Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	143872
Gene name	Rho GTPase activating protein 42
Gene symbol	ARHGAP42
Synonyms (NCBI Gene)	AD031GRAF3TMEM133
Chromosome	11
Chromosome location	11q22.1
Summary	This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone a

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Show/Hide all (313)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046977	hsa-miR-221-3p	CLASH	23622248
MIRT367645	hsa-miR-138-5p	PAR-CLIP	21572407
MIRT367644	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT046977	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT508071	hsa-miR-4511	PAR-CLIP	21572407
MIRT508070	hsa-miR-4428	PAR-CLIP	21572407
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	21572407
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	21572407
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT367642	hsa-miR-28-5p	PAR-CLIP	21572407
MIRT367649	hsa-miR-3139	PAR-CLIP	21572407
MIRT367648	hsa-miR-708-5p	PAR-CLIP	21572407
MIRT508067	hsa-miR-885-5p	PAR-CLIP	21572407
MIRT508066	hsa-miR-93-3p	PAR-CLIP	21572407
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	21572407
MIRT367651	hsa-miR-4299	PAR-CLIP	21572407
MIRT508064	hsa-miR-3185	PAR-CLIP	21572407
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	21572407
MIRT508063	hsa-miR-6131	PAR-CLIP	21572407
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	21572407
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	21572407
MIRT367654	hsa-miR-6071	PAR-CLIP	21572407
MIRT508062	hsa-miR-587	PAR-CLIP	21572407
MIRT367645	hsa-miR-138-5p	PAR-CLIP	23446348
MIRT367644	hsa-miR-222-3p	PAR-CLIP	23446348
MIRT046977	hsa-miR-221-3p	PAR-CLIP	23446348
MIRT508071	hsa-miR-4511	PAR-CLIP	23446348
MIRT508070	hsa-miR-4428	PAR-CLIP	23446348
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	23446348
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	23446348
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	23446348
MIRT367642	hsa-miR-28-5p	PAR-CLIP	23446348
MIRT367649	hsa-miR-3139	PAR-CLIP	23446348
MIRT367648	hsa-miR-708-5p	PAR-CLIP	23446348
MIRT508067	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT508066	hsa-miR-93-3p	PAR-CLIP	23446348
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	23446348
MIRT367651	hsa-miR-4299	PAR-CLIP	23446348
MIRT508064	hsa-miR-3185	PAR-CLIP	23446348
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	23446348
MIRT508063	hsa-miR-6131	PAR-CLIP	23446348
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	23446348
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	23446348
MIRT367654	hsa-miR-6071	PAR-CLIP	23446348
MIRT508062	hsa-miR-587	PAR-CLIP	23446348
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT046977	hsa-miR-221-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367644	hsa-miR-222-3p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367642	hsa-miR-28-5p	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT367649	hsa-miR-3139	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT508064	hsa-miR-3185	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT367651	hsa-miR-4299	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508070	hsa-miR-4428	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT508071	hsa-miR-4511	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	26701625
MIRT508062	hsa-miR-587	PAR-CLIP	26701625
MIRT508062	hsa-miR-587	PAR-CLIP	26701625
MIRT508062	hsa-miR-587	PAR-CLIP	26701625
MIRT508062	hsa-miR-587	PAR-CLIP	26701625
MIRT508062	hsa-miR-587	PAR-CLIP	26701625
MIRT508062	hsa-miR-587	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT367654	hsa-miR-6071	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT508063	hsa-miR-6131	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT367648	hsa-miR-708-5p	PAR-CLIP	26701625
MIRT508067	hsa-miR-885-5p	PAR-CLIP	26701625
MIRT508067	hsa-miR-885-5p	PAR-CLIP	26701625
MIRT508067	hsa-miR-885-5p	PAR-CLIP	26701625
MIRT508067	hsa-miR-885-5p	PAR-CLIP	26701625
MIRT508067	hsa-miR-885-5p	PAR-CLIP	26701625
MIRT508067	hsa-miR-885-5p	PAR-CLIP	26701625
MIRT508067	hsa-miR-885-5p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT508066	hsa-miR-93-3p	PAR-CLIP	26701625
MIRT367645	hsa-miR-138-5p	PAR-CLIP	21572407
MIRT367644	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT046977	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT508071	hsa-miR-4511	PAR-CLIP	21572407
MIRT508070	hsa-miR-4428	PAR-CLIP	21572407
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	21572407
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	21572407
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT367642	hsa-miR-28-5p	PAR-CLIP	21572407
MIRT367649	hsa-miR-3139	PAR-CLIP	21572407
MIRT367648	hsa-miR-708-5p	PAR-CLIP	21572407
MIRT508067	hsa-miR-885-5p	PAR-CLIP	21572407
MIRT508066	hsa-miR-93-3p	PAR-CLIP	21572407
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	21572407
MIRT367651	hsa-miR-4299	PAR-CLIP	21572407
MIRT508064	hsa-miR-3185	PAR-CLIP	21572407
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	21572407
MIRT508063	hsa-miR-6131	PAR-CLIP	21572407
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	21572407
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	21572407
MIRT367654	hsa-miR-6071	PAR-CLIP	21572407
MIRT508062	hsa-miR-587	PAR-CLIP	21572407
MIRT367645	hsa-miR-138-5p	PAR-CLIP	23446348
MIRT367644	hsa-miR-222-3p	PAR-CLIP	23446348
MIRT046977	hsa-miR-221-3p	PAR-CLIP	23446348
MIRT508071	hsa-miR-4511	PAR-CLIP	23446348
MIRT508070	hsa-miR-4428	PAR-CLIP	23446348
MIRT508069	hsa-miR-3173-3p	PAR-CLIP	23446348
MIRT508068	hsa-miR-6891-5p	PAR-CLIP	23446348
MIRT367646	hsa-miR-376c-3p	PAR-CLIP	23446348
MIRT367642	hsa-miR-28-5p	PAR-CLIP	23446348
MIRT367649	hsa-miR-3139	PAR-CLIP	23446348
MIRT367648	hsa-miR-708-5p	PAR-CLIP	23446348
MIRT508067	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT508066	hsa-miR-93-3p	PAR-CLIP	23446348
MIRT367652	hsa-miR-3692-5p	PAR-CLIP	23446348
MIRT367651	hsa-miR-4299	PAR-CLIP	23446348
MIRT508064	hsa-miR-3185	PAR-CLIP	23446348
MIRT508065	hsa-miR-133a-5p	PAR-CLIP	23446348
MIRT508063	hsa-miR-6131	PAR-CLIP	23446348
MIRT367653	hsa-miR-4633-3p	PAR-CLIP	23446348
MIRT367655	hsa-miR-6500-5p	PAR-CLIP	23446348
MIRT367654	hsa-miR-6071	PAR-CLIP	23446348
MIRT508062	hsa-miR-587	PAR-CLIP	23446348
MIRT794904	hsa-miR-1228	CLIP-seq
MIRT794905	hsa-miR-138	CLIP-seq
MIRT794906	hsa-miR-221	CLIP-seq
MIRT794907	hsa-miR-222	CLIP-seq
MIRT794908	hsa-miR-329	CLIP-seq
MIRT794909	hsa-miR-338-3p	CLIP-seq
MIRT794910	hsa-miR-362-3p	CLIP-seq
MIRT794911	hsa-miR-376c	CLIP-seq
MIRT794912	hsa-miR-4302	CLIP-seq
MIRT794913	hsa-miR-4530	CLIP-seq
MIRT794914	hsa-miR-488	CLIP-seq
MIRT794915	hsa-miR-548aa	CLIP-seq
MIRT794916	hsa-miR-556-3p	CLIP-seq
MIRT794917	hsa-miR-582-5p	CLIP-seq
MIRT794918	hsa-miR-708	CLIP-seq
MIRT1934711	hsa-miR-1305	CLIP-seq
MIRT1934712	hsa-miR-4714-3p	CLIP-seq
MIRT2174435	hsa-miR-203	CLIP-seq
MIRT2174436	hsa-miR-3117-3p	CLIP-seq
MIRT2174437	hsa-miR-3123	CLIP-seq
MIRT2174438	hsa-miR-362-5p	CLIP-seq
MIRT2174439	hsa-miR-3919	CLIP-seq
MIRT2174440	hsa-miR-4520a-3p	CLIP-seq
MIRT2174441	hsa-miR-4756-3p	CLIP-seq
MIRT2174442	hsa-miR-500b	CLIP-seq
MIRT2174443	hsa-miR-545	CLIP-seq
MIRT2174444	hsa-miR-651	CLIP-seq
MIRT2384423	hsa-miR-3145-3p	CLIP-seq
MIRT2477989	hsa-miR-1183	CLIP-seq
MIRT2477990	hsa-miR-1272	CLIP-seq
MIRT2477991	hsa-miR-1322	CLIP-seq
MIRT2477992	hsa-miR-155	CLIP-seq
MIRT2477993	hsa-miR-2355-5p	CLIP-seq
MIRT2477994	hsa-miR-297	CLIP-seq
MIRT2477995	hsa-miR-3117-5p	CLIP-seq
MIRT2477996	hsa-miR-3149	CLIP-seq
MIRT2477997	hsa-miR-3529	CLIP-seq
MIRT2477998	hsa-miR-3679-3p	CLIP-seq
MIRT2477999	hsa-miR-3691-3p	CLIP-seq
MIRT2478000	hsa-miR-379	CLIP-seq
MIRT2478001	hsa-miR-382	CLIP-seq
MIRT2478002	hsa-miR-4252	CLIP-seq
MIRT2478003	hsa-miR-4312	CLIP-seq
MIRT2478004	hsa-miR-4451	CLIP-seq
MIRT2478005	hsa-miR-4633-5p	CLIP-seq
MIRT2478006	hsa-miR-4650-3p	CLIP-seq
MIRT2478007	hsa-miR-4659a-3p	CLIP-seq
MIRT2478008	hsa-miR-4659b-3p	CLIP-seq
MIRT2478009	hsa-miR-4703-3p	CLIP-seq
MIRT2478010	hsa-miR-532-5p	CLIP-seq
MIRT794917	hsa-miR-582-5p	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003085	Process	Negative regulation of systemic arterial blood pressure	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	24335996
GO:0005096	Function	GTPase activator activity	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IEA
GO:0090630	Process	Activation of GTPase activity	IDA	24335996
GO:1904694	Process	Negative regulation of vascular associated smooth muscle contraction	IEA

MIM	HGNC	e!Ensembl
615936	26545	ENSG00000165895

A6NI28

Protein name

Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42)

Protein function

May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16746	BAR_3	6 → 249		Domain
PF00169	PH	266 → 371	PH domain	Domain
PF00620	RhoGAP	396 → 549	RhoGAP domain	Domain
PF14604	SH3_9	823 → 872	Variant SH3 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly and selectively expressed in smooth muscle cells. {ECO:0000269|PubMed:24335996}.

Sequence

MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF
SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR
KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE
YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE
STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM
SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA
NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG
VNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIA
VKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTL
MRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLS
TGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKSG
GIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDLV
KKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCR
RLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSHELSFPQG
AIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL

Sequence length

874

Interactions

View interactions

	Reactome
			Rho GTPase cycle

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL ADENOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MASTOCYTOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Cancer of Nasopharynx	Nasopharyngeal Cancer	BEFREE	29936709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31277598	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	30940143		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conotruncal cardiac defects	Conotruncal cardiac defect	Pubtator	32710738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778, 30104761		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertension	Hypertension	Pubtator	30903111, 37175507	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertensive disease	Hypertension	GWASCAT_DG	21909115, 30487518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	GWASDB_DG	21909115		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	24335996, 28112683, 30903111		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of nasopharynx	Nasopharyngeal carcinoma	BEFREE	29936709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29936709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	29936709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	29936709	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Neoplasms	Nasopharyngeal carcinoma	Pubtator	29936709	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Niemann-Pick Disease, Type C	Niemann-Pick Disease	BEFREE	29936709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	37176017	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Retention	Urinary retention	Pubtator	39222669	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ARHGAP42 (Rho GTPase activating protein 42)