Gene Gene information from NCBI Gene database.
Entrez ID 1445
Gene name C-terminal Src kinase
Gene symbol CSK
Synonyms (NCBI Gene)
-
Chromosome 15
Chromosome location 15q24.1
Summary The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-re
miRNA miRNA information provided by mirtarbase database.
74
miRTarBase ID miRNA Experiments Reference
MIRT003960 hsa-miR-140-5p Microarray 17875710
MIRT030606 hsa-miR-24-3p Microarray 19748357
MIRT035928 hsa-miR-1180-3p CLASH 23622248
MIRT755804 hsa-miR-192-3p Luciferase reporter assayWestern blottingqRT-PCRRNA pull down assay 36914869
MIRT911892 hsa-miR-1225-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
53
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002682 Process Regulation of immune system process IEA
GO:0004672 Function Protein kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
124095 2444 ENSG00000103653
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P41240
Protein name Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Protein function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) inc
PDB 1BYG , 1CSK , 3D7T , 3D7U , 3EAC , 3EAZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 15 62 SH3 domain Domain
PF00017 SH2 82 156 SH2 domain Domain
PF07714 PK_Tyr_Ser-Thr 195 440 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.
Sequence
Sequence length 450
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Epithelial cell signaling in Helicobacter pylori infection   GAB1 signalosome
Phosphorylation of CD3 and TCR zeta chains
Integrin signaling
PD-1 signaling
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
19
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CELIAC DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
15q24 Microdeletion 15q24 Microdeletion BEFREE 22216833
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 15208781, 27092776, 28874816 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 28874816 Inhibit
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 23359562, 23946333, 24333531, 26458874, 28874816
★☆☆☆☆
Found in Text Mining only
Bone neoplasms Bone neoplasms BEFREE 18337451
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 11007774, 12941830, 14704150, 29987050
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 14704150, 20010872, 29987050 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 24648518
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 32335258, 40612868 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Lobular Lobular carcinoma Pubtator 19583841 Associate
★☆☆☆☆
Found in Text Mining only