Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	139599
Gene name	MAGE family member E2
Gene symbol	MAGEE2
Synonyms (NCBI Gene)	HCA3
Chromosome	X
Chromosome location	Xq13.3
Summary	This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]

Show/Hide all (9)

miRTarBase ID	miRNA	Experiments
MIRT1125752	hsa-miR-4495	CLIP-seq
MIRT1125753	hsa-miR-607	CLIP-seq
MIRT1125754	hsa-miR-656	CLIP-seq
MIRT2035531	hsa-miR-1260	CLIP-seq
MIRT2035532	hsa-miR-1260b	CLIP-seq
MIRT2035533	hsa-miR-188-3p	CLIP-seq
MIRT2035534	hsa-miR-3156-3p	CLIP-seq
MIRT2035535	hsa-miR-4731-3p	CLIP-seq
MIRT2035536	hsa-miR-4801	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0007420	Process	Brain development	IEA
GO:0048854	Process	Brain morphogenesis	IEA

MIM	HGNC	e!Ensembl
300760	24935	ENSG00000186675

Q8TD90

Protein name

Melanoma-associated antigen E2 (Hepatocellular carcinoma-associated protein 3) (MAGE-E2 antigen)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01454	MAGE	95 → 264	MAGE family	Family

Sequence

MSLVSQNARHCSAEITADYGDGRGEIQATNASGSPTSMLVVDAPQCPQAPINSQCVNTSQ
AVQDPNDLEVLIDEQSRRLGALRVHDPLEDRSIALVNFMRMKSQTEGSIQQSEMLEFLRE
YSDQFPEILRRASAHLDQVFGLNLRVIDPQADTYNLVSKRGFQITDRIAESLDMPKASLL
ALVLGHILLNGNRAREASIWDLLLKVDMWDKPQRINNLFGNTRNLLTTDFVCMRFLEYWP
VYGTNPLEFEFLWGSRAHREITKMEALKFVSDAHDEEPWSWPEEYNKALEGDKTKERSLT
AGLEFWSEDTMNDKANDLVQLAISVTEEMLPIHQDELLAHTGKEFEDVFPNILNRATLIL
DMFYGLSLIEVDTSEHIYLLVQQPESEEEQVMLESLGRPTQEYVMPILGLIFLMGNRVKE
ANVWNLLRRFSVDVGRKHSITRKLMRQRYLECRPLSYSNPVEYELLWGPRAHHETIKMKV
LEYMARLYRKRPQNWPEQYREAVEDEEARAKSEATIMFFLDPT

Sequence length

523

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arteriosclerosis	Arteriosclerosis	BEFREE	30270326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	30270326		★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	26785681	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	25839160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26808385	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Funisitis (disorder)	Funisitis	BEFREE	27450900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25839160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25839160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30270326		★★★★★ ★☆☆☆☆ Found in Text Mining only

MAGEE2 (MAGE family member E2)