Gene Gene information from NCBI Gene database.
Entrez ID 1408
Gene name Cryptochrome circadian regulator 2
Gene symbol CRY2
Synonyms (NCBI Gene)
HCRY2PHLL2
Chromosome 11
Chromosome location 11p11.2
Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulatio
miRNA miRNA information provided by mirtarbase database.
1223
miRTarBase ID miRNA Experiments Reference
MIRT019611 hsa-miR-340-5p Sequencing 20371350
MIRT020147 hsa-miR-130b-3p Sequencing 20371350
MIRT028006 hsa-miR-93-5p Sequencing 20371350
MIRT028213 hsa-miR-33a-5p Sequencing 20371350
MIRT037929 hsa-miR-532-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Transcription factor Regulation Reference
ARNTL Activation 22750052
ARNTL Unknown 17660446
CLOCK Activation 22750052
CLOCK Unknown 17660446
NPAS2 Unknown 17660446
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
69
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 12397359, 14672706, 15147242
GO:0000166 Function Nucleotide binding IEA
GO:0000719 Process Photoreactive repair IDA 12627958
GO:0000976 Function Transcription cis-regulatory region binding IEA
GO:0000976 Function Transcription cis-regulatory region binding ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603732 2385 ENSG00000121671
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q49AN0
Protein name Cryptochrome-2
Protein function Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in g
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00875 DNA_photolyase 24 187 DNA photolyase Domain
PF03441 FAD_binding_7 305 505 FAD binding domain of DNA photolyase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest level
Sequence
Sequence length 593
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Circadian rhythm  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEPRESSIVE DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MENTAL DEPRESSION Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 34142702 Associate
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety disorder Pubtator 38102312 Associate
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety Disorder BEFREE 23951166
★☆☆☆☆
Found in Text Mining only
Attention Deficit and Disruptive Behavior Disorders Attention deficit hyperactivity disorder Pubtator 31708917 Inhibit
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder PSYGENET_DG 16528748, 20072116, 20856823, 22538398
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar disorder Pubtator 20195522, 20856823, 23951166, 25989161 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar Disorder BEFREE 20856823
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma BEFREE 20233903, 20334671, 20978934, 25229211, 25740058, 28579430, 29455641, 31358835
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 20233903, 25485508, 25740058, 29958276, 31358835, 31739444, 39193850 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 31358835 Stimulate
★☆☆☆☆
Found in Text Mining only