Gene Gene information from NCBI Gene database.
Entrez ID 140707
Gene name BRI3 binding protein
Gene symbol BRI3BP
Synonyms (NCBI Gene)
BNAS1HCCR-1HCCR-2HCCRBP-1HCCRBP-3KG19
Chromosome 12
Chromosome location 12q24.31
miRNA miRNA information provided by mirtarbase database.
1338
miRTarBase ID miRNA Experiments Reference
MIRT001380 hsa-miR-1-3p pSILAC 18668040
MIRT021031 hsa-miR-155-5p Proteomics 18668040
MIRT023337 hsa-miR-122-5p Microarray 17612493
MIRT001380 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT001380 hsa-miR-1-3p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11860200, 17943721, 30983867, 33112233
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IBA
GO:0005739 Component Mitochondrion IDA 17943721
GO:0005739 Component Mitochondrion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615627 14251 ENSG00000184992
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WY22
Protein name BRI3-binding protein (I3-binding protein) (Cervical cancer 1 proto-oncogene-binding protein KG19) (HCCRBP-1)
Protein function Involved in tumorigenesis and may function by stabilizing p53/TP53.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14965 BRI3BP 49 239 Family
Tissue specificity TISSUE SPECIFICITY: Most abundantly expressed in brain, liver and kidney (PubMed:11860200). Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas (PubMed:17943721). {ECO:0000269|PubMed:11860200, ECO:0000269|PubMed:17943721}.
Sequence
Sequence length 251
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 14691448, 31424657
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 12879013
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 21796456
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 14691448, 17943721, 22851403, 31424657
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of liver Liver Cancer BEFREE 21796456
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of pancreas Pancreatic cancer BEFREE 20423485
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of stomach Stomach Neoplasms BEFREE 31293658
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 12879013, 20591135, 21796456
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 12879013, 17943721, 22851403, 31293658
★☆☆☆☆
Found in Text Mining only
Pancreatic carcinoma Pancreatic carcinoma BEFREE 20423485
★☆☆☆☆
Found in Text Mining only