Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1393
Gene name	Corticotropin releasing hormone binding protein
Gene symbol	CRHBP
Synonyms (NCBI Gene)	CRF-BPCRFBP
Chromosome	5
Chromosome location	5q13.3
Summary	Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002477	hsa-miR-16-5p	proteomics analysis	18362358
MIRT909527	hsa-miR-25	CLIP-seq
MIRT909528	hsa-miR-297	CLIP-seq
MIRT909529	hsa-miR-3149	CLIP-seq
MIRT909530	hsa-miR-32	CLIP-seq
MIRT909531	hsa-miR-363	CLIP-seq
MIRT909532	hsa-miR-367	CLIP-seq
MIRT909533	hsa-miR-4783-5p	CLIP-seq
MIRT909534	hsa-miR-567	CLIP-seq
MIRT909535	hsa-miR-92a	CLIP-seq
MIRT909536	hsa-miR-92b	CLIP-seq
MIRT909537	hsa-miR-933	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
ESR1	Activation	15345745

Show/Hide all (57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001963	Process	Synaptic transmission, dopaminergic	IEA
GO:0001963	Process	Synaptic transmission, dopaminergic	ISS
GO:0002125	Process	Maternal aggressive behavior	IEA
GO:0005515	Function	Protein binding	IPI	18234674
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	1846945, 18559919
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005767	Component	Secondary lysosome	ISS
GO:0005771	Component	Multivesicular body	ISS
GO:0005783	Component	Endoplasmic reticulum	IDA	21624661
GO:0005794	Component	Golgi apparatus	IDA	21624661
GO:0005874	Component	Microtubule	ISS
GO:0006954	Process	Inflammatory response	IDA	18559919
GO:0007165	Process	Signal transduction	TAS	7477348
GO:0007565	Process	Female pregnancy	IDA	18559919
GO:0007565	Process	Female pregnancy	IEP	1846945
GO:0007611	Process	Learning or memory	TAS	7477348
GO:0009755	Process	Hormone-mediated signaling pathway	IBA
GO:0009755	Process	Hormone-mediated signaling pathway	IDA	18234674
GO:0030141	Component	Secretory granule	IDA	21624661
GO:0030425	Component	Dendrite	ISS
GO:0031045	Component	Dense core granule	ISS
GO:0035865	Process	Cellular response to potassium ion	IDA	21624661
GO:0042277	Function	Peptide binding	ISS
GO:0042445	Process	Hormone metabolic process	IEA
GO:0043196	Component	Varicosity	ISS
GO:0043204	Component	Perikaryon	ISS
GO:0043679	Component	Axon terminus	ISS
GO:0045055	Process	Regulated exocytosis	IDA	21624661
GO:0048149	Process	Behavioral response to ethanol	IMP	21039637
GO:0051424	Function	Corticotropin-releasing hormone binding	IBA
GO:0051424	Function	Corticotropin-releasing hormone binding	IDA	1846945
GO:0051424	Function	Corticotropin-releasing hormone binding	IEA
GO:0051424	Function	Corticotropin-releasing hormone binding	IPI	18234674
GO:0051459	Process	Regulation of corticotropin secretion	IDA	13150566
GO:0051460	Process	Negative regulation of corticotropin secretion	IBA
GO:0051460	Process	Negative regulation of corticotropin secretion	IDA	1846945
GO:0071277	Process	Cellular response to calcium ion	IEA
GO:0071277	Process	Cellular response to calcium ion	ISS
GO:0071314	Process	Cellular response to cocaine	ISS
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0071320	Process	Cellular response to cAMP	ISS
GO:0071356	Process	Cellular response to tumor necrosis factor	IDA	15345745
GO:0071391	Process	Cellular response to estrogen stimulus	IDA	15345745
GO:0071392	Process	Cellular response to estradiol stimulus	IDA	15345745
GO:0071392	Process	Cellular response to estradiol stimulus	IEA
GO:0071466	Process	Cellular response to xenobiotic stimulus	IEA
GO:0071466	Process	Cellular response to xenobiotic stimulus	ISS
GO:0080135	Process	Regulation of cellular response to stress	IMP	21039637
GO:0097211	Process	Cellular response to gonadotropin-releasing hormone	IEA
GO:0097211	Process	Cellular response to gonadotropin-releasing hormone	ISS
GO:1900011	Process	Negative regulation of corticotropin-releasing hormone receptor activity	IDA	18234674
GO:2000310	Process	Regulation of NMDA receptor activity	ISS

MIM	HGNC	e!Ensembl
122559	2356	ENSG00000145708

P24387

Protein name

Corticotropin-releasing factor-binding protein (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP)

Protein function

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05428	CRF-BP	1 → 307	Corticotropin-releasing factor binding protein (CRF-BP)	Family

Sequence

MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC
LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG
EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL
FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI
GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ
LEPYELENPNGNSIGEFCLSGL

Sequence length

322

Interactions

View interactions

	Reactome
			Class B/2 (Secretin family receptors)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (43)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
ACTH-Secreting Pituitary Adenoma	Pituitary adenoma	BEFREE	10768834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	18974851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety disorder	Pubtator	18974851	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	18974851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety disorder	Pubtator	18974851	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	17728670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	LHGDN	17728670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36788602	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31277598	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	23607589	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	27695045	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	9118350		★★★★★ ★☆☆☆☆ Found in Text Mining only
CNS disorder	CNS Disorder	BEFREE	9118350		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	27695045, 31570754		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	17467808, 9118350		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive disorder	Mental Depression	PSYGENET_DG	17467808, 20368512, 9118350		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyperandrogenism	Hyperandrogenism	BEFREE	30224242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	26882083		★★★★★ ★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable bowel syndrome	Pubtator	26882083	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	23607589	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	27695045	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30127978		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	14573312, 17599466		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	PSYGENET_DG	14573312		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	23607589		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31277598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	17467808, 9118350		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mental Depression	Mental Depression	PSYGENET_DG	17467808, 9118350		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mental disorders	Mental Disorders	BEFREE	21810631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	BEFREE	17599466, 17728670		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	PSYGENET_DG	17599466, 17728670		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	23607589, 30127978		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	8986836		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian diseases	Pubtator	31646556	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27695045	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Recurrent major depressive episodes	Mental Depression	BEFREE	17599466		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	23607589		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	27695045, 31570754		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	21810631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stress Disorders, Traumatic	Stress Disorder	BEFREE	31641098		★★★★★ ★☆☆☆☆ Found in Text Mining only
Unipolar Depression	Mental Depression	BEFREE	14573312		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Unipolar Depression	Mental Depression	PSYGENET_DG	14573312		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CRHBP (corticotropin releasing hormone binding protein)