Gene Gene information from NCBI Gene database.
Entrez ID 140809
Gene name Sulfiredoxin 1
Gene symbol SRXN1
Synonyms (NCBI Gene)
C20orf139Npn3SRXSRX1
Chromosome 20
Chromosome location 20p13
miRNA miRNA information provided by mirtarbase database.
426
miRTarBase ID miRNA Experiments Reference
MIRT003772 hsa-miR-1-3p Luciferase reporter assayMicroarray 15685193
MIRT003772 hsa-miR-1-3p Microarray 15685193
MIRT003772 hsa-miR-1-3p Microarray 18668037
MIRT027877 hsa-miR-96-5p Sequencing 20371350
MIRT691917 hsa-miR-3974 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005515 Function Protein binding IPI 18172504
GO:0005524 Function ATP binding IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617583 16132 ENSG00000271303
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BYN0
Protein name Sulfiredoxin-1 (EC 1.8.98.2)
Protein function Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625). Does not act on PRDX5 or PRDX6 (PubMed:154481
PDB 1XW3 , 1XW4 , 1YZS , 2B6F , 2RII , 3CYI , 3HY2 , 7LJ1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02195 ParBc 42 133 ParB-like nuclease domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in kidney, lung, spleen and thymus. {ECO:0000269|PubMed:15448164}.
Sequence
Sequence length 137
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Atrophy Atrophy Pubtator 35242306 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 22964583
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 30863778, 31000628, 35965686 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 32955798, 33771191 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 21595034 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 28351308 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 35965686 Associate
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Cerebral Infarction BEFREE 28552673
★☆☆☆☆
Found in Text Mining only
Cerebrovascular Disorders Cerebrovascular Disorders BEFREE 27226772
★☆☆☆☆
Found in Text Mining only
Cerebrovascular Disorders Cerebrovascular disorder Pubtator 27226772 Associate
★☆☆☆☆
Found in Text Mining only