Gene Gene information from NCBI Gene database.
Entrez ID 142679
Gene name Dual specificity phosphatase 19
Gene symbol DUSP19
Synonyms (NCBI Gene)
DUSP17LMWDSP3SKRP1TS-DSP1
Chromosome 2
Chromosome location 2q32.1
Summary Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues.
miRNA miRNA information provided by mirtarbase database.
610
miRTarBase ID miRNA Experiments Reference
MIRT681235 hsa-miR-320e HITS-CLIP 23706177
MIRT457325 hsa-miR-1910-3p HITS-CLIP 23706177
MIRT457324 hsa-miR-6511a-5p HITS-CLIP 23706177
MIRT457323 hsa-miR-4257 HITS-CLIP 23706177
MIRT681234 hsa-miR-3192-5p HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IEA
GO:0004860 Function Protein kinase inhibitor activity ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611437 18894 ENSG00000162999
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WTR2
Protein name Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating pho
Protein function Has a dual specificity toward Ser/Thr and Tyr-containing proteins.
PDB 3S4E , 4D3P , 4D3Q , 4D3R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 73 203 Dual specificity phosphatase, catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest. {ECO:0000269|PubMed:12479873}.
Sequence
Sequence length 217
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Cone-Rod Dystrophy 2 Cone-rod dystrophy BEFREE 31813339
★☆☆☆☆
Found in Text Mining only
Degenerative polyarthritis Arthritis BEFREE 26751999
★☆☆☆☆
Found in Text Mining only