory process. May regulate cell architecture and adhesion.
• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in endothelial cells. {ECO:0000269|PubMed:15527968}.
• Sequence:

  MWCLERLRLGPECLRRSGDWLLPGRARGAKSRTTAACANVLTPDRIPEFCIPPRLMPRLA
  LAALRNSWVEEAGMDEGAGRTDWDPRSQAALSLPHLPRVRTAYGFCALLESPHTRRKESL
  LLGGPPAPRPRAHTYGGGGGPDALLGTLRVPRAPGPATPAAPGCPRPPQDALARRPRGCR
  LLRVPDGLLSRALRAGRSRRLTRVRSVSSGNEDKERRAGSQSPARAPSTSPPSSRVPFPE
  RLEAEGTVALGRAGDALRLAAEYCPGTGRLRLRLLRAESPAGGAPGPRAVSCRLSLVLRP
  PGTALRQCSTVVGRSRKASFDQDFCFDGLSEDEVRRLAVRVKARDEGRGRERGRLLGQGE
  LSLGALLLL

• Sequence length: 369

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, TYPE 2	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal atresia	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Pyloric stenosis	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autism Spectrum Disorder	Autism	Pubtator	37328585	Inhibit	★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	36518255	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	23185617, 31527256		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	23185617, 31527256		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	21799836, 21873549	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	20818381, 21799836, 21909839, 29625024		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	CTD_human_DG	20818381		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	36750863	Associate	★☆☆☆☆ Found in Text Mining only