TMEM86A (transmembrane protein 86A)

Gene

• Entrez ID: 144110
• Gene name: Transmembrane protein 86A
• Gene symbol: TMEM86A
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11p15.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT533694	hsa-miR-665	PAR-CLIP	22012620
MIRT533693	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT533692	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT533691	hsa-miR-4323	PAR-CLIP	22012620
MIRT533690	hsa-miR-6782-5p	PAR-CLIP	22012620
MIRT533688	hsa-miR-1298-3p	PAR-CLIP	22012620
MIRT533689	hsa-miR-4459	PAR-CLIP	22012620
MIRT533687	hsa-miR-6840-3p	PAR-CLIP	22012620
MIRT533686	hsa-miR-1285-3p	PAR-CLIP	22012620
MIRT533685	hsa-miR-3187-5p	PAR-CLIP	22012620
MIRT533684	hsa-miR-5189-5p	PAR-CLIP	22012620
MIRT533683	hsa-miR-612	PAR-CLIP	22012620
MIRT533682	hsa-miR-6860	PAR-CLIP	22012620
MIRT533681	hsa-miR-4486	PAR-CLIP	22012620
MIRT533679	hsa-miR-378g	PAR-CLIP	22012620
MIRT533680	hsa-miR-3150b-3p	PAR-CLIP	22012620
MIRT533678	hsa-miR-4784	PAR-CLIP	22012620
MIRT533677	hsa-miR-1914-3p	PAR-CLIP	22012620
MIRT533676	hsa-miR-5194	PAR-CLIP	22012620
MIRT533674	hsa-miR-6738-5p	PAR-CLIP	22012620
MIRT533675	hsa-miR-185-5p	PAR-CLIP	22012620
MIRT533673	hsa-miR-4306	PAR-CLIP	22012620
MIRT533672	hsa-miR-4644	PAR-CLIP	22012620
MIRT533670	hsa-miR-765	PAR-CLIP	22012620
MIRT533671	hsa-miR-874-5p	PAR-CLIP	22012620
MIRT533669	hsa-miR-296-5p	PAR-CLIP	22012620
MIRT533668	hsa-miR-6724-5p	PAR-CLIP	22012620
MIRT533667	hsa-miR-6773-5p	PAR-CLIP	22012620
MIRT533694	hsa-miR-665	PAR-CLIP	22012620
MIRT533693	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT533692	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT533691	hsa-miR-4323	PAR-CLIP	22012620
MIRT533690	hsa-miR-6782-5p	PAR-CLIP	22012620
MIRT533688	hsa-miR-1298-3p	PAR-CLIP	22012620
MIRT533689	hsa-miR-4459	PAR-CLIP	22012620
MIRT533687	hsa-miR-6840-3p	PAR-CLIP	22012620
MIRT533686	hsa-miR-1285-3p	PAR-CLIP	22012620
MIRT533685	hsa-miR-3187-5p	PAR-CLIP	22012620
MIRT533684	hsa-miR-5189-5p	PAR-CLIP	22012620
MIRT533683	hsa-miR-612	PAR-CLIP	22012620
MIRT533682	hsa-miR-6860	PAR-CLIP	22012620
MIRT533681	hsa-miR-4486	PAR-CLIP	22012620
MIRT533679	hsa-miR-378g	PAR-CLIP	22012620
MIRT533680	hsa-miR-3150b-3p	PAR-CLIP	22012620
MIRT533678	hsa-miR-4784	PAR-CLIP	22012620
MIRT533677	hsa-miR-1914-3p	PAR-CLIP	22012620
MIRT533676	hsa-miR-5194	PAR-CLIP	22012620
MIRT533674	hsa-miR-6738-5p	PAR-CLIP	22012620
MIRT533675	hsa-miR-185-5p	PAR-CLIP	22012620
MIRT533673	hsa-miR-4306	PAR-CLIP	22012620
MIRT533672	hsa-miR-4644	PAR-CLIP	22012620
MIRT533670	hsa-miR-765	PAR-CLIP	22012620
MIRT533671	hsa-miR-874-5p	PAR-CLIP	22012620
MIRT533669	hsa-miR-296-5p	PAR-CLIP	22012620
MIRT533668	hsa-miR-6724-5p	PAR-CLIP	22012620
MIRT533667	hsa-miR-6773-5p	PAR-CLIP	22012620
MIRT1439188	hsa-miR-1231	CLIP-seq
MIRT1439189	hsa-miR-1254	CLIP-seq
MIRT1439190	hsa-miR-1976	CLIP-seq
MIRT1439191	hsa-miR-204	CLIP-seq
MIRT1439192	hsa-miR-211	CLIP-seq
MIRT1439193	hsa-miR-2117	CLIP-seq
MIRT1439194	hsa-miR-3116	CLIP-seq
MIRT1439195	hsa-miR-3128	CLIP-seq
MIRT1439196	hsa-miR-3145-5p	CLIP-seq
MIRT1439197	hsa-miR-3150a-3p	CLIP-seq
MIRT1439198	hsa-miR-3175	CLIP-seq
MIRT1439199	hsa-miR-329	CLIP-seq
MIRT1439200	hsa-miR-362-3p	CLIP-seq
MIRT1439201	hsa-miR-3689d	CLIP-seq
MIRT1439202	hsa-miR-3919	CLIP-seq
MIRT1439203	hsa-miR-3941	CLIP-seq
MIRT1439204	hsa-miR-4267	CLIP-seq
MIRT1439205	hsa-miR-4286	CLIP-seq
MIRT1439206	hsa-miR-4433	CLIP-seq
MIRT1439207	hsa-miR-4438	CLIP-seq
MIRT1439208	hsa-miR-4443	CLIP-seq
MIRT1439209	hsa-miR-4645-5p	CLIP-seq
MIRT1439210	hsa-miR-4667-3p	CLIP-seq
MIRT1439211	hsa-miR-4673	CLIP-seq
MIRT1439212	hsa-miR-4691-5p	CLIP-seq
MIRT1439213	hsa-miR-4695-5p	CLIP-seq
MIRT1439214	hsa-miR-4711-5p	CLIP-seq
MIRT1439215	hsa-miR-4720-5p	CLIP-seq
MIRT1439216	hsa-miR-4722-3p	CLIP-seq
MIRT1439217	hsa-miR-4728-5p	CLIP-seq
MIRT1439218	hsa-miR-4733-3p	CLIP-seq
MIRT1439219	hsa-miR-4755-5p	CLIP-seq
MIRT1439220	hsa-miR-4768-3p	CLIP-seq
MIRT1439221	hsa-miR-4768-5p	CLIP-seq
MIRT1439222	hsa-miR-4799-3p	CLIP-seq
MIRT1439223	hsa-miR-485-5p	CLIP-seq
MIRT1439224	hsa-miR-491-5p	CLIP-seq
MIRT1439225	hsa-miR-541	CLIP-seq
MIRT1439226	hsa-miR-603	CLIP-seq
MIRT1439227	hsa-miR-615-5p	CLIP-seq
MIRT1439228	hsa-miR-623	CLIP-seq
MIRT1439229	hsa-miR-654-3p	CLIP-seq
MIRT1439230	hsa-miR-654-5p	CLIP-seq
MIRT1439231	hsa-miR-661	CLIP-seq
MIRT1439232	hsa-miR-939	CLIP-seq
MIRT1554992	hsa-miR-15a	CLIP-seq
MIRT1554993	hsa-miR-15b	CLIP-seq
MIRT1554994	hsa-miR-16	CLIP-seq
MIRT1554995	hsa-miR-195	CLIP-seq
MIRT1554996	hsa-miR-214	CLIP-seq
MIRT1554997	hsa-miR-3619-5p	CLIP-seq
MIRT1554998	hsa-miR-424	CLIP-seq
MIRT1554999	hsa-miR-497	CLIP-seq
MIRT1555000	hsa-miR-513c	CLIP-seq
MIRT1555001	hsa-miR-514b-5p	CLIP-seq
MIRT1555002	hsa-miR-761	CLIP-seq
MIRT2131535	hsa-miR-125a-5p	CLIP-seq
MIRT2131536	hsa-miR-125b	CLIP-seq
MIRT2131537	hsa-miR-1262	CLIP-seq
MIRT1554996	hsa-miR-214	CLIP-seq
MIRT1554997	hsa-miR-3619-5p	CLIP-seq
MIRT1439204	hsa-miR-4267	CLIP-seq
MIRT2131538	hsa-miR-4271	CLIP-seq
MIRT2131539	hsa-miR-4319	CLIP-seq
MIRT2131540	hsa-miR-4481	CLIP-seq
MIRT2131541	hsa-miR-4701-3p	CLIP-seq
MIRT2131542	hsa-miR-4717-3p	CLIP-seq
MIRT2131543	hsa-miR-4725-3p	CLIP-seq
MIRT1439217	hsa-miR-4728-5p	CLIP-seq
MIRT2131544	hsa-miR-4745-5p	CLIP-seq
MIRT2131545	hsa-miR-4793-5p	CLIP-seq
MIRT2131546	hsa-miR-4795-5p	CLIP-seq
MIRT2131547	hsa-miR-501-5p	CLIP-seq
MIRT1439227	hsa-miR-615-5p	CLIP-seq
MIRT1555002	hsa-miR-761	CLIP-seq
MIRT2352796	hsa-miR-1205	CLIP-seq
MIRT2352797	hsa-miR-1228	CLIP-seq
MIRT2352798	hsa-miR-1252	CLIP-seq
MIRT2352799	hsa-miR-1255a	CLIP-seq
MIRT2352800	hsa-miR-1255b	CLIP-seq
MIRT2131535	hsa-miR-125a-5p	CLIP-seq
MIRT2131536	hsa-miR-125b	CLIP-seq
MIRT2352801	hsa-miR-1273e	CLIP-seq
MIRT2352802	hsa-miR-1285	CLIP-seq
MIRT2352803	hsa-miR-149	CLIP-seq
MIRT1554992	hsa-miR-15a	CLIP-seq
MIRT1554993	hsa-miR-15b	CLIP-seq
MIRT1554994	hsa-miR-16	CLIP-seq
MIRT2352804	hsa-miR-1914	CLIP-seq
MIRT2352805	hsa-miR-1915	CLIP-seq
MIRT1554995	hsa-miR-195	CLIP-seq
MIRT1439190	hsa-miR-1976	CLIP-seq
MIRT1554996	hsa-miR-214	CLIP-seq
MIRT2352806	hsa-miR-2355-5p	CLIP-seq
MIRT2352807	hsa-miR-2682	CLIP-seq
MIRT2352808	hsa-miR-3064-5p	CLIP-seq
MIRT2352809	hsa-miR-3065-3p	CLIP-seq
MIRT2352810	hsa-miR-3120-3p	CLIP-seq
MIRT2352811	hsa-miR-3121-5p	CLIP-seq
MIRT2352812	hsa-miR-3126-5p	CLIP-seq
MIRT2352813	hsa-miR-3132	CLIP-seq
MIRT2352814	hsa-miR-3145-3p	CLIP-seq
MIRT1439197	hsa-miR-3150a-3p	CLIP-seq
MIRT2352815	hsa-miR-3173-3p	CLIP-seq
MIRT1439198	hsa-miR-3175	CLIP-seq
MIRT2352816	hsa-miR-3179	CLIP-seq
MIRT2352817	hsa-miR-3617	CLIP-seq
MIRT2352818	hsa-miR-3618	CLIP-seq
MIRT1554997	hsa-miR-3619-5p	CLIP-seq
MIRT2352819	hsa-miR-3665	CLIP-seq
MIRT2352820	hsa-miR-3672	CLIP-seq
MIRT2352821	hsa-miR-3682-5p	CLIP-seq
MIRT2352822	hsa-miR-3689a-5p	CLIP-seq
MIRT2352823	hsa-miR-3689b	CLIP-seq
MIRT2352824	hsa-miR-3689e	CLIP-seq
MIRT2352825	hsa-miR-3689f	CLIP-seq
MIRT2352826	hsa-miR-370	CLIP-seq
MIRT1439202	hsa-miR-3919	CLIP-seq
MIRT2352827	hsa-miR-3925-3p	CLIP-seq
MIRT2352828	hsa-miR-3974	CLIP-seq
MIRT2352829	hsa-miR-410	CLIP-seq
MIRT1554998	hsa-miR-424	CLIP-seq
MIRT1439204	hsa-miR-4267	CLIP-seq
MIRT2352830	hsa-miR-4269	CLIP-seq
MIRT1439205	hsa-miR-4286	CLIP-seq
MIRT2131539	hsa-miR-4319	CLIP-seq
MIRT2352831	hsa-miR-4324	CLIP-seq
MIRT2352832	hsa-miR-4329	CLIP-seq
MIRT2352833	hsa-miR-4419a	CLIP-seq
MIRT2352834	hsa-miR-4451	CLIP-seq
MIRT2352835	hsa-miR-449c	CLIP-seq
MIRT2352836	hsa-miR-4509	CLIP-seq
MIRT2352837	hsa-miR-4510	CLIP-seq
MIRT2352838	hsa-miR-4514	CLIP-seq
MIRT2352839	hsa-miR-4635	CLIP-seq
MIRT2352840	hsa-miR-4643	CLIP-seq
MIRT2352841	hsa-miR-4677-3p	CLIP-seq
MIRT2352842	hsa-miR-4692	CLIP-seq
MIRT2352843	hsa-miR-4708-5p	CLIP-seq
MIRT2131542	hsa-miR-4717-3p	CLIP-seq
MIRT2352844	hsa-miR-4726-3p	CLIP-seq
MIRT1439217	hsa-miR-4728-5p	CLIP-seq
MIRT2352845	hsa-miR-4731-5p	CLIP-seq
MIRT2352846	hsa-miR-4742-5p	CLIP-seq
MIRT1439219	hsa-miR-4755-5p	CLIP-seq
MIRT2352847	hsa-miR-4782-5p	CLIP-seq
MIRT2131545	hsa-miR-4793-5p	CLIP-seq
MIRT2352848	hsa-miR-4794	CLIP-seq
MIRT2352849	hsa-miR-4802-3p	CLIP-seq
MIRT1439224	hsa-miR-491-5p	CLIP-seq
MIRT2352850	hsa-miR-494	CLIP-seq
MIRT1554999	hsa-miR-497	CLIP-seq
MIRT2352851	hsa-miR-499-3p	CLIP-seq
MIRT2352852	hsa-miR-499a-3p	CLIP-seq
MIRT2131547	hsa-miR-501-5p	CLIP-seq
MIRT1555000	hsa-miR-513c	CLIP-seq
MIRT1555001	hsa-miR-514b-5p	CLIP-seq
MIRT2352853	hsa-miR-518a-5p	CLIP-seq
MIRT2352854	hsa-miR-527	CLIP-seq
MIRT2352855	hsa-miR-548m	CLIP-seq
MIRT2352856	hsa-miR-622	CLIP-seq
MIRT2352857	hsa-miR-627	CLIP-seq
MIRT2352858	hsa-miR-640	CLIP-seq
MIRT2352859	hsa-miR-641	CLIP-seq
MIRT2352860	hsa-miR-657	CLIP-seq
MIRT1555002	hsa-miR-761	CLIP-seq
MIRT2352861	hsa-miR-889	CLIP-seq
MIRT2352862	hsa-miR-924	CLIP-seq
MIRT2352863	hsa-miR-934	CLIP-seq
MIRT1439232	hsa-miR-939	CLIP-seq
MIRT1439191	hsa-miR-204	CLIP-seq
MIRT1439192	hsa-miR-211	CLIP-seq
MIRT2352807	hsa-miR-2682	CLIP-seq
MIRT2352830	hsa-miR-4269	CLIP-seq
MIRT2396055	hsa-miR-4436b-3p	CLIP-seq
MIRT2352835	hsa-miR-449c	CLIP-seq
MIRT2352838	hsa-miR-4514	CLIP-seq
MIRT2352842	hsa-miR-4692	CLIP-seq
MIRT2352846	hsa-miR-4742-5p	CLIP-seq
MIRT2352853	hsa-miR-518a-5p	CLIP-seq
MIRT2352854	hsa-miR-527	CLIP-seq
MIRT2461858	hsa-miR-1245b-3p	CLIP-seq
MIRT2461859	hsa-miR-136	CLIP-seq
MIRT2461860	hsa-miR-1470	CLIP-seq
MIRT2461861	hsa-miR-2113	CLIP-seq
MIRT2352826	hsa-miR-370	CLIP-seq
MIRT2461862	hsa-miR-3944-5p	CLIP-seq
MIRT2461863	hsa-miR-4469	CLIP-seq
MIRT1439210	hsa-miR-4667-3p	CLIP-seq
MIRT2131545	hsa-miR-4793-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0047408	Function	Alkenylglycerophosphocholine hydrolase activity	IDA	36592658
GO:0047408	Function	Alkenylglycerophosphocholine hydrolase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N2M4
• Protein name: Lysoplasmalogenase TMEM86A (EC 3.3.2.2) (Transmembrane protein 86A)
• Protein function: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of pla
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07947	YhhN	38 → 224	YhhN family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the macrophages. {ECO:0000269|PubMed:36592658}.
• Sequence:

  MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSTLIKCLPIFCLWLFLLAHGLG
  FLLAHPSATRIFVGLVFSAVGDAFLIWQDQGYFVHGLLMFAVTHMFYASAFGMQPLALRT
  GLVMAALSGLCYALLYPCLSGAFTYLVGVYVALIGFMGWRAMAGLRLAGADWRWTELAAG
  SGALFFIISDLTIALNKFCFPVPYSRALIMSTYYVAQMLVALSAVESREPVEHYRLTKAN
  

• Sequence length: 240

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CATARACT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations