Gene Gene information from NCBI Gene database.
Entrez ID 141
Gene name ADP-ribosylarginine hydrolase
Gene symbol ADPRH
Synonyms (NCBI Gene)
ARH1hARH1
Chromosome 3
Chromosome location 3q13.33
Summary The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternative
miRNA miRNA information provided by mirtarbase database.
575
miRTarBase ID miRNA Experiments Reference
MIRT022142 hsa-miR-124-3p Microarray 18668037
MIRT609547 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT609545 hsa-miR-4287 HITS-CLIP 23824327
MIRT609544 hsa-miR-4685-3p HITS-CLIP 23824327
MIRT609543 hsa-miR-7110-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 19407395, 30472116
GO:0000287 Function Magnesium ion binding IEA
GO:0003875 Function ADP-ribosylarginine hydrolase activity IDA 30472116
GO:0003875 Function ADP-ribosylarginine hydrolase activity IEA
GO:0003875 Function ADP-ribosylarginine hydrolase activity IMP 8349667
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603081 269 ENSG00000144843
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P54922
Protein name ADP-ribosylhydrolase ARH1 (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ([Protein ADP-ribosylarginine] hydrolase) (ADP-ribosylarginine hydrolase) (hARH1)
Protein function Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
PDB 3HFW , 6G28 , 6G2A , 6IUX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03747 ADP_ribosyl_GH 6 326 ADP-ribosylglycohydrolase Family
Sequence
Sequence length 357
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
OSTEOARTHRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VITILIGO GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 25077680
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy BEFREE 30429362
★☆☆☆☆
Found in Text Mining only
Epithelial ovarian cancer Ovarian cancer BEFREE 25077680
★☆☆☆☆
Found in Text Mining only
Hypercholesterolemia Hypercholesterolemia BEFREE 11897284
★☆☆☆☆
Found in Text Mining only
HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE Hypercholesterolemia BEFREE 12464675, 19477448, 29153781
★☆☆☆☆
Found in Text Mining only
Hypercholesterolemia, Familial Hypercholesterolemia BEFREE 29153781
★☆☆☆☆
Found in Text Mining only
Hyperlipoproteinemia Type IIa Hyperlipoproteinemia BEFREE 29153781
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 29228209, 30267646
★☆☆☆☆
Found in Text Mining only