Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	139716
Gene name	GRB2 associated binding protein 3
Gene symbol	GAB3
Synonyms (NCBI Gene)	-
Chromosome	X
Chromosome location	Xq28
Summary	This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind S

151

Show/Hide all (151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018672	hsa-miR-335-5p	Microarray	18185580
MIRT022935	hsa-miR-124-3p	Microarray	18668037
MIRT1009315	hsa-miR-1260	CLIP-seq
MIRT1009316	hsa-miR-1260b	CLIP-seq
MIRT1009317	hsa-miR-1286	CLIP-seq
MIRT1009318	hsa-miR-188-3p	CLIP-seq
MIRT1009319	hsa-miR-216a	CLIP-seq
MIRT1009320	hsa-miR-302f	CLIP-seq
MIRT1009321	hsa-miR-3156-3p	CLIP-seq
MIRT1009322	hsa-miR-362-5p	CLIP-seq
MIRT1009323	hsa-miR-3934	CLIP-seq
MIRT1009324	hsa-miR-4264	CLIP-seq
MIRT1009325	hsa-miR-4704-3p	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT1009327	hsa-miR-4722-5p	CLIP-seq
MIRT1009328	hsa-miR-4797-3p	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT1009330	hsa-miR-500b	CLIP-seq
MIRT1009331	hsa-miR-501-5p	CLIP-seq
MIRT1009332	hsa-miR-515-5p	CLIP-seq
MIRT1009333	hsa-miR-1184	CLIP-seq
MIRT1009334	hsa-miR-1205	CLIP-seq
MIRT1009335	hsa-miR-1273g	CLIP-seq
MIRT1009336	hsa-miR-155	CLIP-seq
MIRT1009337	hsa-miR-2113	CLIP-seq
MIRT1009338	hsa-miR-3117-5p	CLIP-seq
MIRT1009339	hsa-miR-3158-5p	CLIP-seq
MIRT1009340	hsa-miR-346	CLIP-seq
MIRT1009341	hsa-miR-365	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT1009343	hsa-miR-3665	CLIP-seq
MIRT1009323	hsa-miR-3934	CLIP-seq
MIRT1009344	hsa-miR-4288	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009346	hsa-miR-4432	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT1009348	hsa-miR-4477a	CLIP-seq
MIRT1009349	hsa-miR-4711-3p	CLIP-seq
MIRT1009350	hsa-miR-499-5p	CLIP-seq
MIRT1009351	hsa-miR-514	CLIP-seq
MIRT1009352	hsa-miR-514b-3p	CLIP-seq
MIRT1009353	hsa-miR-526b	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT1009355	hsa-miR-592	CLIP-seq
MIRT1009356	hsa-miR-599	CLIP-seq
MIRT1009357	hsa-miR-632	CLIP-seq
MIRT1009358	hsa-miR-657	CLIP-seq
MIRT1999083	hsa-miR-3180-5p	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT1999085	hsa-miR-4267	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT1999086	hsa-miR-548aa	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT2232754	hsa-miR-1226	CLIP-seq
MIRT2232755	hsa-miR-1236	CLIP-seq
MIRT1009335	hsa-miR-1273g	CLIP-seq
MIRT2232756	hsa-miR-132	CLIP-seq
MIRT2232757	hsa-miR-212	CLIP-seq
MIRT1009338	hsa-miR-3117-5p	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT2232758	hsa-miR-377	CLIP-seq
MIRT2232759	hsa-miR-421	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT2232760	hsa-miR-4642	CLIP-seq
MIRT2232761	hsa-miR-4709-5p	CLIP-seq
MIRT1009351	hsa-miR-514	CLIP-seq
MIRT1009352	hsa-miR-514b-3p	CLIP-seq
MIRT1009353	hsa-miR-526b	CLIP-seq
MIRT1999086	hsa-miR-548aa	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT2437343	hsa-miR-1179	CLIP-seq
MIRT2437343	hsa-miR-1179	CLIP-seq
MIRT2449984	hsa-miR-22	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT2449986	hsa-miR-548v	CLIP-seq
MIRT2449987	hsa-miR-552	CLIP-seq
MIRT2449984	hsa-miR-22	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT2449986	hsa-miR-548v	CLIP-seq
MIRT2449987	hsa-miR-552	CLIP-seq
MIRT2536246	hsa-miR-1298	CLIP-seq
MIRT2536247	hsa-miR-147	CLIP-seq
MIRT2536248	hsa-miR-149	CLIP-seq
MIRT2536249	hsa-miR-193a-5p	CLIP-seq
MIRT2536250	hsa-miR-1976	CLIP-seq
MIRT2536251	hsa-miR-205	CLIP-seq
MIRT2536252	hsa-miR-2110	CLIP-seq
MIRT2536253	hsa-miR-224	CLIP-seq
MIRT2536254	hsa-miR-2467-3p	CLIP-seq
MIRT2536255	hsa-miR-3064-5p	CLIP-seq
MIRT2536256	hsa-miR-3151	CLIP-seq
MIRT2536257	hsa-miR-3155	CLIP-seq
MIRT2536258	hsa-miR-3155b	CLIP-seq
MIRT2536259	hsa-miR-3185	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT2536260	hsa-miR-3672	CLIP-seq
MIRT2536261	hsa-miR-3678-3p	CLIP-seq
MIRT2536262	hsa-miR-3690	CLIP-seq
MIRT2536263	hsa-miR-3714	CLIP-seq
MIRT2536264	hsa-miR-3911	CLIP-seq
MIRT2536265	hsa-miR-4254	CLIP-seq
MIRT2536266	hsa-miR-4268	CLIP-seq
MIRT2536267	hsa-miR-4271	CLIP-seq
MIRT2536268	hsa-miR-4283	CLIP-seq
MIRT2536269	hsa-miR-4314	CLIP-seq
MIRT2536270	hsa-miR-4438	CLIP-seq
MIRT2536271	hsa-miR-4447	CLIP-seq
MIRT2536272	hsa-miR-4472	CLIP-seq
MIRT2536273	hsa-miR-4487	CLIP-seq
MIRT2536274	hsa-miR-4489	CLIP-seq
MIRT2536275	hsa-miR-450b-5p	CLIP-seq
MIRT2536276	hsa-miR-4660	CLIP-seq
MIRT2536277	hsa-miR-4687-3p	CLIP-seq
MIRT2536278	hsa-miR-4717-3p	CLIP-seq
MIRT2536279	hsa-miR-4725-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT2536280	hsa-miR-484	CLIP-seq
MIRT2536281	hsa-miR-491-5p	CLIP-seq
MIRT2536282	hsa-miR-492	CLIP-seq
MIRT2536283	hsa-miR-513a-5p	CLIP-seq
MIRT2536284	hsa-miR-644	CLIP-seq
MIRT2536285	hsa-miR-711	CLIP-seq
MIRT2536286	hsa-miR-760	CLIP-seq
MIRT2536246	hsa-miR-1298	CLIP-seq
MIRT2681278	hsa-miR-1343	CLIP-seq
MIRT2536249	hsa-miR-193a-5p	CLIP-seq
MIRT2536250	hsa-miR-1976	CLIP-seq
MIRT2536251	hsa-miR-205	CLIP-seq
MIRT2681279	hsa-miR-3074-5p	CLIP-seq
MIRT2681280	hsa-miR-3179	CLIP-seq
MIRT2681281	hsa-miR-3202	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT2536262	hsa-miR-3690	CLIP-seq
MIRT2681282	hsa-miR-376a	CLIP-seq
MIRT2681283	hsa-miR-376b	CLIP-seq
MIRT2681284	hsa-miR-3936	CLIP-seq
MIRT2536265	hsa-miR-4254	CLIP-seq
MIRT2536269	hsa-miR-4314	CLIP-seq
MIRT2681285	hsa-miR-4464	CLIP-seq
MIRT2681286	hsa-miR-4476	CLIP-seq
MIRT2681287	hsa-miR-4748	CLIP-seq
MIRT2681288	hsa-miR-4760-3p	CLIP-seq
MIRT2536282	hsa-miR-492	CLIP-seq
MIRT2536285	hsa-miR-711	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0030225	Process	Macrophage differentiation	IEA
GO:0035591	Function	Signaling adaptor activity	IBA

MIM	HGNC	e!Ensembl
300482	17515	ENSG00000160219

Q8WWW8

Protein name

GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	6 → 117	PH domain	Domain

Sequence

MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI
DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH
LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL
PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH
GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL
DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG
QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG
SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF
LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS
ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV

Sequence length

586

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colitis	Colitis	BEFREE	30936879		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28115166		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	19430480		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	19430480		★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	Pubtator	40140746	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28291820		★★★★★ ★☆☆☆☆ Found in Text Mining only
HEMOCHROMATOSIS, TYPE 1	Hemochromatosis	BEFREE	28334935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28291820		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28115166, 28291820		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36275756	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GAB3 (GRB2 associated binding protein 3)