SESN3 (sestrin 3)

Gene

• Entrez ID: 143686
• Gene name: Sestrin 3
• Gene symbol: SESN3
• Synonyms (NCBI Gene): SEST3
• Chromosome: 11
• Chromosome location: 11q21
• Summary: This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO tr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016230	hsa-miR-590-3p	Sequencing	20371350
MIRT017124	hsa-miR-335-5p	Microarray	18185580
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT574441	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT565744	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT565745	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT565743	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT565742	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT565740	hsa-miR-496	PAR-CLIP	20371350
MIRT565741	hsa-miR-3153	PAR-CLIP	20371350
MIRT565739	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT565738	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT565737	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT565736	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT565735	hsa-miR-152-3p	PAR-CLIP	20371350
MIRT565734	hsa-miR-148b-3p	PAR-CLIP	20371350
MIRT565733	hsa-miR-148a-3p	PAR-CLIP	20371350
MIRT565732	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT565731	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT565730	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT565729	hsa-miR-3654	PAR-CLIP	20371350
MIRT565728	hsa-miR-1243	PAR-CLIP	20371350
MIRT565727	hsa-miR-4519	PAR-CLIP	20371350
MIRT565726	hsa-miR-5191	PAR-CLIP	20371350
MIRT565725	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT565724	hsa-miR-3657	PAR-CLIP	20371350
MIRT565723	hsa-miR-4669	PAR-CLIP	20371350
MIRT565722	hsa-miR-592	PAR-CLIP	20371350
MIRT468479	hsa-miR-1279	PAR-CLIP	20371350
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	20371350
MIRT468478	hsa-miR-569	PAR-CLIP	20371350
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT468474	hsa-miR-337-3p	PAR-CLIP	20371350
MIRT468473	hsa-miR-202-5p	PAR-CLIP	20371350
MIRT468472	hsa-miR-2053	PAR-CLIP	20371350
MIRT468471	hsa-miR-3685	PAR-CLIP	20371350
MIRT468470	hsa-miR-384	PAR-CLIP	20371350
MIRT565721	hsa-miR-606	PAR-CLIP	20371350
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565719	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT565718	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT565709	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT565707	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT565706	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT565705	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT565704	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT565703	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT565702	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT565701	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT565700	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT565699	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT565698	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT565697	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT565696	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT565695	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT565694	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT565693	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT565692	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT565691	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT565690	hsa-miR-3143	PAR-CLIP	20371350
MIRT565689	hsa-miR-4672	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT505698	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561621	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT561620	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT561619	hsa-miR-6830-5p	PAR-CLIP	20371350
MIRT561618	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT561617	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT561616	hsa-miR-106a-3p	PAR-CLIP	20371350
MIRT561615	hsa-miR-4503	PAR-CLIP	20371350
MIRT561614	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT561613	hsa-miR-507	PAR-CLIP	20371350
MIRT561612	hsa-miR-557	PAR-CLIP	20371350
MIRT561611	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT542682	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT542681	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT542680	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT542679	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT542678	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT542677	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542676	hsa-miR-6856-3p	PAR-CLIP	21572407
MIRT542675	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT542673	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT542674	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT542671	hsa-miR-4317	PAR-CLIP	21572407
MIRT542672	hsa-miR-5589-3p	PAR-CLIP	21572407
MIRT505702	hsa-miR-133b	PAR-CLIP	23446348
MIRT505701	hsa-miR-133a-3p	PAR-CLIP	23446348
MIRT505700	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT505699	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT505698	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT505697	hsa-miR-4712-3p	PAR-CLIP	23446348
MIRT505696	hsa-miR-622	PAR-CLIP	23446348
MIRT505695	hsa-miR-581	PAR-CLIP	23446348
MIRT505694	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT505693	hsa-miR-3148	PAR-CLIP	23446348
MIRT505692	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT505691	hsa-miR-5587-5p	PAR-CLIP	23446348
MIRT468490	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468489	hsa-miR-3159	PAR-CLIP	23592263
MIRT468488	hsa-miR-5190	PAR-CLIP	23592263
MIRT468487	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468486	hsa-miR-3152-3p	PAR-CLIP	23592263
MIRT468485	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT468484	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT468483	hsa-miR-4276	PAR-CLIP	23592263
MIRT468482	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT468481	hsa-miR-4436b-5p	PAR-CLIP	23592263
MIRT468479	hsa-miR-1279	PAR-CLIP	23592263
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	23592263
MIRT468478	hsa-miR-569	PAR-CLIP	23592263
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT468474	hsa-miR-337-3p	PAR-CLIP	23592263
MIRT468473	hsa-miR-202-5p	PAR-CLIP	23592263
MIRT468472	hsa-miR-2053	PAR-CLIP	23592263
MIRT468471	hsa-miR-3685	PAR-CLIP	23592263
MIRT468470	hsa-miR-384	PAR-CLIP	23592263
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT574441	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT565744	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT565745	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT565743	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT565742	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT565740	hsa-miR-496	PAR-CLIP	20371350
MIRT565741	hsa-miR-3153	PAR-CLIP	20371350
MIRT565739	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT565738	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT565737	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT565736	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT565735	hsa-miR-152-3p	PAR-CLIP	20371350
MIRT565734	hsa-miR-148b-3p	PAR-CLIP	20371350
MIRT565733	hsa-miR-148a-3p	PAR-CLIP	20371350
MIRT565732	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT565731	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT565730	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT565729	hsa-miR-3654	PAR-CLIP	20371350
MIRT565728	hsa-miR-1243	PAR-CLIP	20371350
MIRT565727	hsa-miR-4519	PAR-CLIP	20371350
MIRT565726	hsa-miR-5191	PAR-CLIP	20371350
MIRT565725	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT565724	hsa-miR-3657	PAR-CLIP	20371350
MIRT565723	hsa-miR-4669	PAR-CLIP	20371350
MIRT565722	hsa-miR-592	PAR-CLIP	20371350
MIRT468479	hsa-miR-1279	PAR-CLIP	20371350
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	20371350
MIRT468478	hsa-miR-569	PAR-CLIP	20371350
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT468474	hsa-miR-337-3p	PAR-CLIP	20371350
MIRT468473	hsa-miR-202-5p	PAR-CLIP	20371350
MIRT468472	hsa-miR-2053	PAR-CLIP	20371350
MIRT468471	hsa-miR-3685	PAR-CLIP	20371350
MIRT468470	hsa-miR-384	PAR-CLIP	20371350
MIRT565721	hsa-miR-606	PAR-CLIP	20371350
MIRT565720	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT565719	hsa-miR-218-2-3p	PAR-CLIP	20371350
MIRT565718	hsa-miR-758-5p	PAR-CLIP	20371350
MIRT565717	hsa-miR-4491	PAR-CLIP	20371350
MIRT565716	hsa-miR-4657	PAR-CLIP	20371350
MIRT565715	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT565714	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT565713	hsa-miR-219a-1-3p	PAR-CLIP	20371350
MIRT565712	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT565711	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT565710	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT565709	hsa-miR-584-5p	PAR-CLIP	20371350
MIRT565708	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT565707	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT565706	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT565705	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT565704	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT565703	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT565702	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT565701	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT565700	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT565699	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT565698	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT565697	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT565696	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT565695	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT565694	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT565693	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT565692	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT565691	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT565690	hsa-miR-3143	PAR-CLIP	20371350
MIRT565689	hsa-miR-4672	PAR-CLIP	20371350
MIRT561622	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT505698	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT561621	hsa-miR-409-3p	PAR-CLIP	20371350
MIRT561620	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT561619	hsa-miR-6830-5p	PAR-CLIP	20371350
MIRT561618	hsa-miR-6792-5p	PAR-CLIP	20371350
MIRT561617	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT561616	hsa-miR-106a-3p	PAR-CLIP	20371350
MIRT561615	hsa-miR-4503	PAR-CLIP	20371350
MIRT561614	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT561613	hsa-miR-507	PAR-CLIP	20371350
MIRT561612	hsa-miR-557	PAR-CLIP	20371350
MIRT561611	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT542682	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT542681	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT542680	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT542679	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT542678	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT542677	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT542676	hsa-miR-6856-3p	PAR-CLIP	21572407
MIRT542675	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT542673	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT542674	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT542671	hsa-miR-4317	PAR-CLIP	21572407
MIRT542672	hsa-miR-5589-3p	PAR-CLIP	21572407
MIRT505702	hsa-miR-133b	PAR-CLIP	23446348
MIRT505701	hsa-miR-133a-3p	PAR-CLIP	23446348
MIRT505700	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT505699	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT505698	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT505697	hsa-miR-4712-3p	PAR-CLIP	23446348
MIRT505696	hsa-miR-622	PAR-CLIP	23446348
MIRT505695	hsa-miR-581	PAR-CLIP	23446348
MIRT505694	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT505693	hsa-miR-3148	PAR-CLIP	23446348
MIRT505692	hsa-miR-6801-5p	PAR-CLIP	23446348
MIRT505691	hsa-miR-5587-5p	PAR-CLIP	23446348
MIRT468490	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468489	hsa-miR-3159	PAR-CLIP	23592263
MIRT468488	hsa-miR-5190	PAR-CLIP	23592263
MIRT468487	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468486	hsa-miR-3152-3p	PAR-CLIP	23592263
MIRT468485	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT468484	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT468483	hsa-miR-4276	PAR-CLIP	23592263
MIRT468482	hsa-miR-6509-3p	PAR-CLIP	23592263
MIRT468481	hsa-miR-4436b-5p	PAR-CLIP	23592263
MIRT468479	hsa-miR-1279	PAR-CLIP	23592263
MIRT468480	hsa-miR-3927-5p	PAR-CLIP	23592263
MIRT468478	hsa-miR-569	PAR-CLIP	23592263
MIRT468477	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT468476	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT468475	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT468474	hsa-miR-337-3p	PAR-CLIP	23592263
MIRT468473	hsa-miR-202-5p	PAR-CLIP	23592263
MIRT468472	hsa-miR-2053	PAR-CLIP	23592263
MIRT468471	hsa-miR-3685	PAR-CLIP	23592263
MIRT468470	hsa-miR-384	PAR-CLIP	23592263
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT444204	hsa-miR-3680-5p	PAR-CLIP	22100165
MIRT444203	hsa-miR-576-3p	PAR-CLIP	22100165
MIRT444202	hsa-miR-205-3p	PAR-CLIP	22100165
MIRT444201	hsa-miR-1245b-3p	PAR-CLIP	22100165
MIRT444200	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT444199	hsa-miR-8068	PAR-CLIP	22100165
MIRT444197	hsa-miR-5100	PAR-CLIP	22100165
MIRT444198	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT444196	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT756307	hsa-miR-675-3p	Luciferase reporter assay, Western blotting, qRT-PCR	34409922
MIRT1339372	hsa-miR-25	CLIP-seq
MIRT1339373	hsa-miR-32	CLIP-seq
MIRT1339374	hsa-miR-323-3p	CLIP-seq
MIRT1339375	hsa-miR-363	CLIP-seq
MIRT1339376	hsa-miR-367	CLIP-seq
MIRT1339377	hsa-miR-92a	CLIP-seq
MIRT1339378	hsa-miR-92b	CLIP-seq
MIRT1339372	hsa-miR-25	CLIP-seq
MIRT1339373	hsa-miR-32	CLIP-seq
MIRT1339374	hsa-miR-323-3p	CLIP-seq
MIRT1339375	hsa-miR-363	CLIP-seq
MIRT1339376	hsa-miR-367	CLIP-seq
MIRT1339377	hsa-miR-92a	CLIP-seq
MIRT1339378	hsa-miR-92b	CLIP-seq
MIRT1339372	hsa-miR-25	CLIP-seq
MIRT1339373	hsa-miR-32	CLIP-seq
MIRT1339374	hsa-miR-323-3p	CLIP-seq
MIRT1339375	hsa-miR-363	CLIP-seq
MIRT1339376	hsa-miR-367	CLIP-seq
MIRT1339377	hsa-miR-92a	CLIP-seq
MIRT1339378	hsa-miR-92b	CLIP-seq
MIRT2100368	hsa-miR-146a	CLIP-seq
MIRT2100369	hsa-miR-146b-5p	CLIP-seq
MIRT2100370	hsa-miR-3117-5p	CLIP-seq
MIRT2100371	hsa-miR-3123	CLIP-seq
MIRT2100372	hsa-miR-3925-5p	CLIP-seq
MIRT2100373	hsa-miR-4427	CLIP-seq
MIRT2100374	hsa-miR-4704-5p	CLIP-seq
MIRT2100375	hsa-miR-4775	CLIP-seq
MIRT2325126	hsa-miR-3074-3p	CLIP-seq
MIRT2325127	hsa-miR-4719	CLIP-seq
MIRT2394246	hsa-miR-1262	CLIP-seq
MIRT2394247	hsa-miR-3189-3p	CLIP-seq
MIRT2394248	hsa-miR-425	CLIP-seq
MIRT2394249	hsa-miR-4701-3p	CLIP-seq
MIRT2394250	hsa-miR-502-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HSF1	Unknown	23388456

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25263562, 26449471
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	25263562
GO:0005737	Component	Cytoplasm	IEA
GO:0016239	Process	Positive regulation of macroautophagy	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016684	Function	Oxidoreductase activity, acting on peroxide as acceptor	IBA
GO:0031932	Component	TORC2 complex	IEA
GO:0032868	Process	Response to insulin	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IMP	25263562
GO:0038203	Process	TORC2 signaling	IEA
GO:0042149	Process	Cellular response to glucose starvation	IEA
GO:0042149	Process	Cellular response to glucose starvation	IMP	25263562
GO:0042593	Process	Glucose homeostasis	IEA
GO:0046626	Process	Regulation of insulin receptor signaling pathway	IEA
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0061700	Component	GATOR2 complex	IDA	25263562, 26449471
GO:0070728	Function	L-leucine binding	IBA
GO:0071230	Process	Cellular response to amino acid stimulus	IEA
GO:0071233	Process	Cellular response to L-leucine	IBA
GO:1901031	Process	Regulation of response to reactive oxygen species	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IBA
GO:1904262	Process	Negative regulation of TORC1 signaling	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	25263562
GO:1990253	Process	Cellular response to leucine starvation	IBA

Other IDs

• MIM: 607768
• HGNC: 23060
• e!Ensembl: ENSG00000149212

Protein

• UniProt ID: P58005
• Protein name: Sestrin-3 (EC 1.11.1.-)
• Protein function: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04636	PA26	39 → 491	PA26 p53-induced protein (sestrin)	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12607115}.
• Sequence:

  MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTN
  FLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQ
  CSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKT
  GENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLAND
  NNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFV
  VSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHG
  FSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDY
  DYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAEL
  LYALRAITRHLT

• Sequence length: 492

Pathways

KEGG:

p53 signaling pathway
Longevity regulating pathway

Reactome:

TP53 Regulates Metabolic Genes

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	31217489	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	39930543	Associate	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	28397812		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	28397812	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34409922, 38305606	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	27881463		★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Carotid artery stenosis	Pubtator	32626541	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25973791	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24129397	Stimulate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	24129397		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	31073887	Associate	★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	24833709		★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	31215672		★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	31215672		★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	33082554	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	32626541	Stimulate	★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral Disc Degeneration	BEFREE	28430387		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	36703207	Associate	★☆☆☆☆ Found in Text Mining only
Lewy Body Disease	Lewy Body Disease	BEFREE	29966750		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31351129		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	27881463	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	27881463		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	24763052		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17504987		★☆☆☆☆ Found in Text Mining only
Mycosis Fungoides	Mycosis fungoides	Pubtator	36400759	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31351129		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	28869600, 31591479	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	27881463		★☆☆☆☆ Found in Text Mining only
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	BEFREE	31215672		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29966750, 31217489		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	31217489	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	24763052		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Steatohepatitis	Fatty Liver	BEFREE	24833709		★☆☆☆☆ Found in Text Mining only