ASB7 (ankyrin repeat and SOCS box containing 7)

Gene

• Entrez ID: 140460
• Gene name: Ankyrin repeat and SOCS box containing 7
• Gene symbol: ASB7
• Synonyms (NCBI Gene): -
• Chromosome: 15
• Chromosome location: 15q26.3
• Summary: The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-bin

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT710636	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT710635	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT710634	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT710633	hsa-miR-4308	HITS-CLIP	19536157
MIRT710632	hsa-miR-4292	HITS-CLIP	19536157
MIRT710631	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT710630	hsa-miR-3927-5p	HITS-CLIP	19536157
MIRT710629	hsa-miR-5193	HITS-CLIP	19536157
MIRT710628	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT710627	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT710626	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT710625	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT710624	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT710623	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT496870	hsa-miR-580-5p	PAR-CLIP	22291592
MIRT496869	hsa-miR-6512-5p	PAR-CLIP	22291592
MIRT496868	hsa-miR-9-3p	PAR-CLIP	22291592
MIRT710636	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT710635	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT710634	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT710633	hsa-miR-4308	HITS-CLIP	19536157
MIRT710632	hsa-miR-4292	HITS-CLIP	19536157
MIRT710631	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT710630	hsa-miR-3927-5p	HITS-CLIP	19536157
MIRT710629	hsa-miR-5193	HITS-CLIP	19536157
MIRT710628	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT710627	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT710626	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT710625	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT710624	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT710623	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT496870	hsa-miR-580-5p	PAR-CLIP	22291592
MIRT496869	hsa-miR-6512-5p	PAR-CLIP	22291592
MIRT496868	hsa-miR-9-3p	PAR-CLIP	22291592
MIRT802472	hsa-miR-1178	CLIP-seq
MIRT802473	hsa-miR-1193	CLIP-seq
MIRT802474	hsa-miR-1205	CLIP-seq
MIRT802475	hsa-miR-1243	CLIP-seq
MIRT802476	hsa-miR-128	CLIP-seq
MIRT802477	hsa-miR-1286	CLIP-seq
MIRT802478	hsa-miR-1290	CLIP-seq
MIRT802479	hsa-miR-132	CLIP-seq
MIRT802480	hsa-miR-1470	CLIP-seq
MIRT802481	hsa-miR-15a	CLIP-seq
MIRT802482	hsa-miR-15b	CLIP-seq
MIRT802483	hsa-miR-16	CLIP-seq
MIRT802484	hsa-miR-193a-3p	CLIP-seq
MIRT802485	hsa-miR-193b	CLIP-seq
MIRT802486	hsa-miR-195	CLIP-seq
MIRT802487	hsa-miR-1976	CLIP-seq
MIRT802488	hsa-miR-2110	CLIP-seq
MIRT802489	hsa-miR-212	CLIP-seq
MIRT802490	hsa-miR-224	CLIP-seq
MIRT802491	hsa-miR-2467-3p	CLIP-seq
MIRT802492	hsa-miR-27a	CLIP-seq
MIRT802493	hsa-miR-27b	CLIP-seq
MIRT802494	hsa-miR-3120-3p	CLIP-seq
MIRT802495	hsa-miR-3128	CLIP-seq
MIRT802496	hsa-miR-3150a-3p	CLIP-seq
MIRT802497	hsa-miR-3152-3p	CLIP-seq
MIRT802498	hsa-miR-3160-5p	CLIP-seq
MIRT802499	hsa-miR-3167	CLIP-seq
MIRT802500	hsa-miR-3654	CLIP-seq
MIRT802501	hsa-miR-3663-3p	CLIP-seq
MIRT802502	hsa-miR-3920	CLIP-seq
MIRT802503	hsa-miR-3942-5p	CLIP-seq
MIRT802504	hsa-miR-410	CLIP-seq
MIRT802505	hsa-miR-424	CLIP-seq
MIRT802506	hsa-miR-4257	CLIP-seq
MIRT802507	hsa-miR-4260	CLIP-seq
MIRT802508	hsa-miR-4265	CLIP-seq
MIRT802509	hsa-miR-4277	CLIP-seq
MIRT802510	hsa-miR-4296	CLIP-seq
MIRT802511	hsa-miR-4302	CLIP-seq
MIRT802512	hsa-miR-4322	CLIP-seq
MIRT802513	hsa-miR-4432	CLIP-seq
MIRT802514	hsa-miR-4446-5p	CLIP-seq
MIRT802515	hsa-miR-4450	CLIP-seq
MIRT802516	hsa-miR-4477a	CLIP-seq
MIRT802517	hsa-miR-450b-3p	CLIP-seq
MIRT802518	hsa-miR-4653-3p	CLIP-seq
MIRT802519	hsa-miR-4666-5p	CLIP-seq
MIRT802520	hsa-miR-4667-3p	CLIP-seq
MIRT802521	hsa-miR-4701-5p	CLIP-seq
MIRT802522	hsa-miR-4703-5p	CLIP-seq
MIRT802523	hsa-miR-4704-5p	CLIP-seq
MIRT802524	hsa-miR-4720-5p	CLIP-seq
MIRT802525	hsa-miR-4722-5p	CLIP-seq
MIRT802526	hsa-miR-4733-3p	CLIP-seq
MIRT802527	hsa-miR-4756-3p	CLIP-seq
MIRT802528	hsa-miR-4762-3p	CLIP-seq
MIRT802529	hsa-miR-4763-5p	CLIP-seq
MIRT802530	hsa-miR-4799-3p	CLIP-seq
MIRT802531	hsa-miR-483-3p	CLIP-seq
MIRT802532	hsa-miR-495	CLIP-seq
MIRT802533	hsa-miR-497	CLIP-seq
MIRT802534	hsa-miR-509-3p	CLIP-seq
MIRT802535	hsa-miR-513a-3p	CLIP-seq
MIRT802536	hsa-miR-513a-5p	CLIP-seq
MIRT802537	hsa-miR-545	CLIP-seq
MIRT802538	hsa-miR-548aa	CLIP-seq
MIRT802539	hsa-miR-570	CLIP-seq
MIRT802540	hsa-miR-588	CLIP-seq
MIRT802541	hsa-miR-603	CLIP-seq
MIRT802542	hsa-miR-604	CLIP-seq
MIRT802543	hsa-miR-647	CLIP-seq
MIRT802544	hsa-miR-7	CLIP-seq
MIRT802545	hsa-miR-759	CLIP-seq
MIRT802546	hsa-miR-769-3p	CLIP-seq
MIRT802547	hsa-miR-876-5p	CLIP-seq
MIRT1936905	hsa-miR-1246	CLIP-seq
MIRT1936906	hsa-miR-208a	CLIP-seq
MIRT1936907	hsa-miR-208b	CLIP-seq
MIRT1936908	hsa-miR-3117-5p	CLIP-seq
MIRT802496	hsa-miR-3150a-3p	CLIP-seq
MIRT1936909	hsa-miR-340	CLIP-seq
MIRT1936910	hsa-miR-3622b-5p	CLIP-seq
MIRT1936911	hsa-miR-3650	CLIP-seq
MIRT1936912	hsa-miR-3667-5p	CLIP-seq
MIRT1936913	hsa-miR-3676	CLIP-seq
MIRT1936914	hsa-miR-3978	CLIP-seq
MIRT802504	hsa-miR-410	CLIP-seq
MIRT1936915	hsa-miR-4318	CLIP-seq
MIRT1936916	hsa-miR-4470	CLIP-seq
MIRT1936917	hsa-miR-4691-5p	CLIP-seq
MIRT1936918	hsa-miR-4693-5p	CLIP-seq
MIRT1936919	hsa-miR-4800-3p	CLIP-seq
MIRT1936920	hsa-miR-487a	CLIP-seq
MIRT1936921	hsa-miR-490-5p	CLIP-seq
MIRT1936922	hsa-miR-498	CLIP-seq
MIRT1936923	hsa-miR-499-5p	CLIP-seq
MIRT1936924	hsa-miR-548al	CLIP-seq
MIRT1936925	hsa-miR-602	CLIP-seq
MIRT802545	hsa-miR-759	CLIP-seq
MIRT1936926	hsa-miR-892a	CLIP-seq
MIRT2176717	hsa-miR-1273d	CLIP-seq
MIRT2176718	hsa-miR-129-3p	CLIP-seq
MIRT2176719	hsa-miR-1299	CLIP-seq
MIRT802481	hsa-miR-15a	CLIP-seq
MIRT802482	hsa-miR-15b	CLIP-seq
MIRT802483	hsa-miR-16	CLIP-seq
MIRT2176720	hsa-miR-194	CLIP-seq
MIRT802486	hsa-miR-195	CLIP-seq
MIRT2176721	hsa-miR-19a	CLIP-seq
MIRT2176722	hsa-miR-19b	CLIP-seq
MIRT802490	hsa-miR-224	CLIP-seq
MIRT2176723	hsa-miR-298	CLIP-seq
MIRT1936908	hsa-miR-3117-5p	CLIP-seq
MIRT2176724	hsa-miR-3194-3p	CLIP-seq
MIRT1936913	hsa-miR-3676	CLIP-seq
MIRT802503	hsa-miR-3942-5p	CLIP-seq
MIRT802505	hsa-miR-424	CLIP-seq
MIRT2176725	hsa-miR-4420	CLIP-seq
MIRT2176726	hsa-miR-4434	CLIP-seq
MIRT1936916	hsa-miR-4470	CLIP-seq
MIRT2176727	hsa-miR-4502	CLIP-seq
MIRT2176728	hsa-miR-4516	CLIP-seq
MIRT2176729	hsa-miR-4652-3p	CLIP-seq
MIRT2176730	hsa-miR-4690-3p	CLIP-seq
MIRT2176731	hsa-miR-4693-3p	CLIP-seq
MIRT802522	hsa-miR-4703-5p	CLIP-seq
MIRT2176732	hsa-miR-4712-3p	CLIP-seq
MIRT2176733	hsa-miR-4719	CLIP-seq
MIRT2176734	hsa-miR-4760-3p	CLIP-seq
MIRT802528	hsa-miR-4762-3p	CLIP-seq
MIRT2176735	hsa-miR-4775	CLIP-seq
MIRT2176736	hsa-miR-4782-5p	CLIP-seq
MIRT1936919	hsa-miR-4800-3p	CLIP-seq
MIRT1936920	hsa-miR-487a	CLIP-seq
MIRT802533	hsa-miR-497	CLIP-seq
MIRT2176737	hsa-miR-499-3p	CLIP-seq
MIRT2176738	hsa-miR-499a-3p	CLIP-seq
MIRT2176739	hsa-miR-508-5p	CLIP-seq
MIRT2176740	hsa-miR-516b	CLIP-seq
MIRT1936924	hsa-miR-548al	CLIP-seq
MIRT2176741	hsa-miR-579	CLIP-seq
MIRT2176742	hsa-miR-590-3p	CLIP-seq
MIRT1936925	hsa-miR-602	CLIP-seq
MIRT2176743	hsa-miR-664	CLIP-seq
MIRT2176744	hsa-miR-665	CLIP-seq
MIRT802545	hsa-miR-759	CLIP-seq
MIRT2176745	hsa-miR-875-3p	CLIP-seq
MIRT2176746	hsa-miR-892b	CLIP-seq
MIRT2384523	hsa-miR-942	CLIP-seq
MIRT2426531	hsa-miR-4485	CLIP-seq
MIRT2480076	hsa-miR-1184	CLIP-seq
MIRT802474	hsa-miR-1205	CLIP-seq
MIRT2480077	hsa-miR-1208	CLIP-seq
MIRT1936905	hsa-miR-1246	CLIP-seq
MIRT2480078	hsa-miR-1251	CLIP-seq
MIRT2480079	hsa-miR-1287	CLIP-seq
MIRT2176719	hsa-miR-1299	CLIP-seq
MIRT2480080	hsa-miR-185	CLIP-seq
MIRT2480081	hsa-miR-1912	CLIP-seq
MIRT2480082	hsa-miR-2117	CLIP-seq
MIRT2480083	hsa-miR-2355-3p	CLIP-seq
MIRT1936908	hsa-miR-3117-5p	CLIP-seq
MIRT2480084	hsa-miR-3121-3p	CLIP-seq
MIRT2480085	hsa-miR-3140-5p	CLIP-seq
MIRT2480086	hsa-miR-3148	CLIP-seq
MIRT802496	hsa-miR-3150a-3p	CLIP-seq
MIRT2480087	hsa-miR-3158-5p	CLIP-seq
MIRT2480088	hsa-miR-3175	CLIP-seq
MIRT2176724	hsa-miR-3194-3p	CLIP-seq
MIRT1936910	hsa-miR-3622b-5p	CLIP-seq
MIRT2480089	hsa-miR-3647-3p	CLIP-seq
MIRT2480090	hsa-miR-3652	CLIP-seq
MIRT2480091	hsa-miR-3662	CLIP-seq
MIRT1936913	hsa-miR-3676	CLIP-seq
MIRT2480092	hsa-miR-3681	CLIP-seq
MIRT2480093	hsa-miR-371-5p	CLIP-seq
MIRT1936914	hsa-miR-3978	CLIP-seq
MIRT2480094	hsa-miR-4261	CLIP-seq
MIRT2480095	hsa-miR-4273	CLIP-seq
MIRT2480096	hsa-miR-4287	CLIP-seq
MIRT2480097	hsa-miR-4306	CLIP-seq
MIRT1936915	hsa-miR-4318	CLIP-seq
MIRT2480098	hsa-miR-4320	CLIP-seq
MIRT2480099	hsa-miR-4427	CLIP-seq
MIRT2480100	hsa-miR-4430	CLIP-seq
MIRT2480101	hsa-miR-4469	CLIP-seq
MIRT1936916	hsa-miR-4470	CLIP-seq
MIRT2480102	hsa-miR-4501	CLIP-seq
MIRT2480103	hsa-miR-4504	CLIP-seq
MIRT2480104	hsa-miR-4505	CLIP-seq
MIRT2480105	hsa-miR-4528	CLIP-seq
MIRT2480106	hsa-miR-4539	CLIP-seq
MIRT2480107	hsa-miR-4644	CLIP-seq
MIRT2176729	hsa-miR-4652-3p	CLIP-seq
MIRT2480108	hsa-miR-4667-5p	CLIP-seq
MIRT2480109	hsa-miR-4680-3p	CLIP-seq
MIRT2480110	hsa-miR-4684-5p	CLIP-seq
MIRT2480111	hsa-miR-4685-3p	CLIP-seq
MIRT1936917	hsa-miR-4691-5p	CLIP-seq
MIRT1936918	hsa-miR-4693-5p	CLIP-seq
MIRT2480112	hsa-miR-4700-5p	CLIP-seq
MIRT2480113	hsa-miR-4709-3p	CLIP-seq
MIRT2480114	hsa-miR-4713-5p	CLIP-seq
MIRT2480115	hsa-miR-4731-5p	CLIP-seq
MIRT802528	hsa-miR-4762-3p	CLIP-seq
MIRT2480116	hsa-miR-4766-5p	CLIP-seq
MIRT2480117	hsa-miR-4778-5p	CLIP-seq
MIRT2176736	hsa-miR-4782-5p	CLIP-seq
MIRT2480118	hsa-miR-4790-3p	CLIP-seq
MIRT1936919	hsa-miR-4800-3p	CLIP-seq
MIRT1936920	hsa-miR-487a	CLIP-seq
MIRT1936921	hsa-miR-490-5p	CLIP-seq
MIRT2176740	hsa-miR-516b	CLIP-seq
MIRT1936924	hsa-miR-548al	CLIP-seq
MIRT2480119	hsa-miR-549	CLIP-seq
MIRT2480120	hsa-miR-591	CLIP-seq
MIRT1936925	hsa-miR-602	CLIP-seq
MIRT2176743	hsa-miR-664	CLIP-seq
MIRT2480121	hsa-miR-676	CLIP-seq
MIRT2480122	hsa-miR-760	CLIP-seq
MIRT2176745	hsa-miR-875-3p	CLIP-seq
MIRT2480123	hsa-miR-888	CLIP-seq
MIRT1936926	hsa-miR-892a	CLIP-seq
MIRT2480124	hsa-miR-939	CLIP-seq
MIRT1936905	hsa-miR-1246	CLIP-seq
MIRT2480084	hsa-miR-3121-3p	CLIP-seq
MIRT1936910	hsa-miR-3622b-5p	CLIP-seq
MIRT2480091	hsa-miR-3662	CLIP-seq
MIRT1936915	hsa-miR-4318	CLIP-seq
MIRT1936917	hsa-miR-4691-5p	CLIP-seq
MIRT1936918	hsa-miR-4693-5p	CLIP-seq
MIRT1936921	hsa-miR-490-5p	CLIP-seq
MIRT1936926	hsa-miR-892a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16325183, 21145461, 25416956, 28514442, 32296183, 32814053, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0016567	Process	Protein ubiquitination	IEA
GO:0035556	Process	Intracellular signal transduction	IEA

Other IDs

• MIM: 615052
• HGNC: 17182
• e!Ensembl: ENSG00000183475

Protein

• UniProt ID: Q9H672
• Protein name: Ankyrin repeat and SOCS box protein 7 (ASB-7)
• Protein function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a role in spindle
• PDB: 8Y1U
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12796	Ank_2	18 → 111	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	106 → 180	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	184 → 274	Ankyrin repeats (3 copies)	Repeat
  PF07525	SOCS_box	275 → 313	SOCS box	Domain

• Sequence:

  MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE
  RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP
  LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN
  GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT
  NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDE
  LPIAKVMKDYLKHKFDDI

• Sequence length: 318

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations