Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	139105
Gene name	BEN domain containing 2
Gene symbol	BEND2
Synonyms (NCBI Gene)	CXorf20
Chromosome	X
Chromosome location	Xp22.13
Summary	This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in mul

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miRTarBase ID	miRNA	Experiments
MIRT820688	hsa-miR-1225-3p	CLIP-seq
MIRT820689	hsa-miR-1233	CLIP-seq
MIRT820690	hsa-miR-1254	CLIP-seq
MIRT820691	hsa-miR-3064-3p	CLIP-seq
MIRT820692	hsa-miR-3116	CLIP-seq
MIRT820693	hsa-miR-3180-5p	CLIP-seq
MIRT820694	hsa-miR-4327	CLIP-seq
MIRT820695	hsa-miR-4433	CLIP-seq
MIRT820696	hsa-miR-4715-3p	CLIP-seq
MIRT820697	hsa-miR-520a-5p	CLIP-seq
MIRT820698	hsa-miR-525-5p	CLIP-seq
MIRT820699	hsa-miR-526b	CLIP-seq
MIRT820700	hsa-miR-552	CLIP-seq
MIRT820701	hsa-miR-636	CLIP-seq
MIRT820702	hsa-miR-642a	CLIP-seq
MIRT820703	hsa-miR-661	CLIP-seq
MIRT820704	hsa-miR-665	CLIP-seq
MIRT820705	hsa-miR-764	CLIP-seq
MIRT820688	hsa-miR-1225-3p	CLIP-seq
MIRT820689	hsa-miR-1233	CLIP-seq
MIRT1942551	hsa-miR-1283	CLIP-seq
MIRT1942552	hsa-miR-1297	CLIP-seq
MIRT1942553	hsa-miR-1298	CLIP-seq
MIRT1942554	hsa-miR-1307	CLIP-seq
MIRT1942555	hsa-miR-1915	CLIP-seq
MIRT1942556	hsa-miR-1976	CLIP-seq
MIRT1942557	hsa-miR-26a	CLIP-seq
MIRT1942558	hsa-miR-26b	CLIP-seq
MIRT1942559	hsa-miR-3157-5p	CLIP-seq
MIRT820693	hsa-miR-3180-5p	CLIP-seq
MIRT1942560	hsa-miR-3199	CLIP-seq
MIRT1942561	hsa-miR-3924	CLIP-seq
MIRT1942562	hsa-miR-4279	CLIP-seq
MIRT820695	hsa-miR-4433	CLIP-seq
MIRT1942563	hsa-miR-4457	CLIP-seq
MIRT1942564	hsa-miR-4465	CLIP-seq
MIRT1942565	hsa-miR-4638-5p	CLIP-seq
MIRT1942566	hsa-miR-4691-3p	CLIP-seq
MIRT1942567	hsa-miR-4722-3p	CLIP-seq
MIRT1942568	hsa-miR-4726-3p	CLIP-seq
MIRT1942569	hsa-miR-513b	CLIP-seq
MIRT820697	hsa-miR-520a-5p	CLIP-seq
MIRT820698	hsa-miR-525-5p	CLIP-seq
MIRT820700	hsa-miR-552	CLIP-seq
MIRT1942570	hsa-miR-630	CLIP-seq
MIRT820703	hsa-miR-661	CLIP-seq
MIRT1942571	hsa-miR-664	CLIP-seq
MIRT820704	hsa-miR-665	CLIP-seq
MIRT1942554	hsa-miR-1307	CLIP-seq
MIRT1942556	hsa-miR-1976	CLIP-seq
MIRT2181319	hsa-miR-3155	CLIP-seq
MIRT2181320	hsa-miR-3155b	CLIP-seq
MIRT1942559	hsa-miR-3157-5p	CLIP-seq
MIRT2181321	hsa-miR-3664-5p	CLIP-seq
MIRT2181322	hsa-miR-3934	CLIP-seq
MIRT1942562	hsa-miR-4279	CLIP-seq
MIRT2181323	hsa-miR-4284	CLIP-seq
MIRT2181324	hsa-miR-4418	CLIP-seq
MIRT1942565	hsa-miR-4638-5p	CLIP-seq
MIRT2181325	hsa-miR-4639-3p	CLIP-seq
MIRT1942566	hsa-miR-4691-3p	CLIP-seq
MIRT1942567	hsa-miR-4722-3p	CLIP-seq
MIRT2181326	hsa-miR-4799-5p	CLIP-seq
MIRT2181327	hsa-miR-484	CLIP-seq
MIRT2181328	hsa-miR-509-3-5p	CLIP-seq
MIRT2181329	hsa-miR-509-5p	CLIP-seq
MIRT820700	hsa-miR-552	CLIP-seq
MIRT820690	hsa-miR-1254	CLIP-seq
MIRT1942552	hsa-miR-1297	CLIP-seq
MIRT1942555	hsa-miR-1915	CLIP-seq
MIRT1942556	hsa-miR-1976	CLIP-seq
MIRT1942557	hsa-miR-26a	CLIP-seq
MIRT1942558	hsa-miR-26b	CLIP-seq
MIRT820691	hsa-miR-3064-3p	CLIP-seq
MIRT820692	hsa-miR-3116	CLIP-seq
MIRT1942559	hsa-miR-3157-5p	CLIP-seq
MIRT1942560	hsa-miR-3199	CLIP-seq
MIRT1942562	hsa-miR-4279	CLIP-seq
MIRT820694	hsa-miR-4327	CLIP-seq
MIRT1942564	hsa-miR-4465	CLIP-seq
MIRT1942566	hsa-miR-4691-3p	CLIP-seq
MIRT820696	hsa-miR-4715-3p	CLIP-seq
MIRT1942567	hsa-miR-4722-3p	CLIP-seq
MIRT1942568	hsa-miR-4726-3p	CLIP-seq
MIRT2444776	hsa-miR-4794	CLIP-seq
MIRT820700	hsa-miR-552	CLIP-seq
MIRT820701	hsa-miR-636	CLIP-seq
MIRT820703	hsa-miR-661	CLIP-seq
MIRT820705	hsa-miR-764	CLIP-seq
MIRT820690	hsa-miR-1254	CLIP-seq
MIRT2484657	hsa-miR-129-5p	CLIP-seq
MIRT1942552	hsa-miR-1297	CLIP-seq
MIRT1942555	hsa-miR-1915	CLIP-seq
MIRT1942556	hsa-miR-1976	CLIP-seq
MIRT1942557	hsa-miR-26a	CLIP-seq
MIRT1942558	hsa-miR-26b	CLIP-seq
MIRT820691	hsa-miR-3064-3p	CLIP-seq
MIRT820692	hsa-miR-3116	CLIP-seq
MIRT2484658	hsa-miR-3149	CLIP-seq
MIRT1942559	hsa-miR-3157-5p	CLIP-seq
MIRT1942560	hsa-miR-3199	CLIP-seq
MIRT1942562	hsa-miR-4279	CLIP-seq
MIRT820694	hsa-miR-4327	CLIP-seq
MIRT1942564	hsa-miR-4465	CLIP-seq
MIRT1942566	hsa-miR-4691-3p	CLIP-seq
MIRT820696	hsa-miR-4715-3p	CLIP-seq
MIRT1942567	hsa-miR-4722-3p	CLIP-seq
MIRT1942568	hsa-miR-4726-3p	CLIP-seq
MIRT2444776	hsa-miR-4794	CLIP-seq
MIRT820700	hsa-miR-552	CLIP-seq
MIRT820701	hsa-miR-636	CLIP-seq
MIRT820703	hsa-miR-661	CLIP-seq
MIRT820705	hsa-miR-764	CLIP-seq
MIRT820690	hsa-miR-1254	CLIP-seq
MIRT2484657	hsa-miR-129-5p	CLIP-seq
MIRT1942552	hsa-miR-1297	CLIP-seq
MIRT2675946	hsa-miR-136	CLIP-seq
MIRT1942555	hsa-miR-1915	CLIP-seq
MIRT1942556	hsa-miR-1976	CLIP-seq
MIRT1942557	hsa-miR-26a	CLIP-seq
MIRT1942558	hsa-miR-26b	CLIP-seq
MIRT820691	hsa-miR-3064-3p	CLIP-seq
MIRT820692	hsa-miR-3116	CLIP-seq
MIRT2484658	hsa-miR-3149	CLIP-seq
MIRT2675947	hsa-miR-3156-5p	CLIP-seq
MIRT1942559	hsa-miR-3157-5p	CLIP-seq
MIRT1942560	hsa-miR-3199	CLIP-seq
MIRT2675948	hsa-miR-371-5p	CLIP-seq
MIRT2675949	hsa-miR-371b-5p	CLIP-seq
MIRT1942562	hsa-miR-4279	CLIP-seq
MIRT820694	hsa-miR-4327	CLIP-seq
MIRT1942564	hsa-miR-4465	CLIP-seq
MIRT1942566	hsa-miR-4691-3p	CLIP-seq
MIRT2675950	hsa-miR-4698	CLIP-seq
MIRT820696	hsa-miR-4715-3p	CLIP-seq
MIRT1942567	hsa-miR-4722-3p	CLIP-seq
MIRT1942568	hsa-miR-4726-3p	CLIP-seq
MIRT2444776	hsa-miR-4794	CLIP-seq
MIRT820700	hsa-miR-552	CLIP-seq
MIRT820701	hsa-miR-636	CLIP-seq
MIRT820703	hsa-miR-661	CLIP-seq
MIRT820705	hsa-miR-764	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	31429579
GO:0005634	Component	Nucleus	IEA

MIM	HGNC	e!Ensembl
301150	28509	ENSG00000177324

Q8NDZ0

Protein name

BEN domain-containing protein 2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10523	BEN	504 → 577	BEN domain	Domain
PF10523	BEN	689 → 762	BEN domain	Domain

Sequence

MSERTQEQDFVIITVDDSDDNNDCSIEMVEVSETADNSTNDIADDSTYVTADNPTDDTAT
QPNFPGGNDGHHRPLQMSYGSGSVTQAGVQWHDHSSLQPQPLGLKQFFHLSLPSSWDDRR
TPPCPVAHGDQIVSQINHPVHLRRYSYNSEEVDFPKRGRFYTPEVQSSISPPAERQETHA
WASPAVTSLESAACHELQEADLSESLSYPRIVSSSSLQQYVAQGGSFPCFGMPWNFISGG
AESTNAVISFANATTAVPMAVLSRRESSLANNPGVVNYSALPENENVGPGRALSSFCFHP
NLEMPERPANSSKNSTETANYPTLMGNYNGQNTASLSVFIPPYFAEKIILTEMPGTTETN
VENNSQTVYYPALSGNTSAPYPASSYLPITSNFESGPQMSYGTMSYSTEMKNNCDQDDAS
ASACLTPDFALLPLNILVKVDTNTENSVNTMNRSTLLDSDSGQDSSSSSVCIPPKYGYLG
DPKRNVRVLKIHLLAVQNMAKPKQAACYLVRILFSKEILISSSVDIHLKDSQSLDPNKMA
ALREYLATTFPTCDLHEHGKDWQDCISGINSMIYCLCSEGKSTPKTVRKNKKRTNRVASA
SADRNDQRGRDGGEGCSWMFQPMNNSKMREKRNLQPNSNAIPEGMREPSTDNPEEPGEAW
SYFGRPWRNIRMPCSVLTLAKTKSCASLSARYLIQKLFTKDVLVQSNVYGNLKHGLCALD
PNKISALREFLQENYPICDLSENGRDWKSCVTSINSGIRSLRHDVRRAEARSQSLPAVTP
PELEQESKPGDPDATDPST

Sequence length

799

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, JUVENILE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Azoospermia Nonobstructive	Nonobstructive azoospermia	Pubtator	36017582	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cushing Syndrome	Cushing syndrome	Pubtator	36690805	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35757013	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	39529180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gliosarcoma	Gliosarcoma	Pubtator	35757013	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile psoriatic arthritis	Juvenile arthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile-Onset Still Disease	Still Disease	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29348602		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	32124419, 36690805	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Negative	Seronegative polyarthritis	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Positive	Polyarthritis, Rheumatoid Factor Positive	CTD_human_DG	19565504		★★★★★ ★☆☆☆☆ Found in Text Mining only

BEND2 (BEN domain containing 2)