ADPRH (ADP-ribosylarginine hydrolase)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 141 |
| Gene name | ADP-ribosylarginine hydrolase |
| Gene symbol | ADPRH |
| Synonyms (NCBI Gene) |
ARH1hARH1
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| Chromosome | 3 |
| Chromosome location | 3q13.33 |
| Summary | The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternative |
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miRNA
miRNA information provided by mirtarbase database.
575
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P54922 | ||||||||||
| Protein name | ADP-ribosylhydrolase ARH1 (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ([Protein ADP-ribosylarginine] hydrolase) (ADP-ribosylarginine hydrolase) (hARH1) | ||||||||||
| Protein function | Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. | ||||||||||
| PDB | 3HFW , 6G28 , 6G2A , 6IUX | ||||||||||
| Family and domains |
Pfam
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| Sequence | |||||||||||
| Sequence length | 357 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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